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51. 发明公开

EP1935419A1 HEMODYNAMICS IMPROVING AGENT 审中-公开
标题翻译： MITTEL ZUR VERBESSERUNG DERHÄMODYNAMIK
公开(公告)号：EP1935419A1
公开(公告)日：2008-06-25
申请号：EP06798165.4
申请日：2006-09-14
申请人： Ajinomoto Co., Inc.
发明人： KATSUDA, Shin-ichiro , HAZAMA, Akihiro , KOYAMA, Naoto , SUZUKI, Katsuya
IPC分类号： A61K31/4045 , A23L1/30 , A61K36/28 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , C07D209/16
CPC分类号： C07D209/16 , A23L33/10 , A23L33/105 , A61K31/4045 , A61K36/28
摘要： The invention provides a novel agent for improving hemodynamics, which prevents or improves deterioration of hemodynamics associated with aging and progression of cardiovascular diseases. An agent for improving hemodynamics, which contains a serotonin derivative as an active ingredient.
摘要翻译：本发明提供了用于改善血液动力学的新型药剂，其预防或改善与心血管疾病的老化和进展相关的血液动力学的恶化。用于改善血液动力学的药剂，其含有5-羟色胺衍生物作为活性成分。

52. 发明授权

EP1264821B1 NOVEL CRYSTAL OF STILBENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：新的结晶二苯乙烯衍生物和方法及其
公开(公告)号：EP1264821B1
公开(公告)日：2008-05-14
申请号：EP01912367.8
申请日：2001-03-14
申请人： Ajinomoto Co., Inc.
发明人： TAKAHASHI, Shinichiro Pharmaceu. Research Lab. , SUGAWARA, Yoko , MATSUEDA, Hiroyuki Pharmaceutical Research Lab.
IPC分类号： C07C237/04 , C07C231/24 , A61K31/167 , A61P35/00
CPC分类号： A61K31/167 , C07C231/24 , C07C237/08 , C07C237/04
摘要： A IV-form crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serine amide hydrochloride which can be obtained through a crystallization step employing a solvent containing at most 2 wt.% water and which, when examined by X-ray powder diffractometry, gives a pattern having peaks at least at 13.4°, 18.7°, 19.4°, and 22.5° (2υ). This compound is useful as an active ingredient for a carcinostatic agent. By the process, a crystal is obtained which has excellent properties desirable from the standpoint of the production of medicinal products, i.e., considerably reduced moisture adsorption and extremely high stability to water. Also provided are a process for producing the IV-form crystal and a method of using the crystal.

53. 发明公开

EP1873187A1 METHOD OF REMOVING RESIDUAL ETHYLENE OXIDE MONOMER FROM POLYETHYLENE OXIDE 有权
标题翻译： VERFAHREN ZUR ENTFERNUNG VON乙二醇氧基甲基丙烯酸聚氧乙烯
公开(公告)号：EP1873187A1
公开(公告)日：2008-01-02
申请号：EP06731680.2
申请日：2006-04-12
申请人： SUMITOMO SEIKA CHEMICALS CO., LTD.
发明人： KOBAYASHI, Shinji c/o SUMITOMO SEIKA CHEMICALS CO., LTD.. , TERAMOTO, Masaki c/o SUMITOMO SEIKA CHEMICALS CO., LTD. , KATOU, Makoto c/o SUMITOMO SEIKA CHEMICALS CO., LTD. , IDO, Tohru c/o SUMITOMO SEIKA CHEMICALS CO., LTD.
IPC分类号： C08G65/30
CPC分类号： C08G65/30
摘要： The present invention relates to a method of removing a residual ethylene oxide monomer in polyethylene oxide used as a raw material for pharmaceutical preparations. More particularly, the method of the present invention comprises retaining high-molecular weight polyethylene oxide particles at a temperature not higher than a crystal melting point of the polyethylene oxide in the absence of an aggregation inhibitor under an atmospheric pressure in the standing state and, then, cooling the particles to 40 °C or lower under an atmospheric pressure and in the standing state, thereby, reducing a residual ethylene oxide monomer concentration to 1 ppm or lower without influencing on physical properties such as a specific surface area of the high-molecular weight polyethylene oxide particles.
摘要翻译：本发明涉及一种去除用作药物制剂原料的聚环氧乙烷中残留的环氧乙烷单体的方法。更具体地说，本发明的方法包括在常压下在不存在聚集抑制剂的情况下，在不高于聚环氧乙烷的结晶熔点的温度下保持高分子量聚环氧乙烷粒子，然后，，在大气压下和在常压状态下将颗粒冷却至40℃或更低，从而将残留环氧乙烷单体浓度降低至1ppm或更低，而不影响物理性能如高分子量比表面积重量的聚环氧乙烷颗粒。

54. 发明公开

EP1849765A1 METHOD FOR PRODUCING PYRIMIDINE COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER PYRIMIDINVERBINDUNG
公开(公告)号：EP1849765A1
公开(公告)日：2007-10-31
申请号：EP06713355.3
申请日：2006-02-02
申请人： Ajinomoto Co., Inc.
发明人： TAKAHASHI, Daisuke c/o AJINOMOTO CO., INC. , IZAWA, Kunisuke c/o AJINOMOTO CO., INC.
IPC分类号： C07C67/31 , C07D239/38 , C07C69/738 , C07D239/42
CPC分类号： C07D239/38 , C07C67/31 , C07C69/738 , C07D239/42
摘要： Compound (II) and compound (III) are reacted to give compound (IVa) and/or compound (IVb); which are/is then reacted with compound (V) to give compound (I).

wherein X is a methylthio group and the like, R 1 and R 2 are each a lower alkyl group optionally having substituent(s), an aryl group optionally having substituent(s) and the like, R 3 is a lower alkyl group, R 4 is a hydrogen atom, a lower alkyl group optionally having substituent(s) and the like, and Q is a carboxylate group and the like.
摘要翻译：使化合物（II）和化合物（III）反应，得到化合物（IVa）和/或化合物（IVb）; 然后将其与化合物（V）反应，得到化合物（I）。其中X为甲硫基等，R 1和R 2各自为任选具有取代基的低级烷基，任选具有取代基的芳基等，R 3为低级烷基，R 4是氢原子，任选具有取代基的低级烷基等，Q是羧酸酯基等。

55. 发明公开

EP1849761A1 PROCESS FOR PRODUCTION OF 4-ACETYLPYRIMIDINES AND CRYSTALS THEREOF 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG VON 4-ACETYLPYRIMIDINEN UND KRISTALLEN DAVON
公开(公告)号：EP1849761A1
公开(公告)日：2007-10-31
申请号：EP06713353.8
申请日：2006-02-02
申请人： Ajinomoto Co., Inc.
发明人： TAKAHASHI, Daisuke c/o AJINOMOTO CO., INC. , IZAWA, Kunisuke c/o AJINOMOTO CO., INC.
IPC分类号： C07C45/64 , C07C49/255 , C07D239/26 , C07D239/38 , C07D239/42
CPC分类号： C07D239/38 , C07C45/68 , C07C45/70 , C07C49/255
摘要： Compound (II) is reacted with formate in the presence of an alkali metal alkoxide and the like to give compound (III); then this is reacted with compound (IVa) or compound (IVb) to give compound (V); then this is reacted with compound (VI) to give compound (VII); and then this is deprotected to give compound (I).
The present invention provides an industrially advantageous production method of a 4-acetylpyrimidine compound useful as a synthetic intermediate for a pharmaceutical product:

wherein X is a methylthio group and the like, R 1 is a lower alkyl group and the like, R 2 is a lower alkyl group optionally having substituent(s) and the like, M is an alkali metal and X 1 is a halogen atom.
摘要翻译：在碱金属醇盐等存在下使化合物（II）与甲酸酯反应，得到化合物（III）; 然后使其与化合物（IVa）或化合物（IVb）反应，得到化合物（V）; 然后使其与化合物（VI）反应，得到化合物（VII）; 然后将其脱保护，得到化合物（I）。本发明提供了可用作药物合成中间体的4-乙酰基嘧啶化合物的工业上有利的制备方法：其中X是甲硫基等，R 1是低级烷基等，R 2是任选具有取代基的低级烷基等，M是碱金属，X 1是卤素原子。

56. 发明公开

EP1847527A1 NOVEL BENZAMIDINE COMPOUND 审中-公开
标题翻译： NEEN BENZAMIDINVERBINDUNGEN
公开(公告)号：EP1847527A1
公开(公告)日：2007-10-24
申请号：EP06713345.4
申请日：2006-02-02
申请人： Ajinomoto Co., Inc.
发明人： TAKAYANAGI, Masaru , TAKEHANA, Shunji , OTANI, Kayo , SAITOU, Yuki
IPC分类号： C07C257/18 , A61K31/235 , A61K31/40 , A61K31/4025 , A61K31/4164 , A61K31/445 , A61K31/4545 , A61M1/14 , A61P7/02 , A61P7/08 , A61P43/00 , C07D211/46 , C07D211/62 , C07D233/26 , C07D295/12 , C07D295/20 , C07D401/04
CPC分类号： C07D401/04 , A61M1/3672 , C07C257/18 , C07D207/22 , C07D211/46 , C07D211/62 , C07D233/26 , C07D295/13
摘要： The present invention relates to a novel compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof.

wherein each symbol is as defined in the specification.
According to the present invention, an activated blood coagulation factor X inhibitor, and a novel anticoagulant for an extracorporeal blood circuit can be provided.
Moreover, the present invention relates to an anticoagulant for an extracorporeal blood circuit, which contains, as an active ingredient, an FXa selective low-molecular weight FXa inhibitor having a short half-life in blood.
摘要翻译：本发明涉及由下式（1）表示的新化合物或其药学上可接受的盐。其中每个符号如说明书中所定义。根据本发明，可以提供活化凝血因子X抑制剂和用于体外血液回路的新型抗凝血剂。此外，本发明涉及一种体外血液回路抗凝剂，其含有血液半衰期短的FXa选择性低分子量FXa抑制剂作为活性成分。

57. 发明公开

EP1832284A1 ADIPONECTIN INDUCER OR SECRETAGOGUE 审中-公开
标题翻译： MITTEL ZUR INDUKTION VON ADIPONECTIN ODER SEKRETAGOG
公开(公告)号：EP1832284A1
公开(公告)日：2007-09-12
申请号：EP05822407.2
申请日：2005-12-28
申请人： Ajinomoto Co., Inc.
发明人： TAKEHANA, Kenji, c/o AJINOMOTO CO., INC. , MITSUI, Akira, c/o AJINOMOTO CO., INC. , ISHIDA, Nozomu, c/o AJINOMOTO CO., INC. , FUKUCHI, Naoyuki, c/o AJINOMOTO CO., INC. , MAEZONO, Katsumi, c/o AJINOMOTO CO., INC.
IPC分类号： A61K31/198 , A61P1/16 , A61P3/04 , A61P3/06 , A61P9/00 , A61P9/12 , A61P29/00 , A61P43/00 , A23L1/305 , A23L2/00
CPC分类号： A61K31/198 , A23L33/175 , A61K31/519 , A61K45/06
摘要： The present invention discloses an adiponectin inducer or secretagogue which comprises an amino acid(s) selected from the group consisting of leucine, isoleucine, valine, methionine, cystein, alanine and a mixture(s) thereof, and a therapeutic agent of hypoadiponectinemia, hyperlipemia, hypertension or vascular disorders or an anti-inflammatory agent, which comprises the adiponectin inducer or secretagogue.
摘要翻译：本发明公开了一种脂联素诱导剂或促分泌素，其包含选自亮氨酸，异亮氨酸，缬氨酸，甲硫氨酸，半胱氨酸，丙氨酸及其混合物的氨基酸，以及低脂联素血症，高脂血症，高血压或血管疾病或抗炎剂，其包含脂联素诱导剂或促分泌素。

58. 发明公开

EP1808083A1 SWEETENER COMPOSITION 有权
标题翻译： SÜSSMITTELPRODUKT
公开(公告)号：EP1808083A1
公开(公告)日：2007-07-18
申请号：EP05795761.5
申请日：2005-10-14
申请人： Ajinomoto Co., Inc.
发明人： MORI, Ken-ichi, Ajinomoto Co., Inc.
IPC分类号： A23L1/22 , A23L2/60 , A23L3/3526
CPC分类号： C07D209/20 , A23L2/60 , A23L27/31 , A23L27/32 , A23L27/70 , A61K8/347 , A61K8/492 , A61K8/4926 , A61K8/498 , A61K8/60 , A61K8/676 , A61K9/0056 , A61K47/12 , A61Q11/00 , C07D403/06 , C07D405/06
摘要： The present invention provides a sweetener composition containing monatin or a salt thereof, which is undecomposable by exposure to ultraviolet light or in an acidic condition, a preservation stabilizer of monatin or a salt thereof, and a method for preserving monatin or a salt thereof. According to the present invention, a sweetener composition containing monatin or a salt thereof and a radical scavenger and the like are provided.
摘要翻译：本发明提供了含有莫纳甜或其盐的甜味剂组合物，其通过暴露于紫外线或酸性条件下是不可分解的，莫纳甜的保存稳定剂或其盐，以及保留莫纳甜或其盐的方法。根据本发明，提供含有莫纳甜或其盐和自由基清除剂等的甜味剂组合物。

59. 发明公开

EP1762213A1 MEDICINE CONTAINING SEALED BODY 有权
标题翻译： EINEN VERSCHLOSSENENKÖRPER认为MEDIKAMENT
公开(公告)号：EP1762213A1
公开(公告)日：2007-03-14
申请号：EP05728499.4
申请日：2005-04-08
申请人： Ajinomoto Co., Inc.
发明人： MIYAJIMA, Chiharu, AJINOMOTO CO., INC. , MURAMATSU, Yasuhiro, AJINOMOTO CO., INC.
IPC分类号： A61J1/10 , A61J1/05 , B65D81/32
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2024 , A61M5/162 , A61M39/1011
摘要： A medicine discharge stopper for a medical bag of a type where a multiple of medicines are mixed, aiming to positively exclude a possibility of generation of erroneous operation that administration is done without opening the mixing seal. The medical bag is formed from a soft film and has an inner space, which is divided into compartments 20 and 22. An outlet port 12 is provided so that it is opened to the first compartment 20. The stopper includes split halves, which, when tied, form an inner space 34 of the outlet port 12. The combination is done under a resilient force by cantilever fashioned extending parts 38. When the weak seal portion is opened, an impact-like hydraulic force is generated and the bag is widened, which causes the flaps 30 and 32 to be opened against the resilient force, resulting in a release of the stopper. The flaps 30 and 32 are made separable from the body parts, which allows the stopper to be also utilized for a holder of needle during the execution of infusion process.
摘要翻译：一种用于混合多种药物的医用袋药物排出塞，旨在肯定地排除在不打开混合密封的情况下进行投药的错误操作的可能性。医疗袋由软膜形成，并具有分隔成隔室20和22的内部空间。出口端口12设置成使其向第一隔间20敞开。塞子包括分开的一半，结合在一起形成出口12的内部空间34.通过悬臂形延伸部分38的弹性力进行组合。当弱密封部分打开时，产生冲击状的液压力并且袋变宽，这使得折板30和32抵抗弹性力打开，导致止动件的释放。翼片30和32可以与身体部分分离，这允许止动器在执行输注过程期间也用于针的保持器。

60. 发明授权

EP1000606B1 Weak acid skin cleanser containing an alkali salt of N-acyl-amino acid 有权
标题翻译：弱的含有N-酰基氨基酸的碱金属盐的酸性皮肤清洁剂
公开(公告)号：EP1000606B1
公开(公告)日：2007-02-14
申请号：EP99122558.2
申请日：1999-11-12
申请人： Ajinomoto Co., Inc.
发明人： Hamano, Yohei, c/o Shiseido Research Center 1, , Hayashi, Toshikatsu, c/o Shiseido Rese. Center 1, , Nakamura, Shin, c/o Shiseido Company, Ltd. , Fujiwara, Yumiko, c/o Shiseido Company, Ltd. , Namba, Tomiyuki, c/o Shiseido Company, Ltd.
IPC分类号： A61K8/365 , A61K8/44 , A61K8/60 , A61K8/86 , A61Q19/00 , A61Q19/10 , C11D1/10
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/44 , A61K8/60 , A61K8/86 , A61Q19/10

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