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41. 发明公开

EP0624580A1 Styrylcoumarin compound, photosensitive resin composition, and hologram recording medium 失效
标题翻译： Styrylcoumarin Verbindung，fotoempfindliche Harzzusammenstellung und AufzeichnungmaterialfürHologramme。
公开(公告)号：EP0624580A1
公开(公告)日：1994-11-17
申请号：EP94107227.4
申请日：1994-05-09
申请人： CANON KABUSHIKI KAISHA
发明人： Yoshinaga, Yoko, c/o Canon Kabushiki Kaisha , Matsumara, Susumu, c/o Canon Kabushiki Kaisha , Taniguchi, Naosato, c/o Canon Kabushiki Kaisha , Kobayashi, Shin, c/o Canon Kabushiki Kaisha , Sudo, Toshiyuki, c/o Canon Kabushiki Kaisha , Morishima, Hideki, c/o Canon Kabushiki Kaisha , Kaneko, Tadashi, c/o Canon Kabushiki Kaisha
IPC分类号： C07D311/16 , C07D455/04 , C07D455/02 , G03C1/73 , G03H1/02 , C07D491/16
CPC分类号： G03H1/02 , C07D311/16 , C07D455/04 , G03C1/73 , G03H2001/0264
摘要： A styrylcoumarin compound jointing a styryl group by - (C = C)n - portion and having -NR, R 2 group, wherein n is an integer of 2 to 4, and each R is a proton or an alkyl group having 1 to 10 carbon atoms. A photopolymerizable composition comprises the styrylcoumarin compound as a photosensitizer, a polymerization initiator and a polymerizable compound. A photocrosslinking composition comprises the styrylcoumarin compound as a photosensitizer, a crosslinking agent and a polymerizable compound. A volume phase hologram recording medium which comprises the styrylcoumarin compound, a crosslinking agent and a polymer comprising a carbazole.
摘要翻译：苯乙烯基香豆素化合物，其通过 - （C = C）n - 部分并具有-NR 1 R 2基团连接苯乙烯基，其中n为2至4的整数，并且每个R为质子或具有1至10个碳原子的烷基。可光聚合组合物包含作为光敏剂的苯乙烯基香豆素化合物，聚合引发剂和可聚合化合物。光交联组合物包含作为光敏剂的苯乙烯基香豆素化合物，交联剂和可聚合化合物。一种体积相全息记录介质，其包含苯乙烯基香豆素化合物，交联剂和包含咔唑的聚合物。

42. 发明公开

EP0527889A4 QUINOLIZINONE TYPE COMPOUNDS 失效
标题翻译：喹诺酮类化合物
公开(公告)号：EP0527889A4
公开(公告)日：1994-08-10
申请号：EP91909628
申请日：1991-05-01
申请人： ABBOTT LAB
发明人： CHU DANIEL T , LEE CHEUK M , LI QUN , COOPER CURT S , PLATTNER JACOB J
IPC分类号： A61K31/435 , A61K31/47 , A61K31/505 , A61K31/535 , A61K31/54 , A61K38/00 , A61P31/04 , C07D213/68 , C07D455/02 , C07D471/04 , C07D471/08 , C07D491/10 , C07D491/16 , C07D495/16 , C07D519/00 , C07K5/06
CPC分类号： C07D471/04 , A61K38/00 , C07D213/68 , C07D455/02 , C07K5/06026

43. 发明公开

EP4397665A3 DIARYL MACROCYCLE POLYMORPH 审中-实审
公开(公告)号：EP4397665A3
公开(公告)日：2024-08-21
申请号：EP24158643.7
申请日：2016-07-05
申请人： Turning Point Therapeutics, Inc.
发明人： CUI, Jingrong J. , ROGERS, Evan W.
IPC分类号： C07D491/16 , A61K31/519 , A61K31/52 , C07D491/12 , C07D491/18 , C07D498/18
CPC分类号： C07C271/16 , C07B2200/0720130101 , C07D498/18 , A61P35/00 , Y02P20/55
摘要： This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotiidecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.

44. 发明公开

EP4289851A1 CAMPTOTHECIN COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 审中-实审
公开(公告)号：EP4289851A1
公开(公告)日：2023-12-13
申请号：EP22749041.4
申请日：2022-01-27
申请人： Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
发明人： TIAN, Qiang , ZHANG, Yitao , MIAO, Yu , WANG, Bo , YE, Jian , WANG, Xiaobei , LI, Deliang , LI, Fen , SONG, Hongmei
IPC分类号： C07D491/147 , C07D491/16 , C07D491/22 , A61K31/437 , A61P35/00
摘要： The present invention relates to a Camptothecin compound having anti-tumor activity, a preparation method therefor, and an application thereof. Specifically, the present invention relates to a compound as shown below or a pharmaceutically acceptable form thereof, a pharmaceutical composition thereof, a preparation method therefor, and a use thereof. The compound can be used as a drug for treating diseases in abnormal cell proliferation,

45. 发明授权

EP2970107B1 PHOTOSWITCHABLE HDAC INHIBITORS 有权
公开(公告)号：EP2970107B1
公开(公告)日：2023-11-15
申请号：EP14774678.8
申请日：2014-03-13
发明人： MAZITSCHEK, Ralph , GHOSH, Balaram , HENDRICKS, James Adam , REIS, Surya , HAGGARTY, Stephen John
IPC分类号： C07C245/06 , C07C259/06 , C07C259/10 , C07F5/02 , C07D409/14 , C07D333/20 , A61K41/00 , A61P27/02 , A61P35/00 , C07D491/16 , C07C245/08

46. 发明授权

EP3330272B1 FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS 有权转让
公开(公告)号：EP3330272B1
公开(公告)日：2021-02-17
申请号：EP17201148.8
申请日：2014-04-18
发明人： Coleman, Paul J. , Hartingh, Timothy J. , Raheem, Izzat T. , Schreier, John , Sisko, John T. , Wai, John , Graham, Thomas , Hu, Lihong , Peng, Xuanjia
IPC分类号： C07D491/16 , C07D471/16 , C07D487/16 , A61K31/5025 , A61K31/5365 , A61P31/18

47. 发明授权

EP3274334B1 CYANATED BENZOXANTHENE AND BENZOTHIOXANTHENE COMPOUNDS 有权
公开(公告)号：EP3274334B1
公开(公告)日：2019-07-10
申请号：EP16713808.0
申请日：2016-03-24
申请人： BASF SE
发明人： KOENEMANN, Martin , WAGENBLAST, Gerhard , IVANOVICI, Sorin , MATTERN, Gabriele , MITGUDE, Martina , WEBER, Gerd
IPC分类号： C07D221/18 , C09K11/06 , H01L31/048 , H01L31/055 , H01L33/50 , C07D241/00 , H01L51/00 , C07D491/06 , C07D491/16 , C07D493/06 , C09B5/62 , C09B57/08 , H01L51/52 , C07D495/06

48. 发明公开

EP3464293A1 MOLECULAR PROBES FOR DETECTION AND IMAGING OF PANCREATIC CANCER 有权
公开(公告)号：EP3464293A1
公开(公告)日：2019-04-10
申请号：EP17803405.4
申请日：2017-05-23
申请人： Portland State University
发明人： STRONGIN, Robert, M. , SIBRIAN-VAZQUEZ, Martha , WANG, Lei , ESCOBEDO CORDOVA, Jorge, O. , LOWRY, Mark, A.
IPC分类号： C07D491/16 , C07D311/82 , G01N21/64 , G01N33/483 , C09B11/04

49. 发明公开

EP3330272A1 FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS 有权转让
公开(公告)号：EP3330272A1
公开(公告)日：2018-06-06
申请号：EP17201148.8
申请日：2014-04-18
申请人： MERCK SHARP & DOHME CORP.
发明人： Coleman, Paul J. , Hartingh, Timothy J. , Raheem, Izzat T. , Schreier, John , Sisko, John T. , Wai, John , Graham, Thomas , Hu, Lihong , Peng, Xuanjia
IPC分类号： C07D491/16 , C07D471/16 , C07D487/16 , A61K31/5025 , A61K31/5365 , A61P31/18
CPC分类号： C07D498/16 , A61K31/4985 , A61K31/5383 , A61K45/06 , C07D471/16 , C07D487/16 , C07D491/16
摘要： The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I):

and pharmaceutically acceptable salts thereof, wherein R 1 -R 8 , A, X and n are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and the Fused Tricyclic Heterocycle Derivatives for use in treating or preventing HIV infection in a subject.

50. 发明公开

EP3235876A1 QUENCHER 审中-实审转让
标题翻译：骤冷
公开(公告)号：EP3235876A1
公开(公告)日：2017-10-25
申请号：EP15870088.0
申请日：2015-12-18
申请人： Wako Pure Chemical Industries, Ltd.
发明人： SUZUKI Katsufumi , TSURUMI Yoshihisa , KAWANO Kei , IMAZEKI Shigeaki , MURASE Tetsuji
IPC分类号： C09B11/28 , C07D311/78 , C07D311/82 , C07D491/16 , C07D493/10 , C08F20/30 , G02B5/20
CPC分类号： C07D209/88 , C07D491/16 , C07D493/10 , C08F20/30 , C09B11/24 , C09B69/06 , C09B69/103 , G02B5/20
摘要： Conventional quenchers do not have quenching ability enough to suppress fluorescence emission of compounds having fluorescent property. Accordingly, it is an object of the present invention to provide a quencher capable of sufficiently quenching fluorescence of the compound having fluorescent property, including a xanthene-based dye.
The present invention relates to a quencher, or the like, comprising a compound represented by the following general formula (1):

[wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An - represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer;
and the following structure (1-10) in the general formula (1) is an asymmetric structure;

(wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).].
摘要翻译：常规猝灭剂不具有足以抑制具有荧光特性的化合物的荧光发射的猝灭能力。因此，本发明的目的是提供能够充分猝灭包括x吨系染料在内的具有荧光性的化合物的荧光的猝灭剂。本发明涉及包含由下述通式（1）表示的化合物的猝灭剂等：[其中R 5各自独立地表示卤素原子，烷基，烷氧基，烷硫基，氨基具有或不具有取代基的取代基，羟基，芳基，芳氧基或芳基烷基; R6表示具有聚合性不饱和基团，羟基等的基团; Y1表示氧原子等; An-代表阴离子; Ar1表示特定的环结构; *和**代表结合位置; Ar 2表示苯环，萘环或蒽环; n1表示特定的整数; 以及通式（1）中的以下结构（1-10）为不对称结构; （其中R5，Y1，Ar1，Ar2，n1，*和**与上述相同。）。]。

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