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    • 41. 发明公开
    • Hydroxyalkyl starch derivatives
    • Hydroxyalkylstärke衍
    • EP1398328A1
    • 2004-03-17
    • EP03020425.9
    • 2003-09-11
    • Fresenius Kabi Deutschland GmbH
    • Zander, Norbert
    • C08B31/12A61K47/48C07K14/505C07K17/10
    • C08B31/12A61K9/0021A61K38/00A61K47/61C07K14/505C07K14/53C07K14/5412C07K14/55C07K14/56C07K14/565C07K17/10C08B31/00C08B31/006C08B31/08C08B31/185C08H1/00
    • The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (1)
      at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II)

              R'-NH-R"     (II)

      wherein R 1 , R 2 and R 3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R' or R" or R' and R" comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.
    • 羟烷基淀粉衍生物的制备涉及羟基烷基淀粉在其还原端与氨基化合物的反应。 还原末端在反应之前不被氧化。 羟烷基淀粉衍生物的制备包括式(I)的羟烷基淀粉在其还原端与式R a-NH-R b(II)的氨基化合物反应。 [图像] R 1-R 3H,直链或支链羟烷基; R是在反应之前或之后能够与至少一种其它化合物反应的至少一个官能团X; R ba官能团X或W; W = -NH-,-NH-C(= G) - , - NH-C(= G)-G-,-NH-S(O)2 - 或-NH-C(= G)-NH-; X:-SH,-NH 2,-O-NH 2,-NH-O-烷基,-C(= G)-NH-NH 2,-GC(= G)-NH-NH 2,-NH-C (= G)-NH-NH 2或-S(O)2-NH-NH 2; 包括羟烷基淀粉衍生物(其中(I)与(II)的反应产物)通过(II)中的官能团X与其它化合物((II))反应的药物组合物包括独立权利要求 III)或(II)在与(I)反应之前通过官能团X与(III)反应,并且(I)和(II)的反应产物与交联化合物的反应与多肽反应)。 活动:Antianemic。 羟基乙基淀粉促红细胞生成素(HES-EPO)通过正常经络小鼠系统中的EPO生物测定法测定,其比活性为344000U / mg,比国际BRP-促红细胞生成素参考标准品的3倍。 行动机制:无给予。
    • 47. 发明公开
    • Novel starch ether derivatives, a method for the preparation thereof and their use in paper
    • 淀粉醚衍生物,它们的制备方法和它们在造纸中使用。
    • EP0025830A1
    • 1981-04-01
    • EP80104113.8
    • 1980-07-15
    • National Starch and Chemical Corporation
    • Tessler, Martin M.
    • C08B31/12D21H3/28
    • C08B31/125C07F9/3808C08B31/08
    • Starch ether derivatives are prepared by reacting a starch base with N-(2-haloethyl)iminobis (methylene)diphosphonic acid or with a N-(alkyl)-N -(2-haloethyl)aminomethylphosphonic acid. The derivatives contain aminophosphonic acid groups (or their salts) as zwitterion substituents which consist of either one or two anionic methylene phosphonic acid groups bound to a cationic nitrogen. Their cationic or anionic characteristics may be increased by introducing suitable cationic or anionic groups either by simultaneous reaction with the aminophosphonic acid reagent or by consecutive reaction either prior to or subsequent to the aminophosphonic acid reaction. They are especially useful as pigment retention aids in papermaking processes.
    • (2-卤代乙基)氨基甲基膦酸 - 淀粉醚衍生物是通过使与N-(2-卤代乙基)亚氨基双(亚甲基)二膦酸或用N-(烷基)-N淀粉碱制备。 所述衍生物含有氨基膦酸基团(或其盐)作为两性离子取代基,其由任一个或结合于阳离子氮2个阴离子亚甲基膦酸基团。 其阳离子或阴离子特性可通过调节或者通过与氨基膦酸试剂同时反应或通过之前或之后的氨基膦酸反应连续反应引入适宜的阳离子或阴离子基团而增加。 他们的爱情如造纸过程中的色素助留剂特别有用。