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41. 发明授权

EP0675730B1 THERAPEUTIC COMBINATION CONTAINING INTERFERON 失效
标题翻译：治疗组合制备含干扰素
公开(公告)号：EP0675730B1
公开(公告)日：2001-03-14
申请号：EP94902910.2
申请日：1993-12-20
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： PRIETO VALTUENA, Jesus , BELOQUI RUIZ, Oscar
IPC分类号： A61K38/21 , A61K38/06
CPC分类号： A61K38/21 , A61B17/320725 , A61B17/32075 , A61B17/3211 , A61B17/3417 , A61B17/3474 , A61B17/3476 , A61B17/3496 , A61B18/1487 , A61B2018/0019 , A61K31/195 , A61K38/063 , A61K38/212 , A61K45/06 , A61M13/003 , A61K2300/00 , A61K38/06
摘要： The present invention relates to a therapeutic combination therapy involving the use of human interferon. The therapy involves the treatment of conditions susceptible to treatment with human interferon, with a combination of a human interferon and a free radical scavenger or precursor or inducer.

42. 发明授权

EP0764037B1 LOCALLY FLEXIBLE DILATOR SHEATH 失效
标题翻译： LOCAL灵活DILATORHÜLSE
公开(公告)号：EP0764037B1
公开(公告)日：2000-08-09
申请号：EP95923724.9
申请日：1995-06-05
申请人： COOK PACEMAKER CORPORATION
发明人： GOODE, Louis , LUI, Chun Kee
IPC分类号： A61N1/05 , A61B17/22
CPC分类号： A61N1/057 , A61B17/221 , A61B17/320016 , A61B17/32053 , A61B17/320708 , A61B17/32075 , A61B17/3468 , A61B2017/00243 , A61B2017/00247 , A61B2017/00292 , A61B2018/00392 , A61N1/056 , A61N2001/0578
摘要： A locally flexible dilator sheath (10) for separating encapsulating tissue from an implanted cardiac electrical lead. The dilator sheath includes an elongated tubular member (11) of a rigid stainless steel material, which is sized for placement of the tubular member over a cardiac lead that is implanted in the vascular system of a patient. The distal end (13) of the rigid tubular member is beveled to ease the separation of extremely tough tissue that encapsulates an implanted cardiac lead. To ease insertion around curves in the vascular system of the patient, the elongated tubular member includes a relieved portion (14). The relieved portion includes a relief pattern (15) of apertures (16, 17, 19, 23) in the elongated tubular member. The relief apertures preferably include diametrically opposed slots (24, 25) that extend perpendicularly into the tubular member. Adjacent pairs (44, 45) of slots are circumferentially offset at 90° angle (26) to add further lateral flexiblity to the relieved portion. A polyester shrink tube (41) surrounds the relief apertures to provide integrity to the tubular member should the tubular member fracture when separating encapsulating tissue from the implanted lead.

43. 发明公开

EP0836431A4 UNITARY REMOVAL OF PLAQUE 失效
标题翻译：斑块均匀的移除
公开(公告)号：EP0836431A4
公开(公告)日：1999-12-01
申请号：EP96908673
申请日：1996-02-22
申请人： ENDOVASCULAR INSTR INC
发明人： KELLY THOMAS L , WIITA THOMAS A
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61M29/02
CPC分类号： A61B17/32075 , A61B17/320758 , A61B17/320783 , A61B2017/00473 , A61B2017/00685 , A61B2017/22038 , A61B2017/22094 , A61B2017/320008 , A61B2017/320044 , A61M25/104
摘要： Novel apparatus (20) and related methods are disclosed by which plaque is connected to the head (34) of a removal instrument (20) for removal of a unitary segment of plaque from an artery intact to increase blood flow through the artery.

44. 发明公开

EP0855879A4 APPARATUS AND METHOD FOR DISRUPTING VEIN VALVES 失效
标题翻译： VORRICHTUNG UND VERFAHREN ZUM UNTERBRECHEN VON VENENKLAPPEN
公开(公告)号：EP0855879A4
公开(公告)日：1999-03-10
申请号：EP96936723
申请日：1996-10-17
申请人： APPLIED MED RESOURCES
发明人： HART CHARLES C , CHI SING EDUARDO , ASHBY MARK P
IPC分类号： A61B17/22
CPC分类号： A61B17/32075 , A61B2017/22097
摘要： A valvulotome for disrupting valve cusps in the vein of a patient includes a shaft (14) and a cutting member (12) which extends along an axis that defines an axial direction as well as an angular direction. First and second portions of the cutting member define respective cutting edges which extend outwardly of the axis in an angular relationship and an axial relationship with each other. The first and second cutting edges engage and disrupt different cusps of the valve when the shaft is withdrawn axially from the vein. Each of the cutting edges is protected by a proximate shoulder (123) which inhibits the engagement of side branches by the associated cutting edge. The cutting member may be formed as a helical blade, a wire or a cylinder and may be provided with a swivel coupling (158) as well as a sheath (131) operable to cover or expose the cutting member.
摘要翻译：用于破坏患者静脉中的瓣膜瓣膜的瓣膜刀包括轴（14）和沿限定轴向和角度方向的轴延伸的切割构件（12）。切割构件的第一部分和第二部分限定相应的切割边缘，所述切割边缘以彼此成角度关系和轴向关系的方式从所述轴线向外延伸。当轴从静脉轴向抽出时，第一和第二切割边缘接合并破坏瓣膜的不同尖端。每个切割边缘由一个邻近的肩部（123）保护，该肩部阻止相关切割边缘与侧分支的接合。切割构件可以形成为螺旋叶片，线或圆柱体并且可以设置有旋转接头（158）以及可操作以覆盖或暴露切割构件的护套（131）。

45. 发明授权

EP0616793B1 Instrument médical pour l'élimination de dépôts formés sur les parois intérieures des artères ou des veines 失效
标题翻译：动脉或静脉的内壁上的医疗器械，用于去除沉积物
公开(公告)号：EP0616793B1
公开(公告)日：1996-01-03
申请号：EP93810602.8
申请日：1993-08-24
申请人： FERROMEC S.A.
发明人： Kropf, Laurent , Baumgartner, Hugues , Damone, Umberto
IPC分类号： A61B17/22
CPC分类号： A61B17/32075 , A61B17/320725 , A61B2017/22074

46. 发明公开

EP0479433A2 Tissue excision catheter system 失效
标题翻译： Kathetersystem zur Entnahme von Gewebe。
公开(公告)号：EP0479433A2
公开(公告)日：1992-04-08
申请号：EP91308146.9
申请日：1991-09-05
申请人： Fischell, Robert E.
发明人： Fischell, Robert E.
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/132 , A61B17/32075
摘要： A tissue excision catheter system is described, e.g. an atherectomy catheter, that is capable of creating an opening through obstructing tissue in a blood vessel that is greater than the outside diameter of the catheter. The system comprises the combination of:

(i) a catheter sub-assembly (10) carrying at its distal end a cutting head (30) that can be inserted through the plaque and then retracted so as to excise the obstructing tissue by means of a rearwardly directed cutting edge (32a), and
(ii) and inflatable cuff (22) that can be placed around the limb and inflated so as to compress the blood vessel at the site of the obstruction during the excision of the obstructing tissue. Following that excision the pressure is released so that the blood vessel expands back to its normal diameter, thereby creating a passageway through the tissue that is greater than the diameter of the cutting edge. Preferably the catheter sub-assembly comprises a central member (45) that is stationary relative to the cutting head and which determines the extend of collapse of the blood vessel under the applied pressure thereby to determine the precise thickness of the layer of tissue removed by virtue of the radial distance of the cutting edge (32a) from the stationary member (45).
摘要翻译：组织切除导管系统如下描述。动脉粥样硬化切除术导管，其能够通过阻塞血管中的组织而形成开口，所述组织大于导管的外径。该系统包括以下组合：（i）导管子组件（10），其导管子组件（10）在其远端承载切割头（30），切割头（30）可插入通过牙斑，然后缩回以便通过以下方式切除阻塞组织向后定向的切割边缘（32a）和（ii）和可充气的袖带（22），其可以放置在肢体周围并且被充气以便在切除阻塞性组织期间在阻塞部位压缩血管。在切除之后，释放压力使得血管膨胀回其正常直径，由此产生通过组织的通道，其大于切割边缘的直径。优选地，导管子组件包括相对于切割头静止的中心构件（45），并且在施加的压力下确定血管的塌陷的延伸，从而确定通过美德去除的组织层的精确厚度的切割边缘（32a）与固定构件（45）的径向距离。

47. 发明公开

EP0436149A1 Venenklappenschneidmesser 失效
标题翻译： Venenklappenschneidmesser。
公开(公告)号：EP0436149A1
公开(公告)日：1991-07-10
申请号：EP90123708.1
申请日：1990-12-10
申请人： OLYMPUS OPTICAL CO. (EUROPA) GMBH
发明人： Stierli, Peter, Dr.
IPC分类号： A61B17/32 , A61B17/22
CPC分类号： A61B17/32075 , A61B17/320016 , A61B2017/22097
摘要： Ein Messer zum Aufschneiden von Venenklappen (3) mit einem langen, dünnen, einen Kanal aufweisenden Schaft (4) und einer an dessen distalem Ende radial abstehend angeordneten Klinge (5) mit rückwärts gerichteter Schneide (6) ist dadurch gekennzeichnet, daß der Kanal als am distalen Ende mit gekrümmtem Übergang seitlich abgewinkelter Arbeitskanal ausgebildet ist.
摘要翻译：一种用于切割静脉瓣（3）的切割器，其具有带有通道的长而细的轴（4），并且具有在其远端径向突出并具有向后定向的切割刃（6）的刀片（5），其特征在于该通道被设计为在远端具有弯曲过渡的横向成角度的操作通道。

48. 发明公开

EP0394260A1 ATHERECTOMY DEVICE AND METHOD 失效
标题翻译： DEVICE FOR旋切术。
公开(公告)号：EP0394260A1
公开(公告)日：1990-10-31
申请号：EP88906478.0
申请日：1988-07-05
申请人： DEVICES FOR VASCULAR INTERVENTION, INC.
发明人： GIFFORD, Hanson, S. , SIMPSON, John, B. , BROWN, Peter, S.
IPC分类号： A61B17
CPC分类号： A61B17/320758 , A61B17/32075 , A61B2017/22038
摘要： Le cathéter pour athérectomie décrit, qui sert à éliminer l'accumulation de plaque sur les parois d'un vaisseau sanguin, comprend une unité coupante portée à proximité de l'extrémité distale d'un élément tubulaire flexible (12), lequel peut être introduit dans un vaisseau sanguin et dirigé vers l'occlusion. L'unité coupante comporte un couteau (4) présentant une surface coupante annulaire s'étendant vers l'avant (5). Une unité d'actuateur proximale (3) est destinée à imprimer un mouvement à la fois rotatif et axial au couteau (4). Un fil de guidage (8), pourvu d'une extrémité à ressort flexible (22) s'étend à l'avant du couteau (4) et sert à guider le couteau lors de son avance axiale dans l'artère. La totalité de la plaque athéromateuse retirée est recueillie à l'intérieur du dispositif et un élément de retenue (20) porté par le fil de guidage (8) et placé à l'avant du couteau forme un couvercle servant à retenir la plaque athéromateuse recueillie. Dans un mode de réalisation décrit, l'élément de retenue est expansible.

49. 发明授权

EP2906128B1 SURGICAL CUTTING INSTRUMENT 有权转让
标题翻译：手术切割器械
公开(公告)号：EP2906128B1
公开(公告)日：2018-04-04
申请号：EP13783167.3
申请日：2013-10-10
申请人： Ethicon LLC
发明人： KOCH, Robert L., Jr. , BECKMAN, Andrew T. , THOMPSON, Eric W. , CLAIR, Rachel M.
IPC分类号： A61B17/072 , A61B17/3207
CPC分类号： A61B17/07207 , A61B17/32075 , A61B2017/07285
摘要： A surgical cutting instrument includes a first jaw member, a second jaw member movably supported relative to the first jaw member for selective movement between an open position and a closed position to clamp tissue therebetween upon application of a closing motion thereto, and a cutting member comprising a tissue cutting edge to cut the tissue clamped between the first jaw member and the second jaw member upon application of a retraction motion to the cutting member.

50. 发明公开

EP3215034A1 A THROMBECTOMY DEVICE 审中-公开
标题翻译：一个THROMBECTOMY设备
公开(公告)号：EP3215034A1
公开(公告)日：2017-09-13
申请号：EP15801693.1
申请日：2015-11-06
申请人： National University of Ireland Galway
发明人： BRUZZI, Mark , HENEGHAN, Paul , KASIRI GHAHI, Saeid , O'SULLIVAN, Gerard
IPC分类号： A61B17/3207 , A61B17/221 , A61B17/22
CPC分类号： A61B17/320758 , A61B17/22004 , A61B17/221 , A61B17/320725 , A61B17/32075 , A61B2017/00685 , A61B2017/00867 , A61B2017/22067 , A61B2017/22079 , A61B2017/22084 , A61B2017/2212 , A61B2017/320766 , A61B2017/320775 , A61B2090/034
摘要： A thrombectomy device for removing thrombus from a body lumen comprises an elongated catheter member (2) having a distal part and a proximal part, a thrombus blocking body (5) disposed on the distal part of the catheter member and radially expansible between a contracted orientation and an expanded, thrombus-blocking, orientation, a thrombus capture body (3) disposed on the distal part of the catheter member in an axially spaced-apart relationship to the thrombus blocking body, and radially expansible between a contracted orientation and an expanded, thrombus-capture, orientation, deployment means actuable to deploy and retract the thrombus capture body and thrombus blocking body; and an elongated control arm operably connected to the thrombus capture body. The thrombus capture body is a cage having an inwardly tapering leading end, the elongated control arm is operably connected to the leading end of the cage, and a thrombus extractor or macerator mechanism is disposed within the cage.
摘要翻译：一种用于从体腔去除血栓的血栓切除装置包括具有远端部分和近端部分的细长导管部件（2），布置在导管部件的远端部分上并可在收缩方位之间径向膨胀的血栓阻塞体（5）以及膨胀的血栓阻塞取向;布置在导管构件的远侧部分上的血栓捕获体（3），其与血栓阻塞体轴向间隔开，并且在收缩的取向与扩张的血栓阻塞体之间可径向膨胀; 血栓捕获，取向，展开装置，其可致动以展开和缩回血栓捕获体和血栓阻塞体; 和可操作地连接到血栓捕获体的细长控制臂。血栓捕获体是具有向内逐渐变细的前端的笼，细长的控制臂可操作地连接到笼的前端，并且血栓抽取器或浸软机构布置在笼内。

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