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    • 49. 发明公开
    • GRAFT POLYMER AND MOLDINGS THEREOF FOR MEDICAL SUPPLY
    • PFROPFPOLYMERE UND DEREN VERWENDUNG in MEDISINISCHER APPARATUR
    • EP0952168A1
    • 1999-10-27
    • EP97909734.2
    • 1997-11-04
    • TORAY INDUSTRIES, INC.
    • TANAHASHI, Kazuhiro
    • C08F291/00A61L2/16
    • C08F291/00A01N25/10A01N37/12A61L27/16A61L27/18A61L27/34A61L27/54A61L29/041A61L29/085A61L31/16A61L2300/208A61L2300/404C08F259/04C08L33/14C08L101/02
    • The present invention relates to graft polymer which is characterized in that it is formed by graft polymerization of structural units containing a quaternary ammonium group represented by general formula (A),


      (R 2 and R 3 each represent an alkyl group with from 1 to 3 carbons, and R 4 represents an alkyl group with from 3 to 18 carbons. X represents at least one type of ion selected from halogen, sulphate, hydroxide and carboxylic acid ions.),
      preferably to graft polymer where the structural units containing a quaternary ammonium group represented by general formula (A) are structural units which are represented by general formula (I),

      (R 1 represents at least one species selected from hydrogen, the methyl group and the ethyl group, and n represents an integer in the range 1 to 12. A represents at least one species selected from O, S and NR 5 . R 5 represents hydrogen or an alkyl group with 1 to 12 carbons.) or
      graft polymer formed by the graft polymerization of structural units containing a quaternary ammonium group and structural units containing an alkoxypolyalkylene glycol moiety represented by the general formula (B),

              -(R 5 O) n R 6      (B)


      (n represents an integer in the range 1 to 100. R 5 represents a straight-chain or branched alkylene group with from 1 to 4 carbons, and R 6 represents at least one species selected from hydrogen and straight-chain or branched alkyl groups with from 1 to 4 carbons.).

      By applying or incorporating the graft polymer to/in medical devices which are left in the body for a long period, it is possible to prevent microbial infection arising via these medical devices.
    • 本发明涉及接枝聚合物,其特征在于其通过含有由通式(A)表示的季铵基的结构单元的接枝聚合,(R2和R3各自表示烷基,从1至 3个碳,R4表示碳原子数为3〜18的烷基,X表示选自卤素,硫酸根,氢氧根和羧酸离子中的至少一种离子),优选为含有季铵的结构单元的接枝聚合物 由通式(A)表示的基团是由通式(I)表示的结构单元,(R 1表示选自氢,甲基和乙基中的至少一种,n表示 A表示选自O,S和NR5中的至少一种,R 5表示氢或具有1至12个碳的烷基)或通过结构单元的接枝聚合形成的接枝聚合物 (B)表示的烷氧基聚亚烷基二醇部分的结构单元, - (R5O)nR6(n表示1〜100的整数。R5表示直链或支链亚烷基 具有1至4个碳,并且R 6表示选自氢和具有1至4个碳的直链或支链烷基中的至少一种。 通过将移植物聚合物施用或并入长时间留在体内的医疗装置中,可以防止通过这些医疗装置产生的微生物感染。