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41. 发明公开

EP2321406A1 METHOD FOR SELECTING SECONDARY NEUROSPHERE DERIVED FROM DIFFERENTIATED CELL-DERIVED PLURIPOTENT STEM CELL, CLONE SELECTED BY THE METHOD AND USE OF THE CLONE 有权
标题翻译：一种用于选择二次NEURO SPHERE从细胞诱导多能干细胞
公开(公告)号：EP2321406A1
公开(公告)日：2011-05-18
申请号：EP09804740.0
申请日：2009-08-05
申请人： Keio University , Kyoto University
发明人： OKANO, Hideyuki , TSUJI, Osahiko , NAKAMURA, Masaya , YAMANAKA, Shinya , MIURA, Kyoko
IPC分类号： C12N5/00 , G01N33/48
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/385 , C12N2501/60 , C12N2506/45 , C12N2510/00 , C12Q1/6886 , C12Q2600/158
摘要： In order to provide a therapeutic agent for nerve injury which contains iPS-derived neural stem cells and has low or no risk of side effects, as well as a method for treating a nerve injury using the iPS cells, by efficiently establishing in vivo the iPS-derived neural stem having low or no risk of tumor formation, neurospheres are formed following formation of embryoid bodies from the iPS cells, and a clone whose ratio of cells in which the promoter of Nanog gene is activated is 0.01% or less is selected, and the clone is administered to a patient suffering from the nerve injury.

42. 发明公开

EP2302077A1 PSMB9 is a marker of immunological tolerance and transplant rejection 审中-公开
标题翻译： PSMB9 ist ein Marker von immunologischer Toleranz und Transplantsabstossung
公开(公告)号：EP2302077A1
公开(公告)日：2011-03-30
申请号：EP10182282.3
申请日：2005-05-30
申请人： Keio University
发明人： Tanigawara, Yusuke , Iketani, Osamu , Mihara, Kiyoshi
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/50
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N2333/4703 , G01N2333/82 , G01N2333/96466 , G01N2800/245
摘要： [PROBLEMS]
To provide a gene marker which enables diagnosis of rejection, evaluation of the efficacy of an immunosuppressive agent, and determination of the presence or absence of immunological tolerance; methods that can be performed in a quick, simple, and convenient manner by using a gene marker as an indicator for diagnosing rejection, evaluating the efficacy of an immunosuppressive agent, identifying an immunosuppressive agent, selecting an immunosuppressive agent, determining the dose of an immunosuppressive agent, and judging the presence or absence of immunological tolerance; and a kit.
[MEANS FOR SOLVING PROBLEMS]
Immune-related genes whose expression levels were increased by 1.5-fold or more because of rejection and whose expression levels were decreased by 1.5-fold or more because of immunosuppressive agents have been identified as gene markers. By using the expression level of one of these gene markers as an indicator, it becomes possible to diagnose rejection, evaluate the efficacy of an immunosuppressive agent, and judge the presence or absence of immunological tolerance in a quick, simple, and convenient manner.
摘要翻译： [问题]提供能够诊断排斥，评估免疫抑制剂的功效和测定有无免疫耐受性的基因标记物。可以通过使用基因标记物作为诊断排斥反应的指标，评估免疫抑制剂的功效，鉴定免疫抑制剂，选择免疫抑制剂，确定免疫抑制剂的剂量的方法，可以以快速，简单和方便的方式进行代理，判断是否存在免疫耐受; 和一个工具包。用于解决问题的手段由于排斥，其表达水平由于免疫抑制剂而降低了1.5倍以上的免疫相关基因已经被鉴定为基因标记。通过使用这些基因标记之一的表达水平作为指标，可以诊断排斥反应，评价免疫抑制剂的功效，并以快速，简单和方便的方式判断免疫耐受性的有无。

43. 发明公开

EP2241334A1 METHOD FOR DETERMINATION OF SENSITIVITY TO ANTI-CANCER AGENT 审中-公开
标题翻译： VERFAHREN ZUR BESTIMMUNG DER EMPFINDLICHKEITGEGENÜBEREINEM ANTI-KREBS-MITTEL
公开(公告)号：EP2241334A1
公开(公告)日：2010-10-20
申请号：EP09706388.7
申请日：2009-01-30
申请人： Keio University , Kabushiki Kaisha Yakult Honsha
发明人： TANIGAWARA, Yusuke , SUZUKI, Sayo , SUGIMOTO, Shinji
IPC分类号： A61K45/00 , A61K31/282 , A61P35/00 , A61P43/00 , G01N27/62 , G01N33/15 , G01N33/50 , G01N33/574
CPC分类号： A61K31/282 , A61K45/06 , G01N33/5011 , G01N33/57484 , G01N2333/4727 , G01N2800/52 , A61K2300/00
摘要： Provided are an marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a calcium-binding protein S100A7, S100A8, or S100A10.
摘要翻译：提供了用于确定对能够区分个体患者的治疗反应的抗癌剂的敏感性的标记和使用该标记的癌症治疗的新手段。用于确定对抗癌剂的敏感性的标记物含有钙结合蛋白S100A7，S100A8或S100A10。

44. 发明公开

EP2237042A1 MARKER FOR DETERMINATION OF SENSITIVITY TO ANTI-CANCER AGENT 有权
标题翻译： MARKER ZUR BESTIMMUNG DER EMPFINDLICHKEITFÜREIN ANTIKREBSMITTEL
公开(公告)号：EP2237042A1
公开(公告)日：2010-10-06
申请号：EP09705658.4
申请日：2009-01-30
申请人： Keio University , Kabushiki Kaisha Yakult Honsha
发明人： TANIGAWARA, Yusuke , WATANABE, Mitsuhiro , ARITA, Eri , NISHIMUTA, Akito , YAMAYOSHI, Yasuko , MATSUZAKI, Takeshi , SUGIMOTO, Shinji
IPC分类号： G01N33/68 , A61K31/4745 , A61K45/00 , A61P35/00 , G01N27/447 , G01N27/62 , G01N33/15 , G01N33/50
CPC分类号： A61K31/4745 , A61K45/06 , G01N33/5011 , G01N33/6812 , G01N2800/52 , Y10S436/813 , A61K2300/00
摘要： Provided are a marker for determining sensitivity to an anticancer agent capable of distinguishing a therapeutic response of an individual patient and a novel means for a cancer therapy using the marker. The marker for determining sensitivity to an anticancer agent contains a substance in a metabolic pathway in which L-phenylalanine and/or N,N-dimethyl glycine are/is involved.
摘要翻译：提供了用于确定对能够区分个体患者的治疗反应的抗癌剂的敏感性的标记和使用该标记的癌症治疗的新手段。用于确定对抗癌剂的敏感性的标记物含有涉及L-苯丙氨酸和/或N，N-二甲基甘氨酸的代谢途径中的物质。

45. 发明公开

EP2130911A1 Feeder cell derived from tissue stem cell 审中-公开
标题翻译： Feeder-Zellen，aus Gewebestammzellen
公开(公告)号：EP2130911A1
公开(公告)日：2009-12-09
申请号：EP09012264.9
申请日：2007-01-17
申请人： Keio University
发明人： Shimmura, Shigeto , Miyashita, Hideyuki , Yoshida, Satoru , Tsubota, Kazuo
IPC分类号： C12N5/06 , A61F2/14 , A61L27/00
CPC分类号： A61K35/28 , A61K35/12 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0623 , C12N5/0656 , C12N2500/25 , C12N2501/11 , C12N2501/39 , C12N2501/81 , C12N2502/03 , C12N2502/08 , C12N2506/08 , C12N2509/00 , C12N2533/56
摘要： It is an object of the present invention to provide a feeder cell with less variation in quality. The present invention relates to a feeder cell derived from a tissue stem and/or progenitor cell. A method of preparation of the feeder cell, a method of preparation of a cultured cell using the feeder cell, and a cell culturing kit are also provided.
摘要翻译：本发明的目的是提供一种质量变化较小的饲养池。本发明涉及源自组织干细胞和/或祖细胞的饲养细胞。还提供了饲养细胞的制备方法，使用饲养细胞的培养细胞的制备方法和细胞培养试剂盒。

46. 发明公开

EP2112817A1 COMPOSITION ANALYSIS METHOD, IMAGE DEVICE HAVING COMPOSITION ANALYSIS FUNCTION, COMPOSITION ANALYSIS PROGRAM, AND COMPUTER-READABLE RECORDING MEDIUM 审中-公开
标题翻译：成分分析法，用成分分析功能，成分分析程序和记录介质的计算机可读成像装置
公开(公告)号：EP2112817A1
公开(公告)日：2009-10-28
申请号：EP08792004.7
申请日：2008-07-31
申请人： Keio University , Olympus Corporation
发明人： SAKAMOTO, Yasuhiro , INAKAGE, Masahiko , HARADA, Kentaro
IPC分类号： H04N1/387 , G06T7/00 , G06T13/00 , H04N5/225
CPC分类号： H04N1/3872 , G06K9/00624 , G06T7/0002 , G06T11/60 , G06T13/80
摘要： A technology is disclosed for easily executing a compositional analysis to obtain a preferred composition. Image data is acquired (S1), the image data is analyzed, and a plurality of composition lines expressing the feature of the image data on the composition are acquired (S6). On the composition formed of the plurality of acquired composition lines, the ratio of lengths of two sides selected from the plurality of sides in the region partitioned by the plurality of composition lines is detected to be a specified value (for example, the golden ratio) (S7).
摘要翻译：甲技术是游离缺失盘用于容易地执行构图分析以获得优选的组合物。图像数据被获取（S1）时，图像数据被分析，和表达的该组合物的图像数据的特征的组合物线。多个被获取（S6）。形成获取的构图线的多个组合物中，检测到双方从侧面在由构图线的多个隔开的区域中的多个所选择的长度的比率为规定值（例如，黄金比例）（S7）。

47. 发明公开

EP2065422A1 RICINOLEIC ACID POLYESTER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF 审中-公开
标题翻译：蓖麻酸聚酯组合物及其生产方法
公开(公告)号：EP2065422A1
公开(公告)日：2009-06-03
申请号：EP07806680.0
申请日：2007-09-04
申请人： Keio University
发明人： EBATA, Hiroki , MATSUMURA, Shuichi
IPC分类号： C08G63/06 , C08G63/82 , C12P7/62
CPC分类号： C08G63/06 , C08G63/82 , C08L67/06 , C12P7/625 , C08K3/011
摘要： A process is disclosed wherein ricinoleic acid from petroleum alternative vegetable castor oil that has a hydroxyl group at the 12-position or a derivative thereof (an ester or a hydrogenated compound thereof) is polymerized in the presence of a synthetic zeolite and an immobilized lipase at around normal temperature without using any harmful polymerization catalysts or organic solvents which can cause environmental pollution whereby a polyester useful in the industry that has a weight average molecular weight of 20,000 or more is obtained. This high-molecular weight polyester is crosslinked to give a crosslinked elastomers that is comparable to synthetic rubbers.
摘要翻译：公开了一种方法，其中将在12位具有羟基的石油替代植物蓖麻油中的蓖麻油酸或其衍生物（酯或其氢化化合物）在合成沸石和固定化脂肪酶的存在下聚合而无需使用任何可导致环境污染的有害聚合催化剂或有机溶剂，从而获得重均分子量为20,000或更高的工业中有用的聚酯。该高分子量聚酯交联得到与合成橡胶相当的交联弹性体。

48. 发明公开

EP2025354A1 AGENT FOR PREVENTING ORGAN ADHESION AND METHOD FOR PREVENTING ADHESION USING THE SAME 审中-公开
标题翻译： MITTEL ZUR PRAVENTION VONORGANADHÄSION
公开(公告)号：EP2025354A1
公开(公告)日：2009-02-18
申请号：EP07743205.2
申请日：2007-05-11
申请人： Keio University , Meiji Seika Kaisha Ltd.
发明人： IZUMI, Yotaro , KAWAMURA, Masafumi , KOBAYASHI, Koichi , ENDO, Takeshi , NAGAI, Atsushi , SHICHINOHE, Makoto
IPC分类号： A61L31/00 , A61K31/785 , A61P7/04 , A61P41/00
CPC分类号： A61K31/785 , A61L31/06 , C08L77/04
摘要： There is disclosed an organ-adhesion preventing agent comprising a chemically-crosslinked γ-polyglutamic acid as an effective ingredient, as well as a process for preventing organ from adhesion comprising a step of bringing the adhesion-preventing agent into contact with or depositing the same onto the surface of a local organ and optionally the neighborhood thereof to be prevented from the post-operative adhesion. According to the present invention, there is provided an adhesion-preventing agent which is capable of effectively preventing the surfaces of organs from adhesion, and which can be absorbed in the body with high safety and be produced with ease and has high practical usefulness, as well as a process for preventing organ from adhesion by using the adhesion-preventing agent.
摘要翻译：公开了一种包含化学交联的3-聚谷氨酸作为有效成分的器官粘附防止剂，以及防止器官粘连的方法，包括使粘附防止剂与其接触或沉积的步骤到局部器官的表面上，并且可选地，其附近被防止术后粘连。根据本发明，提供了一种能够有效地防止器官表面粘附的粘合防止剂，其能够以高安全性被吸收在身体中并且易于制造并且具有高实用性，如以及通过使用防粘连剂防止器官粘连的方法。

49. 发明公开

EP2003447A2 METHOD FOR MEASURING PROTEIN 审中-公开
标题翻译： PROTEINMESSVERFAHREN
公开(公告)号：EP2003447A2
公开(公告)日：2008-12-17
申请号：EP07740305.3
申请日：2007-03-29
申请人： Horiba, Ltd. , Keio University , Matsumoto, Koichi
发明人： EINAGA, Yasuaki , IVANDINI ANGGRANINGRUM, Tribidasari , CHIKU, Masanobu , YAMANUKI, Mikito
IPC分类号： G01N27/416 , G01N27/30
CPC分类号： G01N33/5438 , G01N27/48 , G01N33/6827 , G01N2333/76 , G01N2800/347
摘要： The present claimed invention is to provide a method for measuring a protein that enables to detect the protein with high accuracy and high sensitivity through an electrochemical method at a high speed with a simple operation using a simple device. With the method, a working electrode 5 and a counter electrode 4 are made to contact with a sample solution 1 containing the protein as being an object to be measured, and a voltage is impressed between the working electrode 5 and the counter electrode 4 so that a current value at the voltage can be measured and the protein can be electrochemically analyzed.
摘要翻译：本发明提供一种蛋白质的测定方法，其能够通过使用简单的装置的简单操作，通过高速电化学方法以高精度和高灵敏度检测蛋白质。利用该方法，使工作电极5和对电极4与包含蛋白质的样品溶液1作为被测量物体接触，并且在工作电极5和对电极4之间施加电压，使得可以测量电压下的电流值，并可以电化学分析蛋白质。

50. 发明公开

EP2003198A2 PEPTIDE FOR INHIBITION OF INFLUENZA INFECTION, INHIBITOR OF INFLUENZA INFECTION, LIPOSOME, AND PROPHYLACTIC/THERAPEUTIC AGENT FOR INFLUENZA 审中-公开
标题翻译：肽用于抑制FLU感染，流感病毒感染抑制剂，和针对FLU LIPOSOME预防/治疗剂
公开(公告)号：EP2003198A2
公开(公告)日：2008-12-17
申请号：EP07737966.7
申请日：2007-03-07
申请人： Keio University
发明人： SATO, Toshinori , MATSUBARA, Teruhiko
IPC分类号： C12N15/09 , A61K38/00 , A61P31/16 , C07K7/06 , C07K7/08 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
CPC分类号： C07K14/005 , A61K38/00 , C07K5/06026 , C07K5/0806 , C07K5/1008 , C07K5/1024 , C12N2760/16122
摘要： To provide a peptide having high affinity for hemagglutinin and a peptide having high inhibitory activity against influenza virus infection, as well as a pharmaceutical composition containing such peptides, the polypeptides having any one of SEQ ID NOs: 2 to 7, 9 to 10, and 12 to 18 are obtained by introducing mutation into a peptide having the sequence of ARLSPTMVHPNGAQP (peptide A-1: SEQ ID NO: 1) and screening for peptides having higher affinity for hemagglutinin. Further, the inhibitory activity of the peptide of SEQ ID NO: 3 against influenza virus infection can be enhanced by truncating the C-terminus of SEQ ID NO: 3 with leaving ARLPR or ARLP. In addition, an influenza virus-infection inhibitor and an influenza preventive/therapeutic agent can be prepared by formulating these influenza virus receptor-binding peptides.
摘要翻译：为了提供对血凝素的高亲和力和具有针对甲型流感病毒感染抑制活性高的肽的肽，以及含有寻求肽的药物组合物，具有该多肽为SEQ ID NO中的任一个：2月9日至10日至7，和 12至18中引入突变而具有ARLSPTMVHPNGAQP的序列的肽获得（：SEQ ID NO：肽A-1 1）和筛选具有血凝素较高的亲和力的肽。此外，SEQ ID NO：2的肽的抑制活性：与离开ARLPR或ARLP 3：针对流感病毒感染3可以通过截短SEQ ID NO：2的C端来增强。除了流感病毒感染抑制剂和流感的预防/治疗剂可通过配制论文流感病毒的受体结合的肽来制备。

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