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41. 发明公开

EP1531815A1 GLUCOKINASE ACTIVATORS 有权
标题翻译：葡萄糖激酶激活
公开(公告)号：EP1531815A1
公开(公告)日：2005-05-25
申请号：EP03761446.8
申请日：2003-06-27
申请人： NOVO NORDISK A/S
发明人： POLISETTI, Dharma, Rao , KODRA, János, Tibor , LAU, Jesper , BLOCH, Paw , VALCARCE-LOPEZ,Maria,Carmen, , BLUME, Niels , GUZEL, Mustafa , SANTHOSH, Kalpathy, Chidambareswaran , MJALLI, Adnan, M., M. , ANDREWS, Robert, Carl , SUBRAMANIAN, Govindan , ANKERSEN, Michael , VEDSOE, Per , MURRAY, Anthony , JEPPESEN, Lone , LAU, Jesper
IPC分类号： A61K31/433 , A61P3/10 , A61P3/06 , A61P3/04 , C07D277/48 , C07D277/52 , C07D213/75 , C07D417/12 , C07D277/56 , C07D417/06 , C07D417/14 , C07D285/16 , C07D487/04 , C07D277/54
CPC分类号： C07D277/38 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/55 , A61K45/06 , C07D213/75 , C07D277/46 , C07D277/48 , C07D277/52 , C07D277/54 , C07D277/56 , C07D285/135 , C07D417/06 , C07D417/12 , C07D417/14 , C07D473/38
摘要： This invention relates to aryl carbonyl derivatives of the general formula (I), which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.(Formul 1).

42. 发明公开

EP1254102A1 ALKYNYLSUBSTITUTED PROPIONIC ACID DERIVATIVES AND THEIR USE AGAINST DIABETES AND OBESITY 审中-公开
标题翻译： BY炔基取代丙及其应用程序来进行战斗肥胖和糖尿病
公开(公告)号：EP1254102A1
公开(公告)日：2002-11-06
申请号：EP01946845.3
申请日：2001-01-26
申请人： Novo Nordisk A/S
发明人： MOGENSEN, John, Patrick , SAUERBERG, Per , BURY, Paul, Stanley , JEPPESEN, Lone , PETTERSSON, Ingrid
IPC分类号： C07C69/734 , A61K31/216 , C07C59/64 , A61K31/192 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07C59/68 , C07C69/734
摘要： The present invention relates to compounds of formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

43. 发明公开

EP1171431A1 COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译：化合物，它们的用途及其用途
公开(公告)号：EP1171431A1
公开(公告)日：2002-01-16
申请号：EP00918724.6
申请日：2000-04-17
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone , SAUERBERG, Per , MURRAY, Anthony , BURY, Paul, Stanley
IPC分类号： C07D265/38 , A61K31/538 , A61P3/10 , A61P3/04
CPC分类号： C07D265/38
摘要： The present invention relates to compounds of general formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

44. 发明公开

EP1123292A1 NEW COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新的化合物，其生产和使用
公开(公告)号：EP1123292A1
公开(公告)日：2001-08-16
申请号：EP99950501.9
申请日：1999-10-19
申请人： NOVO NORDISK A/S , Dr. Reddy's Research Foundation
发明人： JEPPESEN, Lone , BURY, Paul, Stanley , SAUERBERG, Per
IPC分类号： C07D471/12 , C07D493/12 , C07D495/14 , A61K31/343 , A61K31/381 , A61K31/4353 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04 , A61K31/343 , A61K31/38 , A61K31/403 , A61K31/435 , A61K31/495 , C07D493/04 , C07D495/04
摘要： The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

45. 发明公开

EP1123279A1 NEW COMPOUNDS, THEIR PREPARATION AND USE 审中-公开
标题翻译：化合物，其生产和使用
公开(公告)号：EP1123279A1
公开(公告)日：2001-08-16
申请号：EP99948738.2
申请日：1999-10-19
申请人： NOVO NORDISK A/S , DR. REDDY'S RESEARCH FOUNDATION
发明人： JEPPESEN, Lone , BURY, Paul, Stanley , SAUERBERG, Per
IPC分类号： C07D209/80 , C07D223/22 , C07D273/01 , C07D279/22 , C07D471/14 , A61K31/403 , A61K31/55 , A61K31/395 , A61K31/437 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04 , C07D209/86 , C07D209/88 , C07D223/22 , C07D273/06 , C07D279/34
摘要： The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or preventionof conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).

46. 发明公开

EP1080068A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES 审中-公开
标题翻译：蛋白酪氨酸磷酸酶的调节剂
公开(公告)号：EP1080068A1
公开(公告)日：2001-03-07
申请号：EP99907336.4
申请日：1999-03-12
申请人： Novo Nordisk A/S , Ontogen Corporation
发明人： RICHTER, Lutz Stefan , ANDERSEN, Henrik Sune , VAGNER, Josef , JEPPESEN, Claus, Becker , MOELLER, Niels P H , BRANNER, Sven , JEPPESEN, Lone , OLSEN, Ole Hvilsted , IVERSEN, Lars Fogh , HOLSWORTH, Daniel Dale , AXE, Frank Urban , GE, Yu , JONES, Todd, Kevin , RIPKA, William Charles , UYEDA, Roy Teruyuki , SU, Jing , BAKIR, Farid , JUDGE, Luke Milburn
IPC分类号： C07C235/84
CPC分类号： C07D213/79 , C07C233/56 , C07C237/22 , C07D207/34 , C07D209/08 , C07D209/14 , C07D213/80 , C07D231/40 , C07D239/42 , C07D239/557 , C07D241/26 , C07D261/08 , C07D271/07 , C07D271/10 , C07D271/113 , C07D333/38 , C07D333/66 , C07D333/68 , C07D409/04 , C07D409/06 , C07D413/04 , C07D495/04 , C07D495/10 , C07D495/14
摘要： The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPν, PTPδ, PTPσ, PTPz, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes.

47. 发明公开

EP0891363A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE 失效
标题翻译：杂环化合物和其生产和使用
公开(公告)号：EP0891363A1
公开(公告)日：1999-01-20
申请号：EP97915354.0
申请日：1997-04-02
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone , OLESEN, Preben, H. , SAUERBERG, Per
IPC分类号： A61K31 , A61P1 , A61P9 , A61P13 , A61P15 , A61P25 , A61P27 , A61P43 , C07D487
CPC分类号： C07D487/08
摘要： The present invention relates to therapeutically active azatricyclic compounds of formula (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a disease in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.

48. 发明授权

EP0698024B1 [1,2,4]TRIAZOLO [4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE 失效
标题翻译： [-1,2,4-三唑并〔4,3-a〕喹喔生产和使用
公开(公告)号：EP0698024B1
公开(公告)日：1997-01-22
申请号：EP94915514.7
申请日：1994-04-28
申请人： NOVO NORDISK A/S
发明人： JACOBSEN, Poul , NIELSEN, Flemming, Elmelund , JEPPESEN, Lone
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： [1,2,4]triazolo[4,3-a]quinoxaline derivatives of general formula (I) wherein one of R?1 and R2¿ is a 5- or 6-membered N-containing heterocyclic ring optionally substituted, or a fused ring system comprising a 5- or 6-membered N-containing heterocyclic ring optionally substituted; and the other of R?1 and R2¿ is H, alkyl, alkoxy, halogen, NO¿2?, NH2, CN, CF3, COC1-6-alkyl or SO2NR'R', wherein R' and R' are independently H or alkyl and X is O or S; and pharmaceutically acceptable salts thereof have affinity for the AMPA receptors and are antagonists in connection with this type of receptors which makes them useful in the treatment of CNS ailments, especially in the treatment of any of the numerous indications caused by hyperactivity of excitatory amino acids.

49. 发明公开

EP0743945A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE 无效
标题翻译：杂环化合物和其生产和使用
公开(公告)号：EP0743945A1
公开(公告)日：1996-11-27
申请号：EP95909651.0
申请日：1995-01-30
申请人： NOVO NORDISK A/S
发明人： JEPPESEN, Lone
IPC分类号： A61K31 , A61P1 , A61P3 , A61P25 , A61P29 , C07D487
CPC分类号： C07D487/04
摘要： Imidazol[1,2-a]quinoxalinone derivatives of general formula (I) wherein R?1, R2, R3¿ are the same or independently are H, alkyl, alkoxy, halogen, NO¿2?, NH2, CF3, CN, SO2CH3, SO2CF3, SO2NR'R' or a 5- or 6- membered N-containing heterocyclic ring, optionally substituted, and R', R' are independently H or alkyl; and R?4¿ is H or CH¿2?-R?6; and R6¿ is H, halogen, POR'''R'''', NR7R8 or a 5- or 6-membered N-containing heterocyclic ring optionally substituted, and R''', R'''' are independently hydroxy or alkoxy; and R7, R8 are the same or independently are H, (a) or alkyl optionally substituted; and n is 1, 2, or 3; (b), CH¿2?OH, CHNOH, CN, (c) or (d) and R?9¿ is OH, alkoxy, H or NR?10R11; and R10, R11¿ are the same or independently are H, NH¿2? or OH; and X is O or S; and Y is O, S or NH2, and pharmaceutically acceptable salts thereof, have affinity for the AMPA receptors and are antagonists in connection with this type of receptor which makes them useful in the treatment of CNS ailments, especially in the treatment of any of the numerous indications caused by hyperactivity of excitatory amino acids.

50. 发明公开

EP0679085A1 CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE 失效
标题翻译：化学化合物，它们的制备和用途。
公开(公告)号：EP0679085A1
公开(公告)日：1995-11-02
申请号：EP92924586.0
申请日：1992-11-25
申请人： NOVO NORDISK A/S
发明人： HANSEN, John Bondo , JEPPESEN, Lone , GRONVALD, Frederick Christian
IPC分类号： A61K31 , A61P1 , A61P9 , A61P25 , A61P37 , C07D401 , C07D405 , C07D413
摘要： The present invention relates to therapeutically active piperidine derivatives (I), a method of preparing the same and to pharmaceutical compositions comprising the compounds. The compounds are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders, wherein A represents a straight or branched saturated hydrocarbon chain containing from 2 to 6 carbon atoms, R1 is (II).

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