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41. 发明公开

EP3056562A1 INDUCED SMOOTH MUSCLE-TYPE CELLS, METHODS FOR THE PRODUCTION THEREOF, AND USES THEREOF IN CELL-BASED TISSUE REGENERATION AND TREATMENT OF VASCULAR OCCLUSION 审中-公开
标题翻译：诱导的平滑肌，方法其制造及其使用单元格基于组织再生和冠状动脉治疗
公开(公告)号：EP3056562A1
公开(公告)日：2016-08-17
申请号：EP16155308.6
申请日：2016-02-11
申请人： University College Cork-National University of Ireland, Cork
发明人： Caplice, Noel
IPC分类号： C12N5/071
CPC分类号： C12N5/0691 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2501/604 , C12N2510/00
摘要： An induced smooth muscle-like cell (iSMC) is described. The iSMC is prepared by reprogramming a primitive progenitor cell comprising introducing into the cell an agent capable of increasing the expression of myocardin in the primitive progenitor cell. The agent may be a nucleic acid construct comprising a KLF4 knockdown agent, an artificial myocardinspecific transactivator, or a myocardin transgene typically under the control of a transcriptional promotor. Methods of producing the cells, and the use of the cells in autologous tissue regeneration therapy or treatment of vascular occlusion in humans is also described.
摘要翻译：的诱导的平滑肌细胞样细胞（ISMC）进行说明。该ISMC通过重编程原始祖细胞，其包含导入细胞增加在祖细胞心肌素的表达能够原始的试剂制备。所述试剂可以是核酸构建体，包含KLF4敲低剂，人工反myocardinspecific活化剂，或一个转录启动子的控制下，典型地，转基因心肌素。由此描述生产细胞，并且使用在自体组织再生治疗或在人类中治疗血管闭塞的细胞的方法。

42. 发明公开

EP3047861A2 INTRACORONARY INFUSION OF IGF-1 FOR MYOCARDIAL REPAIR 有权
标题翻译： IGF-1在心脏修复中的应用
公开(公告)号：EP3047861A2
公开(公告)日：2016-07-27
申请号：EP16152830.2
申请日：2009-11-27
申请人： University College Cork-National University of Ireland, Cork
发明人： Caplice, Noel
IPC分类号： A61L29/04 , A61L29/16
CPC分类号： A61L29/048 , A61L29/16 , A61L2300/414 , A61L2300/602
摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25pg to 950pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
摘要翻译：本文提供了用于治疗患有（患有）急性心肌梗塞的个体和用于治疗此类个体的药物洗脱支架的方法。这些方法包括通过例如通过手术插入在急性心肌梗塞部位上游的急性冠状动脉闭塞部位引入能够从25pg至950pg的药物洗脱支架（DES）洗脱的药物洗脱支架（DES） IGF-1直接进入冠脉循环。该治疗具体针对刺激受损心肌或左心室重构的修复或存活。

43. 发明公开

EP2941299A1 A THORACOSCOPIC ELECTROPORATION DEVICE WITH A SUCTION HEAD AND WITH NEEDLE ELECTRODES 有权
标题翻译：用吸头，针与铅电胸腔镜
公开(公告)号：EP2941299A1
公开(公告)日：2015-11-11
申请号：EP13811540.7
申请日：2013-12-19
申请人： University College Cork-National University of Ireland, Cork
发明人： SODEN, Declan , HINCHION, John
IPC分类号： A61N1/32 , A61B18/14
CPC分类号： A61N1/325 , A61B17/00234 , A61B18/1482 , A61B2017/00292 , A61B2017/00809 , A61B2017/00867 , A61B2017/308 , A61B2018/00291 , A61B2018/00541 , A61B2018/00613 , A61B2018/143 , A61B2018/1475 , A61N1/0502 , A61N1/327
摘要： A thoracoscopic electroporation device for carrying out electroporation on tissue includes a suction head and a plurality of needle electrodes. The needle electrodes include a central needle providing a first electrode and a plurality of second needles which are spaced-apart around the periphery of the suction head. The electrodes are movable from a retracted configuration to a deployed configuration and in the deployed configuration the needles extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head includes a suitable flexible material for biasing the suction head into the expanded deployed configuration. The suction head has channels for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the peripheral needles.

44. 发明公开

EP2760883A1 ACCUMULATION OF METABOLIC PRODUCTS IN BACTERIAL MICROCOMPARTMENTS 审中-公开
标题翻译：巴克斯坦薄荷酮中的阿萨姆门多芬
公开(公告)号：EP2760883A1
公开(公告)日：2014-08-06
申请号：EP12777872.8
申请日：2012-09-27
申请人： University College Cork, National University of Ireland Cork , University of Kent
发明人： PRENTICE, Michael , WARREN, Martin , LIANG, Mingzhi
IPC分类号： C07K14/195 , C12N1/20 , A23L1/30 , A61K35/74 , C02F3/30 , C12N9/12
CPC分类号： C12P3/00 , A23L33/135 , A61K38/45 , C07K14/195 , C12N1/20 , C12N9/1229 , C12N15/70 , C12P21/00 , C12Y207/04001 , Y02A50/473
摘要： A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is genetically engineered to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolised to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.
摘要翻译：在细菌细胞质中在细菌微室内积聚聚合物或高分子量分子产物的非治疗方法，该方法使用重组细菌，其被遗传工程化以表达含有能够将低分子量底物转化为聚合物或高分子量产物，该方法包括以下步骤：将重组细菌与低分子量底物或低分子量底物的前体一起孵育，该前体能够被代谢至重组细菌内的底物，如底物或前体被细菌吸收，其中基质进入微室，微室内的酶将底物转化为聚合物或高分子量分子产物，并且其中聚合或高分子量分子产物积聚在微型房间到期到它的大小。

45. 发明公开

EP2560357A1 Analysis of calls recorded at a call centre for selecting calls for agent evaluation 审中-公开
标题翻译：评估，在呼叫中心捕获，来电，来评估操作人员选择呼叫
公开(公告)号：EP2560357A1
公开(公告)日：2013-02-20
申请号：EP11177610.0
申请日：2011-08-15
申请人： University College Cork-National University of Ireland, Cork
发明人： Curran, Dara , Sutton, Kevin
IPC分类号： H04M3/51
CPC分类号： G06F17/30746 , H04M3/42221 , H04M3/5175
摘要： This invention relates to a method and system for selecting a call centre agent's call for evaluation. Presently, calls are selected at random for evaluation by the call centre team leader. Generally speaking, this is an inefficient way to choose the calls, is time consuming and can result in an unfair evaluation of the agent's performance. According to the present invention there is provided a method and system for selecting an agent's calls for evaluation which entails analysing each of the calls, extracting certain call audio features and using the extracted features to score the calls based on the call's features. Once the calls have been scored, they are clustered into groups of similarly-featured calls. In this way, calls that are typical and atypical of an agent's performance may be retrieved more reliably and faster than was heretofore the case. According to one particularly preferred embodiment, a selection of calls suitable for evaluation can be presented to the call centre team leader.
摘要翻译：本发明涉及一种用于选择呼叫中心座席的呼叫进行评估的方法和系统。目前，呼叫随机由呼叫中心团队领导选择进行评估。一般来说，这是选择电话方式效率极低，非常耗时，而且可以在代理人的业绩不公平的评价结果英寸。根据本发明，提供了用于选择代理的评价这需要实现分析每个呼叫，提取某些呼叫的音频特征并使用所提取的特征的得分基于呼叫的功能的呼叫的呼叫的方法和系统。一旦通话havebeen进球，他们都聚集到类似功能的通话组。通过这种方式，电话确实是典型的和非典型的代理的性能可能会更可靠地检索和比迄今的情况下更快。。根据一个特别优选实施方案，选择适合于评价的呼叫可被呈现给呼叫中心组长。

46. 发明授权

EP2371925B1 A sensor material, and uses thereof to simultaneously sense two analytes 有权
标题翻译：传感器材料及其两种分析的同时扫描用途
公开(公告)号：EP2371925B1
公开(公告)日：2012-12-12
申请号：EP10158270.8
申请日：2010-03-29
申请人： University College Cork, National University of Ireland, Cork
发明人： Papkovsky, Dmitri Boris
IPC分类号： C09K9/02 , C07D207/04 , C07F15/00 , G01N21/64 , G01N21/77 , G01N21/80 , A61K49/00
CPC分类号： C09K9/02 , C09K2211/1029 , C09K2211/185 , G01N31/225 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/7786

47. 发明授权

EP1874917B1 PROBIOTIC COMPOSITION SUITABLE FOR ANIMALS 有权
标题翻译：适于动物益生菌制品
公开(公告)号：EP1874917B1
公开(公告)日：2012-03-14
申请号：EP06728131.1
申请日：2006-04-06
申请人： TEAGASC, The Agriculture and Food Development Authority , University College Cork-National University of Ireland, Cork
发明人： STANTON, Catherine , HILL, Colin, Department of Microbiology , FITZGERALD, Ger, Department of Microbiology , ROSS, Paul
IPC分类号： C12N1/20 , A23L1/30 , A23K1/00
CPC分类号： A23K10/18
摘要： The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.

48. 发明公开

EP2328574A1 TREATMENT OF RETINAL DEGENERATION 审中-公开
标题翻译：治疗视网膜再生研究
公开(公告)号：EP2328574A1
公开(公告)日：2011-06-08
申请号：EP09787411.9
申请日：2009-08-05
申请人： University College Cork-National University of Ireland, Cork , Consejo Superior De Investigaciones Científicas (90%)
发明人： COTTER Thomas , DOONAN Francesca , SANVICENS DIEZ Nuria , O'DRISCOLL Carolyn , MESSEGUER PEYPOCH Angel Ramon
IPC分类号： A61K31/353 , A61P27/02 , A61P25/00
CPC分类号： A61K31/353 , A61K9/0048 , A61K9/0051
摘要： The use of a compound of general formula (I) : or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment or prevention of a disease or condition characterised by apoptosis or degeneration of mammalian cells, wherein: R1 is a alkoxy, alkyl, ether or ester group; R2 is H or has the formula wherein Y is linear or branched, saturated or unsaturated, aliphatic group with from 2 to 23 carbon atoms, or a cyclic group, and which can contain substituents selected from the group consisting of hydroxyl, alkoxy, amino, carboxyl, cyano, nitro, alkylsuphonyl or halogen atoms, X is O or S; and R3 is any substituent.

49. 发明公开

EP2303929A1 A MACROCYCLIC DERIVATIVE AND ASSEMBLIES FORMED THEREFROM 审中-实审
标题翻译：大环衍生物及其制品作出安排
公开(公告)号：EP2303929A1
公开(公告)日：2011-04-06
申请号：EP09772569.1
申请日：2009-07-06
申请人： University College Dublin National University Of Ireland, Dublin , University College Cork-National University of Ireland, Cork
发明人： DARCY, Raphael , O'DRISCOLL, Caitriona
IPC分类号： C08B37/00 , C08L5/16 , A61K47/48
CPC分类号： C08B37/0012 , A61K47/60 , C08L5/16
摘要： The present invention is directed to a macrocyclic derivative which is formed by modification of a macrocycle. The invention further relates to assemblies formed by the self-assembly of such macrocyclic derivatives in aqueous solvent, and includes bilayer vesicles, micelles, monolayers, nanoparticles, colloidal assemblies and surface-coated assemblies.

50. 发明授权

EP1465730B1 AN ASSAY DEVICE AND METHOD FOR CHEMICAL OR BIOLOGICAL SCREENING 有权
标题翻译：测试装置和方法进行化学或生物筛选
公开(公告)号：EP1465730B1
公开(公告)日：2011-03-09
申请号：EP03700978.4
申请日：2003-01-16
申请人： University College Cork - National University of Ireland, Cork
发明人： PAPKOVSKY, Dmitri , ALDERMAN, John, Charles , O'CONNOR, Rosemary
IPC分类号： B01L3/00 , G01N21/64 , G01N21/03
CPC分类号： B01L3/50853 , B01L2200/0689 , B01L2300/048 , C12M23/12 , C12M23/20 , C12M23/22 , C12M23/38 , C12M41/46 , Y10S435/808
摘要： An assay device (1) comprises a base (2) and glass plate lid (3). The base (2) has an array of shallow microwells (4), each having a flat rim (9), all rims being co-planar. When the lid (3) is placed on the base (2) a thin capillary gap (10) is formed on each rim, acting as a liquid seal for a microwell chamber. The liquid is excess sample liquid and further excess is accommodated in overspill cavities (6) between the microwells (4). Because of the liquid seal and shallow configuration the benefits of microfluidic devices are achieved together with the handling convenience and use of conventional detection equipment of conventional microplate devices.

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