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    • 41. 发明公开
    • OPHTHALMIC OIL-IN-WATER EMULSIONS CONTAINING CYCLOSPORINE OR A POLYPHENOL
    • OPHTHALMISCHEÖL-in-WASSER-EMULSIONEN MIT CYCLOSPORIN ODER EINEM POLYPHENOL
    • EP2437722A1
    • 2012-04-11
    • EP10722891.8
    • 2010-06-02
    • Abbott Medical Optics Inc.
    • YU, Zhi-jianHUTH, Stanley, W.DEMICHELE, Stephen, J.
    • A61K9/00A61K9/107A61K38/13A61K31/12A61K36/9066
    • A61K9/0048A61K9/1075A61K38/13
    • Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A or polyphenol in an amount effective to relieve dry eye symptoms.
    • 本文公开了具有平均粒度小于1μm的稳定的水包油乳液眼用局部液体组合物,其包含除蓖麻油之外的至少一种植物来源的油,其中所述油仅包含没有极性侧基的脂族侧链。 水包油乳液眼用局部液体组合物还包括HLB值在约10至14之间的亲水性表面活性剂,具有不饱和侧链的植物油衍生的疏水性非共 - 嵌段表面活性剂,其含有少于四个具有 约4至6之间的HLB值为室温下的液体。 本文公开的水包油乳液眼用局部液体组合物还可包含一定量的有效缓解眼睛干眼症状的环孢菌素A。