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31. 发明公开

EP2159219A2 An improved process for the preparation of armodafinil 审中-公开
标题翻译： Verbeetes Verfahren zur Zubereitung von Armodafinil
公开(公告)号：EP2159219A2
公开(公告)日：2010-03-03
申请号：EP09011543.7
申请日：2007-03-01
申请人： Teva Pharmaceutical Industries Ltd.
发明人： Moshkovits-Kaptsan, Rinat , Braude, Viviana , Chen, Kobi , Adler, Miri
IPC分类号： C07C315/06 , C07C317/44
CPC分类号： C07C315/06 , C07B57/00 , C07B2200/07 , C07C319/24 , C07C317/44 , C07C321/20
摘要： The invention encompasses a process for reducing the amount of bis(diphenylmethyl)disulfide in armodafinil, which comprises suspending armodafinil in a C 5 to C 12 hydrocarbon.
摘要翻译：本发明包括减少臂多巴尼尼双（二苯基甲基）二硫化物的量的方法，该方法包括将羧甲纤维素悬浮于C 5至C 12烃中。

32. 发明公开

EP2115079A2 FORMULATION DU DIMETHYLSULFOXYDE EN MELANGE AVEC UN ADDITIF PERMETTANT D'ABAISSER LE POINT DE CRISTALLISATION DE CE DERNIER, ET APPLICATIONS DE CE MELANGE 有权转让
标题翻译：二甲基亚砜配制在一个混合物在其异径KRISTALLISIERUNGSPUNKTES添加剂和复合应用程序
公开(公告)号：EP2115079A2
公开(公告)日：2009-11-11
申请号：EP08761992.0
申请日：2008-01-28
申请人： ARKEMA FRANCE
发明人： LALLIER, Jean-Pierre , LE VILAIN, Fabienne
IPC分类号： C09D9/00 , C07C315/06 , C08K5/053
摘要： The invention concerns the use of at least one diol and/or at least one triol as an additive to dimethylsulfoxide (DMSO) in order to lower the crystallization point of same. The DMSO formulation is used in combination with the aforementioned additive as a paint-stripping composition, surface-cleaning composition, graffiti-cleaning composition, surface-cleaning composition in the microelectronics field as a photoresist-stripping agent, DMSO-based agrochemical composition or as a constituent of an aforementioned composition, as a solvent for dissolving polymers, or as a constituent of a composition that is usable in the field of cosmetology or pharmacy.
摘要翻译：使用至少一种二醇和/或三醇，其特征如结晶点降低为二甲亚砜（DMSO）添加剂（I）。独立权利要求中包括了：（1）（I）的含DMSO的制剂（A）; （2）用于剥离涂料，清洁表面或除去涂鸦，包括（A）10-50重量％和10-50重量％的中等极性，非传统的助溶剂（S）（B）（任选的组合物（II）与常规添加剂一起：如活化剂，增稠剂，软化剂和表面活性剂）; 和（3）用于剥离涂料，清洁表面或除去涂鸦，涉及通过刷涂施加（II），留下（II）与所述表面接触30分钟并除去的漆，污物的残留物或使用油漆涂鸦的方法刮刀。

33. 发明公开

EP1787980A2 Crystalline and pure modafinil, and process of preparing the same 有权
标题翻译：结晶和纯的莫达非尼及其制备方法
公开(公告)号：EP1787980A2
公开(公告)日：2007-05-23
申请号：EP07000780.2
申请日：2001-07-27
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD.
发明人： Singer, Claude , Gershon, Neomi , Ceausu, Arina , Lieberman, Anita , Aronhime, Judith
IPC分类号： C07C317/44 , A61K31/165 , C07C315/02 , C07C315/06
CPC分类号： C07C317/44 , A61K31/165 , C07B2200/13 , C07C315/02 , C07C315/06 , C30B7/00 , C30B29/54
摘要： The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI.
摘要翻译：本发明提供了一种改进的制备莫达非尼的方法，由此它可以通过单一结晶以高纯度分离。该方法生产不含过氧化物和其他副产物的砜产品的莫达非尼。本发明进一步提供了莫达非尼的新结晶形式II-VI及其制备方法。每种新形式都通过独特的粉末X射线衍射图来区分。本发明进一步提供了含有新型莫达非尼晶型II-IV和VI的药物组合物。

34. 发明公开

EP1775285A1 METHOD OF CRYSTALLIZING BICALUTAMIDE 有权
标题翻译： VERFAHREN ZUR KRISTALLISATION VON BICALUTAMID
公开(公告)号：EP1775285A1
公开(公告)日：2007-04-18
申请号：EP05766195.1
申请日：2005-07-13
申请人： Sumitomo Chemical Company, Limited
发明人： KATSURA, Tadashi , MIZUNO, Tadashi , ITAYA, Nobushige
IPC分类号： C07C315/06 , C07C317/46
CPC分类号： C07C315/06 , C07C317/46
摘要： The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10µm of Dp 10 , 10 to 25 µm of Dp 50 and 25 to 100 µm of Dp 90 , and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 µm of Dp 10 , 2 to 5 µm of Dp 50 and 5 to 15 µm of Dp 90 .
摘要翻译：本发明提供了比卡鲁胺的结晶方法，其包括向水中加入含有比卡鲁胺的丙酮溶液; 其中晶体的粒度分布为Dp 10的1〜10μm，Dp 50为10〜25μm，Dp 90为25〜100μm，并且可以通过上述方法得到晶体。和比卡鲁胺的晶体，其中晶体的粒度分布为Dp 10为1〜3μm，Dp为2〜5μm，Dp为90〜15μm。

35. 发明公开

EP1740534A1 PROCESS FOR PURIFYING MESOTRIONE 有权转让
标题翻译：法提纯硝磺草酮
公开(公告)号：EP1740534A1
公开(公告)日：2007-01-10
申请号：EP05707695.2
申请日：2005-03-03
申请人： Syngenta Participations AG
发明人： BENKE, Alan, Henry , WICHERT, Julie, Marie
IPC分类号： C07C315/06 , C07C317/24
CPC分类号： C07C315/06 , C07C317/24
摘要： A method for reducing the cyanide levels in a mesotrione sample, said method comprising: (i) taking an aqueous solution of the mesotrione sample in an aqueous solvent, (ii) adjusting the pH of said aqueous solution to a value of 9.5 or higher, and (iii) crystallising the mesotrione out of solution is disclosed.

36. 发明公开

EP1723103A1 VERFAHREN ZUR AUFARBEITUNG VON BETA-SULFATOETHYLSULFONYLANILIN -2-SULFONSAURE 有权转让
标题翻译： VERFAHREN ZUR AUFARBEITUNG VON BETA-SULFATOETHYLSULFONYLANILIN-2-SULFONSAURE
公开(公告)号：EP1723103A1
公开(公告)日：2006-11-22
申请号：EP05733648.9
申请日：2005-02-26
申请人： BASF Aktiengesellschaft
发明人： SOMOGYI, Laszlo
IPC分类号： C07C315/06 , C07C317/36
CPC分类号： C07C315/06 , C07C317/36
摘要： The invention relates to a method for processing ß-sulphatoethylsulphonylaniline-2-sulphonic acid which is present as a solution in an aqueous sulphuric acid. In a first step, the ß-sulphatoethylsulphonylaniline-2-sulphonic acid is precipitated, separated and dissolved in water by adding (earth)alkali and/or ammonium salts, or the sulphuric acid is precipitated by adding calcium salts, the calcium sulphate thus arising is optionally separated, and in a second step, the solution thus arising is adjusted to a pH value of between 1 and 5 by adding (earth)alkali or ammonium hydroxide, carbonate, hydrogen carbonate and/or acetate, the existing calcium sulphate is separated, and the ß-sulphatoethylsulphonylaniline-2-sulphonic acid is isolated from the solution and the thus produced ß-sulphatoethylsulphonylaniline-2-sulphonic acid.
摘要翻译：本发明涉及一种处理在硫酸水溶液中存在的β-硫酸根合乙磺酰基苯胺-2-磺酸的方法。在第一步中，通过加入（土）碱和/或铵盐将β-磺酸基乙磺基苯胺-2-磺酸沉淀，分离并溶于水中，或者通过加入钙盐使硫酸沉淀，由此产生硫酸钙任选分离，并且在第二步中，通过添加（土）碱或氢氧化铵，碳酸盐，碳酸氢盐和/或乙酸盐将由此产生的溶液调节至1至5之间的pH值，将现有的硫酸钙分离从溶液中分离出β-磺基乙基磺酰基苯胺-2-磺酸并由此生成β-磺基乙基磺酰基苯胺-2-磺酸。

37. 发明公开

EP1468987A4 PROCESS FOR PRODUCING 2,4'-DIHYDROXYDIPHENYL SULFONE 有权
标题翻译：用于生产2,4'-二羟基二苯基砜
公开(公告)号：EP1468987A4
公开(公告)日：2006-05-03
申请号：EP03731628
申请日：2003-01-22
申请人： NICCA CHEMICAL CO
发明人： YOSHINO GOU , TOMODA YUICHI , TANIGUCHI NORIHIRO , IGARASHI KAZUAKI , HASEGAWA TAKEO
IPC分类号： C07C315/00 , C07C315/04 , C07C315/06 , C07C317/22 , C07C315/02
CPC分类号： C07C315/04 , C07C315/06 , C07C317/22
摘要： A process for producing 2,4'-dihydroxydiphenyl sulfone which comprises: subjecting a mixture which has been obtained by the dehydrating reaction of phenol with sulfuric acid or phenolsulfonic acid and contains 4,4'-dihydroxydiphenyl sulfone, 2,4'-dihydroxydiphenyl sulfone, phenolsulfonic acid, and phenol to crystallization to separate the 4,4'-dihydroxydiphenyl sulfone from the mixture and thereby obtain a mixture in which the content of 2,4'-dihydroxydiphenyl sulfone is not lower than that of 4,4'-dihydroxydiphenyl sulfone; regulating the mixture so as to have a solvent composition having a phenol/water ratio of from 10/90 to 90/10 by weight; crystallizing the 2,4'-dihydroxydiphenyl sulfone; and isolating the 2,4'-dihydroxydiphenyl sulfone by filtration. Also provided is a process for producing 2,4'-dihydroxydiphenyl sulfone in which the filtrate resulting from the filtration is utilized as a feed material for the subsequent dehydrating reaction.

38. 发明公开

EP0431612A1 Purification of halogenated aromatic sulfones or ketones 失效
标题翻译：芳香香精和香豆素。
公开(公告)号：EP0431612A1
公开(公告)日：1991-06-12
申请号：EP90123431.0
申请日：1990-12-06
申请人： PHILLIPS PETROLEUM COMPANY
发明人： Herd, Melvin Dale , Holba, Albert Gene , Straw, Jimmy Joe
IPC分类号： C07C315/06 , C07C45/78 , C07C317/14
CPC分类号： C07C315/06 , C07C45/81 , C07C317/14
摘要： A process for purifying a halogenated aromatic sulfone or ketone compound comprising contacting the compound with a solvent having a normal boiling point less than about 225°C to form a mixture, heating the mixture to a temperature above the normal boiling point of the solvent in a closed system to form a solution, cooling the solution to recrystallize the compound, and recovering the compound. A second embodiment of the invention comprises repeating the purification process steps at least once to further purify the halogenated aromatic sulfone or ketone compound.
摘要翻译：一种用于纯化卤代芳族砜或酮化合物的方法，包括使化合物与正常沸点小于约225℃的溶剂接触以形成混合物，将混合物加热至高于溶剂的标准沸点的温度，封闭体系形成溶液，冷却溶液使化合物重结晶，并回收化合物。本发明的第二个实施方案包括重复纯化工艺步骤至少一次以进一步纯化卤代芳香砜或酮化合物。

39. 发明公开

EP0380159A1 Process for purifying crude tetrabromobisphenol sulfone by extraction 失效
标题翻译： Verfahren zur Reinigung von rohem四氯双酚苯磺酸溶液萃取。
公开(公告)号：EP0380159A1
公开(公告)日：1990-08-01
申请号：EP90200111.4
申请日：1990-01-16
申请人： Akzo Nobel N.V.
发明人： Telschow, Jeffrey Earl
IPC分类号： C07C315/06 , C07C317/22
CPC分类号： C07C315/06 , C07C317/22
摘要： Crude tetrabromobisphenol S compositions can be purified by extracting impurities therefrom with a quantity of organic solvent which is insufficient to substantially dissolve the tetrabromobisphenol S, followed by the removal of the tetrabromobisphenol compound from the solvent.
摘要翻译：粗制四溴双酚S组合物可以通过用一定量的不足以基本上溶解四溴双酚S的有机溶剂提取杂质，然后从溶剂中除去四溴双酚化合物来纯化。

40. 发明授权

EP0279387B1 Verfahren zur Isolierung von 4,4'-Dichlordiphenylsulfon 失效
标题翻译：分离4,4'-二氯苯基磺酸的方法
公开(公告)号：EP0279387B1
公开(公告)日：1990-05-02
申请号：EP88102126.5
申请日：1988-02-13
申请人： BASF Aktiengesellschaft
发明人： Schaefer, Gerhard, Dr. , Eilingsfeld, Heinz, Dr. , Neumann, Peter, Dr. , Stumpp, Michael, Dr.
IPC分类号： C07C315/06
CPC分类号： C07C317/00

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