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31. 发明公开

EP0766555A1 NANOPARTICULES STABILISEES ET FILTRABLES DANS DES CONDITIONS STERILES 失效
标题翻译：稳定并在无菌条件下过滤纳米
公开(公告)号：EP0766555A1
公开(公告)日：1997-04-09
申请号：EP95923414.0
申请日：1995-06-20
申请人： RHONE-POULENC RORER S.A.
发明人： LABORIE, Michel , VACUS, Joel , VERRECCHIA, Thierry , BISSERY, Marie-Christine
IPC分类号： A61K9 , B01F3 , B01F17 , B01J13
CPC分类号： A61K9/5153 , A61K9/5192 , Y10S977/773 , Y10S977/788 , Y10S977/795 , Y10S977/906
摘要： Nanoparticles stabilized and filterable in sterile conditions characterized in that they comprise at least one hydrophobic, non-hydrosoluble and non-hydrodispersible polymer or copolymer (and optionally an active ingredient) emulsified in a phospholipid and biliary salt solution.

32. 发明公开

EP0711127A1 METHODS OF PREPARING GAS-FILLED LIPOSOMES 失效
标题翻译：方法脂质体与气体包裹的准备
公开(公告)号：EP0711127A1
公开(公告)日：1996-05-15
申请号：EP94919184.0
申请日：1994-05-19
申请人： UNGER, Evan C , FRITZ, Thomas A. , MATSUNAGA, Terry , RAMASWAMI, VaradaRajan , YELLOWHAIR, David , WU, Guanli
发明人： UNGER, Evan C , FRITZ, Thomas A. , MATSUNAGA, Terry , RAMASWAMI, VaradaRajan , YELLOWHAIR, David , WU, Guanli
IPC分类号： A61B8 , A61K8 , A61K9 , A61K41 , A61K47 , A61K48 , A61K49 , A61Q19 , B01J13 , A61M5
CPC分类号： A61K9/1278 , A61K9/127 , A61K9/1277 , A61K41/0028 , A61K41/0052 , A61K47/6925 , A61K49/1815 , A61K49/22 , A61K49/223 , A61K49/227 , A61M5/3145 , Y10S977/795 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/907 , Y10S977/927 , Y10S977/929 , Y10S977/962
摘要： Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

33. 发明公开

EP0671906A1 BIOADHESIVE MICROSPHERES AND THEIR USE AS DRUG DELIVERY AND IMAGING SYSTEMS 失效
标题翻译：生物粘附微球和它们作为药物供应系统和成像系统。
公开(公告)号：EP0671906A1
公开(公告)日：1995-09-20
申请号：EP93910745.0
申请日：1993-04-23
申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
发明人： MATHIOWITZ, Edith , CHICKERING, Donald , JACOB, Jules Serge
IPC分类号： A61K47 , A61K9 , G01N33
CPC分类号： A61K9/1641 , A61K9/167 , Y10S977/795 , Y10S977/906 , Y10S977/929
摘要： Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm2 (110 N/m2). Techniques for the fabrication of bioadhesive microspheres, as well as a method for measuring bioadhesive forces between microspheres and selected segments of the gastrointestinal tract in vitro are also described. This quantitative method provides a means to establish a correlation between the chemical nature, the surface morphology and the dimensions of drug-loaded microspheres on one hand and bioadhesive forces on the other, allowing the screening of the most promising materials from a relatively large group of natural and synthetic polymers which, from theoretical consideration, should be used for making bioadhesive microspheres.

34. 发明公开

EP0578148A3 Biologisch erkennende Schichten auf Festphasen sowie ein Verfahren zur Herstellung dieser Schichten 有权转让
标题翻译：生物识别固体相上的层及其生产方法
公开(公告)号：EP0578148A3
公开(公告)日：1994-09-14
申请号：EP93110595.1
申请日：1993-07-02
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Barner, Richard , Huber, Walter , Hübscher, Josef , Hurst, Jürg , Schlatter, Daniel
IPC分类号： G01N33/543 , G01N33/547 , G01N33/531
CPC分类号： G01N33/5438 , G01N33/54353 , Y10S436/823 , Y10S436/828 , Y10S977/714 , Y10S977/795 , Y10S977/92
摘要： Die biologisch erkennende Schicht auf einer Festphase besteht aus biologisch erkennenden Molekülen, welche den Analyten erkennende (bindende) Molekülbereiche und den Analyten nicht erkennende (nicht bindende) Molekülbereiche aufweisen. Die biologisch erkennenden Moleküle sind über Analyt nicht erkennende Molekülbereiche an einer geeignet modifizierten Oberfläche ausgerichtet. Die biologisch erkennende Moleküle sind mit dieser ausrichtenden Oberfläche quervernetzt und somit kovalent verändert. Die den Analyten erkennende Molekülbereiche werden durch die kovalente Bindung nicht verändert und bewahren ihre Bindungsaktivität. Die Herstellung dieser Schicht erfolgt durch ein neues Zweistufenverfahren. Im ersten Schritt erfolgt die Adsorption der biologisch erkennenden Moleküle, der ausrichtenden Moleküle sowie der Trägermoleküle. Im zweiten Schritt erfolgt die kovalente Verankerung durch Vernetzung der Moleküle untereinander. Die Vernetzung erfolgt durch photolytische Aktivierung des mit den Trägermolekülrn verbundenen Reagenz. Dieses Reagenz enthält auch nach seiner Umsetzung mit den Trägermolekülen wasserlöslich machende Gruppen.

35. 发明公开

EP0578148A2 Biologisch erkennende Schichten auf Festphasen sowie ein Verfahren zur Herstellung dieser Schichten 有权转让
标题翻译：在固相上的生物识别层以及用于制备这些层的方法。
公开(公告)号：EP0578148A2
公开(公告)日：1994-01-12
申请号：EP93110595.1
申请日：1993-07-02
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Barner, Richard , Huber, Walter , Hübscher, Josef , Hurst, Jürg , Schlatter, Daniel
IPC分类号： G01N33/543 , G01N33/547 , G01N33/531
CPC分类号： G01N33/5438 , G01N33/54353 , Y10S436/823 , Y10S436/828 , Y10S977/714 , Y10S977/795 , Y10S977/92
摘要： Die biologisch erkennende Schicht auf einer Festphase besteht aus biologisch erkennenden Molekülen, welche den Analyten erkennende (bindende) Molekülbereiche und den Analyten nicht erkennende (nicht bindende) Molekülbereiche aufweisen.
Die biologisch erkennenden Moleküle sind über Analyt nicht erkennende Molekülbereiche an einer geeignet modifizierten Oberfläche ausgerichtet. Die biologisch erkennende Moleküle sind mit dieser ausrichtenden Oberfläche quervernetzt und somit kovalent verändert. Die den Analyten erkennende Molekülbereiche werden durch die kovalente Bindung nicht verändert und bewahren ihre Bindungsaktivität.
Die Herstellung dieser Schicht erfolgt durch ein neues Zweistufenverfahren. Im ersten Schritt erfolgt die Adsorption der biologisch erkennenden Moleküle, der ausrichtenden Moleküle sowie der Trägermoleküle. Im zweiten Schritt erfolgt die kovalente Verankerung durch Vernetzung der Moleküle untereinander. Die Vernetzung erfolgt durch photolytische Aktivierung des mit den Trägermolekülrn verbundenen Reagenz. Dieses Reagenz enthält auch nach seiner Umsetzung mit den Trägermolekülen wasserlöslich machende Gruppen.
摘要翻译：在其上具有其识别（绑定）不承认（未结合）分析物分子区域中的分析物和分子生物学的区域识别分子的固相besteht生物识别层。生物识别分子通过其不识别在适当修改的表面被分析物分子的区域对准。生物识别分子是交联的此定向表面和被共价修饰。识别分析物的分子的区域不被共价键合修饰的，并保留其结合活性。 ThisLayer是在两阶段过程中产生的。在第一步骤中有吸附载体的对准分子和分子的生物识别分子，。在第二步骤中有共价通过彼此交联分子锚定。交联通过连接到载体分子试剂的光解活化发生。这种试剂含有无声基团其与载体分子反应后在水中溶解度的。

36. 发明公开

EP2408821A4 DYNAMIC BIO-NANOPARTICLE ELEMENTS 审中-公开
标题翻译：动态BIONANOPARTICLE元素
公开(公告)号：EP2408821A4
公开(公告)日：2012-03-07
申请号：EP10749086
申请日：2010-02-05
申请人： VITALIANO FRANCO , VITALIANO GORDANA
发明人： VITALIANO FRANCO , VITALIANO GORDANA
IPC分类号： C07K17/00 , A61K9/50 , A61K9/51
CPC分类号： A61K9/5169 , A61K38/17 , A61K38/1709 , A61K38/45 , A61K38/465 , A61K45/06 , A61K47/42 , A61K47/62 , A61K47/6949 , A61K49/0004 , B82Y5/00 , B82Y15/00 , B82Y30/00 , C07K14/47 , C12Y205/01018 , C12Y301/03048 , G01N33/15 , G01N35/00722 , G06N5/02 , Y10S977/773 , Y10S977/795 , Y10S977/904 , Y10S977/906 , Y10S977/919 , Y10S977/923 , Y10S977/932
摘要： The invention relates generally to the field of nanoparticles, and more specifically, in one embodiment, to bio-nanoparticle elements formed from materials comprised of self-assembling protein molecules, which are capable of coating one or more type of elements. In another invention embodiment, the invention relates to a protein that coats one or more elements in order to modify or improve one or more characteristic of the element, including, but not limited to, stability, rigidity, or functionality of the element that is coated with the instant invention.
摘要翻译：合适的实施方案中的本发明涉及使用纯化的非笼状网格蛋白，用于协助药物发现和开发。在一个方面，由全部或部分一个或多个蛋白质序列组成的分离的，合成的和/或重组的氨基酸残基全部或部分形成的工具组合物形成用于进行各种元件和活性的一种或多种类型的工具的药物发现与发展。

37. 发明公开

EP2305775A3 Functionalized fluorescent nanocrystals, and methods for their preparation and use 审中-公开
标题翻译：功能化的荧光纳米晶及其制备方法和用途
公开(公告)号：EP2305775A3
公开(公告)日：2011-06-08
申请号：EP10183581.7
申请日：2005-10-28
申请人： Molecular Probes, Inc.
发明人： Naasani, Imad
IPC分类号： C09K11/54 , G01N33/58
CPC分类号： B82Y15/00 , C09K11/025 , C09K11/883 , G01N33/588 , Y10S977/773 , Y10S977/792 , Y10S977/793 , Y10S977/795 , Y10S977/811 , Y10S977/827 , Y10S977/83 , Y10T428/2991 , Y10T428/2993
摘要： Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.

38. 发明公开

EP2305775A2 Functionalized fluorescent nanocrystals, and methods for their preparation and use 审中-公开
标题翻译：功能化的荧光纳米晶及其制备方法和用途
公开(公告)号：EP2305775A2
公开(公告)日：2011-04-06
申请号：EP10183581.7
申请日：2005-10-28
申请人： Molecular Probes, Inc.
发明人： Naasani, Imad
IPC分类号： C09K11/54 , G01N33/58
CPC分类号： B82Y15/00 , C09K11/025 , C09K11/883 , G01N33/588 , Y10S977/773 , Y10S977/792 , Y10S977/793 , Y10S977/795 , Y10S977/811 , Y10S977/827 , Y10S977/83 , Y10T428/2991 , Y10T428/2993
摘要： Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.
摘要翻译：功能化的荧光纳米晶体复合物及制备和使用这些组合物的方法是游离缺失盘。所述组合物是涂覆有至少一种材料的荧光纳米晶体。该涂层材料具有官能团或部分具有共轭电子和用于赋予溶解性在wässrige溶液涂覆的荧光纳米晶结构部分的化学化合物或配体。涂层材料提供用于官能化纳米晶体的荧光组合物，其是水溶性的，化学性质稳定，而且发射光具有高量子产率和/或发光效率当与光激发。因此，该涂层材料可以具有与部分的化学化合物或配体用于结合到靶向用于交联涂层的分子和细胞以及部分。在适于反应以形成覆盖层的试剂的存在下，在涂层中的化合物可形成与可操作地接合到覆盖层的涂层化合物的荧光纳米晶体的封盖层。

39. 发明公开

EP1621635A3 Self-assembling recombinant HP16 papillomavirus capsid proteins 失效
标题翻译：从重组HPV16乳头瘤病毒自组装的衣壳蛋白
公开(公告)号：EP1621635A3
公开(公告)日：2009-10-21
申请号：EP04078323.5
申请日：1993-09-03
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Lowy, Douglas R., National Institutes of Health , Schiller, John T. , Kirnbauer, Reinhard, Univ.of Vienna Medical School
IPC分类号： C12N15/37 , C12N7/04 , C12N15/86 , C12N5/10 , A61K39/12 , G01N33/53 , C07K14/025
CPC分类号： C12N7/00 , A01K2227/10 , A61K39/00 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2800/30 , Y10S435/975 , Y10S977/795 , Y10S977/804 , Y10S977/918 , Y10S977/927
摘要： Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

40. 发明公开

EP1538209A3 SELF-ASSEMBLING RECOMBINANT HPV16 PAPILLOMAVIRUS CAPSID PROTEINS 失效
标题翻译：自组装的衣壳蛋白的重组HPV16 FROM乳头瘤病毒
公开(公告)号：EP1538209A3
公开(公告)日：2008-02-20
申请号：EP04104531.1
申请日：1993-09-03
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Lowy, Douglas R , Schiller, John T , Kirnbauer, Reinhard
IPC分类号： C12N15/37 , C12N7/04 , C12N15/86 , C12N5/10 , A61K39/12 , G01N33/53 , C07K14/025
CPC分类号： C12N7/00 , A01K2227/10 , A61K39/00 , A61K2039/525 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2800/30 , Y10S435/975 , Y10S977/795 , Y10S977/804 , Y10S977/918 , Y10S977/927
摘要： Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

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