专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明公开

EP2860259A4 METHOD FOR PRODUCING PROTEIN BY PRECIPITATION 有权
标题翻译：方法产生蛋白质的沉淀BY
公开(公告)号：EP2860259A4
公开(公告)日：2016-01-13
申请号：EP14751491
申请日：2014-02-18
申请人： AJINOMOTO KK
发明人： NONAKA TAKAHIRO , MANNEN TERUHISA , TSURUI NORIKO
IPC分类号： C12P21/02 , C07K1/30 , C07K14/32 , C07K14/34 , C07K14/815 , C07K19/00 , C12N15/09
CPC分类号： C07K1/30 , C07K1/34 , C07K1/36 , C07K14/00 , C07K14/32 , C07K14/34 , C07K14/62 , C07K14/635 , C07K14/815 , C07K2319/00 , C07K2319/50 , C07K2319/70

32. 发明公开

EP2951552A2 DISPOSABLE DIRECT CAPTURE DEVICE 审中-公开
标题翻译： WEGWERFBARE DIREKTERFASSUNGSVORRICHTUNG
公开(公告)号：EP2951552A2
公开(公告)日：2015-12-09
申请号：EP13874031.1
申请日：2013-12-13
申请人： EMD Millipore Corporation
发明人： CACACE, Benjamin
IPC分类号： G01N1/10 , G01N33/50 , G01N33/68 , C12Q1/68 , C12N15/10
CPC分类号： G01N1/34 , B01J39/26 , B01J41/20 , B01J47/014 , B01J47/022 , B01J47/127 , B01L3/505 , B01L2200/12 , B01L2300/0681 , B01L2300/123 , C07K1/14 , C07K1/36 , G01N1/405
摘要： The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.
摘要翻译：本发明涉及一种液体样品制备装置，例如一次性，可折叠，柔性聚合物袋，其包含用于从液体样品直接捕获生物分子的官能化成形聚合物纤维床的吸附帘。功能化成形的聚合物纤维床包括原纤化的，脊状或翼状的纤维结构，其显着增加纤维的表面积，导致当液体样品接触吸附窗帘时，含有生物分子的液体样品的增强的分离，保留和/或纯化的功能化成形纤维。液体样品包括未澄清的液体进料或含有一种或多种感兴趣的生物分子的其它液体，包括但不限于疫苗，重组蛋白，细胞，干细胞，单克隆抗体（mAb），蛋白质，抗体，肽，寡肽，核酸，寡核苷酸，RNA，DNA，寡糖和多糖。

33. 发明公开

EP2791176A4 A METHOD OF ANTIBODY PURIFICATION 有权转让
标题翻译：方法抗体清洗
公开(公告)号：EP2791176A4
公开(公告)日：2015-08-19
申请号：EP12857495
申请日：2012-12-14
申请人： HANWHA CHEMICAL CORP
发明人： YOON JI YONG , LEE DONG EUN , KIM WON KYUM , YOUN JEONG WON , BAEK JUNG EUN
IPC分类号： C07K16/28 , C07K1/18 , C07K1/20 , C07K1/34
CPC分类号： C07K1/20 , C07K1/18 , C07K1/36 , C07K16/065 , C07K16/32
摘要： The present invention relates to a method for preparing a population of antibodies to have high purity and high quality by removing antibody isoforms and impurities through the use of a cation exchange column, a hydrophobic interaction column, and an anion exchange column successively, without using a protein A column; and to a population of antibodies prepared by the above method.

34. 发明公开

EP2773959A4 PROTEIN FRACTIONATION BASED ON pI 审中-公开
标题翻译： PROTEINFRAKTIONIERUNG AUF PL-BASIS
公开(公告)号：EP2773959A4
公开(公告)日：2015-07-22
申请号：EP12844702
申请日：2012-11-05
申请人： BIO RAD LABORATORIES , TECHNION RES & DEV FOUNDATION
发明人： PAULUS ARAN , DIGES CAMILLE , BOGOEV ROUMEN , BANDHAKAVI SRICHARAN , HAHN-WINDGASSEN ANNETT , POSCH ANTON , BROD ELAD , SIVAN URI
IPC分类号： G01N33/559 , C07K1/26 , C07K1/28 , C07K1/36 , G01N27/447
CPC分类号： G01N27/44795 , C07K1/28 , C07K1/36 , G01N27/26
摘要： Methods and devices for detecting and collection analytes fractionated based on pI, separating analytes via electrophoresis and pI, and purifying a target molecule using pI focusing and subsequent crystallization are provided.
摘要翻译：提供了基于pI分离分离的分析物的方法和装置，通过电泳和pI分离分析物，并使用pI聚焦和随后的结晶纯化目标分子。

35. 发明公开

EP2773439A4 CHROMATOGRAPHY PROCESS FOR RESOLVING HETEROGENEOUS ANTIBODY AGGREGATES 审中-公开
标题翻译：色谱法测定解决方案不均一的抗体骨料
公开(公告)号：EP2773439A4
公开(公告)日：2015-07-01
申请号：EP12846186
申请日：2012-10-25
申请人： MERCK SHARP & DOHME
发明人： NTIGYABAAH JOSEPH , MEISSNER SANDRA , CHMIELOWSKI REBECCA , KONIETZKO JANELLE
IPC分类号： C12P21/08 , B01D15/36 , B01D15/38 , C07K16/00 , C07K16/24
CPC分类号： C07K1/165 , B01D15/363 , B01D15/3809 , C07K1/36 , C07K16/00 , C07K16/241 , B01D15/327 , B01D15/3847
摘要： Disclosed are methods and processes utilizing multi-modal chromatography as a polishing step to separate heterogeneously charged (basic and acidic) aggregates and other impurities from partially a partially purified bulk product monoclonal antibody product. The resulting chromatographic process provides a scaleable production process that is cost effective and increases the productivity of the purification process over a platform utilizing a combination of anion and cation exchange chromatography to resolve heterogeneous aggregates.

36. 发明公开

EP2630153A4 METHODS FOR PROCESSING INCLUSION BODIES 审中-公开
标题翻译：一种用于处理包涵体
公开(公告)号：EP2630153A4
公开(公告)日：2015-06-03
申请号：EP11835117
申请日：2011-10-20
申请人： MEDIMMUNE LLC
发明人： O'CONNOR ELLEN T
IPC分类号： C07K1/113 , C07K1/34
CPC分类号： C07K1/36 , C07K1/113 , C07K1/1133 , C07K1/1136 , C07K1/145 , C07K1/34

37. 发明公开

EP2864346A1 METHOD OF PURIFYING AN ANTIBODY 有权转让
标题翻译： VERFAHREN ZUR REINIGUNG EINES防刺针
公开(公告)号：EP2864346A1
公开(公告)日：2015-04-29
申请号：EP12728608.6
申请日：2012-06-21
申请人： Synthon Biopharmaceuticals B.V.
发明人： KOKKE, Bastiaan Pieter Arian , VAN WIJK-BASTEN, Everdina Josephina Wilhelmina , DE BEIJER, Thomas Antonius Bernardus , EPPINK, Michel Hendrikus Maria , MARZÁ PÉREZ, Maria
IPC分类号： C07K1/36
CPC分类号： C07K1/36 , C07K1/18 , C07K1/34 , C07K16/065 , C07K16/32 , C07K2317/14
摘要： A method of purifying an antibody composition comprises application of anion exchange chromatography late in the purification process. An ultrafiltration/diafiltration-purified antibody composition is subjected to anion exchange chromatography (AEX) to form a pharmaceutically-pure antibody composition.
摘要翻译：纯化抗体组合物的方法包括在纯化过程中晚期应用阴离子交换色谱法。将超滤/渗滤纯化的抗体组合物进行阴离子交换层析（AEX）以形成药物纯的抗体组合物。

38. 发明公开

EP2832745A1 HIGH PURITY CYCLOPEPTIDE COMPOUND AS WELL AS PREPARATION METHOD AND USE THEREOF 审中-公开
标题翻译：维多利亚·多芬（VERWENDUNG DAVON）的HOCHREINE CYCLOPEPTIDVERBINDUNG SOWIE HERSTELLUNGSVERFAHREN
公开(公告)号：EP2832745A1
公开(公告)日：2015-02-04
申请号：EP13769311.5
申请日：2013-03-29
申请人： Shanghai Techwell Biopharmaceutical Co., Ltd
发明人： LIU, Shidong , ZHANG, Zhaoli , WANG, Xiusheng , ZHANG, Xiao , JIAO, Guangjun , HE, Bingming , TANG, Zhijun , JI, Xiaoming
IPC分类号： C07K7/56 , C12P21/04 , A61K38/12 , A61P31/10
CPC分类号： C07K1/36 , A61K38/00 , A61K38/12 , C07K1/306 , C07K1/34 , C07K7/56
摘要： Disclosed is a high purity cyclopeptide compound, the chemical structure of which is represented by formula (I). R represents H or a cation capable of forming a pharmaceutically acceptable salt, the purity being greater than or equal to 99.0%. Further disclosed are preparation method and use of the high purity cyclopeptide compound.
摘要翻译：公开了一种高纯度环肽化合物，其化学结构由式（I）表示。 R表示H或能够形成药学上可接受的盐的阳离子，纯度大于或等于99.0％。还公开了高纯度环肽化合物的制备方法和用途。

39. 发明公开

EP2825555A1 IMPROVED PROCESS FOR PRODUCTION OF FIBRINOGEN AND FIBRINOGEN PRODUCED THEREBY 有权
标题翻译： VERBESSERTES VERFAHREN ZUR FIBRINOGENHERSTELLUNG UNDE DADURCH HERGESTELLTES FIBRINOGEN
公开(公告)号：EP2825555A1
公开(公告)日：2015-01-21
申请号：EP13709190.6
申请日：2013-03-12
申请人： Octapharma AG
发明人： SCHULZ, Petra , GEHRINGER, Werner , PAPE, Rainer , LEITINGER, Caroline , SCHÖN, Friedrich , RÖMISCH, Jürgen
IPC分类号： C07K14/75
CPC分类号： C07K1/36 , C07K14/75
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterised in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
摘要翻译：一种通过在一种或多种螯合剂存在下由含纤维蛋白原溶液沉淀纤维蛋白原的纤维蛋白原来净化纤维蛋白原的方法，并从纤维蛋白原浆糊中除去上清液，其特征在于纤维蛋白原为从形成含有纤维蛋白原的液体部分的糊剂中提取，以及与液体分离的未溶解残余物。

40. 发明授权

EP2215117B1 ANTIBODY PURIFICATION BY CATION EXCHANGE CHROMATOGRAPHY 有权
标题翻译：抗体纯化阳离子交换层析
公开(公告)号：EP2215117B1
公开(公告)日：2014-12-31
申请号：EP08844379.1
申请日：2008-10-29
申请人： Genentech, Inc.
发明人： LEBRETON, Benedicte Andree , O'CONNOR, Deborah Ann , SAFTA, Aurelia , SHARMA, Mandakini
IPC分类号： C07K16/06 , C07K1/18 , C07K16/28 , C07K16/22
CPC分类号： C07K1/18 , C07K1/36 , C07K16/065 , C07K16/22 , C07K16/2887 , C07K2317/24
摘要： A method for purifying an antibody by cation exchange chromatography is described in which a high pH wash step is used to remove of contaminants prior to eluting the desired antibody using an elution buffer with increased conductivity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式