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31. 发明公开

EP2519101A4 AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME 有权
标题翻译：喹硫平的氨基酸偶联物，方法及其使用和
公开(公告)号：EP2519101A4
公开(公告)日：2013-06-26
申请号：EP10841599
申请日：2010-12-22
申请人： KEMPHARM INC
发明人： MICKLE TRAVIS , GUENTHER SVEN , BERA SANJIB
IPC分类号： C07D267/18 , A61K31/554 , A61P25/00
CPC分类号： A61K47/48038 , A61K9/0053 , A61K31/553 , A61K31/554 , A61K45/06 , A61K47/542 , C07D267/18
摘要： The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.

32. 发明公开

EP2489657A3 Inhibitors of histone deacetylase 审中-公开
标题翻译：蛋白去乙酰化酶抑制剂
公开(公告)号：EP2489657A3
公开(公告)日：2012-11-28
申请号：EP11187842.7
申请日：2007-10-26
申请人： MethylGene Inc. , Envivo Pharmaceuticals, Inc.
发明人： Deziel, Robert , Leit, Silvana , Beaulieu, Patrick , Chantigny, Yves Andre , Mancuso, John , Tessier, Pierre , Shapiro, Gideon , Chesworth, Richard , Smil, David
IPC分类号： C07D209/00 , C07D223/00 , C07D239/00 , C07D243/00 , C07D267/00 , C07D279/00 , A61K31/55 , A61P43/00 , C07D403/00 , C07D413/00 , C07D471/00
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.

33. 发明公开

EP2161320A3 Fluorene derivatives and organic electroluminescent device using the same 审中-公开
标题翻译： Fluoren Derivate und organische Elektrolumineszenzvorrichtung damit
公开(公告)号：EP2161320A3
公开(公告)日：2010-07-14
申请号：EP09250919.9
申请日：2009-03-30
申请人： Gracel Display Inc.
发明人： Kim, Young Gil , Cho, Young Jun , Kwon, Hyuck Joo , Kim, Bong Ok , Kim, Sung Min , Yoon, Seung Soo , Kim, Chi Sik , Eum, Sung Jin
IPC分类号： C09K11/06
CPC分类号： C09K11/06 , C07C211/61 , C07C217/92 , C07C2603/18 , C07C2603/26 , C07C2603/42 , C07C2603/48 , C07C2603/50 , C07C2603/52 , C07C2603/94 , C07D209/86 , C07D213/38 , C07D213/74 , C07D215/38 , C07D217/22 , C07D219/02 , C07D223/22 , C07D241/46 , C07D251/22 , C07D267/18 , C07D279/22 , C07D333/20 , C07D333/76 , C07D401/14 , C07F7/0816 , C07F7/0818 , C07F9/65683 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/1059 , C09K2211/1092 , C09K2211/1096 , H01L51/0058 , H01L51/006 , H01L51/0061 , H01L51/0072 , H01L51/0085 , Y02E10/549
摘要： Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same as an electroluminescent material. The disclosed organic electroluminescent compound is represented by Chemical Formula 1:

wherein
Ar represents (C6-C60)arylene, (C3-C60)heteroarylene containing one or more heteroatom(s) selected from N, O and S, 5- or 6-membered heterocycloalkylene containing one or more heteroatom(s) selected from N, O and S, (C3-C60)cycloalkylene, adamantylene, (C7-C60)bicycloalkylene, (C2-C60)alkenylene, (C2-C60)alkynylene, (C1-C60)alkylenethio, (C6-C60)alkyleneoxy, (C6-C60)aryleneoxy, (C6-C60)arylenethio or
摘要翻译：提供了一种新的有机电致发光化合物和使用其作为电致发光材料的有机电致发光器件。所公开的有机电致发光化合物由化学式1表示：其中Ar表示（C6-C60）亚芳基，（C3-C60）亚杂芳基，其含有一个或多个选自N，O和S的杂原子，5-或6-元含有一个或多个选自N，O和S的杂原子的杂环亚烷基，（C 3 -C 60）亚环烷基，金刚烷基，（C 7 -C 60）双环亚烷基，（C 2 -C 60）亚烯基，（C 2 -C 60）亚炔基，（C 1 -C 60） C60）亚烷基硫代，（C6-C60）亚烷基氧基，（C6-C60）亚芳氧基，（C6-C60）亚芳基硫醚或

34. 发明公开

EP2161320A2 Fluorene derivatives and organic electroluminescent device using the same 审中-公开
标题翻译：芴衍生物及使用其的有机电致发光器件
公开(公告)号：EP2161320A2
公开(公告)日：2010-03-10
申请号：EP09250919.9
申请日：2009-03-30
申请人： Gracel Display Inc.
发明人： Kim, Young Gil , Cho, Young Jun , Kwon, Hyuck Joo , Kim, Bong Ok , Kim, Sung Min , Yoon, Seung Soo , Kim, Chi Sik , Eum, Sung Jin
IPC分类号： C09K11/06
CPC分类号： C09K11/06 , C07C211/61 , C07C217/92 , C07C2603/18 , C07C2603/26 , C07C2603/42 , C07C2603/48 , C07C2603/50 , C07C2603/52 , C07C2603/94 , C07D209/86 , C07D213/38 , C07D213/74 , C07D215/38 , C07D217/22 , C07D219/02 , C07D223/22 , C07D241/46 , C07D251/22 , C07D267/18 , C07D279/22 , C07D333/20 , C07D333/76 , C07D401/14 , C07F7/0816 , C07F7/0818 , C07F9/65683 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1044 , C09K2211/1059 , C09K2211/1092 , C09K2211/1096 , H01L51/0058 , H01L51/006 , H01L51/0061 , H01L51/0072 , H01L51/0085 , Y02E10/549
摘要： Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same as an electroluminescent material. The disclosed organic electroluminescent compound is represented by Chemical Formula 1:

wherein
Ar represents (C6-C60)arylene, (C3-C60)heteroarylene containing one or more heteroatom(s) selected from N, O and S, 5- or 6-membered heterocycloalkylene containing one or more heteroatom(s) selected from N, O and S, (C3-C60)cycloalkylene, adamantylene, (C7-C60)bicycloalkylene, (C2-C60)alkenylene, (C2-C60)alkynylene, (C1-C60)alkylenethio, (C6-C60)alkyleneoxy, (C6-C60)aryleneoxy, (C6-C60)arylenethio or
摘要翻译：提供了一种新颖的有机电致发光化合物和使用其作为电致发光材料的有机电致发光器件。所公开的有机电致发光化合物由化学式1表示：其中Ar表示包含一个或多个选自N，O和S的杂原子的（C 6 -C 60）亚芳基，（C 3 -C 60）亚杂芳基，5-或6-元（C3-C60）亚环烷基，亚金刚烷基，（C7-C60）二亚环烷基，（C2-C60）亚烯基，（C2-C60）亚炔基，（C1- C60）亚烷基硫基，（C6-C60）亚烷基氧基，（C6-C60）亚芳基氧基，（C6-C60）亚芳基硫基或

35. 发明公开

EP2049483A2 INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译： N-羟基-2-甲基-2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚-8-羧酰胺偶氮乙酰化酶
公开(公告)号：EP2049483A2
公开(公告)日：2009-04-22
申请号：EP07863550.5
申请日：2007-10-26
申请人： Methylgene, Inc. , Envivo Pharmaceuticals, Inc.
发明人： DEZIEL, Robert , LEIT Silvana , BEAULIEU Patrick , CHANTIGNY Yves Andre , MANCUSO John , TESSIER Pierre , SHAPIRO Gideon , CHESWORTH Richard , SMIL David
IPC分类号： C07D209/22 , C07D209/70 , C07D221/12 , C07D223/26 , C07D225/08 , C07D239/28 , A61K31/55 , A61K31/554 , A61K31/5513 , A61P43/00 , C07D239/34 , C07D239/42 , C07D243/14 , C07D243/24 , A61K31/553
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein (B), Q, J, L and Z are as defined in the specification.

36. 发明公开

EP1471060A1 5,11-Dihydrodibenzo[b,e][1,4]-oxazepine derivatives as calcium channel antagonists 审中-公开
标题翻译： 5,11-二氢二苯并（e）-1,4-氧氮杂 - 维生素E钙钙拮抗剂
公开(公告)号：EP1471060A1
公开(公告)日：2004-10-27
申请号：EP04014975.9
申请日：2000-01-11
申请人： Ajinomoto Co., Inc.
发明人： Sakata, Katsutoshi , Tsuji, Takashi , Sasaki, Noriko , Takahasi, Kazuyoshi
IPC分类号： C07D267/18 , C07D413/04 , C07D413/14 , A61K31/553 , A61P1/00
CPC分类号： C07D413/06 , C07D267/18 , C07D413/04 , C07D413/12 , C07D413/14
摘要： 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives of following general formula [Ib], stereoisomers thereof, pharmacologically acceptable salts thereof or hydrates thereof:
wherein R 1 to R 5 may be the same or different from each other and they each represent hydrogen atom, a halogen atom, cyano group, hydroxyl group, a lower alkyl group, a lower alkoxyl group, amino group or a lower alkylamino group, or R 1 and R 2 , R 2 and R 3 , R 3 and R 4 or R 4 and R 5 together represent -O(CH 2 ) n O- group (n being 1, 2 or 3),
A represents CH 2 , CHOH, CO or O, B represents CH 2 , CHOH or CO, or A-B represents CH=CH, and D represents CH 2 , CH 2 -CH 2 or CH 2 -CH 2 - CH 2 , or B-D represents CH 2 , and pharmaceutical compositions containing them are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, particularly irritable bowel syndrome.
摘要翻译：二苯并[b，e] [1,4]氧氮杂衍生物（I）是新的。式（I）的二苯并[b，e] [1,4]氧氮杂衍生物及其盐和水合物是新的。 [图] Q：CH2VDBAPh，V1DBAPh或CH2CH2N（R6）DBAPh; V：哌啶-1,2-二基，吗啉-3,4-二基，硫代吗啉-3,4-二基）或全部通过N连接到D的4-甲基 - 哌嗪-1,2-二基; 通过N连接到D的V1吡咯烷-1,3-二基; Ph：任选被1-5个卤素，CN，OH，低级烷基，低级烷氧基或低级烷基氨基取代的苯基，或被O（CH 2）n O取代在2个相邻的C上; n：1-3; R6H或低级烷基; A：CH2，CHOH，CO或O; B：CH 2，CHOH或CO; 或A + B：CH = CH; D：CH2，CH2CH2或CH2CH2CH2; 或BD：CH2。活性：抗炎。作用机制：钙拮抗剂。在体外测定（R）-5,11-二氢-5- [1-（4-甲氧基苯乙基）吡咯烷-3-基]二苯并[b，e] [1,4]氧氮杂（Ia）.HCl具有IC50值对于大鼠血管和肠钙通道活性分别为92nM和18nM。

37. 发明公开

EP0402699A3 Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates 失效
标题翻译：色素二苯并恶唑酮和二苯并噻吩酮酶基质
公开(公告)号：EP0402699A3
公开(公告)日：1991-01-30
申请号：EP90110198.0
申请日：1990-05-30
申请人： MILES INC.
发明人： Corey, Paul F.
IPC分类号： C07H15/26 , C07H17/00 , C12Q1/34
CPC分类号： C07F9/6536 , C07D267/18 , C07D281/14 , C07F9/6527 , C07H17/00 , C12Q1/34 , C12Q2334/00 , G01N2333/924
摘要： Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.

38. 发明授权

EP0074304B1 Ethers tricycliques, leur préparation et les compositions pharmaceutiques les contenant 有权
标题翻译：三氯乙烯及其制备方法及其在药物制剂中的应用
公开(公告)号：EP0074304B1
公开(公告)日：1985-04-03
申请号：EP82401567.1
申请日：1982-08-24
申请人： ADIR
发明人： Malen, Charles , Poignant, Jean-Claude
IPC分类号： C07D313/12 , C07D267/18 , C07D311/80 , A61K31/335 , A61K31/35 , A61K31/55
CPC分类号： C07D313/12 , C07D267/18 , C07D311/80

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