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31. 发明公开

EP2166340A1 Method and apparatus for sorting cells 有权
标题翻译： Verfahren und Vorrichtung zur Sortierung von Zellen
公开(公告)号：EP2166340A1
公开(公告)日：2010-03-24
申请号：EP09176836.6
申请日：2006-02-01
申请人： Arryx, Inc.
发明人： Mueth, Daniel , Anderson, Amy L. , Knutson, Christopher R. , Plewa, Joseph
IPC分类号： G01N21/01 , G01N33/00 , G01N15/14
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： An apparatus for sorting and orienting sperm cells includes a pair of walls in confronting arrangement and forming a flow chamber having an inlet, a downstream outlet, and an intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted, forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects the desired cells and a sorter downstream of the detector, sorts the desired cells from the stream.
摘要翻译：用于分选和定向精子细胞的装置包括一对面对面的布置并形成具有入口，下游出口和中间检测器区域的流动室。入口容纳第一和第二间隔的输入流体流和含有待分选细胞的第三流样品流体。第一和第二流具有相对于第三流的相应流速，使得第三流收缩，形成相对较窄的样品流，使得电池平行于壁取向。检测器检测所需的细胞和检测器下游的分选器，从流中分选所需的细胞。

32. 发明公开

EP1500311A4 APPARATUS AND METHOD TO GENERATE AND CONTROL OPTICAL TRAPS TO MANIPULATE SMALL PARTICLES 有权
标题翻译：设备和方法产生和控制进行操纵的小颗粒的光阱
公开(公告)号：EP1500311A4
公开(公告)日：2009-02-18
申请号：EP03721600
申请日：2003-04-10
申请人： ARRYX INC
发明人： GRIER DAVID , LOPES WARD
IPC分类号： G02B21/32 , G21K1/00 , B01J19/12
CPC分类号： G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： The present invention relates generally to an apparatus and method to generate and control optical traps (1000, 1002) for manipulation of small particles. An upstream modification of an input laser beam (12, 22) provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps (1000, 1002) with a corresponding cross section of intensity.

33. 发明公开

EP1846748A2 METHOD AND APPARATUS FOR SORTING CELLS 有权
标题翻译：方法和装置细胞分选
公开(公告)号：EP1846748A2
公开(公告)日：2007-10-24
申请号：EP06720022.0
申请日：2006-02-01
申请人： Arryx, Inc.
发明人： MUETH, Daniel , ANDERSON, Amy, L. , KNUTSON, Christopher, R. , PLEWA, Joseph
IPC分类号： G01N21/01 , G01N33/00
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： Apparatus for sorting and orienting sperm cells has a pair or walls (314, 316) in confronting relationship forming a flow chamber (312) having inlet, a downstream outlet, and intermediate detector region (338). The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid (328) containing the cells (330) to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells (330) are oriented parallel to the walls (314, 316). A detector (340) detect desired cells (330) and a sorter (356) downstream of the detector (340) for sorting the desired cells (330) from the stream.

34. 发明公开

EP1793249A3 Optical switches and routers and optical filters 审中-公开
标题翻译：光交换机和路由器和光滤波器
公开(公告)号：EP1793249A3
公开(公告)日：2007-08-29
申请号：EP07104668.4
申请日：2002-06-20
申请人： Arryx, Inc. , Bradley, Kenneth A.
发明人： Bradley, Kenneth A. , Lopes, Ward
IPC分类号： G02B6/28 , G02F1/313 , G02F1/01 , G02B6/12
CPC分类号： G02F1/011 , G02B6/2706 , G02B6/29338 , G02B6/29341 , G02B6/29343 , G02B6/2935 , G02B6/29395 , G02F1/3132 , G02F2203/15 , G02F2203/585
摘要： Our invention relates generally to an optical switch (31) and an optical router (10) to rapidly route signals from particular channels (22, 24) within an optical band by using optical switches (20) which utilize a controlled whispering gallery mode (WGM) resonance of dielectric microspheres (S1, S2, S3) to optically switch signals. Another invention relates to optical filters which use a WGM resonate structure (150) to isolate and switch specific optical signals between waveguides (F1, F2). In other inventions, the filter (100) is switched "on/off" by signal loss within a WGM resonate structure (150) which disrupts the WGM resonance; the filter (100) isolates and switches a specific wavelength signal from among a group of signals of different wavelengths; and is switched "off" by adjusting the index of refraction of the resonate structure to become substantially similar to the index of refraction of the surrounding medium.

35. 发明公开

EP1687663A2 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：系统和方法进行操纵和材料的改性使用全息光学撷取
公开(公告)号：EP1687663A2
公开(公告)日：2006-08-09
申请号：EP04817812.3
申请日：2004-10-28
申请人： Arryx, Inc.
发明人： PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： G02B5/32 , G03H1/22 , G03H1/08
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method for trapping particles where a characteristic of a particle is selected, a laser is used to generate a holographic optical trap, and the beams are modulated and focused as desired.

36. 发明公开

EP1663460A2 MULTIPLE LAMINAR FLOW-BASED PARTICLE AND CELLULAR SEPARATION WITH LASER STEERING 有权
标题翻译： ONMEHRFACHLAMINARSTRÖMEN基于颗粒分离和细胞激光控制
公开(公告)号：EP1663460A2
公开(公告)日：2006-06-07
申请号：EP04783338.9
申请日：2004-09-03
申请人： Arryx, Inc.
发明人： Rosenbaum, Neil, Harris , ANDERSON, Amy , GRUBER, Lewis , MUETH, Dan , PLEWA, Joseph , SHIREMAN, Jessica
IPC分类号： B01D61/00
CPC分类号： A61M1/36 , A61M1/38 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , H05H3/04
摘要： An apparatus (100) for separating a plurality of components (A, B, C, E) in a fluid includes an optically transparent sorting channel (110) having a first inlet (120) for a first flow (W) and a second inlet (120) for a second flow (X), and a first outlet (130) for the first flow (W) and a second outlet (130) for the second flow (X); and a holographic optical trap system (210) coupled to the optically transparent sorting channel (200) for selectively moving a first component (A) of the plurality of components (A, B, C, E) in the first flow (W) into the second flow (X) to form an enriched second flow (X).

37. 发明公开

EP1438182A1 OPTICAL TOOLS MANIPULATED BY OPTICAL TRAPS 审中-公开
标题翻译： BY光阱使用光敏工具
公开(公告)号：EP1438182A1
公开(公告)日：2004-07-21
申请号：EP02796453.5
申请日：2002-09-03
申请人： Arryx, Inc.
发明人： GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： B29D11/00 , H05H3/04
CPC分类号： B82Y20/00 , B82Y10/00 , B82Y30/00 , G02B21/32
摘要： Micrometer and nanometer-sized tools (69), refered to as MOTS an d NOTS, respectively, are manipulated in the illumination (71) of an optical trap (70) and are able to alter the physical, chemical or electronic structure or orientation of a workpiece (68).

38. 发明公开

EP1410080A1 OPTICAL SWITCHES AND ROUTERS AND OPTICAL FILTERS 审中-公开
标题翻译：光交换机和路由器和光滤波器
公开(公告)号：EP1410080A1
公开(公告)日：2004-04-21
申请号：EP02747920.3
申请日：2002-06-20
申请人： Arryx, Inc. , Bradley, Kenneth A.
发明人： BRADLEY, Kenneth, A. , LOPES, Ward
IPC分类号： G02B6/28
CPC分类号： G02F1/011 , G02B6/2706 , G02B6/29338 , G02B6/29341 , G02B6/29343 , G02B6/2935 , G02B6/29395 , G02F1/3132 , G02F2203/15 , G02F2203/585
摘要： Our invention relates generally to an optical switch (31) and an optical router (10) to rapidly route signals from particular channels (22, 24) within an optical band by using optical switches (20) which utilize a controlled whispering gallery mode (WGM) resonance of dielectric microspheres (S1, S2, S3) to optically switch signals. Another invention relates to optical filters which use a WGM resonate structure (150) to isolate and switch specific optical signals between waveguides (F1, F2). In other inventions, the filter (100) is switched 'on/off' by signal loss within a WGM resonate structure (150) which disrupts the WGM resonance; the filter (100) isolates and switches a specific wavelength signal from among a group of signals of different wavelengths; and is switched 'off' by adjusting the index of refraction of the resonate structure to become substantially similar to the index of refraction of the surrounding medium.

39. 发明公开

EP1395856A2 IMPROVED APPARATUS, SYSTEM AND METHOD FOR APPLYING OPTICAL GRADIENT FORCES 审中-公开
标题翻译：改进的设备，用于光学梯度力更好地利用改进系统和方法
公开(公告)号：EP1395856A2
公开(公告)日：2004-03-10
申请号：EP02734431.6
申请日：2002-05-14
申请人： Arryx, Inc.
发明人： GRIER, David , LOPES, Ward , DUFRESNE, Eric
IPC分类号： G02B5/18
CPC分类号： G02B21/32
摘要： An apparatus to produce and monitor at least two optical traps (1002, 1004) comprising a phase patterning element (12), a single transfer lens (L1), a beam splitter (51).

40. 发明公开

EP2883063A1 METHODS AND DEVICES FOR IMMUNODIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于免疫诊断应用的方法和设备
公开(公告)号：EP2883063A1
公开(公告)日：2015-06-17
申请号：EP13756745.9
申请日：2013-08-07
申请人： Arryx, Inc.
发明人： KNUTSON, Christopher, R. , KURELLA, Sridevi , DOORNEWEERD, Derek, D. , GRANT, Christopher, F. , KLINE, Timothy, R.
IPC分类号： G01N33/80 , G01N33/68
CPC分类号： G01N33/80 , G01N33/6854
摘要： Methods and devices for evaluating a sample, e.g., a plasma sample, from a subject, for detecting a target red blood cell protein or antibody are disclosed. In one embodiment, optimized antibody screening methods and devices significantly reduce the level of non-specific binding to a surface (e.g., a test surface bound with a red blood cell (rbcm) preparation), thus allowing for more efficient detection and reduced test time. In one embodiment, the optimized antibody screening method includes an immunoglobulin G (IgG) binding moiety that binds selectively and specifically to the plasma IgG present relative to the binding to the lysed rbcm preparation. In another embodiment, an optimized antibody screening method is disclosed whereby non-specific binding caused by lysed red blood cell membrane preparations can be reduced by an agent that specifically cleaves a human IgG in the hinge region. In other embodiments, the invention provides methods and devices for target capturing that include a substantially planar surface, optionally having an optimized angle, for capture. Alternative solid phase geometries for capture are disclosed. Optimized methods for cell deposition are also disclosed. Thus, optimized methods, devices, kits, assays for evaluating a sample are disclosed.
摘要翻译：公开了用于评估来自受试者的样品（例如血浆样品）以检测目标红细胞蛋白质或抗体的方法和装置。在一个实施方案中，优化的抗体筛选方法和装置显着降低与表面（例如与红细胞（rbcm）制备物结合的测试表面）的非特异性结合水平，从而允许更有效的检测和减少测试时间。在一个实施方案中，优化的抗体筛选方法包括免疫球蛋白G（IgG）结合部分，其相对于与溶解的rbcm制备物的结合选择性且特异性地结合存在的血浆IgG。在另一个实施方案中，公开了一种优化的抗体筛选方法，其中由裂解的红细胞膜制剂引起的非特异性结合可以通过特异性裂解铰链区中的人IgG的试剂降低。在其他实施例中，本发明提供了用于目标捕获的方法和装置，其包括用于捕获的基本上平坦的表面，可选地具有优化的角度。公开了用于捕获的替代固相几何形状。还公开了优化的细胞沉积方法。因此，公开了用于评估样品的优化的方法，装置，试剂盒，分析。

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