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31. 发明授权

EP3010552B1 COMPOSITIONS FOR USE IN ONCOLOGY 有权
公开(公告)号：EP3010552B1
公开(公告)日：2019-04-17
申请号：EP14731952.9
申请日：2014-06-19
申请人： Nanobiotix
发明人： POUL, Laurence , LEVY, Laurent , BERJAUD, Céline , GERMAIN, Matthieu , POTTIER, Agnès
IPC分类号： A61K49/04 , A61P35/00

32. 发明公开

EP3229776A1 PHARMACEUTICAL COMPOSITION COMBINING AT LEAST TWO DISTINCT NANOPARTICLES AND A PHARMACEUTICAL COMPOUND, PREPARATION AND USES THEREOF 有权转让
标题翻译：至少两种不同的纳米颗粒及其药物组合物的药物组合物及其制备和用途
公开(公告)号：EP3229776A1
公开(公告)日：2017-10-18
申请号：EP15800777.3
申请日：2015-11-24
申请人： Nanobiotix
发明人： GERMAIN, Matthieu , MEYRE, Marie-Edith , POTTIER, Agnès , LEVY, Laurent
IPC分类号： A61K9/00 , A61K41/00 , A61K9/127 , A61K51/12
CPC分类号： A61K9/127 , A61K9/00 , A61K31/704
摘要： The present invention relates to a pharmaceutical composition comprising the combination of (i) at least two distinct biocompatible nanoparticles and (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the at least two distinct biocompatible nanoparticles potentiate the compound(s) of interest efficiency. The at least two biocompatible nanoparticles can be administered sequentially or simultaneously to the subject but are to be administered separately, typically with an interval of between more than about 5 minutes and about 72 hours, from the at least one compound of interest, preferably before the administration of the at least one compound of interest, to said subject. The longest dimension of the at least two biocompatible nanoparticles is typically between about 4 nm and about 500 nm. The absolute surface charge value of a first biocompatible nanoparticle is of at least |10 mV| and the absolute surface charge value of the second biocompatible nanoparticle, or of any additional biocompatible nanoparticle, has a difference of at least 10 mV with the absolute surface charge value of the first biocompatible nanoparticle.
摘要翻译：本发明涉及一种药物组合物，其包含（i）至少两种不同的生物相容性纳米颗粒和（ii）至少一种目标化合物（典型地至少一种药用化合物）的组合，待施用于需要至少一种感兴趣的化合物，其中所述至少两种不同的生物相容性纳米颗粒增强目标化合物的效率。所述至少两种生物相容性纳米颗粒可以先后或同时施用于受试者，但通常以至少一种感兴趣的化合物的间隔在大于约5分钟至约72小时之间的时间间隔分开施用，优选在施用将所述至少一种感兴趣的化合物施用于所述受试者。该至少两种生物相容性纳米颗粒的最长尺寸通常在约4nm与约500nm之间。第一生物相容性纳米颗粒的绝对表面电荷值至少为| 10mV | 并且第二生物相容性纳米粒子或任何另外的生物相容性纳米粒子的绝对表面电荷值与第一生物相容性纳米粒子的绝对表面电荷值具有至少10mV的差异。

33. 发明公开

EP3178494A1 METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF 有权
标题翻译：金属纳米粒子，其制备和用途
公开(公告)号：EP3178494A1
公开(公告)日：2017-06-14
申请号：EP17152585.0
申请日：2010-07-09
申请人： Nanobiotix
发明人： LEVY, Laurent , POTTIER, Agnès , POUL, Laurence , MAGGIORELLA, Laurence
IPC分类号： A61K41/00 , A61P35/00
CPC分类号： A61K41/0038 , A61N5/10 , A61N2005/1098
摘要： The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.
摘要翻译：本申请涉及可用于卫生部门，特别是人类健康的打乱，改变或破坏靶细胞，组织或器官的活性纳米粒子。更具体地说，涉及当暴露于电离辐射时可产生显着有效的治疗效果的纳米颗粒。本发明的纳米粒子是具有最大尺寸的金属纳米粒子，其尺寸在约80和105nm之间，所述金属优选具有至少25的原子序数（Z）。本发明还涉及药物组合物，其包含如前所定义的纳米粒子以及它们的用途。

34. 发明公开

EP3150227A1 INORGANIC NANOPARTICLES OF HIGH DENSITY TO DESTROY CELLS IN-VIVO 无效
标题翻译： ANORGANISCHE NANOPARTIKEL，HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP3150227A1
公开(公告)日：2017-04-05
申请号：EP16187263.5
申请日：2009-06-04
申请人： Nanobiotix
发明人： LEVY, Laurent , POTTIER, Agnès , ROUET, Annabelle , MARILL, Julie , DEVAUX, Corinne , GERMAIN, Matthieu
IPC分类号： A61K41/00 , A61P35/00 , B82Y5/00
CPC分类号： A61K41/0038 , B82Y5/00 , Y10S977/904
摘要： The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X-Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.
摘要翻译：本申请涉及可用于健康部门的新型可兴奋颗粒。更具体地说，涉及当通过电离辐射如X射线，3-射线，放射性同位素和/或电子束激发时能够产生电子和/或高能光子的颗粒，以及其在健康中的用途，特别是在人类健康。本发明的颗粒由包含氧，特别是氧化物的无机材料制成，所述材料具有足够的密度，并且可以通过可控的外部激发在体外，离体或体内活化，以便干扰，改变或破坏靶细胞，组织或器官。本发明还涉及生产所述颗粒的方法以及含有该颗粒的药物或医疗装置组合物。

35. 发明公开

EP2790682A1 NANOPARTICLES COMPRISING METALLIC AND HAFNIUM OXIDE MATERIALS, PREPARATION AND USES THEREOF 无效
标题翻译：具有金属氧化铪材料和生产及其应用纳米粒子
公开(公告)号：EP2790682A1
公开(公告)日：2014-10-22
申请号：EP12806026.6
申请日：2012-12-17
申请人： Nanobiotix
发明人： POTTIER, Agnès , LEVY, Laurent , MEYRE, Marie-Edith
IPC分类号： A61K9/51 , A61K33/24 , A61P35/00
CPC分类号： A61K9/5115 , A61K9/0009 , A61K9/51 , A61K33/24 , A61K41/0038 , A61K41/0052 , A61K49/00 , A61K49/04 , A61K51/1244 , A61K2123/00 , A61N5/10
摘要： The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with an hafnium oxide material or embedded therein. When compared to existing products, these nanoparticles offer a remarkable benefit over risk ratio. Specifically, these nanoparticles potentiate the efficiency of known metallic nanoparticles. Indeed, they retain the metal intrinsic properties and are now in addition safely usable in a mammal, in particular in a human being. The invention also relates to methods for producing said nanoparticles, to compositions containing same, and to uses thereof.

36. 发明公开

EP2300054A2 INORGANIC NANOPARTICLES OF HIGH DENSITY TO DESTROY CELLS IN-VIVO 有权
标题翻译：用高密度无机纳米微粒在体内细胞，破坏
公开(公告)号：EP2300054A2
公开(公告)日：2011-03-30
申请号：EP09757595.5
申请日：2009-06-04
申请人： Nanobiotix
发明人： LEVY, Laurent , POTTIER, Agnès , ROUET, Annabelle , MARILL, Julie , DEVAUX, Corinne , GERMAIN, Matthieu
IPC分类号： A61K41/00 , A61P35/00
CPC分类号： A61K41/0038 , B82Y5/00 , Y10S977/904
摘要： The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated
in vitro ,
ex vivo , or
in vivo , by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.

37. 发明授权

EP1744789B1 PARTICULES ACTIVABLES PAR DES RAYONS X ET/OU UV, LEUR PREPARATION ET LEUR UTILISATION THÉRAPEUTIQUE OU DIAGNOSTIQUE 有权转让
标题翻译：用X射线和/或紫外线活化的颗粒，生产及其用途诊断和治疗
公开(公告)号：EP1744789B1
公开(公告)日：2008-08-06
申请号：EP05769516.5
申请日：2005-05-09
申请人： Nanobiotix
发明人： LEVY, Laurent , HOCHEPIED, Jean-François , BALENCIE, Jérémy , PRASAD, Paras, Nath , BERGEY, Earl, Jim , PANAK, Edouard, André , BOUSSAHA, Abdel, Kader
IPC分类号： A61K51/12 , A61K9/14 , A61P35/04
CPC分类号： A61N5/062 , A61K41/0038 , A61K41/0052 , A61K49/0423 , A61N5/10 , A61N2005/0661 , A61N2005/1098 , B82Y5/00 , C12N13/00
摘要： The invention relates to activatable novel particles which can be used in the health sector. The invention more particularly relates to composite particles which can generate free radicals or heat when excited by X-rays. The invention also relates to the uses thereof in human health. The inventive particles comprise an inorganic-based, and optionally organic-based, nucleus and can be activated in vivo in order to mark or affect cells, tissue or organs. The invention further relates to methods for the production of said particles, and pharmaceutical or diagnostic compositions containing them.

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