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31. 发明公开

EP3250647A2 WATERBORNE COMPLEX, COATING PROCEDURE AND USE AS A FLAME RETARDANT 审中-公开
标题翻译：水性复合物，涂层程序和用作阻燃剂
公开(公告)号：EP3250647A2
公开(公告)日：2017-12-06
申请号：EP16744080.9
申请日：2016-01-28
申请人： The Texas A&M University System
发明人： GRUNLAN, Jaime C. , LEISTNER, Marcus , HAILE, Merid M.
IPC分类号： C09D5/18 , C09D201/00 , C09D7/12
CPC分类号： C09D5/185 , C09D5/18 , C09D7/40 , C09D179/02 , C09D201/00 , C09D201/005 , D06M11/72 , D06M15/61 , D06M2101/06 , D06M2200/30 , C08K2003/321
摘要： A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes preparing an aqueous solution. The aqueous solution comprises a phosphate material, a cationic material, and a water. The method further includes exposing the substrate to the aqueous solution to produce a coating on the substrate. The coating includes the cationic material and the phosphate material. The method also includes exposing the coating on the substrate to a melamine solution.

32. 发明公开

EP3240640A1 THIN FILM DIFFUSION BARRIER 审中-公开
标题翻译：薄膜扩散阻挡层
公开(公告)号：EP3240640A1
公开(公告)日：2017-11-08
申请号：EP14909664.6
申请日：2014-12-30
申请人： Compagnie Générale des Etablissements Michelin , MICHELIN Recherche et Technique S.A. , The Texas A&M University System
发明人： GRUNLAN, Jaime C. , WINSTON, Paul , STEVENS, Barton E.
IPC分类号： B05D5/12 , B05D7/02 , H01B1/12
CPC分类号： B65D81/24 , B01D71/021 , B05D3/0254 , B05D3/06 , B05D3/101 , B05D3/107 , B05D7/02 , B05D7/5883 , C09D5/4403
摘要： A rubber substrate has a material diffusion barrier, and a method produces the same. In an embodiment, a method for producing a material diffusion barrier on a rubber substrate include exposing the rubber substrate to a cationic solution to produce a cationic layer on the rubber substrate. The method also includes exposing the cationic layer to an anionic solution 5 to produce an anionic layer on the cationic layer. The anionic layer comprises graphene oxide. The layer includes the cationic layer and the anionic layer. The layer comprises the material diffusion barrier.

33. 发明公开

EP3195327A2 ORGANIC THERMOELECTRIC COMPOSITES AND THEIR USES 审中-公开
标题翻译：有机热电复合材料及其用途
公开(公告)号：EP3195327A2
公开(公告)日：2017-07-26
申请号：EP15836549.4
申请日：2015-06-12
申请人： The Texas A&M University System
发明人： YU, Choongho , GRUNLAN, Jaime C. , CHO, Chungyeon
IPC分类号： H01B1/12 , H01L35/12
CPC分类号： H01L35/24 , F25B21/02 , H01B1/24 , H01L23/38 , H01L35/02 , H01L35/32 , H01L35/34
摘要： Embodiments of the invention are directed to conducting polymers are used to produce polymer composites through the addition of graphitic carbon. The concentration of graphitic carbons such as carbon nanotubes is low enough to produce many non-percolated networks of graphitic carbons. Potential commercial applications include self-powered energy harvesting units operated by any type and grade heat including body heat and waste heat. Embodiments of the invention are also directed to a process for a thermoelectric nanocomposite thin film comprising organic conducting polymers and organic conducting nanomaterials.
摘要翻译：本发明的实施方案涉及通过添加石墨碳来使用导电聚合物来生产聚合物复合材料。石墨碳如碳纳米管的浓度足够低以产生许多石墨碳的非渗透网络。潜在的商业应用包括由任何类型和等级的热量运行的自供能量收集单元，包括体热和废热。本发明的实施方案还涉及包含有机导电聚合物和有机导电纳米材料的热电纳米复合薄膜的方法。

34. 发明公开

EP3188734A1 METHOD OF TREATING ORGANOPHOSPHATE INTOXICATION 审中-公开
标题翻译：治疗有机磷中毒的方法
公开(公告)号：EP3188734A1
公开(公告)日：2017-07-12
申请号：EP15838694.6
申请日：2015-09-01
申请人： The Texas A&M University System
发明人： REDDY, Doodipala, Samba
IPC分类号： A61K31/56 , A61K9/48 , A61P25/28
CPC分类号： A61K31/57 , A61K31/565 , A61K31/573
摘要： The present invention provides new compositions and methods for treating and/or reversing organophosphate intoxication, manifested by both cholinergic and non-cholinergic crisis, in a mammal resulting from exposure to organophosphate compounds. The neurosteroidal compounds of this invention are those having the general structural formula of pregnane, androstane, 19-norandrostanes, and norpregnane with further moieties as defined herein. These compounds include, but are not limited to, ganaxolone, pregnanolone, and androstanediol and their analogs, salts and prodrugs. The present invention further relates to combining a therapeutically effective amount of a neurosteroidal compound with a standard organophosphate antidote (e.g. atropine, pralidoxime). The data suggests that neurosteroids are effective or more effective than benzodiazepines, whether given earlier or later than 40-min (up to several hours) after organophosphate compound exposure. Neurosteroids are effective to attenuate long-term neuropsychiatric deficits caused by organophosphate exposure.
摘要翻译：本发明提供了用于治疗和/或逆转由有机磷酸酯化合物暴露引起的哺乳动物中胆碱能和非胆碱能危机所表现的有机磷酸酯中毒的新组合物和方法。本发明的神经类固醇化合物是具有通用结构式为孕甾烷，雄甾烷，19-去甲雄烷和具有本文所定义的其它部分的去甲孕烷的那些化合物。这些化合物包括但不限于加奈索酮，怀孕酮和雄甾烷二醇及其类似物，盐和前体药物。本发明还涉及将治疗有效量的神经甾体化合物与标准有机磷酸盐解毒剂（例如阿托品，哌拉西肟）组合。数据表明，神经类固醇比苯二氮卓有效或更有效，不论是在有机磷酸酯化合物暴露之后早于或晚于40分钟（直至数小时）给予。神经甾体可有效减轻由有机磷暴露引起的长期神经精神缺陷。

35. 发明公开

EP3151858A2 ANTIBODY GUIDED VACCINES AND METHODS OF USE FOR GENERATION OF RAPID MATURE IMMUNE RESPONSES 审中-公开
标题翻译：制导抗体疫苗和方法中使用快速轮胎免疫反应的产生
公开(公告)号：EP3151858A2
公开(公告)日：2017-04-12
申请号：EP15802830.8
申请日：2015-06-04
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System
发明人： BERGHMAN, Luc , CHEN, Chang-Hsin , CHOU, Wen-Ko , VUONG, Christine , WAGHELA, Suryakant , MWANGI, Waithaka , HARGIS, Billy , ABI-GHANEM, Daad , BIELKE, Lisa
IPC分类号： A61K39/395
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0048 , A61K9/0056 , A61K9/08 , A61K9/10 , A61K39/145 , A61K47/36 , A61K47/6881 , A61K2039/505 , A61K2039/5252 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/575 , A61K2039/6056 , A61K2039/6087 , A61K2039/625 , C07K16/1018 , C07K16/1282 , C07K16/2878 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6878
摘要： Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and sIgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided.
摘要翻译：助剂组合物，疫苗，构建了准备佐剂和疫苗组合物和使用佐剂组合物和疫苗，以增强个体的免疫应答中提供的方法。特别地，快速抗体响应于所述疫苗包含两种IgG的（在循环中）和分泌型IgA（粘膜分泌型IgA）被引出。佐剂和疫苗可用于皮下或粘膜给药使成本低，受试者有效接种。因此，提供的表位作图的方法快速识别的抗原表位。

36. 发明公开

EP3131748A1 IMPROVED HAND FOR NANOCOATED FABRIC 审中-公开
标题翻译： VERBESSERTESTASTGEFÜHLFÜRNANOBESCHICHTETES GEWEBE
公开(公告)号：EP3131748A1
公开(公告)日：2017-02-22
申请号：EP15768662.7
申请日：2015-03-27
申请人： The Texas A&M University System
发明人： GRUNLAN, Jaime C. , GUIN, Tyler C.
IPC分类号： B32B5/02 , D06M13/44
CPC分类号： C09D5/185 , B32B5/02 , C08J9/365 , C08J2201/038 , C08J2205/05 , C08J2205/06 , C08J2375/04 , C08J2375/06 , C08J2405/08 , C08J2479/02 , D06M10/02 , D06M11/72 , D06M11/79 , D06M13/44 , D06M15/285 , D06M15/61 , D06M2101/06 , D06M2200/30
摘要： A method includes coating a substrate to provide a flame resistant substrate. In an embodiment, the method includes exposing the substrate to a cationic solution to produce a cationic layer deposited on the substrate. The cationic solution comprises cationic materials. The cationic materials comprise a polymer, a colloidal particle, a nanoparticle, a nitrogen-rich molecule, a geopolymer, a carbon-based filler, or any combinations thereof. The method also includes agitating the substrate. The method further includes exposing the cationic layer to an anionic solution to produce an anionic layer deposited on the cationic layer to produce a layer comprising the anionic layer and the cationic layer. The anionic solution comprises a layerable material.
摘要翻译：一种方法包括涂覆基底以提供阻燃基底。在一个实施方案中，该方法包括将基底暴露于阳离子溶液以产生沉积在基底上的阳离子层。阳离子溶液包含阳离子材料。阳离子材料包括聚合物，胶体颗粒，纳米颗粒，富氮分子，地质聚合物，碳基填料或其任何组合。该方法还包括搅拌基底。该方法还包括将阳离子层暴露于阴离子溶液以产生沉积在阳离子层上的阴离子层，以产生包含阴离子层和阳离子层的层。阴离子溶液包含可分层材料。

37. 发明公开

EP3110415A1 COMPOSITIONS AND METHODS FOR INHIBITION OF MYCOBACTERIA 审中-公开
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HEMMUNG VON MYOBAKTERIEN
公开(公告)号：EP3110415A1
公开(公告)日：2017-01-04
申请号：EP15756011.1
申请日：2015-02-27
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： REDDY, Manchi, Cm , SACCHETTINI, James, C. , VALLURU, Spandana
IPC分类号： A61K31/381 , A61P31/06
CPC分类号： A61K31/5377 , A61K31/423 , A61K31/428 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/498 , A61K31/501
摘要： A composition comprising a drug selected from the group consisting of an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, a substituted quinol, or a salt, hydrate, or prodrugs thereof, or a combination thereof, in an amount and formulation sufficient to inhibit a mycobacterium is disclosed.
摘要翻译：一种组合物，其组合物包含选自芳基苯氧基丙酸酯衍生物，芳氧基苯氧基乙酸酯衍生物，芳氧基苯乙酸酯衍生物，取代的喹啉或其盐，水合物或其前药或其组合的药物，其量和制剂足以抑制公开了分枝杆菌。

38. 发明公开

EP3057988A2 COMPOSITIONS AND THE USE OF A FIBRINOGN BINDING MOTIF PRESENCE IN EFB AND COA FOR VACCINE AGAINST STAPHYLOCOCCUS AUREUS AND DRUG DELIVERY 审中-公开
标题翻译：组成和EFB和CoA A场景纤维蛋白原结合存在使用的疫苗供应药品及黄色葡萄球菌葡萄球菌
公开(公告)号：EP3057988A2
公开(公告)日：2016-08-24
申请号：EP14789743.3
申请日：2014-10-15
申请人： The Texas A&M University System , University Medical Center Utrecht, The Netherlands
发明人： KO, Ya-Ping , HOOK, Magnus , ROOIJAKKERS, Suzan, HM , BROWNING, Mary, Beth
IPC分类号： C07K16/12 , A61K39/085 , A61K38/36
CPC分类号： A61K39/085 , A61K2039/55516 , C07K14/31 , C07K16/1271 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/40 , G01N33/577 , G01N33/6854 , G01N2500/02
摘要： The present disclosure provides methods and composition including vaccines, monoclonal antibodies, polyclonal antibodies, chimeric molecule of an extracellular fibrinogen binding protein (Efb) and targeted agent delivery pharmaceutical composition comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in inhibiting the fibrinogen binding, C3 binding, or both or administering to a subject a pharmacologically effective amount of a vaccine in a pharmaceutically acceptable excipient, comprising a modified extracellular fibrinogen binding protein comprising at least a portion of a modified N-terminus region, at least a portion of a modified C-terminus region, or both, wherein the modified extracellular fibrinogen binding protein results in not shielding the staphylococcus bacterium from recognition by a phagocytic receptor.
摘要翻译：本公开提供了方法和组合物包括疫苗，单克隆抗体，多克隆抗体，胞外纤维蛋白原结合蛋白（EFB）的嵌合分子和靶向剂递送药物组合物，其包含至少一个修饰的N-末端区域的一部分，至少一部分修饰的C-末端区域，或两者的worin修饰细胞外纤维蛋白原结合蛋白的结果在抑制纤维蛋白原结合，C3结合，或两者或向受试者施用药理学有效量的疫苗在药学上可接受的赋形剂，包括改性的细胞外纤维蛋白原结合蛋白，其包含至少一个修饰的N-末端区域的一部分，至少一个修饰的C末端区域，或两者的一部分，worin修饰细胞外纤维蛋白原在不通过屏蔽从识别所述葡萄球菌结合蛋白的结果吞噬受体。

39. 发明授权

EP2222923B1 GUIDEWAY SWITCHING MECHANISM 有权
标题翻译：软机理导轨
公开(公告)号：EP2222923B1
公开(公告)日：2016-07-27
申请号：EP08837901.1
申请日：2008-10-10
申请人： The Texas A&M University System
发明人： ROOP, Stephen, S.
IPC分类号： E01B7/00 , E01B25/12 , E01B25/34
CPC分类号： E01B7/00 , E01B25/12 , E01B25/34

40. 发明授权

EP1474128B1 S-DIMETHYLARSINO-THIOSUCCINIC ACID, S-DIMETHYLARSINO-2-THIOBENZOIC ACID, S-(DIMETHYLARSINO)GLUTATHIONE AS TREATMENTS FOR CANCER 有权
标题翻译： S-二甲氧基硫代吗啉，S-二甲基二硫代苯甲酸酯，S-（二甲基氨基） - 葡萄糖酸锌（KURBSBEHANDLUNG）
公开(公告)号：EP1474128B1
公开(公告)日：2016-06-01
申请号：EP03705662.9
申请日：2003-01-07
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： ZINGARO, Ralph, A. , FREIREICH, Emil, L. , DUKALE, Hatice , KANTARJIAN, Hagop , VERSTOVSEK, Srdan , SOTELO-LERMA, Merida
IPC分类号： A61K31/285
CPC分类号： C07F9/72

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