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31. 发明公开

EP1846014A2 SELECTIVE DELIVERY OF MOLECULES INTO CELLS OR MARKING OF CELLS IN DISEASED TISSUE REGIONS USING ENVIRONMENTALLY SENSTIVE TRANSMEMBRANE PEPTIDE 有权转让
标题翻译：选择性分子分布或细胞标记细胞在ILL组织区域使用的敏感区域跨膜肽
公开(公告)号：EP1846014A2
公开(公告)日：2007-10-24
申请号：EP06718899.5
申请日：2006-01-18
申请人： The Board of Governors for Higher Education State of Rhode Island and Providence Plantations
发明人： RESHETNYAK, Yana, K. , ANDREEV, Oleg, A. , LEHNERT, Ursula , ENGELMAN, Donald, M.
IPC分类号： A61K38/00
CPC分类号： C07K14/001 , A61K9/0019 , A61K47/64 , C07K14/215 , C07K2319/03
摘要： A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjugated with various functional moieties delivers and accumulates them at cell membrane with low extracellular pH. The functional moiety conjugated with polypeptide terminus placed inside cell are translocated through the cell membrane in cytosol. The peptide and its variants or non-peptide analogs can be used to deliver therapeutic, prophylactic, diagnostic, imaging, gene regulation, cell regulation, or immunologic agents to or inside of cells in vitro or in vivo in tissue at low extracellular pH. The claimed method provides a new approach for diagnostic and treatment diseases with naturally occurred (or artificially created) low pH extracellular environment such as tumors, infarction, stroke, atherosclerosis, inflammation, infection, or trauma. The method allows to translocate cell impermeable molecules (peptides, toxins, drugs, inhibitors, nucleic acids, peptide nucleic acids, imaging probes) into cells at low pH. The method allows to attach to the cell surface a variety of functional moieties and particles including peptides, polysaccharides, virus, antigens, liposomes and nanoparticles made of any materials.
摘要翻译：具有显着疏水序列足够长以跨越一个膜脂双层的跨膜螺旋（TM）和包含一种或多种离解基团的多肽穿膜自发地插入以pH依赖的方式放置内小区的一个末端。与各种官能部分缀合的多肽递送和在细胞膜具有低细胞外pH积累它们。与细胞内放置的多肽缀合末端的官能部分通过细胞膜进入细胞质易位。的肽及其变体或非肽类似物可用于递送治疗剂，预防，诊断，成像，基因调控，细胞调节，或免疫制剂或在体外或在低细胞外pH体内组织细胞的内部。所要求保护的方法提供了用于诊断和治疗疾病的自然发生（或人工产生的）低pH胞外环境中的新方法：如肿瘤，梗塞，中风，动脉粥样硬化，炎症，感染，外伤或。该方法允许易位细胞不可渗透的分子（肽，毒素，药物，酶抑制剂，核酸，肽核酸，成像探针）插入在低pH的细胞。该方法允许附着到细胞表面的各种官能部分和颗粒，包括肽，多糖，病毒，抗原，脂质体和由任何材料制成的纳米颗粒。

32. 发明授权

EP1358452B1 THERMOCHROMIC POLYMERS FOR RAPID VISUAL ASSESSMENT OF TEMPERATURE 有权
标题翻译：热致变色聚合物用于快速VISUAL平均气温
公开(公告)号：EP1358452B1
公开(公告)日：2007-08-22
申请号：EP02780890.6
申请日：2002-01-10
申请人： The Board of Governors for Higher Education State of Rhode Island and Providence Plantations
发明人： LUCHT, Brett, L. , EULER, William, B. , GREGORY, Otto, J.
IPC分类号： G01K11/16 , C08G61/12
CPC分类号： G01N31/229 , C08G61/126
摘要： A thermochromic polymer-based temperature indicator composition which comprises a polythiophene and a carrier medium. The structure of the compound is designed such that when the composition is placed in a heat-exchange relationship with an article, the composition will exhibit a color change when a design temperature or a temperature beyond the design temperature is reached in the article.

33. 发明授权

EP1074266B1 LIVE ATTENUATED BACTERIA FOR USE IN A VACCINE 有权
标题翻译：减毒活细菌作为疫苗使用
公开(公告)号：EP1074266B1
公开(公告)日：2006-12-13
申请号：EP00201985.9
申请日：2000-06-06
申请人： Intervet International BV , The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
发明人： Cohen, Paul S. , Laux, David C. , Nuijten, Petrus Johannes Maria
IPC分类号： A61K39/02 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/542 , A61K2039/552 , Y02A50/482
摘要： The present invention relates to live attenuated bacteria for use as a medicament. The invention also relates to vaccines based thereon that are useful for the prevention of microbial pathogenesis. Further, the invention relates to live attenuated recombinant bacteria carrying a heterologous gene and vaccines based thereon. Finally, the invention relates to methods for the preparation of such vaccines and bacteria.

34. 发明公开

EP1383820A1 WATER SOLUBLE POLYMERIC COMPLEX COMPRISING A CONDUCTING POLYMER AND A BIOPOLYMER 审中-公开
标题翻译：包含导电聚合物和生物聚合物的水溶性聚合物络合物
公开(公告)号：EP1383820A1
公开(公告)日：2004-01-28
申请号：EP02715259.4
申请日：2002-04-02
申请人： The Board of Governors for higher education, State of Rhode Island and providence plantations
发明人： YANG, Sze, Cheng , MCCARTHY, Patrick
IPC分类号： C08G63/48
CPC分类号： C08L101/12
摘要： A molecular complex which comprises a biopolymer having a plurality of ionic functional groups and a conductive polymer having charges therein. The charges bind to the ionic functional groups to form the complex. The conductive polymer is selected from the group consisting essentially of polyaniline, polypyrrole, polythiophene, poly(phenylenevinylene) or poly(phenylene sulfide) and substituted versions thereof.
摘要翻译：包含具有多个离子官能团的生物聚合物和其中具有电荷的导电聚合物的分子复合物。电荷与离子官能团结合形成络合物。导电聚合物选自基本上由聚苯胺，聚吡咯，聚噻吩，聚（亚苯基亚乙烯基）或聚（亚苯基硫醚）及其取代形式组成的组。

35. 发明公开

EP1358452A2 THERMOCHROMIC POLYMERS FOR RAPID VISUAL ASSESSMENT OF TEMPERATURE 有权
标题翻译：热致变色聚合物用于快速VISUAL平均气温
公开(公告)号：EP1358452A2
公开(公告)日：2003-11-05
申请号：EP02780890.6
申请日：2002-01-10
申请人： The Board of Governors for Higher Education State of Rhode Island and Providence Plantations
发明人： LUCHT, Brett, L. , EULER, William, B. , GREGORY, Otto, J.
IPC分类号： G01K11/16
CPC分类号： G01N31/229 , C08G61/126
摘要： A thermochromic polymer-based temperature indicator composition which comprises a polythiophene and a carrier medium. The structure of the compound is designed such that when the composition is placed in a heat-exchange relationship with an article, the composition will exhibit a color change when a design temperature or a temperature beyond the design temperature is reached in the article.

36. 发明公开

EP1169311A1 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES 审中-公开
标题翻译：恶唑和噻唑的组合库
公开(公告)号：EP1169311A1
公开(公告)日：2002-01-09
申请号：EP00919521.5
申请日：2000-03-22
申请人： THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS
发明人： MARTIN, Lenore, M. , HU, Bi-Huang
IPC分类号： C07D277/04 , C07D277/08 , C07D277/20 , C07D277/22 , C07D277/28 , C07D277/30 , C07D275/02 , C07D263/30 , C07D263/34 , C12Q1/00
CPC分类号： C07D263/34 , C07D277/56 , C07D417/04 , C07D417/14 , C40B40/04 , C40B50/14
摘要： This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acides containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.

37. 发明公开

EP2758786A2 SYSTEMS AND METHODS FOR PROVIDING MICROFLUIDIC DEVICES 审中-公开
标题翻译：系统和方法用于提供微流体装置
公开(公告)号：EP2758786A2
公开(公告)日：2014-07-30
申请号：EP12834511.3
申请日：2012-09-24
申请人： The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
发明人： CHEN, Hong , ANAGNOSTOPOULOS, Constantine , FAGHRI, Mohammed , COGSWELL, Jeremy
IPC分类号： G01N35/08 , B81B3/00 , G01N33/53
CPC分类号： B01L3/502738 , B01L3/502707 , B01L2200/0621 , B01L2300/0816 , B01L2300/089 , B01L2300/126 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , F16K99/0017 , F16K99/0021 , F16K2099/0084
摘要： A microfiuidic valve system is disclosed that includes a matrix, a hydrophilic acceptor region a hydrophilic transfer region, and a hydrophobic gap between the acceptor region and the transfer region.

38. 发明公开

EP2519156A1 SYSTEMS FOR SLEEP APNEA DETECTION FROM BREATHING SOUNDS 审中-公开
标题翻译： SYSTEMS FOR呼吸噪声的体认SCHLAFAPNIE
公开(公告)号：EP2519156A1
公开(公告)日：2012-11-07
申请号：EP10798702.6
申请日：2010-12-29
申请人： The Board of Governors for Higher Education, State of Rhode Island and Providence Plantations
发明人： SALISBURY, John, I. , SUN, Ying
IPC分类号： A61B7/00 , A61B7/04
CPC分类号： A61B5/4818 , A61B5/7257 , A61B7/003 , A61F5/56
摘要： A system is disclosed for detecting obstructive sleep apnea in subject. The system includes ran electronic stethoscope for placement, at the subject's suprasternal notch, providing an electrical signal representative of the sounds detected by the head of the electronic stethoscope within a frequency range; a processor for determining an obstructive sleep apnea index based on a ratio of the amount of the electrical signal that is associated with a frequency below a cut-off frequency with respect to a total amount of energy associated with the entire frequency range; and a display for identifying the subject as having obstructive sleep apnea if the obstructive sleep apnea index is above a window maximum or below a window minimum.

39. 发明授权

EP1846014B1 SELECTIVE DELIVERY OF MOLECULES INTO CELLS OR MARKING OF CELLS IN DISEASED TISSUE REGIONS USING ENVIRONMENTALLY SENSITIVE TRANSMEMBRANE PEPTIDE 有权转让
标题翻译：选择性分子分布或细胞标记细胞在ILL组织区域使用的敏感区域跨膜肽
公开(公告)号：EP1846014B1
公开(公告)日：2012-10-24
申请号：EP06718899.5
申请日：2006-01-18
申请人： The Board of Governors for Higher Education State of Rhode Island and Providence Plantations
发明人： RESHETNYAK, Yana, K. , ANDREEV, Oleg, A. , LEHNERT, Ursula , ENGELMAN, Donald, M.
IPC分类号： A61K9/00 , A61K47/48 , A61K38/16 , A61P35/00 , A61P31/00 , A61P9/00
CPC分类号： C07K14/001 , A61K9/0019 , A61K47/64 , C07K14/215 , C07K2319/03

40. 发明公开

EP2297802A1 INHIBITION OF ELECTROLYTE OXIDATION IN LITHIUM ION BATTERIES WITH ELECTROLYTE ADDITIVES 审中-公开
标题翻译：电解氧化在电解液添加剂锂离子电池预防
公开(公告)号：EP2297802A1
公开(公告)日：2011-03-23
申请号：EP09774518.6
申请日：2009-07-02
申请人： The Board of Governors for Higher Education State of Rhode Island and Providence Plantations
发明人： LUCHT, Brett , YANG, Li , XU, Mengqing , XIAO, Ang
IPC分类号： H01M20060101
CPC分类号： H01M10/052 , H01M2/16 , H01M10/0525 , H01M10/056 , H01M10/0567 , H01M2300/0025 , H01M2300/0091 , Y02T10/7011
摘要： A lithium ion battery electrolyte for use in lithium ion batteries. The electrolyte includes LiPF
6 , LiBF
4 , LiB(C
2 0
4 )
2 , or a related salt dissolved in a mixture of organic carbonate, ether or ester solvents with low concentrations of oxidatively unstable additives such that the additives react with a surface of cathode particles to generate a passivation film which prevents oxidation of the electrolyte by the cathode. The additive is a polymerizable organic molecule selected from 2,3-dihydrofuran (2,3-DHF), 2,5-dihydrofuran (2,5-DHF), vinylene carbonate (VC), vinyltrimethoxysilane (VTMS), dimethyl vinylene cabonate (DMVC), and gamma-bixyro lactone, or related unsaturated ethers, esters, or carbonates.

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