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31. 发明公开

EP2677982A1 AN OPTICAL DEVICE FOR THE VISUALLY IMPAIRED 有权转让
标题翻译：光学装置视障
公开(公告)号：EP2677982A1
公开(公告)日：2014-01-01
申请号：EP12714036.6
申请日：2012-02-24
申请人： ISIS Innovation Limited
发明人： HICKS, Stephen
IPC分类号： A61F9/08 , G09B21/00
CPC分类号： G09B21/001 , A61H3/061 , A61H2201/165 , G09B21/008
摘要： The present invention provides an optical device for a visually-impaired individual and a method of operating such a device. In one embodiment, the apparatus comprises a spaced array of discrete light sources and a support arranged to maintain the array in proximate relation to at least one eye of the visually-impaired individual. An image capture device is configured to capture images of at least part of the individual' s immediate environment, wherein the array is configured to convey information to the individual by selectively illuminating one or more of the discrete light sources based on the content of the captured images. In this way, information relating to objects and/or textual language in the individual's environment can be conveyed to the individual by predetermined patterns of illumination (e.g. spatial and/or temporal). The apparatus and method are found to be particularly suited for visually-impaired individuals who retain at least some residual light and/or colour discrimination.

32. 发明公开

EP2579050A3 Utility metering 有权
标题翻译：资源计数
公开(公告)号：EP2579050A3
公开(公告)日：2013-08-21
申请号：EP12199513.8
申请日：2009-07-17
申请人： Isis Innovation Limited
发明人： Donaldson, James , McCulloch, Malcolm
IPC分类号： G01R21/133
CPC分类号： G01R21/133 , G01D4/00 , G01R21/1331 , G01R27/02
摘要： There is described an apparatus for metering the use of electricity supplied to a plurality of appliances. The apparatus comprises: an input section arranged to receive values representative of the total supply of electrical power as a function of time; a transient detector arranged to detect the time at which an appliance is switched on from a change in the received values due to an increase in the electric power being supplied at that time; an analysis section arranged to analyse the received values and to determine: (i) a first value related to the resistance of said appliance at the time of being switched on detected by said transient detector; and (ii) a second value related to the resistance of said appliance when operating in a steady state; and a processing section arranged to identify said appliance based on at least said first and second values, and to determine the electrical energy consumed by said appliance.
There is also described a method for metering the use of electricity supplied to a plurality of appliances. The method comprises: receiving values representative of the total supply of electrical power as a function of time; detecting the time at which an appliance is switched on from a change in the received values due to an increase in the electric power being supplied at that time; analysing the received values and determining: (i) the time when the electrical power being used by the appliance has reached a steady state; and (ii) a classification value related to: the total electrical energy supplied to the appliance from the time of switch on until the time steady state is reached, minus the product of the steady state power and the time from switch on until steady state is reached; and identifying said appliance based on at least said classification value, and determining the total electrical energy consumed by said appliance.

33. 发明公开

EP2606357A1 IDENTIFICATION OF LIGANDS AND THEIR USE 有权转让
标题翻译： IDENTIFYING配体及其用途
公开(公告)号：EP2606357A1
公开(公告)日：2013-06-26
申请号：EP11757919.3
申请日：2011-08-17
申请人： Isis Innovation Limited
发明人： OGG, Graham , HUANG, Li-Chieh , ASLAM, Aamir
IPC分类号： G01N33/569
CPC分类号： G01N33/56977 , C07K17/00 , C12N15/1055 , G01N33/54313 , G01N33/56972 , G01N2333/7051 , G01N2333/70539
摘要： A method to identify a peptide and/or its encoding DNA, wherein the peptide binds to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor, the method comprising: providing a carrier to which is attached a peptide and its encoding DNA; providing an MHC and/or an MHC-like molecule; and exposing the peptide to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor in the presence of the MHC or MHC-like molecule.

34. 发明公开

EP2601522A1 DIAGNOSTIC METHOD 有权
标题翻译：先兆子痫的诊断方法
公开(公告)号：EP2601522A1
公开(公告)日：2013-06-12
申请号：EP11741678.4
申请日：2011-08-03
申请人： Isis Innovation Limited
发明人： SARGENT, Ian , SOUTHCOMBE, Jennifer , GRANNE, Ingrid
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/689 , G01N2333/7155 , G01N2800/368
摘要： It has been demonstrated that the level of sST2 increases in pregnant females suffering from pre-eclampsia. Accordingly, the level of sST2 in a pregnant female can be used to assess risk of developing pre-eclampsia.

35. 发明公开

EP2595717A2 ACOUSTIC SEPARATORS 审中-公开
标题翻译：声学分离器
公开(公告)号：EP2595717A2
公开(公告)日：2013-05-29
申请号：EP11736439.8
申请日：2011-06-24
申请人： Isis Innovation Limited
发明人： COUSSIOS, Constantin , VENTIKOS, Yiannis , TRIPPA, Giuliana , TAGGART, David
IPC分类号： B01D21/28
CPC分类号： B01D21/28 , A61M1/363 , A61M1/3633 , A61M1/3678 , A61M1/3693 , B01D21/283 , B01D2221/10 , Y10T29/49826
摘要： An acoustic separator comprises: two parallel chamber walls defining a separation chamber therebetween, each chamber wall defining one side of the chamber; inlet means through which fluid can flow into the chamber; and outlet means through which fluid can flow out of the chamber. One of the chamber walls includes a transducer arranged to transmit pressure waves across the chamber towards the other of the chamber walls which in turn is arranged to reflect the pressure waves to set up a standing wave in the chamber. The outlet means defines an opening in one of the sides of the chamber.
摘要翻译：声学分离器包括：两个平行的腔室壁，在其间限定分离腔室，每个腔室壁限定腔室的一侧; 入口装置，流体可通过该入口装置流入腔室; 以及流体可以通过其流出腔室的出口装置。室壁中的一个包括换能器，该换能器被设置为穿过室朝向室壁中的另一个壁传送压力波，室壁中的另一个又被布置为反射压力波以在室中建立驻波。出口装置在腔室的一侧限定开口。

36. 发明公开

EP2579050A2 Utility metering 有权
标题翻译：公用计量
公开(公告)号：EP2579050A2
公开(公告)日：2013-04-10
申请号：EP12199513.8
申请日：2009-07-17
申请人： Isis Innovation Limited
发明人： Donaldson, James , McCulloch, Malcolm
IPC分类号： G01R21/133
CPC分类号： G01R21/133 , G01D4/00 , G01R21/1331 , G01R27/02
摘要： There is described an apparatus for metering the use of electricity supplied to a plurality of appliances. The apparatus comprises: an input section arranged to receive values representative of the total supply of electrical power as a function of time; a transient detector arranged to detect the time at which an appliance is switched on from a change in the received values due to an increase in the electric power being supplied at that time; an analysis section arranged to analyse the received values and to determine: (i) a first value related to the resistance of said appliance at the time of being switched on detected by said transient detector; and (ii) a second value related to the resistance of said appliance when operating in a steady state; and a processing section arranged to identify said appliance based on at least said first and second values, and to determine the electrical energy consumed by said appliance.
There is also described a method for metering the use of electricity supplied to a plurality of appliances. The method comprises: receiving values representative of the total supply of electrical power as a function of time; detecting the time at which an appliance is switched on from a change in the received values due to an increase in the electric power being supplied at that time; analysing the received values and determining: (i) the time when the electrical power being used by the appliance has reached a steady state; and (ii) a classification value related to: the total electrical energy supplied to the appliance from the time of switch on until the time steady state is reached, minus the product of the steady state power and the time from switch on until steady state is reached; and identifying said appliance based on at least said classification value, and determining the total electrical energy consumed by said appliance.
摘要翻译：描述了一种用于计量供应给多个电器的电力的使用的设备。该设备包括：输入部分，其被配置为接收表示作为时间的函数的总电力供应的值; 瞬态检测器，其被布置成检测由于此时供应的电力的增加而导致的接收值的变化而导致器具被接通的时间; 分析部分，其被配置为分析所接收的值并且确定：（i）与由所述瞬态检测器检测到的在被接通时所述电器的电阻相关的第一值; 和（ii）与在稳定状态下操作时所述电器的电阻有关的第二值; 以及处理部分，其被设置成至少基于所述第一值和第二值来识别所述电器，并且确定由所述电器消耗的电能。还描述了一种用于计量供应给多个电器的电力的使用的方法。该方法包括：接收代表作为时间的函数的总电力供应的值; 检测由于此时供应的电力的增加而导致的接收值的变化而导致电器被接通的时间; 分析接收到的值并确定：（i）电器正在使用的电力已经达到稳定状态的时间; 和（ii）分类值有关：从接通时间到达到时间稳定状态时提供给电器的总电能减去稳态电力与从接通到稳态之间的时间的乘积到达; 以及至少基于所述分类值来识别所述电器，并且确定由所述电器消耗的总电能。

37. 发明公开

EP2518996A3 Image capture device and method 有权转让
标题翻译：成像装置和方法
公开(公告)号：EP2518996A3
公开(公告)日：2013-04-03
申请号：EP12004356.7
申请日：2008-05-08
申请人： Isis Innovation Limited
发明人： Bub, Gil
IPC分类号： H04N5/232 , H04N5/225
CPC分类号： H04N5/2254 , H04N1/195 , H04N5/232 , H04N5/23245 , H04N5/3535 , H04N2201/0458
摘要： An image capture device (2) includes a sensor (4) having an active area comprising a plurality of pixels (6) and a shutter array (8) for controlling the exposure of individual pixels. The pixels are grouped in a plurality of pixel subsets and are arranged to capture a plurality of time-separated lo-res images, which can be viewed sequentially as a movie or combined to form a hi-res still image.

38. 发明授权

EP2060159B1 CHARGED PARTICLE ACCELERATOR AND RADIATION SOURCE 有权
标题翻译：带电粒子加速器辐射源
公开(公告)号：EP2060159B1
公开(公告)日：2013-03-06
申请号：EP07804232.2
申请日：2007-09-11
申请人： ISIS INNOVATION LIMITED , The University of Strathclyde , Lawrence Berkeley National Laboratory
发明人： HOOKER, Simon Martin , GONSALVES, Anthony Joseph , JAROSZYNSKI, Dino Anthony , LEEMANS, Wim Pieter David
IPC分类号： H05H1/54 , H05G2/00 , H05H15/00
CPC分类号： H05G2/00 , H05H1/54 , H05H15/00

39. 发明公开

EP2534484A1 PEPTIDE TAG SYSTEMS THAT SPONTANEOUSLY FORM AN IRREVERSIBLE LINK TO PROTEIN PARTNERS VIA ISOPEPTIDE BONDS 有权转让
标题翻译： PEPTIDMARKIERUNGSSYSTEME麻省理工学院BILDUNG EINER IRREVERSIBLEN VERBINDUNG ZU PROTEINPARTNERNÜBERISOPEPTIDBINDUNGEN
公开(公告)号：EP2534484A1
公开(公告)日：2012-12-19
申请号：EP11706621.7
申请日：2011-02-11
申请人： Isis Innovation Limited
发明人： HOWARTH, Mark
IPC分类号： G01N33/531 , C07K14/00 , C12N15/00
CPC分类号： G01N33/531 , C07K7/08 , C07K14/315 , C07K2319/21 , C07K2319/70 , G01N33/5306
摘要： Described herein is a protein capable of spontaneously forming an isopeptide bond for the development of a peptide tag and binding partner pair wherein the peptide tag and binding partner are capable of covalently binding to each other via an isopeptide bond. Also provided is a method for developing a peptide tag and binding partner pair which are capable of covalently binding to each other based on a protein which is capable of spontaneously forming an isopeptide bond. Additionally provided are peptide tag and binding partner pairs which are obtainable from isopeptide proteins. Further, specifically developed peptide tags and binding partners are described, together with nucleic acid molecules and vectors which encode those peptides or proteins.
摘要翻译：本文描述的是能够自发形成用于开发肽标签和结合配偶体对的肽链的蛋白质，其中肽标签和结合配偶体能够通过异肽键彼此共价结合。还提供了开发能够自发形成异肽键的蛋白质能够彼此共价结合的肽标签和结合配偶体对的方法。另外提供可从异肽蛋白获得的肽标签和结合配偶体对。此外，与编码那些肽或蛋白质的核酸分子和载体一起描述了专门开发的肽标签和结合配对物。

40. 发明授权

EP1379630B1 ASSAYS, METHODS AND MEANS RELATING TO HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE 有权
标题翻译： HIF羟基酶，方法，MITTEL UND TESTVERFAHREN DIESSELBE BETREFFEND
公开(公告)号：EP1379630B1
公开(公告)日：2012-09-26
申请号：EP02706994.7
申请日：2002-03-21
申请人： ISIS INNOVATION LIMITED
发明人： MAXWELL, P. H., c/o The Henry Wellcome Bld. , PUGH, C. W., c/o The Henry Wellcome Bld. , RATCLIFFE, P. J., c/o The Henry Wellcome Bld. , SCHOFIELD, C. J.; c/o The Dyson Perrins Lab and...
IPC分类号： C12N9/02
CPC分类号： A61K31/455 , A01K2217/05 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/221 , A61K31/223 , A61K31/225 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/327 , A61K31/44 , A61K31/4412 , A61K38/00 , A61K39/3955 , C07C235/80 , C07C323/60 , C07C327/32 , C07D213/80 , C07D213/81 , C07D213/82 , C07K14/4702 , C07K16/40 , C07K2317/30 , C12N9/0071 , C12Q1/26 , C12Q1/34 , G01N33/573 , G01N2333/90245 , G01N2500/04 , G01N2500/20
摘要： A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
摘要翻译：描述了具有SEQ ID NO：2,4,6和8的氨基酸序列以及具有HIF羟基化活性的变体和片段的新一类羟化酶。本发明的多肽特别是脯氨酰羟化酶活性。测定方法监测HIF羟化酶与底物的相互作用。提供HIF羟化酶的调节剂用于治疗与增加或降低的HIF水平或活性相关的病症，或用于治疗期望调节HIF水平或活性的病症。

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