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31. 发明授权

EP2512540B1 IMPLANTS AND BIODEGRADABLE FIDUCIAL MARKERS 有权转让
公开(公告)号：EP2512540B1
公开(公告)日：2019-08-07
申请号：EP10842525.7
申请日：2010-12-15
申请人： Incept, LLC
发明人： CAMPBELL, Patrick , SAWHNEY, Amarpreet S.
IPC分类号： A61L31/18 , A61L27/52 , A61L31/14 , A61K51/12 , A61K49/04 , A61L27/58 , A61L27/50

32. 发明授权

EP2010236B1 METHODS FOR MAKING SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS 有权转让
公开(公告)号：EP2010236B1
公开(公告)日：2018-08-29
申请号：EP07758643.6
申请日：2007-03-15
申请人： Incept, LLC
发明人： SAWHNEY, Amarpreet, S. , BENNETT, Steven , PAI, Suresh, S. , SERSHEN, Scott , CO, Fred, H.
IPC分类号： A61L24/04 , A61L24/10
CPC分类号： A61L24/0031 , A61B2017/0065 , A61L24/046 , A61L24/10 , C08L71/02
摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

33. 发明公开

EP2598044A4 METHODS AND APPARATUS FOR TREATING NEUROVASCULAR VENOUS OUTFLOW OBSTRUCTION 有权
标题翻译：用于治疗障碍物的方法和设备神经血管静脉流出
公开(公告)号：EP2598044A4
公开(公告)日：2016-06-29
申请号：EP11813053
申请日：2011-07-26
申请人： INCEPT LLC
发明人： KHOSRAVI FRED , WATANABE GWENDOLYN , VON HOFFMANN GERARD
IPC分类号： A61B17/02 , A61F2/24
CPC分类号： A61F2/2475 , A61B17/12 , A61F2/01 , A61F2/2418 , A61F2/856 , A61F2/915 , A61F2002/016 , A61F2002/91583 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0054 , A61F2230/0067 , A61F2230/0091 , A61F2230/0093 , A61M25/1011 , A61M25/104 , A61M2025/0175 , A61M2025/1015 , A61M2025/1047 , A61M2025/1086 , A61M2025/109
摘要： Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.

34. 发明公开

EP2787973A1 MEDICAL ORGANOGEL PROCESSES AND COMPOSITIONS 有权转让
标题翻译：医疗ORGANOGELPROZESSE和成分
公开(公告)号：EP2787973A1
公开(公告)日：2014-10-15
申请号：EP12856353.3
申请日：2012-12-05
申请人： INCEPT LLC
发明人： EL-HAYEK, Rami , JARRETT, Peter , SAWHNEY, Amarpreet, S.
IPC分类号： A61K9/08 , A61K9/06 , A61K47/30 , A61K31/436 , A61K31/437
CPC分类号： A61K47/34 , A61K9/0051 , A61K9/06 , A61K38/38 , C07K16/00
摘要： Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.

35. 发明公开

EP2598044A2 METHODS AND APPARATUS FOR TREATING NEUROVASCULAR VENOUS OUTFLOW OBSTRUCTION 有权
标题翻译：用于治疗障碍物的方法和设备神经血管静脉流出
公开(公告)号：EP2598044A2
公开(公告)日：2013-06-05
申请号：EP11813053.3
申请日：2011-07-26
申请人： Incept, LLC
发明人： KHOSRAVI, Fred , WATANABE, Gwendolyn , VON HOFFMANN, Gerard
IPC分类号： A61B17/02
CPC分类号： A61F2/2475 , A61B17/12009 , A61F2/01 , A61F2/2418 , A61F2/856 , A61F2/915 , A61F2002/016 , A61F2002/91583 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0006 , A61F2230/0054 , A61F2230/0067 , A61F2230/0091 , A61F2230/0093 , A61M25/1011 , A61M25/104 , A61M2025/0175 , A61M2025/1015 , A61M2025/1047 , A61M2025/1086 , A61M2025/109
摘要： Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.
摘要翻译：的方法和设备是光盘为游离缺失治疗神经血管静脉流出阻塞，具有或不具有假体瓣膜的植入。该阀可以通过一个支撑，颜色来携带：如支架，其可以是自扩张或球囊扩张的。双方经血管和直接手术进入预期。

36. 发明公开

EP2396070A4 DRUG DELIVERY THROUGH HYDROGEL PLUGS 审中-公开
标题翻译： WIRKSTOFFFREISETZUNG MIT HYDROGEL-PLUGS
公开(公告)号：EP2396070A4
公开(公告)日：2012-09-19
申请号：EP10741771
申请日：2010-02-12
申请人： INCEPT LLC
发明人： SAWHNEY AMARPREET S , JARRETT PETER , BASSETT MICHAEL , BLIZZARD CHARLES D
IPC分类号： A61M31/00 , A61F2/02 , A61F9/007 , A61K9/06 , A61K31/437 , A61K47/30 , A61M5/00 , A61P27/02
CPC分类号： A61K9/0051 , A61B17/12099 , A61B17/12159 , A61B17/1219 , A61F9/00772 , A61F2250/0067 , A61K31/135 , A61K31/437

37. 发明公开

EP2187980A4 HYDROGEL POLYMERIC COMPOSITIONS AND METHODS 有权转让
标题翻译： HYDROGEL-POLYMERZUSAMMENSETZUNGEN UND VERFAHREN
公开(公告)号：EP2187980A4
公开(公告)日：2012-08-08
申请号：EP08754416
申请日：2008-05-14
申请人： INCEPT LLC
发明人： SAWHNEY AMARPREET S , RANSONE WILLIAM H II
IPC分类号： A61L27/00 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译：本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，用于控制释放治疗剂。

38. 发明公开

EP2396070A2 DRUG DELIVERY THROUGH HYDROGEL PLUGS 审中-公开
标题翻译：与水凝胶塞主动释放
公开(公告)号：EP2396070A2
公开(公告)日：2011-12-21
申请号：EP10741771.9
申请日：2010-02-12
申请人： INCEPT LLC
发明人： SAWHNEY, Amarpreet, S. , JARRETT, Peter , BASSETT, Michael , BLIZZARD, Charles, D.
IPC分类号： A61M31/00 , A61M5/00 , A61F9/007 , A61F2/02 , A61K9/06 , A61K47/30 , A61K31/437 , A61P27/02
CPC分类号： A61K9/0051 , A61B17/12099 , A61B17/12159 , A61B17/1219 , A61F9/00772 , A61F2250/0067 , A61K31/135 , A61K31/437
摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a
puncta lacrimali , with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate
in vitro in physiological saline.

39. 发明授权

EP1104324B8 APPARATUS FOR IN SITU FORMATION OF HYDROGELS 有权
标题翻译：用于原位形成水凝胶的装置
公开(公告)号：EP1104324B8
公开(公告)日：2011-06-22
申请号：EP99942172.0
申请日：1999-08-13
申请人： INCEPT LLC
发明人： SAWHNEY, Amarpreet, S. , CAMPBELL, Patrick, K. , MELANSON, David, A.
IPC分类号： A61M37/00 , A61M35/00 , A61B17/00
CPC分类号： A61M35/00 , A61B17/00491 , A61B2017/00495 , A61M25/0071
摘要： Methods, and apparatus of forming in situ tissue adherent barriers are provided using a sprayer (90) capable of applying two or more viscous cross linking solutions to tissue. The sprayer (90) comprises separate spray nozzles (98, 100) for each of two or more cross linking solutions, wherein each nozzle (98, 100) is in communication with a gas pressurized chamber (48) also may include valves (52) that prevent back flow through the supply lines (99, 101) carrying the cross linking solutions, and a venting system (106, 108) for venting excess pressure for laparoscopic applications. In the presence of gas flow, the cross linking solutions are atomized, and mixed to form a spray. Multi-component hydrogel systems suitable for use with the inventive methods, and apparatus are also described.
摘要翻译：使用能够将两种或更多种粘性交联溶液施加到组织的喷雾器（90）来提供形成原位组织粘附屏障的方法和装置。喷雾器（90）包括用于两种或更多种交联溶液中的每一种的单独喷雾喷嘴（98,100），其中每个喷嘴（98,100）与气体加压室（48）连通也可包括阀（52）其防止回流通过承载交联溶液的供应管线（99,101），以及用于排出腹腔镜应用的过压的通气系统（106,108）。在气流存在下，交联溶液被雾化并混合形成喷雾。还描述了适用于本发明方法的多组分水凝胶体系和装置。

40. 发明授权

EP1207933B1 VASCULAR FILTER HAVING ARTICULATION REGION 有权
标题翻译：关节ZONE血管过滤器
公开(公告)号：EP1207933B1
公开(公告)日：2011-05-11
申请号：EP00953752.3
申请日：2000-07-28
申请人： INCEPT LLC
发明人： KHOSRAVI, Farhad , HOPKINS, L., N. , SALAHIEH, Amr , DEMOND, Jackson, F. , KROLIK, Jeff, A.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0008 , A61F2230/008
摘要： Apparatus (20) is provided for use in filtering emboli from a vessel (17) such as the ascending aorta, wherein a vascular device comprises a support hoop (24) having an articulation region (26) connected near a distal end (23) of an elongated member, a blood permeable sac (28) affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac, a guide wire (22), and a delivery sheath. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.

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