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31. 发明公开

EP0898234A1 Method and system for generating a diagnostic index 失效
标题翻译： Verfahren und System zur Generierung eines diagnisechen Indexes
公开(公告)号：EP0898234A1
公开(公告)日：1999-02-24
申请号：EP98118100.1
申请日：1992-10-23
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： Chamoun, Nassib G. , Mead, Peter A. , Chiang Hsing-Hsing , Saini, Vikas
IPC分类号： G06F17/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/16 , A61B5/725 , A61B5/7253 , A61B5/7257 , G06F19/00 , G16H15/00
摘要： A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, comprises the steps of:

sorting said spectral values into predetermined bins of ranges of spectral values;
summing all of the spectral values in each bin;
multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product;
summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.
摘要翻译：产生用于量化由所获取的现象的电信号产生的光谱值表示的现象的存在或不存在的诊断索引的方法包括以下步骤：将所述光谱值分类为光谱值范围的预定的分区; 求和每个仓中的所有光谱值; 将每个仓中的频谱值的总和乘以预定系数以获得仓积; 对所述仓库产品进行总结以获得代表所述现象的存在或不存在程度的诊断指标。

32. 发明授权

EP0489010B1 CARDIAC BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：心脏生物分析系统与方法
公开(公告)号：EP0489010B1
公开(公告)日：1998-11-18
申请号：EP90905061.9
申请日：1990-03-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G.
IPC分类号： G06F17/18
CPC分类号： A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/0464 , A61B5/413 , A61B5/7257 , A61B5/7275 , G06F19/00
摘要： Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.

33. 发明公开

EP0738496A1 Monitor and method for acquiring and processing electrical signals to bodily functions 失效
标题翻译：活体的装置和用于获得方法和处理信号
公开(公告)号：EP0738496A1
公开(公告)日：1996-10-23
申请号：EP96110142.5
申请日：1993-10-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： Shambroom, John R.
IPC分类号： A61B5/00 , A61B5/0424 , A61B5/048
CPC分类号： A61B5/6843 , A61B5/0006 , A61B5/0476 , A61B5/7217 , G06F19/00 , G16H40/63 , Y10S128/901 , Y10S128/902
摘要： An EEG monitor utilizes a portable acquisition module (14) and a substantially stationary processing module (12). The EEG signals are acquired and converted to an oversampled stream of digital signals by a sigma-delta modulator (64) located in the data acquisition module. The signals are then filtered by a decimation filter (62) located in the processing module. Additional means are also provided to monitor the electrode leads to detect when the leads become unplugged. The monitor provides all power to the data acquisition module over a single twisted line (82) which transmits data as well.
摘要翻译：的EEG监测器模块利用便携式采集（14）和一个固定的基本处理模块（12）。的EEG信号被采集并且通过位于数据采集模块中的Σ-Δ调制器（64）在数字信号的过采样流转换为。该信号然后由位于在处理模块中的抽取滤波器（62）进行过滤。因此，提供附加的装置来监测电极引线以检测当引线成为拔出。显示器提供通过一根双绞线线（82）透射数据以及所有电源给数据采集模块。

34. 发明公开

EP0610365A4 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD. 失效
标题翻译： DEVICE AND METHOD FOR脑生物潜力研究。
公开(公告)号：EP0610365A4
公开(公告)日：1995-06-07
申请号：EP92922952
申请日：1992-10-23
申请人： ASPECT MEDICAL SYSTEMS INC
发明人： CHAMOUN NASSIB G , MEAD PETER A , CHIANG HSING-HSING , SAI NI VIKAS
IPC分类号： A61B5/0476 , A61B5/048 , A61B5/16 , G06F17/00 , G06F19/00 , A61B5/04
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/16 , A61B5/725 , A61B5/7253 , A61B5/7257 , G16H15/00
摘要： A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, comprises the steps of: sorting said spectral values into predetermined bins of ranges of spectral values; summing all of the spectral values in each bin; multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.

35. 发明公开

EP0618781A1 DISPOSABLE, PRE-GELLED, SELF-PREPPING ELECTRODE 失效
标题翻译：愿与GEL提供一次领先。
公开(公告)号：EP0618781A1
公开(公告)日：1994-10-12
申请号：EP93921721.0
申请日：1993-09-23
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： FENDROCK, Charles
IPC分类号： A61B5
CPC分类号： A61B5/0408
摘要： L'invention concerne une électrode jetable, à préparation automatique (10) utilisant un ensemble ou coussinet de pointes souples (24) servant à partager les couches supérieures de l'épiderme à impédance élevée, de façon à exposer les couches riches en sang et à impédance basse, sans abrasion ni éraflure. Les pointes (24) sont, de préférence, plongées dans une couche de gel conducteur (14). Dans un autre mode de réalisation, la couche de pointes souples (24), à préparation automatique, plongée dans le gel (14) peut être une couche unique, jetable, à préparation automatique, montée au-dessus d'une électrode permanente (22).

36. 发明公开

EP1624926A4 SYSTEM AND METHOD OF ASSESSMENT OF THE EFFICACY OF TREATMENT OF NEUROLOGICAL DISORDERS USING THE ELECTROENCEPHALOGRAM 审中-公开
标题翻译：系统和方法，以评估使用脑电图神经系统疾病治疗中的效力
公开(公告)号：EP1624926A4
公开(公告)日：2009-05-13
申请号：EP04751433
申请日：2004-05-06
申请人： ASPECT MEDICAL SYSTEMS INC
发明人： DEVLIN PHILIP H , GREENWALD SCOTT D
IPC分类号： A61N1/18 , A61B5/04 , A61B5/048 , A61N1/05 , A61N1/08
CPC分类号： A61B5/048 , A61B5/6814 , A61N1/0529 , A61N1/0534 , A61N1/0551 , A61N1/08 , A61N1/36082
摘要： Disclosed is a system and method of assessing the efficacy of treatment of neurological or psychological disorders. The preferred embodiment uses at least two surface electrodes (15) to acquire EEG signals from the surface of a patient's body, and a processor (35) for computing from the EEG signals various features and indices that are representative of the patient's neurological or psychological state. Changes in these parameters may be used to assess the efficacy of treatment and to modify the treatment to optimize the resultant patient state.

37. 发明公开

EP2007279A2 SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY 有权
标题翻译：用于评估充足性镇痛系统和方法的部件BIOPOTENZIALSCHWANKUNGEN
公开(公告)号：EP2007279A2
公开(公告)日：2008-12-31
申请号：EP07759890.2
申请日：2007-03-30
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： GREENWALD, Scott, D.
IPC分类号： A61B5/05
CPC分类号： A61B5/04012 , A61B5/048 , A61B5/0488 , A61B5/4821
摘要： The system and method for predicting and measuring a subject's analgesic state and analgesic adequacy. Biopotential signals are obtained from a subject through electrodes. A processor will compute a measure that is representative of the subject's sedative state and/or muscle activity. A metric representative of such measures is then determined. In the case where a measure is taken of both the subjects’ sedative state and muscle activity the two measures are combined into an index representative of the subject's analgesic state and analgesic adequacy.

38. 发明公开

EP1856643A1 SYSTEM AND METHOD FOR PREDICTION OF ADVERSE EVENTS DURING TREATMENT OF PSYCHOLOGICAL AND NEUROLOGICAL DISORDERS 审中-公开
标题翻译：系统和方法预测事件不佳的在治疗和精神障碍的神经
公开(公告)号：EP1856643A1
公开(公告)日：2007-11-21
申请号：EP06718167.7
申请日：2006-01-12
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： GREENWALD, Scott, D. , DEVLIN, Philip, H. , SIGL, Jeffrey, C.
IPC分类号： G06F19/00
CPC分类号： A61B5/048 , A61B5/16 , G06F19/00 , G06F19/3456
摘要： The present invention is a system and method of deriving and computing features and indices that predict the likelihood of psychological and neurological adverse events such as suicidal thoughts and/or actions. The method of the present invention further predicts the likelihood of suicidal thoughts and/or actions prior to and or during treatment for psychological disease. To obtain such features and indices, power spectrum and time domain values are derived from biopotential signals acquired from the subject being tested. The system and method identify people who are likely to experience changing, especially worsening, symptoms of psychological and neurological adverse events such as suicidal thoughts or actions and who therefore may be at risk (e.g. suicide).

39. 发明授权

EP0971628B1 SYSTEM AND METHOD FOR ENHANCING AND SEPARATING BIOPOTENTIAL SIGNALS 有权
标题翻译：系统和方法加强和生物电位信号的分离
公开(公告)号：EP0971628B1
公开(公告)日：2005-04-06
申请号：EP99903375.6
申请日：1999-01-25
申请人： Aspect Medical Systems, Inc.
发明人： GREENWALD, Scott, D. , DEVLIN, Philip, H. , SMITH, Charles, P.
IPC分类号： A61B5/0496 , A61B5/0478
CPC分类号： A61B5/0496 , A61B5/0478 , A61B5/7257

40. 发明公开

EP1460933A2 SYSTEM AND METHOD OF ASSESSMENT OF NEUROLOGICAL CONDITIONS USING EEG 有权
标题翻译：系统和方法符合条件的精神障碍脑电图使用
公开(公告)号：EP1460933A2
公开(公告)日：2004-09-29
申请号：EP03703709.0
申请日：2003-01-06
申请人： Aspect Medical Systems, Inc.
发明人： GREENWALD, Scott, D. , SMITH, Charles, P. , SIGL, Jeffrey, C. , DEVLIN, Philip, H.
IPC分类号： A61B5/00
CPC分类号： A61B5/4839 , A61B5/048 , A61B5/16 , A61B5/4088 , G06K9/00523
摘要： The present invention is a system and method that produces features and indices that indicate the presence or absence of a disease or condition, or of the progression of a disease or condition. The system and method of the present invention also produce features and indices that predict responsiveness to medication from a premedication baseline. The system and method of the present invention further incorporates a testing methodology to improve the performance characteristics of the features or indices. To obtain such features and indices, time domain, power spectrum, bispectrum and higher order spectrum values are derived from biopotential signals taken from the subject being tested.

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