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    • 33. 发明公开
    • IMPROVED METHOD FOR PREPARATION OF HIGH ENZYMATIC RESISTANCE HYDROXYALKYLCELLULOSE DERIVATIVES
    • 改进的制备高抗酶羟基烷基糖衍生物的方法
    • EP1828252A1
    • 2007-09-05
    • EP04808466.9
    • 2004-12-17
    • Samsung Fine Chemicals Co., Ltd.
    • KIM, SEOK SOOSO, JUNG HOLEE, IL YONGHWANG, HEE WON, 513-1411 Songgang Cheongsol Apt.
    • C08B11/08
    • C08B11/08C08B11/193
    • The present invention relates to a process of preparing hydroxyalkyl cellulose derivatives having improved enzymatic resistance. In particular, the present invention relates to a process of preparing hydroxyalkyl cellulose derivatives by reacting cellulose and ethylene oxide in the presence of alkali metal hydroxide, wherein the reaction between cellulose and ethylene oxide is performed in the presence of isopropyl alcohol azeotropic solvent in a horizontally agitated reactor, wherein the ethylene oxide is supplied via two steps, thus resulting in a two-step reaction, and the amount of alkali metal hydroxide remaining after the first reaction is controlled, thereby enabling to provide hydroxyalkyl cellulose derivatives having improved enzymatic resistance and turbidity and to remarkably decrease the solvent usage to have economical and environmental advantages.
    • 本发明涉及制备具有改进的酶抗性的羟烷基纤维素衍生物的方法。 具体地说,本发明涉及通过在碱金属氢氧化物存在下使纤维素和环氧乙烷反应制备羟烷基纤维素衍生物的方法,其中纤维素和环氧乙烷之间的反应是在异丙醇共沸溶剂存在下在水平 其中通过两个步骤供应环氧乙烷,由此导致两步反应,并且控制第一反应后剩余的碱金属氢氧化物的量,由此能够提供具有改进的酶抗性和浊度的羟烷基纤维素衍生物 并显着降低溶剂使用量以具有经济和环境优势。