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    • 32. 发明公开
    • FERMENTATION PROCESS FOR THE PRODUCTION AND CONTROL OF PYRUVATE-DERIVED PRODUCTS
    • 发酵剂ZUR HERSTELLUNG UND STEUERUNG VON PYRUVATDERIVERERTEN PRODUKTEN
    • EP3146058A1
    • 2017-03-29
    • EP15796360.4
    • 2015-05-20
    • Lanzatech New Zealand Limited
    • SMART, Kathleen FrancesLY, Boi San
    • C12P7/40C12P7/16C12P7/18
    • A process for producing and controlling pyruvate derived products during the fermentation of a CO containing substrate by an acetogenic carboxydotrophic microorganism has been developed. The process involves increasing the concentration of at least one nutrient selected from the group consisting of vitamin B1, vitamin B5, vitamin B7 and mixtures thereof above the cellular requirement of the microorganism. When the concentration is increased, the production of 2,3-butanediol (2,3-BDO) increases whereas the production of the other metabolites is virtually unchanged. The effect is reversible so that when the concentration is decreased, the production of 2,3-BDO is also decreased. This allows one to control the ratio of ethanol:2,3-BDO to a desired value which can vary from about 4:1 to about 1:2.
    • 已经开发了在通过乙酰酵素羧基营养型微生物发酵含CO底物期间生产和控制丙酮酸衍生产物的方法。 该方法包括增加选自维生素B1,维生素B5,维生素B7及其混合物中的至少一种营养素的浓度,高于微生物的细胞要求。 当浓度增加时,2,3-丁二醇(2,3-BDO)的产量增加,而其他代谢产物的产量几乎没有变化。 效果是可逆的,因此当浓度降低时,2,3-BDO的产量也降低。 这允许将乙醇:2,3-BDO的比例控制在可以在约4:1至约1:2之间变化的期望值。