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21. 发明公开

EP2397487A4 SHORT-CHAIN CATIONIC POLYAMINO ACID AND USE THEREOF 有权
标题翻译：短链聚阳离子及其用途
公开(公告)号：EP2397487A4
公开(公告)日：2012-10-31
申请号：EP11740552
申请日：2011-02-23
申请人： NANOCARRIER CO LTD , UNIV TOKYO
发明人： KATO YASUKI , ISHII ATSUSHI , SHIBATA NAOYA , HAYASHI TATSUYUKI , KATAOKA KAZUNORI , MIYATA KANJIRO , NISHIYAMA NOBUHIRO
IPC分类号： C07K4/00 , A61K31/7105 , A61K31/713 , A61K47/42 , A61K47/48 , A61K48/00 , C08F212/00 , C08G69/10 , C08G69/48 , C12N15/11
CPC分类号： C08G69/10 , A61K47/60 , A61K47/6455 , C12N15/111 , C12N2310/14 , C12N2320/32

22. 发明授权

EP2002259B1 Disheveled PDZ modulators 有权
标题翻译：蓬乱PDZ调节剂
公开(公告)号：EP2002259B1
公开(公告)日：2012-05-16
申请号：EP07760350.4
申请日：2007-04-09
申请人： Genentech, Inc.
发明人： COSTA, Mike , SIDHU, Sachdev, S. , ZHANG, Yingnan
IPC分类号： G01N33/50 , C07K2/00 , C07K4/00 , C07K5/04 , C07K14/00
CPC分类号： G01N33/57496 , C07K7/06 , C07K2319/01 , G01N2500/02
摘要： The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.

23. 发明授权

EP2199405B1 Polypeptides substrates of LRRK2 and uses thereof 有权
标题翻译： LRRK2的多肽底物及其用途
公开(公告)号：EP2199405B1
公开(公告)日：2012-03-07
申请号：EP09252042.8
申请日：2009-08-24
申请人： Medical Research Council
发明人： Alessi, Dario , Nichols, R. Jeremy
IPC分类号： C12Q1/48 , C07K4/00 , C12N15/00 , G01N33/68
CPC分类号： C12Q1/485 , C12N9/1205 , G01N33/6896 , G01N2800/2835

24. 发明公开

EP2316849A2 Polypeptides comprising RER, derivatives and uses thereof 审中-公开
标题翻译： RER-enthaltende Polypeptidderivate und deren Verwendung
公开(公告)号：EP2316849A2
公开(公告)日：2011-05-04
申请号：EP10012535.0
申请日：2002-04-17
申请人： THE OPEN UNIVERSITY
发明人： Mileusnic, Radmila , Rose, Steven Peter Russell
IPC分类号： C07K14/47 , C07K5/09 , C07K5/11 , C07K5/103 , A61K38/17 , A61P25/28 , A61K38/03 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/16 , C07K4/00 , C07K5/00 , C07K7/06 , C07K14/00
CPC分类号： C07K14/4711 , A61K38/00 , C07K5/081 , C07K5/0817 , C07K5/1013 , C07K5/1019 , Y02P20/55
摘要： The invention provides a compound having formula

in which X 1 and X 2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula:

wherein X 1 and X 2 , which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or a derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.
摘要翻译：本发明提供具有式X 1和X 2至多30个氨基酸残基且Xaa为氨基酸残基的化合物。优选的化合物是对应于人淀粉样蛋白前体蛋白质的氨基酸残基328至330的三肽Arg-Glu-Arg。本发明还提供具有下式的多肽的衍生物：其中X 1和X 2可以相同或不同，各自表示0至30个天然或合成氨基酸残基或其衍生物，Xaa表示天然或合成的氨基酸残基或其衍生物，至少一个所述氨基酸残基或其衍生物的官能团被保护基团保护。认为本发明的化合物可用于治疗阿尔茨海默病和认知增强剂。

25. 发明授权

EP1337858B1 A REAGENT AND KIT FOR DETERMINING THE GLOBAL COAGULABILITY AND THE HEMOSTATIC POTENTIAL 有权
标题翻译：试剂及试剂盒，用于确定全球凝血能力和潜力止血
公开(公告)号：EP1337858B1
公开(公告)日：2011-03-16
申请号：EP01983998.4
申请日：2001-10-18
申请人： Cambridge University Hospitals NHS Foundation Trust
发明人： TEJIDOR, Liliana , BAGLIN, Trevor , DOOBAY, Hema , LUDDINGTON, Roger , FISCHER, Timothy, J.
IPC分类号： G01N33/86 , C07K4/00 , C12Q1/56
CPC分类号： G01N33/86 , Y10T436/10
摘要： A reagent and kit are disclosed for determining if a patient is hypercoagulable, hypocoagulable or normal. The test involves providing a test sample from the patient and initiating coagulation in the sample in the presence of an activator, which is added to the sample in an amount which will result in intrinsic tenase-dependent fibrin. Then the formation of the intrinsic tenase-dependent fibrin polymerization is monitored over time so as to derive a time-dependent profile, with the results of the fibrin polymerization monitoring determining whether the patient is hypercoagulable, normal or hypocoagulable. The coagulation activator is added in an amount that triggers a thrombin explosion that is dependent on the propagation phase and amplification pathways. In this way, a single assay can assess the hemostatic potential of a sample.

26. 发明授权

EP1411962B1 MONOCLONAL ANTIBODY THERAPY FOR PANCREAS CANCER 有权
标题翻译：胰腺癌与单克隆抗体治疗
公开(公告)号：EP1411962B1
公开(公告)日：2011-01-19
申请号：EP02726672.5
申请日：2002-03-15
申请人： Neogenix Oncology, Inc.
发明人： ARLEN, Myron , TSANG, Kwong, Y.
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07H1/00 , C07H5/04 , C07H5/06 , C12N15/57 , C12P7/66
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： An isolated nucleic acid molecule comprising the nucleotide sequences of Figure 2 (SEQ ID NO:1) or Figure 4 (SEQ ID NO:4), each of which encodes the light and heavy chain, respectively, of a recombinant monoclonal antibody that exhibits antibody-dependent cellular cytotoxicity (ADCC) activity specific for colon and pancreatic cancer cells.

27. 发明公开

EP2240505A1 PEPTIDE ACTIVATEUR DE LA SYNTHESE DES AQUAPORINES 失效
标题翻译：肽活化DE LA SYNTHESE DES AQUAPORINES
公开(公告)号：EP2240505A1
公开(公告)日：2010-10-20
申请号：EP08873330.8
申请日：2008-12-17
申请人： Société d'Extraction des Principes Actifs SA (Vincience)
发明人： DAL FARRA, Claude , DOMLOGE, Nouha , BOTTO, Jean-Marie
IPC分类号： C07K4/00 , C07K5/06 , C07K5/08 , C07K5/10 , A61K8/64 , A61K38/05 , A61K38/06 , A61K38/07 , A61Q19/00 , A61P17/00
CPC分类号： C07K4/00 , A61K8/64 , A61K38/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07K5/06 , C07K5/08 , C07K5/0819 , C07K5/0823 , C07K5/1021
摘要： The present invention relates to a peptide of general formula (I): R
1 ‑(AA)
n -X
1 -X
2 -X
3 -Pro-X
4 -X
5 -X
7 -(AA)
P -R
2 , capable of activating the synthesis of proteins of the aquaporin family. The present invention also relates to a cosmetic, nutraceutical or pharmaceutical composition comprising a peptide of general formula (I) as active ingredient. The invention also relates to the use of this novel active ingredient in a cosmetic or nutraceutical composition for improving the hydration and the barrier function of the epidermis and for stimulating skin regeneration. The invention also relates to the use of this novel active ingredient for the preparation of a pharmaceutical, and in particular dermatological, composition for regulating and/or stimulating aquaporin activity and thus treating pathological dryness of the skin or of the mucous membranes. The invention also relates to a cosmetic treatment method for preventing or combating dryness of the skin and of the mucous membranes, and the manifestations of skin ageing.
摘要翻译：本发明涉及通式（I）的肽：R 1 - （AA）n X 1 -X 2 -X 3 -Pro-X 4 -X 5 -X 7-（AA）PR 2，水通道蛋白家族蛋白质的合成。本发明还涉及包含通式（I）的肽作为活性成分的化妆品，营养药物或药物组合物。本发明还涉及这种新型活性成分在美容或营养组合物中用于改善表皮的水合作用和屏障功能并刺激皮肤再生的用途。本发明还涉及该新型活性成分在制备用于调节和/或刺激水通道蛋白活性并因此治疗皮肤或粘膜的病理性干燥的药物，特别是皮肤病学组合物中的用途。本发明还涉及用于预防或防止皮肤和粘膜的干燥以及皮肤老化的表现的美容处理方法。

28. 发明公开

EP1644729A4 ANTI-CD74 IMMUNOCONJUGATES AND METHODS 审中-公开
标题翻译： ANTI-CD74-IMMUNKONJUGATE UND VERFAHREN
公开(公告)号：EP1644729A4
公开(公告)日：2010-09-22
申请号：EP04776666
申请日：2004-06-17
申请人： IMMUNOMEDICS INC
发明人： GRIFFITHS GARY L , HANSEN HANS J , GOLDENBERG DAVID M , LUNDBERG BO B
IPC分类号： G01N33/48 , A61K20060101 , A61K38/00 , A61K39/395 , A61K47/48 , A61K51/12 , A61P35/00 , A61P35/02 , A61P37/06 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K16/28 , C07K17/00 , G01N21/00 , G01N21/75 , G01N33/00 , G01N33/574
CPC分类号： A61K39/395 , A61K45/00 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates compositions in therapeutic and/or diagnostic methods.
摘要翻译：公开了包括抗CD74免疫偶联物和治疗和/或诊断剂的组合物。还公开了在诊断和治疗过程中制备免疫缀合物和使用免疫缀合物的方法。组合物可以是用于在治疗和/或诊断方法中施用抗CD74免疫缀合物组合物的试剂盒的一部分。

29. 发明公开

EP2199405A2 Polypeptides substrates of LRRK2 and uses thereof 有权
标题翻译： LRRK2的多肽底物及其用途
公开(公告)号：EP2199405A2
公开(公告)日：2010-06-23
申请号：EP09252042.8
申请日：2009-08-24
申请人： Medical Research Council
发明人： Alessi, Dario , Nichols, R. Jeremy
IPC分类号： C12Q1/48 , C07K4/00 , C12N15/00 , G01N33/68
CPC分类号： C12Q1/485 , C12N9/1205 , G01N33/6896 , G01N2800/2835
摘要： A method for identifying a compound expected to be useful in modulating, for example inhibiting, LRRK2 protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates, for example inhibits, the protein kinase activity of a LRRK2 polypeptide on a substrate polypeptide and (2) selecting a compound which modulates, for example inhibits, the said LRRK2 polypeptide protein kinase activity, wherein the substrate polypeptide comprises the sequence (W/F/R/K)(W/F/R/K)(R/K)(F/W/H/R)(Y/W/R)( S/T )(L/V/I)(R/K)(R/K)(A/Y) or (W/R)(X)(X)(F/Y/H/T)(Y/W/R)( T )(X)(R/T)(R)(X), where X represents any amino acid. Such a compound may be useful in treating Parkinson's Disease or Parkinsonism. The substrate polypeptide may consist or comprise the sequence RLGWWRFY T LRRARQGNTKQR.
摘要翻译：用于鉴定预期用于调节例如抑制LRRK2蛋白激酶活性的化合物的方法，所述方法包括以下步骤：（1）确定测试化合物是否调节，例如抑制LRRK2多肽的蛋白激酶活性（W / F / R / K）（W / F / R / K）的底物多肽，和（2）选择调节，例如抑制所述LRRK2多肽蛋白激酶活性的化合物。（R / K）（F / W / H / R）（Y / W / R）（S / T）（L / V / I）（R / K）（W / R）（X）（X）（F / Y / H / T）（Y / W / R）（T）（X）（R / T）酸。这种化合物可用于治疗帕金森氏病或帕金森综合征。底物多肽可以包含或包含序列RLGWWRFYTLRRARQGNTKQR。

30. 发明公开

EP2076276A4 SOL-GEL MATERIALS FOR CELLULAR MODULATION 有权
标题翻译：用于细胞调节的溶胶凝胶材料
公开(公告)号：EP2076276A4
公开(公告)日：2009-10-21
申请号：EP07868421
申请日：2007-10-11
申请人： PURDUE RESEARCH FOUNDATION
发明人： RICKUS JENNA LEIGH , JEDLICKA SABRINA S
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： C07K17/14

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