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21. 发明授权

EP0765877B1 Composés aminés de 5,6,7,8-tétrahydronaphto(2,3-b)furane et d'indano(5,6-b)furane, leurs procédés de préparation et compositions pharmaceutiques qui les contiennent 失效
标题翻译： 5,6,7,8- Tetrahydronaphto（2,3-二）呋喃和indano（5,6-二）呋喃氨基化合物，它们的制备方法和含有它们的药物组合物
公开(公告)号：EP0765877B1
公开(公告)日：2003-12-17
申请号：EP96402044.0
申请日：1996-09-26
申请人： LES LABORATOIRES SERVIER
发明人： Peglion, Jean-Louis , Vian, Joel , Dessinges, Aimée , Millan, Mark , Audinot, Valérie
IPC分类号： C07D307/92 , C07D405/12 , A61K31/34
CPC分类号： C07D307/92 , C07D405/12

22. 发明授权

EP1138679B1 HYDRONAPHTHO 2,3-c]FURAN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF 有权
标题翻译： HYDRONAPHTHO 2,3-c]呋喃衍生物及其制备方法
公开(公告)号：EP1138679B1
公开(公告)日：2003-03-19
申请号：EP99959746.1
申请日：1999-12-10
申请人： SAGAMI CHEMICAL RESEARCH CENTER , KYORIN PHARMACEUTICAL CO., LTD.
发明人： TERASHIMA, Shiro , TAKADOI, Masanori , ISHIWATA, Akihiro, 8-32-16-302, Ooizumigakuen-cho , KATOH, Tadashi
IPC分类号： C07D307/92 , C07D493/18
CPC分类号： C07D307/92 , C07D493/08

23. 发明公开

EP1134216A4 ANTI-DRUG RESISTANT STRAIN AGENTS AND ANTICHLAMYDIA AGENTS 有权
标题翻译：细菌对耐药菌株细菌和抗CHLAMYDIAMITTEL
公开(公告)号：EP1134216A4
公开(公告)日：2002-01-30
申请号：EP00962927
申请日：2000-09-28
申请人： JAPAN SCIENCE & TECH CORP
发明人： HIRAI KEIICHI , NAGATA KUMIKO , KOYAMA JUNKO , KISHIMOTO TOSHIO
IPC分类号： A61K31/343 , A61P31/04 , A61P31/10 , C07D307/92
CPC分类号： C07D307/92 , A61K31/343
摘要： Anti-drug resistant strain agents and antichlamydia agents containing as the active ingredient furanonaphtoquinone derivatives represented by general formula (1), wherein each R is represented by one of general formulae (a) to (e): -R' (a), -OR' (b), (c), (d), -SR' (e) wherein R' represents hydrogen, alkyl, hydroxyalkyl or alkoxyalkyl; or R groups adjacent to each other may form a heterocycle mediated by oxygen.

24. 发明公开

EP1171433A1 PREPARATION OF NORLABDANE OXIDE 有权
标题翻译：制造降龙涎香
公开(公告)号：EP1171433A1
公开(公告)日：2002-01-16
申请号：EP00917207.3
申请日：2000-04-10
申请人： QUEST INTERNATIONAL NEDERLAND BV
发明人： DAVEY, Paul Nicholas , TSE, Chi-Lam
IPC分类号： C07D307/92
CPC分类号： C07D307/92
摘要： Norlabdane oxide, which is a well known fragrance material having ambergris-type odours, is prepared from 12-acetoxy-norlabdane oxide by a hydrogenation reaction.

25. 发明公开

EP1134216A1 ANTI-DRUG RESISTANT STRAIN AGENTS AND ANTICHLAMYDIA AGENTS 有权
标题翻译： MITTEL GEGEN MEDIKAMENTENRESISTENTEBAKTERIENSTÄMMEUND ANTI-CHLAMYDIAMITTEL
公开(公告)号：EP1134216A1
公开(公告)日：2001-09-19
申请号：EP00962927.0
申请日：2000-09-28
申请人： Japan Science and Technology Corporation
发明人： HIRAI, Keiichi , NAGATA, Kumiko , KOYAMA, Junko , KISHIMOTO, Toshio
IPC分类号： C07D307/92 , A61K31/343 , A61P31/04 , A61P31/10
CPC分类号： C07D307/92 , A61K31/343
摘要： In order to provide antibacterial agents for drug-resistant bacteria and anti-Chlamydia agents, the furanonaphthoquinone derivative represented by the following formula (1):
wherein each R may be the same or different, representing any one of the following (a) to (e) :

- R' (a)

-OR' (b)

- SR' (e)

(wherein R' is a hydrogen atom, alkyl group, hydroxyalkyl group, or alkoxyalkyl group), or two mutually adjacent Rs may be bonded via an oxygen atom to form a heterocyclic ring is used as the effective component.
摘要翻译：为了提供耐药细菌和抗衣原体剂的抗菌剂，由下式（1）表示的呋喃萘醌衍生物：其中每个R可以相同或不同，表示以下任一项（a ）至（e）：-R'-OR' CHEM-SR'（其中R'为氢原子，烷基，羟基烷基或烷氧基烷基）或两个相互相邻的Rs可以通过使用氧原子形成杂环作为有效成分。

26. 发明公开

EP1077968A1 NAPHTHO[2,3-B]HETEROAR-4-YL DERIVATIVES 审中-公开
标题翻译： NAPHTO2,3-B杂环-4-基-L-衍生物
公开(公告)号：EP1077968A1
公开(公告)日：2001-02-28
申请号：EP99920418.3
申请日：1999-05-10
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： DOLLINGS, Paul, Jeffrey , DIETRICH, Arlene, Joan , WROBEL, Jay, Edward
IPC分类号： C07D333/74 , A61K31/38 , A61K31/34 , A61K31/465 , A61K31/505 , C07D307/92 , C07D409/14 , C07D409/12
CPC分类号： C07D307/92 , C07D333/74 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of structural Formula (I), wherein R?1 and R2¿ are each, independently, hydrogen, nitrile, nitro, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, cycloalkylamino of 3-8 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, halogen, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl mono-, di-, or tri-substituted with halogen, hydroxy, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, or perfluoroalkoxy of 1-6 carbon atoms; R?3 and R4¿ are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, hydroxyalkyl of 1-6 carbon atoms, aminoalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms; R5 is hydrogen, halogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, nitrile, alkoxy of 1-6 carbon atoms, aryloxy, arylalcoxy of 2-12 carbon atoms, arylsulfanyl; W is S, O, or NR9; R9 is hydrogen or alkyl of 1-6 carbon atoms; X is O, -NR6-, or -(CH¿2?)pNR?6-; R6¿ is hydrogen, or alkyl of 1-6 carbon atoms; p is 1 to 4; Y is methylene, carbonyl, -SO¿2?-, or -SO-; Z is phenyl, heteroaryl, or naphthyl; R?7 and R8¿ are each, independently, hydrogen, carboxyl, acyl of 2-7 carbon atoms, hydroxyl, hydroxyalkyl of 1-6 carbon atoms, hydroxyalkanoyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, aryl, aryloxy, aryloxycarbonyl, heteroaryloxycarbonyl, arylalkoxy of 6-12 carbon atoms, heteroaryl, alkanoyloxy of 1-6 carbon atoms, perfluoroalkanoyloxy of 1-6 carbon atoms, heteroaroyloxy, aroyloxy, tetrazolyl, mercapto, nitrile, amino, carbamoy, aminoalkyl of 1-6 carbon atoms, -NHSO¿2?CF3, carboxyaldehyde, halogen, nitro, acylamino, or pyrimidyl optionally substituted with mercapto, 3-hydroxy-cyclobut-3-ene-4-yl-1,2-dione, or tetronic acid; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

27. 发明授权

EP0810198B1 SESQUITERPENE COMPOUNDS 失效
标题翻译： SESQUITERPENVERBINDUNGEN
公开(公告)号：EP0810198B1
公开(公告)日：2000-08-30
申请号：EP96902435.5
申请日：1996-02-14
申请人： TOAGOSEI CO., LTD.
发明人： NOZOE, Shigeo , TAKAHASHI, Akira , MASUDA, Jun-ich , TANAKA, Ken-ichi , SUZUKI, Hideo
IPC分类号： C07C69/708 , C07D307/92 , A01N37/06 , A01N43/08
CPC分类号： C07C69/708 , C07D307/92
摘要： Sesquiterpene compounds represented by general formula (I), wherein one of R1 groups represents -COOR3 and the other represents any of the groups represented by structural formulae (a), (b), (c), (d), (e), (f) and (g); R?2 and R3¿ represent each independently hydrogen or alkyl; and R4 represents hydroxy or alkoxy.

28. 发明授权

EP0745584B1 Composés arylalkyl(thio) carboxamides ayant une affinité pour des récepteurs mélatoninergiques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent 失效转让
标题翻译：芳基烷基（硫代）具有亲和力甲酰胺化合物对褪黑素受体，它们的制备方法和含有它们的药物组合物
公开(公告)号：EP0745584B1
公开(公告)日：2000-01-05
申请号：EP96401159.7
申请日：1996-05-30
申请人： ADIR ET COMPAGNIE
发明人： Lesieur, Isabelle , Depreux, Patrick , Leclerc, Véronique , Delagrange, Philippe , Renard, Pierre , Guardiola Lemaitre, Béatrice
IPC分类号： C07C235/34 , C07C235/36 , C07D209/18 , C07D333/24 , C07D333/32 , C07D307/79 , C07D307/92 , C07D311/92 , A61K31/165 , A61K31/40 , A61K31/38 , A61K31/34
CPC分类号： C07D307/79 , C07C235/34 , C07C235/36 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D209/18 , C07D307/92 , C07D311/92 , C07D333/24

29. 发明公开

EP0810198A4 SESQUITERPENE COMPOUNDS 失效
标题翻译：倍半萜
公开(公告)号：EP0810198A4
公开(公告)日：1998-05-13
申请号：EP96902435
申请日：1996-02-14
申请人： TOA GOSEI CO LTD
发明人： NOZOE SHIGEO , TAKAHASHI AKIRA , MASUDA JUN-ICH , TANAKA KEN-ICHI , SUZUKI HIDEO
IPC分类号： C07C69/708 , C07D307/92 , A01N37/06 , A01N43/08
CPC分类号： C07C69/708 , C07D307/92
摘要： Sesquiterpene compounds represented by general formula (I), wherein one of R1 groups represents -COOR3 and the other represents any of the groups represented by structural formulae (a), (b), (c), (d), (e), (f) and (g); R?2 and R3¿ represent each independently hydrogen or alkyl; and R4 represents hydroxy or alkoxy.

30. 发明授权

EP0558928B1 Ethers furaniques et leur utilisation à titre d'ingrédients parfumants 失效
标题翻译： Furanether及其作为增香剂使用
公开(公告)号：EP0558928B1
公开(公告)日：1998-04-15
申请号：EP93101476.5
申请日：1993-01-30
申请人： FIRMENICH SA
发明人： Snowden, Roger Leslie , Escher, Sina Dorothea
IPC分类号： C07D307/92 , C07C33/14 , C11B9/00 , A61K7/46
CPC分类号： C07D307/92 , C07C33/14 , C11B9/0076

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