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21. 发明公开

EP3044336A4 A TRANSCRIPTOMIC INDEX FOR CHARACTERIZING THE CELLULAR REPAIR RESPONSE AFTER SOFT TISSUE INJURY IN DIARTHRODIAL JOINTS 有权
标题翻译： TRANSKRIPTOMISCHER指数为表征的细胞修复反应后动关节软组织损伤
公开(公告)号：EP3044336A4
公开(公告)日：2017-04-19
申请号：EP14844103
申请日：2014-09-08
申请人： UNIV RUSH MEDICAL CENTER
发明人： CHAN DEVA , LI JUN , PLAAS ANNA H K , SANDY JOHN D , WANG VINCENT
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： One aspect of the Invention provides methods for classifying the quality of a repair response after injury to a joint of a subject. In one embodiment, the method includes providing a tissue sample from the injured region of the joint and determining expression levels in the sample of a plurality of genes, including at least those genes listed in Table 1, Table 2 and Table 3, Another aspect of the Invention provides methods of treating a human or veterinary subject having an injury to a joint based on the classification of the quality of the repair response.

22. 发明公开

EP2970895A4 PODOCYTE CULTURES AND USES THEREOF 有权
标题翻译： PODOCYTE文化及其用途
公开(公告)号：EP2970895A4
公开(公告)日：2016-08-10
申请号：EP14769052
申请日：2014-03-10
申请人： UNIV RUSH MEDICAL CENTER
发明人： HAYS TRISTAN , REISER JOCHEN , GUPTA VINEET
IPC分类号： C12N5/071 , C12Q1/68 , G01N33/50 , G01N33/569
CPC分类号： C12N5/0686 , C12N5/0687 , C12N2510/04 , G01N33/502 , G01N33/5023 , G01N33/5026 , G01N33/5044 , G01N33/56966 , G01N2333/4712 , G01N2800/347
摘要： The following disclosure generally relates to methods of culturing podocytes in vitro. The cultures can be used for drug screening (such as medium or high throughput drug screening), and for studying molecular pathways involved in glomerular diseases. The disclosure also provides methods for analyzing the healthiness of podocytes in a cell culture. The disclosure also relates to diagnosis of kidney diseases.

23. 发明公开

EP2066193A4 JOINT LOAD REDUCING FOOTWEAR 有权
标题翻译：联合开脱罪责的鞋制品
公开(公告)号：EP2066193A4
公开(公告)日：2011-07-27
申请号：EP07843278
申请日：2007-09-27
申请人： UNIV RUSH MEDICAL CENTER
发明人： SHAKOOR NAJIA , LIDTKE ROY
IPC分类号： A43B13/14
CPC分类号： A43B13/141

24. 发明公开

EP2035999A4 MATHEMATICAL DESIGN OF ION CHANNEL SELECTIVITY VIA INVERSE PROBLEMS TECHNOLOGY 审中-公开
标题翻译： MATHEMATISER ENTWURF DERIONENKANALSELEKTIVITÄTÜBERUMKEHRPROBLEMETECHNOLOGIE
公开(公告)号：EP2035999A4
公开(公告)日：2009-07-01
申请号：EP07775219
申请日：2007-04-11
申请人： MATHCONSULT GMBH , UNIV RUSH MEDICAL CENTER
发明人： ENGL HEINZ W , EISENBERG ROBERT SHIM , BURGER MARTIN
IPC分类号： G06F19/00 , G01N33/68 , G06G7/48
CPC分类号： G06F19/16
摘要： Determining the structure of permanent charge for an ion channel formulates an abstract operator, describing ion channel parameters, comprising equations that are ill-posed. The model of ion channel behavior relates the function of the ion channel to the structure of permanent charge within the ion channel and concentrations ions around the ion channel under certain properties and boundary conditions. The model also includes regularization of the abstract operator by approximating the ill-posed equations with a family of well-posed equations. An estimate of the closeness of the well-posed solution to the ill-posed solution is provided. Providing stable and convergent algorithms allows the model to determine a stability for the regularized solution, so that a regularization parameter can determine a balance between the stability and accuracy of the solution.
摘要翻译：确定离子通道的永久电荷结构会形成一个抽象算子，描述离子通道参数，包括不适合的方程。离子通道行为模型将离子通道的功能与离子通道内的永久电荷结构相关联，并且在某些性质和边界条件下将离子通道周围的离子浓缩。该模型还包括抽象算子的正则化，通过将不适定方程与一组适定方程近似。提供了适当解决方案对不适合解决方案的接近度的估计。提供稳定和收敛的算法允许模型确定正则化解的稳定性，以便正则化参数可以确定解的稳定性和准确性之间的平衡。

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