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21. 发明授权

EP1793745B1 DEVICES FOR TISSUE GRASPING AND ASSESSMENT 有权
公开(公告)号：EP1793745B1
公开(公告)日：2019-04-03
申请号：EP05805707.6
申请日：2005-09-27
申请人： Evalve, Inc.
发明人： GOLDFARB, Eric, A. , THORNTON, Troy, L. , RASCHDORF, Alfred, H. , SARABIA, Jaime, E. , MADDEN, John, P. , POWELL, Ferolyn, T. , MARTIN, Brian, B. , WEN-CHIN FAN, Sylvia , KOMTEBEDDE, Jan , LIAO, Yen, C.
IPC分类号： A61F2/00 , A61F2/24 , A61B17/00 , A61B17/29 , A61B17/04

22. 发明公开

EP3359078A1 DEVICES, SYSTEMS, AND METHODS TO SUPPORT, STABILIZE, AND POSITION A MEDICAL DEVICE 有权
公开(公告)号：EP3359078A1
公开(公告)日：2018-08-15
申请号：EP16785055.1
申请日：2016-10-06
申请人： Evalve, Inc.
发明人： HO, Patricia H. , MARSOT, Travis R. , STRAHM, Christopher T. , KOPLIN, Randall S. , ENGLAND, Justen D.
IPC分类号： A61B90/50
CPC分类号： A61B90/11 , A61B90/50 , A61B2017/3405 , A61B2017/3407
摘要： A stabilizer system for supporting a medical device includes a platform and a stabilizer body positioned on the platform and being slidably translatable about the platform. The platform includes a translation actuator configured to engage with a receiving member of the stabilizer body. Actuation of the translation actuator passes a force to the receiving member of the stabilizer body and causes the stabilizer body to translate relative to the platform. The stabilizer body includes a base and one or more support wings extending from the base to support a medical device. A straddle actuator is coupled to a support wing and is configured to engage with the medical device. Actuation of the straddle actuator passes a force to the medical device and causes at least a portion of the medical device to translate relative to the stabilizer body.

23. 发明公开

EP3359053A1 A DELIVERY CATHETER HANDLE AND METHODS OF USE 有权
公开(公告)号：EP3359053A1
公开(公告)日：2018-08-15
申请号：EP16782382.2
申请日：2016-10-06
申请人： Evalve, Inc.
发明人： MARSOT, Travis R. , HO, Patricia H. , ENGLAND, Justen D. , KOPLIN, Randall S. , RODENKIRCH, Douglas S.
IPC分类号： A61B17/00 , A61B17/122 , A61B17/128 , A61B90/50 , A61M25/01 , A61M25/02
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/1227 , A61B17/1285 , A61B90/50 , A61B90/57 , A61B2017/00243 , A61B2017/00336 , A61B2017/00367 , A61B2017/00429 , A61B2017/00477 , A61B2017/00783 , A61B2090/508 , A61F2/2454 , A61F2/246 , A61M25/0136 , A61M2025/024 , A61M2025/028
摘要： Methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. A delivery device for delivering an implantable device to a target area includes a fluid management system for directing fluid and delivery device components to the target area. The delivery device includes a grip line assembly configured to control a gripper in the implantable device for grasping tissue at the target area. The delivery device includes a lock line assembly configured to control a locking mechanism in the implantable device to lock the implantable device in a desired orientation. The delivery device includes a deployment handle configured to provide staged deployment of the implantable device. A delivery assembly includes a housing and a delivery device partially housed within the housing and being adjustable using one-handed operation.

24. 发明授权

EP3143944B1 LOCKING MECHANISMS FOR FIXATION DEVICES 有权
公开(公告)号：EP3143944B1
公开(公告)日：2018-08-01
申请号：EP16196023.2
申请日：2005-05-16
申请人： Evalve, Inc.
发明人： GOLDFARB, Eric A. , SARABIA, Jaime E. , RASCHDORF, Alfred H. , MADDEN, John P.
IPC分类号： A61B17/08 , A61B17/10 , A61B17/00
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.

25. 发明公开

EP3143944A3 LOCKING MECHANISMS FOR FIXATION DEVICES 有权
标题翻译：固定装置的锁定机构
公开(公告)号：EP3143944A3
公开(公告)日：2017-05-31
申请号：EP16196023.2
申请日：2005-05-16
申请人： Evalve, Inc.
发明人： GOLDFARB, Eric A. , SARABIA, Jaime E. , RASCHDORF, Alfred H. , MADDEN, John P.
IPC分类号： A61B17/04 , A61B17/08 , A61B17/10 , A61B17/00
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites. In particular, fixation devices are provided comprising a pair of fixation elements each having a first end, a free end opposite the first end, and an engagement surface therebetween for engaging the tissue, the first ends being movably coupled together such that the fixation elements are moveable between an open position wherein the free ends are spaced apart and a closed position wherein the free ends are closer together with the engagement surfaces generally facing each other. The fixation devices also include a locking mechanism coupled to the fixation elements for locking the fixation elements in place. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues. The invention is particularly useful in those procedures requiring minimally-invasive or endovascular access to remote tissue locations, where the instruments utilized must negotiate long, narrow, and tortuous pathways to the treatment site.
摘要翻译：设备，系统和方法用于治疗部位的组织近似和修复。具体而言，提供了固定装置，其包括一对固定元件，每个固定元件具有第一端，与第一端相对的自由端以及其间的用于接合组织的接合表面，第一端可移动地联接在一起，使得固定元件可在自由端间隔开的打开位置和其中自由端与通常彼此面对的接合面更靠近在一起的闭合位置之间移动。固定装置还包括联接到固定元件的锁定机构，用于将固定元件锁定在适当位置。本发明的装置，系统和方法可用于各种治疗过程，包括血管内，微创和开放性外科手术，并且可用于各种解剖区域，包括腹部，胸部，心血管系统，心脏，肠道，胃，尿道，膀胱，肺和其他器官，血管和组织。本发明在需要微创或血管内接近远端组织位置的那些手术中特别有用，其中所使用的器械必须与治疗部位协商长，窄和曲折的通路。

26. 发明公开

EP3125777A1 DOUBLE ORIFICE DEVICE FOR TRANSCATHETER MITRAL VALVE REPLACEMENT 有权转让
标题翻译： VORRICHTUNG MIT DOPPELTERÖFFNUNGZUR NEUPLATZIERUNG EINER TRANSKATHETER-MITRALKLAPPE
公开(公告)号：EP3125777A1
公开(公告)日：2017-02-08
申请号：EP15715889.0
申请日：2015-03-17
申请人： Evalve Inc.
发明人： HERNANDEZ, Carlos G.
IPC分类号： A61B17/04 , A61B17/08 , A61F2/24 , A61B17/34 , A61B17/00 , A61B90/00
摘要： Valve devices for replacement of mitral valves while preserving valvular and subvalvular mitral valve apparatus. The valve device may be configured as a double orifice valve replacement device, and may include an anchoring and manifold assembly coupleable to a delivery catheter. The assembly may include means for anchoring the device to the mitral valve or to a fixation device already attached to the mitral valve. A peripheral ring anchoring system secured to the assembly may include at least one expandable anchoring ring that is expandable within an orifice of the mitral valve so as to surround the orifice perimeter. A helical suture may be helically disposable about the ring, securing the ring to adjacent leaflet tissue. A trap door valve including a trap door body that seals against the anchoring ring during systole and unseals during the diastolic portion of the cardiac cycle may be provided.
摘要翻译：用于更换二尖瓣的瓣膜装置，同时保留瓣膜和亚瓣膜二尖瓣装置。阀装置可以被配置为双孔瓣更换装置，并且可以包括可耦合到输送导管的锚定和歧管组件。组件可以包括用于将装置锚定到二尖瓣或已经附接到二尖瓣的固定装置的装置。固定到组件上的外围环锚定系统可以包括至少一个可扩张的锚定环，其可在二尖瓣的孔口内扩张，以便围绕孔的周边。螺旋缝合线可以在环周围是螺旋状的，将环固定在相邻的小叶组织上。可以提供一种陷阱门阀，其包括在心脏周期的舒张期期间在收缩期间和开封期间密封锚定环的收集门体。

27. 发明授权

EP1750592B1 LOCKING MECHANISMS FOR FIXATION DEVICES 有权
标题翻译：用于固定锁定机制
公开(公告)号：EP1750592B1
公开(公告)日：2016-12-28
申请号：EP05753261.6
申请日：2005-05-16
申请人： Evalve, Inc.
发明人： GOLDFARB, Eric A. , SARABIA, Jaime E. , RASCHDORF, Alfred H. , MADDEN, John P.
IPC分类号： A61B17/04 , A61B17/08 , A61B17/10 , A61B17/00
CPC分类号： A61B17/08 , A61B17/00234 , A61B17/10 , A61B17/122 , A61B17/1285 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/2946 , A61F2/2442

28. 发明公开

EP1874217A4 DEVICE AND METHODS FOR ENDOSCOPIC ANNULOPLASTY 无效
标题翻译： VORRICHTUNG UND VERFAHRENFÜRENDOSKOPISCHE ANNULOPLASTIE
公开(公告)号：EP1874217A4
公开(公告)日：2014-11-19
申请号：EP06751584
申请日：2006-04-25
申请人： EVALVE INC
发明人： ST GOAR FREDERICK , FANN JAMES , DEEM MARK , GIFFORD III HANSON , DIECK MARTIN , MARTIN BRIAN B , FAN SYLVIA , GOLDFARB ERIC , DELL KENT , POWELL FEROLYN
IPC分类号： A61B19/00 , A61B17/00
CPC分类号： A61B17/00234 , A61B17/0487 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/07207 , A61B17/08 , A61B17/29 , A61B17/2909 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/045 , A61B2017/0474 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/06076 , A61B2017/06171 , A61B2017/0641 , A61B2017/0649 , A61B2017/088 , A61B2017/2905 , A61B2017/2927 , A61B2017/2932 , A61B2017/2944 , A61B2017/2946 , A61B2017/306 , A61F2/2427 , A61F2/2445 , A61F2/2466 , A61M25/0147 , A61M25/0152
摘要： The methods, devices, and systems are provided for performing endovascular repair of atrioventricular and other cardiac valves in the heart. Regurgitation of an atrioventricular valve, particularly a mitral valve, can be repaired by modifying a tissue structure selected from the valve leaflets, the valve annulus, the valve chordae, and the papillary muscles. These structures may be modified by suturing, stapling, snaring, or shortening, using interventional tools which are introduced to a heart chamber. The tissue structures can be temporarily modified prior to permanent modification. For example, opposed valve leaflets may be temporarily grasped and held into position prior to permanent attachment. In one aspect, a structure is deployed in a gutter region of the valve annulus to modify the shape of the valve.
摘要翻译：提供的方法，装置和系统用于进行心脏内房室结和其他心脏瓣膜的血管内修复。可以通过修改选自瓣膜小叶，瓣膜环，瓣膜腱索和乳头肌的组织结构来修复房室瓣膜，特别是二尖瓣的反流。这些结构可以通过缝合，缝合，痉挛或缩短来改变，使用引入心室的介入工具。组织结构可以在永久性修改之前临时修改。例如，相对的瓣叶可以在永久性附着之前被暂时抓住并保持就位。在一个方面，结构被布置在阀环的沟槽区域中以改变阀的形状。

29. 发明公开

EP2760351A1 APPARATUSES AND METHODS FOR CUTTING A TISSUE BRIDGE AND/OR REMOVING A HEART VALVE CLIP OR SUTURE 无效转让
标题翻译：器件和方法为架构大桥切割和/或移除心脏瓣膜剪辑或 -NAHT
公开(公告)号：EP2760351A1
公开(公告)日：2014-08-06
申请号：EP12772680.0
申请日：2012-09-28
申请人： Mitracore Technologies Inc.
发明人： COHEN, Gideon , LAGACE, Etienne , BERRADA, Marwane , PERKINS, Charles , CHU, Boby
IPC分类号： A61B17/295 , A61B17/076 , A61B17/00
CPC分类号： A61B17/295 , A61B10/06 , A61B17/320016 , A61B17/3201 , A61B17/32053 , A61B2017/00243 , A61B2017/00323 , A61B2017/00353 , A61B2017/00398 , A61B2017/00539 , A61B2017/00623 , A61B2017/22039 , A61B2017/2905 , A61B2017/2926 , A61B2017/308 , A61B2017/3488
摘要： A medical device (1;70) for safely and effectively removing a clip or a suture from a heart valve is operable in association with a guidewire (16; 84) for positioning the device in proximity to the heart valve. The apparatus may include a blade (26) for cutting a tissue bridge (5) including the clip and an arrangement for removing the tissue bridge from the heart valve. The apparatus may include two arms (22, 24) that secure the clip. The blade may be deployed to core out a central portion of a tissue bridge, including the clip or the suture, from the heart valve. The blade may be activated by an actuator (3). A retrieval member may be configured to capture the tissue bridge and the clip or suture after excision by the blade.

30. 发明公开

EP1804686A4 FIXATION DEVICES FOR VARIATION IN ENGAGEMENT OF TISSUE 有权
标题翻译：固定装置，用于组织结合变异
公开(公告)号：EP1804686A4
公开(公告)日：2013-11-20
申请号：EP05814102
申请日：2005-10-25
申请人： EVALVE INC
发明人： GOLDFARB ERIC A , RASCHDORF ALFRED H JR , SARABIA JAIME E , FAN SYLVIA WEN CHIN , DELL KENT D , KOMTEBEDDE JAN , POWELL FEROLYN T
IPC分类号： A61B17/122
CPC分类号： A61B17/1285 , A61B17/122 , A61B2017/00243 , A61B2017/00783 , A61B2017/081
摘要： Devices, systems and methods are provided for tissue approximation and repair at treatment sites, particularly in those procedures requiring minimally-invasive or endovascular access to remote tissue locations. Fixation devices are provided to fix tissue in approximation with the use of distal elements. In some embodiments, the fixation devices have at least two distal elements and an actuatable feature wherein actuation of the feature varies a dimension of the at least two distal elements. In other embodiments, the fixation devices have at least two pairs of distal elements wherein the pairs of distal elements are moveable to engage tissue between opposed pairs of distal elements. Systems are also provided having fixation devices and accessories.

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