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    • 21. 发明公开
    • APPARATUS AND METHOD FOR FORMULATING AND ASEPTICALLY FILLING LIQUID PRODUCTS
    • 设备和表达和液体产品无菌灌装方法
    • EP2207427A1
    • 2010-07-21
    • EP08834803.2
    • 2008-10-03
    • Medical Instill Technologies, Inc.
    • PY, Daniel
    • A23B5/005B65B55/00
    • A23L3/04A23L2/46A23L3/22B65B3/04B65B55/025B65B55/10B65B55/12
    • An apparatus and method are provided for formulating and aseptically filling liquid products. A first liquid source includes at least one first liquid component; a second liquid source includes at least one second liquid component; and a container includes a body defining an empty, sterile storage chamber therein that is sealed with respect to ambient atmosphere. The container is introduced into a sterile filling chamber. A first filling member coupled in fluid communication with the first liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the first liquid component is aseptically introduced through the first filling member and into the storage chamber. A second filling member coupled in fluid communication with the second liquid source is placed in fluid communication with the storage chamber of the container located in the sterile filling chamber, and the second liquid component is aseptically introduced through the second filling member and into the storage chamber and, in turn, the first and second liquid components are combined into a liquid product formulation within the sterile chamber of the container. The first and second filling members are withdrawn from fluid communication with the storage chamber of the container located within the sterile filling chamber, and the filled storage chamber is sealed with respect to ambient atmosphere to hermetically seal the liquid product formulation within the storage chamber of the container.
    • 26. 发明公开
    • DISPENSER AND APPARATUS FOR FILLING A DISPENSER
    • 电源设备和设备用于灌装的供应装置
    • EP1636091A2
    • 2006-03-22
    • EP04751967.3
    • 2004-05-12
    • Medical Instill Technologies, Inc.
    • PY, DanielCHAN, Julian, V.
    • B65B1/04
    • B65D83/62A61J1/00A61J1/1443B65B3/30B65B31/044B65D83/425
    • A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
    • 30. 发明公开
    • NEEDLE PENETRABLE AND LASER RESEALABLE LYOPHILIZATION DEVICE AND RELATED METHOD
    • NADELDURCHLÄSSIGEUND VERSIEGELBARE GEFRIERTROCKNUNGSVORRICHTUNG SOWIE ENTSPRECHENDES VERFAHREN
    • EP2013113A2
    • 2009-01-14
    • EP07776238.3
    • 2007-04-24
    • Medical Instill Technologies, Inc.
    • PY, Daniel
    • B65D83/06
    • F26B5/06
    • A device and related method are provided for lyophiliziπg a substance within the device and storing the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.
    • 提供了一种装置和相关方法,用于冻结装置内的物质并将其中的冻干物质储存在其中。 该装置可以由用于将待冷冻干燥物质填充的装置的针穿透,并且通过在激光源上传送激光辐射来激活可重新密封装置中的针孔。 该装置限定用于在其中接收要冷冻干燥的物质的室。 该装置的针穿透和可激光再密封部分可用针刺穿以形成穿过其中的针孔,以通过针将要冻干的物质填充室,并且可激光重新密封以通过对其施加激光辐射来密封针孔 。 过滤器可连接在室的内部和外部之间的流体连通中,以允许流体从腔室的内部到外部的方向流过其中,并且用于基本上防止污染物沿着从外部到外部的方向流过 室内