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21. 发明授权

EP0683890B1 METHOD AND DEVICE FOR CORRECTING THE DRIFT OFFSET OF A PRESSURE SENSOR OF A FLOWMETER 失效
标题翻译：方法及器具的零信号的压力传感器用于流量计的校正
公开(公告)号：EP0683890B1
公开(公告)日：2002-04-03
申请号：EP94907924.8
申请日：1994-01-31
申请人： ARADIGM CORPORATION
发明人： RUBSAMEN, Reid, M. , JOHANSSON, Eric, T.
IPC分类号： G01F1/50
CPC分类号： A61M15/00 , A61J7/0418 , A61M15/0021 , A61M15/008 , A61M15/009 , A61M16/0858 , A61M16/202 , A61M2016/0021 , A61M2016/0039 , A61M2205/50 , A61M2205/60 , A61M2205/6018 , A61M2205/6027 , A61M2205/6036 , A61M2205/6045 , A61M2205/8206 , A61M2205/8212 , B01F3/04049 , B01F15/0201 , B01F15/0254 , G01F1/363 , G01F1/40 , G01F1/50 , G01F13/006 , G01F15/002

22. 发明授权

EP0681491B1 INTRAPULMONARY DELIVERY OF HORMONES 失效
标题翻译：内分泌物HORMONABGABESYSTEM
公开(公告)号：EP0681491B1
公开(公告)日：2000-12-13
申请号：EP94908671.4
申请日：1994-01-27
申请人： ARADIGM CORPORATION
发明人： RUBSAMEN, Reid, M.
IPC分类号： A61M11/00 , A61M16/00 , A61M15/00
CPC分类号： A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/009 , A61M2016/0021
摘要： A method of treating human patients is provided by the intrapulmonary delivery of a pharmaceutically active hormone formulation (4). The formulation is automatically released from a hand-held, self-contained, portable device comprised of a means (7) for automatically releasing a measured amount of a drug into the inspiratory flow path of a patient in response to information obtained from a means (22) for analyzing the inspiratory flow of a patient and after the patient is sent an audible or visual signal. Reproducible dosing is obtained by providing for automatic release in response to a measured inhalation profile. The overadministration of hormone formulations is avoided by providing a preprogrammed microprocessor designed to avoid overdosing.
摘要翻译：通过肺内递送药物活性激素制剂来提供治疗人类患者的方法。该制剂自动地从手持式独立的便携式装置中释放，该装置包括用于响应于从用于分析吸气流量的装置获得的信息而将测量量的药物自动释放到患者的吸气流动路径中的装置并且在患者被发送了可听或视觉信号之后。通过提供响应于测量的吸入曲线的自动释放来获得可再现的给药。通过提供预设的微处理器来避免过量给药激素制剂，以防止过量。

23. 发明公开

EP1011635A1 METHOD OF USE OF MONOMERIC INSULIN AS A MEANS FOR IMPROVING THE REPRODUCIBILITY OF INHALED INSULIN 失效
标题翻译：方法使用胰岛素的单体作为提高再现性吸入性胰岛素的手段
公开(公告)号：EP1011635A1
公开(公告)日：2000-06-28
申请号：EP98903746.0
申请日：1998-01-28
申请人： ARADIGM CORPORATION
发明人： GONDA, Igor , RUBSAMEN, Reid, M. , FARR, Stephen, J.
IPC分类号： A61K9/12
CPC分类号： A61K9/0075 , A61J7/0418 , A61J7/0427 , A61J7/0445 , A61K9/007 , A61K9/0073 , A61K38/28 , A61M11/001 , A61M15/00 , A61M15/0031 , A61M15/0051 , A61M15/0065 , A61M15/0066 , A61M15/008 , A61M15/0085 , A61M15/009 , A61M16/142 , A61M2016/0021 , A61M2202/062 , A61M2202/064 , A61M2205/8206
摘要： The need for the delivery of insulin by injection can be reduced or eliminated by delivering an aerosolized monomeric insulin formulation. Repeatability of dosing and more particularly the repeatability of the blood concentration versus time profile is improved relative to regular insulin. The blood concentration versus time profile is substantially unaffected by specific aspects of the patient's breathing maneuver at delivery. Further, the rate at which blood glucose is lowered is increased by the use of monomeric insulin. Particles of insulin and in particular monomeric insulin delivered to the surface of lung tissue will be absorbed into the circulatory system. The monomeric insulin may be a dry powder but is preferably in a liquid formulation delivered to the patient from a hand-held, self-contained device which automatically releases an aerosolized burst of formulation. The device includes a sensor which is preferably electronic which measures inspiratory flow and volume which measurement can be used to control the point of drug release.
摘要翻译：需要通过注射递送的胰岛素可以减少或通过递送到气雾化单体胰岛素制剂消除。给药和血液浓度对时间曲线的更具体的可重复性的重复性相对于正规胰岛素被改善。血药浓度与时间的曲线是在分娩患者的呼吸动作的具体方面基本上不受影响。此外，在该血糖率降低是通过使用单体胰岛素的增加。在递送至肺组织的表面的特殊单体胰岛素的胰岛素和颗粒将被吸收进入循环系统。所述单体胰岛素可以是干粉，但优选在从手持式，自输送给患者的液体制剂它可以自动载设备释放到制剂的气雾化的爆裂。该装置包括一个传感器，所有这些是优选的电子，其测量吸气流量并且其可以被用于控制药物释放的点体积测量。

24. 发明公开

EP0790843A1 LOCKOUT DEVICE FOR CONTROLLED RELEASE OF DRUG FROM PATIENT-ACTIVATED DISPENSER 失效
标题翻译：快门药物的稳压电源来自患者的活化放电
公开(公告)号：EP0790843A1
公开(公告)日：1997-08-27
申请号：EP95938939.0
申请日：1995-10-27
申请人： ARADIGM CORPORATION
发明人： RUBSAMEN, Reid, M. , LLOYD, Lester, J. , JOHANSSON, Eric, T.
IPC分类号： A61M11 , A61M15 , A61M16 , A61M5
CPC分类号： A61M15/00 , A61M11/001 , A61M15/0023 , A61M15/0045 , A61M15/0048 , A61M15/0066 , A61M15/008 , A61M15/0085 , A61M15/009 , A61M2005/1405 , A61M2016/0021 , A61M2016/0039 , A61M2205/3569 , A61M2205/3592 , A61M2205/8206
摘要： A method of controlling access to a drug in an aerosol drug delivery device by an electronic lock and key means is disclosed. Access is limited to the intended user by providing the intended user with a uniquely coded, machine readable key means that matches the unique code of the lock means. Contacting matching lock and key means signals a controlling means to allow use of the device. Specifically, the method is applied to a method of pain control provided by the intrapulmonary delivery of a pharmaceutically active pain relief formulation. The formulation is automatically released from a hand held, self-contained, portable device (1) comprised of a means to automatically release a measured amount of drug into the inspiratory flow path (11) of a patient in response to information obtained from a means (21) for measuring, and separately determining inspiratory flow rate and inspiratory volume of a patient.

25. 发明公开

EP0788388A1 DEVICE FOR AEROSOLIZED DELIVERY OF PEPTIDE DRUGS 失效
标题翻译： DEVICE FOR肽试剂气溶胶形式交付
公开(公告)号：EP0788388A1
公开(公告)日：1997-08-13
申请号：EP95940560.0
申请日：1995-10-27
申请人： ARADIGM CORPORATION
发明人： LLOYD, Lester, J. , LLOYD, Peter, M. , RUBSAMEN, Reid, M. , SCHUSTER, Jeffrey, A.
IPC分类号： A61K38 , A61M11 , A61M15 , A61P29 , A61P35 , A61P43 , A61J7 , A61M16
CPC分类号： A61M15/0045 , A61J7/0445 , A61M11/001 , A61M11/002 , A61M15/001 , A61M15/0051 , A61M15/0066 , A61M15/008 , A61M15/009 , A61M16/108 , A61M2016/0021 , A61M2202/062 , A61M2202/064 , A61M2205/8206
摘要： A method of treating human patients is provided by the intrapulmonary delivery of a pharmaceutically active peptide formulation (5). The formulation is automatically released in an aerosolized form from a hand-held, self-contained, portable device (40) comprised of a means (23) for automatically releasing a measured amount of drug into the inspiratory flow path (29) of a patient in response to information obtained from a means (37) for measuring the inspiratory flow rate and determining the inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release at the same inspiratory flow rate and inspiratory volume each time drug is released. The device includes a timer to enable a patient to take a drug at the same time each day. Further, overadministration of hormone formulation is avoided by providing a pre-programmed microprocessor (26) designed to avoid overdosing.

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