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21. 发明授权

EP2646449B1 URIDINE DI- OR TRI-PHOSPHATE DERIVATIVES AND USES THEREOF 有权
标题翻译：尿苷二或三磷酸衍生物及其用途
公开(公告)号：EP2646449B1
公开(公告)日：2015-08-19
申请号：EP11808361.7
申请日：2011-12-01
申请人： Bar-Ilan University , Universidad Complutense De Madrid
发明人： FISCHER, Bilha , PINTOR, Jesus Jeronimo , ELYAHU, Shay , GINSBURG-SHMUEL, Tamar
IPC分类号： C07F9/6558 , A61P27/06 , A61K31/665 , C07H19/10 , C07H21/02 , C07H23/00
CPC分类号： C07H23/00 , C07F9/65586 , C07H19/10 , C07H21/02

22. 发明公开

EP2885625A1 RAMAN, INFRARED, OR RAMAN-INFRARED ANALYSIS OF PERIPHERAL BLOOD PLASMA PROTEIN STRUCTURE AND ITS RELATION TO COGNITIVE DEVELOPMENT IN ALZHEIMER'S DISEASE 审中-公开
标题翻译： RAMAN，外周血血浆蛋白结构的红外或拉曼红外分析及其相互关系认知发展AT阿尔茨海默氏病的
公开(公告)号：EP2885625A1
公开(公告)日：2015-06-24
申请号：EP13756001.7
申请日：2013-08-20
申请人： Consejo Superior De Investigaciones Científicas (CSIC) , Fundación Investigación Biomédica Hospital Universitario 12 de Octubre , Instituto de Salud Carlos III , Fundación Cien , Universidad Complutense De Madrid
发明人： CARMONA HERNÁNDEZ, Pedro , TOLEDANO GASCA, Adolfo , CALERO LARA, Miguel , MARTÍNEZ MARTÍN, Pablo , BERMEJO PAREJA, Félix , MOLINA SANTOS, Marina
IPC分类号： G01N21/35 , G01N21/65
CPC分类号： G01N21/3577 , G01N21/65 , G01N33/49 , G01N2201/06113 , G01N2800/2821
摘要： The present invention relates to a Raman spectroscopy method for determining protein structure associated with global cognitive deterioration in Alzheimer's disease from the Raman spectroscopic analysis of a human blood sample, preferably of a human blood plasma sample, comprising obtaining at least one spectral value of at least one of the Raman spectrum regions comprised between 1600-1700 cm -1 , between 910-980 cm -1 , between 730-760 cm -1 and/or between 390-450 cm -1 , and where said spectral value allows obtaining an indication of the presence or absence of protein structure associated with a condition of Alzheimer's disease. The present invention also relates to a method for the infrared spectroscopic analysis of a blood sample, by means of additionally obtaining at least one spectral value of at least one of the infrared spectrum regions comprised between 1600 and 1700 cm -1 and/or between 1000 and 1150 cm -1 . Optionally, the Raman spectroscopy method further comprises the infrared spectroscopic analysis of the same blood sample. The invention also relates to a diagnostic method for diagnosing Alzheimer's disease comprising measuring a Raman spectrum and/or an infrared spectrum of a plasma sample.
摘要翻译：本发明涉及用于从人血液样品的拉曼光谱分析中阿尔茨海默氏病与全球认知退化相关联的确定性采矿蛋白质结构的拉曼光谱的方法，优选的是人血浆样品，其包括获得至少一个频谱值至少 1600-1700 -1之间由拉曼光谱区域中的一个，910-980 -1之间，730-760 -1之间和/或390至450厘米-1，并且其中所述频谱值允许获得指示之间的蛋白质结构与阿尔茨海默氏病的病症相关的存在或不存在。因此，本发明涉及一种用于血液样品，的红外分光分析的方法通过获得另外1600和1700 -1之间和/或1000之间由红外光谱区的至少一个中的至少一个频谱值的平均值和1150 -1。任选地，该拉曼光谱方法还包括将同一血液样品的红外光谱分析。因此，本发明涉及用于诊断阿尔茨海默病包括测量的拉曼光谱和/或血浆样品的红外光谱的诊断方法。

23. 发明公开

EP2719400A2 BIOCERAMIC MATERIALS FOR TREATING OSTEOMYELITIS 审中-公开
标题翻译： BIOKERAMISCHE MATERIALIEN ZUR BEHANDLUNG VON OSTEOMYELITIS
公开(公告)号：EP2719400A2
公开(公告)日：2014-04-16
申请号：EP12797636.3
申请日：2012-06-08
申请人： Universidad Complutense De Madrid
发明人： VALLET REGI, María , MANZANO GARCÍA,Miguel , ESTEBAN MORENO, Jaime , MOLINA MANSO, Diana , GOMEZ BARRENA, Enrique
IPC分类号： A61L27/10 , A61L27/54 , A61L27/58 , A61F2/28 , C01B37/00 , A61P19/00
CPC分类号： A61L27/56 , A61L27/10 , A61L27/54 , A61L2300/406 , A61L2430/02 , C01B37/00 , C01B37/005
摘要： The present invention describes the preparation of ordered mesoporous silica materials, capable of promoting bone development, and the use thereof as a release system for releasing a combination of antibiotics for treating bone infections locally and effectively.
The present invention therefore proposes the use of these materials for the treatment of osteomyelitis, since their high porosity and large specific surface area allows adsorbing a large amount of antibiotics for subsequently releasing them in a modulated manner, depending on patient's requirements. The present invention proposes the use of bioceramic SBA-15 for the adsorption of a combination of three antibiotics, the antimicrobial activity of which has been widely recognized: vancomycin, linezolid and rifampicin.
摘要翻译：本发明描述了能够促进骨发育的有序介孔二氧化硅材料的制备及其作为用于释放用于局部有效地治疗骨感染的抗生素组合的释放体系的用途。因此，本发明提出了这些材料用于治疗骨髓炎的用途，因为它们的高孔隙率和大的比表面积允许吸收大量的抗生素以随后根据患者的要求以调制的方式释放它们。本发明提出了生物陶瓷SBA-15用于吸附三种抗生素的组合，其抗菌活性已被广泛认可：万古霉素，利奈唑胺和利福平。

24. 发明公开

EP2646449A1 URIDINE DI- OR TRI-PHOSPHATE DERIVATIVES AND USES THEREOF 有权
标题翻译：尿苷二或三磷酸衍生物及其用途
公开(公告)号：EP2646449A1
公开(公告)日：2013-10-09
申请号：EP11808361.7
申请日：2011-12-01
申请人： Bar-Ilan University , Universidad Complutense De Madrid
发明人： FISCHER, Bilha , PINTOR, Jesus Jeronimo , ELYAHU, Shay , GINSBURG-SHMUEL, Tamar
IPC分类号： C07F9/6558 , A61P27/06 , A61K31/665
CPC分类号： C07H23/00 , C07F9/65586 , C07H19/10 , C07H21/02
摘要： The invention provides particular uridine di- and tri-phosphate derivatives, and pharmaceutical compositions thereof. These compounds are useful for treatment of diseases, disorders and conditions modulated by P2Y6 receptors, and particularly for lowering intraocular pressure and thereby treating ocular hypertension and/or glaucoma.

25. 发明公开

EP2604265A1 P2x7 antagonists as frontline or adjunctive treatment against status epilepticus 审中-公开
标题翻译： P2x7拮抗剂前列腺癫痫持续状态
公开(公告)号：EP2604265A1
公开(公告)日：2013-06-19
申请号：EP11382386.8
申请日：2011-12-17
申请人： Royal College of Surgeons in Ireland (RCSI) , Universidad Complutense De Madrid
发明人： Henshall, David C. , Engel, Tobias , Díaz Hernández, Miguel , Miras Portugal, María Terasa
IPC分类号： A61K31/41 , A61P25/06
CPC分类号： A61K31/41 , A61K31/192 , A61K31/205 , A61K31/4439 , A61K31/496 , A61K31/515 , A61K31/551 , A61K31/5513 , A61K33/00 , A61K45/06 , A61K2300/00
摘要： P2X7 antagonists as frontline or adjunctive treatment against status epilepticus. It is shown that P2X7 antagonists can be used for frontline or adjunctive treatment for the ameloration or termination of status epilepticus and neonatal seizures, especially refractory status epilepticus or neonatal seizures. Combination with current anticonvulsants, particularly GABA-based anticonvulsants such as benzodiazepines or barbiturates, results in the effective termination of status epilepticus, even when it is refractory.
摘要翻译： P2X7拮抗剂作为前列腺或辅助治疗癫痫持续状态。显示P2X7拮抗剂可用于前列腺或辅助治疗，用于癫痫持续状态和新生儿癫痫发作的褪色或终止，特别是难治性癫痫持续状态或新生儿癫痫发作。与目前的抗惊厥药组合，特别是基于GABA的抗惊厥药如苯二氮卓类或巴比妥类，导致癫痫持续状态的有效终止，即使是难治性的。

27. 发明公开

EP2351665A1 DEVICE AND METHOD FOR DIFFUSED LIGHTING FOR VEHICLE INTERIORS 审中-公开
标题翻译： VORRICHTUNG VERFAHREN ZUR DIFFUSEN BELEUCHTUNG EINES FAHRZEUGINNENRAUMS
公开(公告)号：EP2351665A1
公开(公告)日：2011-08-03
申请号：EP09823103.8
申请日：2009-03-13
申请人： Universidad Complutense de Madrid
发明人： SÁNCHEZ RAMOS, Celia
IPC分类号： B60Q3/02
CPC分类号： B60Q3/72 , B60Q3/53 , Y10T29/49002
摘要： This invention relates to a device for diffused lighting for vehicle interiors that includes one or more light sources and that is located outside the field of vision of the driver of the vehicle. Drivers, especially following refractive surgery, manifest debilitating effects and symptoms of dazzling. The mioisis caused by the diffused light of this invention improves the driver's visual performance, in terms of quality of vision.
摘要翻译：本发明涉及一种用于车辆内部的用于漫射照明的装置，其包括一个或多个光源并且位于车辆驾驶员的视野之外。司机，特别是屈光手术后，显示出虚弱的效果和令人眼花缭乱的症状。由本发明的漫射光造成的瞳孔在视觉质量方面提高了驾驶员的视觉表现。

28. 发明公开

EP2218398A1 PERSON RECOGNITION METHOD AND DEVICE INCORPORATING THE ANATOMIC LOCATION OF THE RETINA AS A BIOMETRIC CONSTANT, CORRESPONDING TO THE PHYSIOLOGICAL LOCATION OF THE PROJECTION OF THE VISUAL AXIS 审中-公开
标题翻译：人检测方法和装置具有AS甲生物测量常量视网膜的解剖学位置与视轴的投影的生理状态根据
公开(公告)号：EP2218398A1
公开(公告)日：2010-08-18
申请号：EP08761458.2
申请日：2008-04-07
申请人： UNIVERSIDAD COMPLUTENSE DE MADRID
发明人： SANCHEZ RAMOS, Celia , PANETSOS PETROVA, Fivos
IPC分类号： A61B5/117 , A61B3/12 , A61B3/15 , G06K9/00
CPC分类号： A61B3/12 , A61B5/117 , A61B5/1171 , G06K9/00604
摘要： The invention relates to a person recognition method and device incorporating the anatomic location of the retina as a biometric constant, corresponding to the physiological location of the projection of the visual axis. More specifically, the invention relates to a person recognition method and a corresponding device incorporating the anatomic location of the retina as an exclusive discriminant biometric constant for each individual, corresponding to the physiological location of the visual axis, taking account of the physiological fixation disparity. The invention combines five elements, namely: an optical input system for examining the fundus of the eye, for example by means of retinal scanning or through the sclera; a system providing an expanded view of the retina, for example formed by converging lenses, diverging lenses and/or prisms or mirrors; a system for identifying and marking the anatomic point corresponding to the physiological point of the projectionof the visual axis, such as a laser; a system of filters having different transmittance and optical density values; and a system for capturing and processing digital images, such as an optical digital camera. In addition, the invention can take the form of a portable, auto-focusing device with automatic control.
摘要翻译：本发明涉及人识别的方法和装置结合的视网膜的解剖位置作为生物测量常量，对应于视轴的突出部的生理位置。更具体地，本发明涉及到的人识别方法和一种相应的装置结合的视网膜的解剖位置，以用于每个单独的专属判别生物测量常量，对应于视轴的生理位置，考虑到生理固定视差。本发明结合五行，即：用于检查眼的眼底的光输入系统，例如，通过视网膜扫描的或通过巩膜装置; 提供在视网膜上的展开图，例如通过会聚透镜，发散透镜和/或棱镜或反射镜构成的系统; 用于识别和标记的解剖点对应于projectionof视轴，检查作为激光的生理点的系统; 具有不同透射率和光密度值滤波器的系统; 以及用于捕获和处理数字图像，颜色的系统：如光学数字相机。此外，本发明可以采取与自动控制便携式，自动聚焦装置的形式。

29. 发明公开

EP2196532A1 USE OF A NEW ISOLATE OF NEOSPORA CANINUM FOR THE DEVELOPMENT OF DIAGNOSTIC TESTS AND FOR PREPARATION OF PRODUCTS FOR TREATMENT AND PREVENTION OF THE INFECTION CAUSED BY NEOSPORA 有权
标题翻译：用改进的隔离关新孢子虫诊断检测的开发和产品用于治疗和预防感染新孢子虫生产
公开(公告)号：EP2196532A1
公开(公告)日：2010-06-16
申请号：EP08805322.8
申请日：2008-07-11
申请人： Universidad Complutense de Madrid
发明人： ORTEGA MORA, Luis , REGIDOR CERRILLO, Javier , GÓMEZ BAUTISTA, Mercedes , AGUADO MARTÍNEZ, Adriana , COLLANTES FERNÁNDEZ, Esther , ADURIZ, Gorka
IPC分类号： C12N1/10 , A61K39/002 , A61K35/68 , G01N33/53 , C12R1/90
CPC分类号： G01N33/56905 , A61K35/68 , A61K39/002 , C07K14/44 , C07K14/45 , C12R1/90
摘要： The present invention relates to the use of a new isolate of Neospora caninum for the development of diagnostic tests and for the manufacture of products for the treatment and prevention of the infection caused by Neospora. The use of a new isolate of Neospora caninum (filed in the Culture Collection of Algae and Protozoa , with access number CCAP 2051/1), and the extracts obtained therefrom, in the preparation of diagnostic tests and in the manufacture of products for the treatment and prevention of the infection caused by Neospora, is based on the ease with which the new isolate converts from the tachyzoite to the bradyzoite stage under in vitro conditions. Additionally and with the same applications, the polypeptides and the polynucleotides obtained from the new isolate and the immunoreactive antibodies developed against Neospora antigens are used.
摘要翻译：本发明涉及使用新孢子虫的新分离物的用于诊断测试的发展和用于产品为感染新孢子虫引起的治疗和预防的用途。使用犬新孢子虫的新分离物（在藻类和原生动物，的培养物保藏日提交的与接入号码CCAP一分之二千〇五十一），并将提取物从那里获得，在诊断测试的准备和在制造的产品，用于治疗和预防感染新孢子虫引起的，是基于与该新分离物从速殖子至缓殖子阶段在体外条件下转换的容易程度。此外，用相同的应用，所述多肽与来自新分离株获得的多核苷酸和抗新孢子虫抗原开发的免疫反应性抗体被使用。

30. 发明公开

EP2157459A1 PREVENTIVE ELEMENT INTENDED TO BE APPLIED TO TRANSPARENT BUILDING SURFACES IN ORDER TO PROVIDE EYE PROTECTION AND THERAPY 审中-公开
标题翻译：对于应用程序透明建筑物表面具体的预防要素，规定保护眼睛治疗
公开(公告)号：EP2157459A1
公开(公告)日：2010-02-24
申请号：EP07788628.1
申请日：2007-06-26
申请人： Universidad Complutense De Madrid
发明人： SANCHEZ RAMOS, Celia
IPC分类号： G02B5/23 , A61F9/00 , E04B1/62
CPC分类号： G02B5/208 , G01J2001/0276 , G02B5/226
摘要： Element for the protection and therapy of eyes applied to the transparent vertical surfaces of buildings. The invention is prepared by applying a yellow pigmented filter to the transparent or translucent surfaces of a building in which a subject may be found, and is designed to protect the eyes from the short wavelengths of the visible spectrum in the range 500 to 380 nm. The invention avoids the difficulties and risks of existing ways of protecting healthy eyes or eyes subjected to cataract surgery, and improves the protection of eyes suffering neurodegeneration, simply by applying a filter to the transparent or translucent surfaces of any building in which a subject may be found to provide protection against the neurodegenerative components of light (short wavelengths).
摘要翻译：元对眼睛适用于建筑物的透明垂直表面的保护和治疗。本发明通过将黄色着色的过滤器到建筑物其中受试者可能发现的透明或半透明的表面而制备，并且被设计来保护从可见光谱的短波长的眼睛在500至380nm范围内。本发明避免的困难和保护进行白内障手术健康的眼睛或眼睛的存在方式的风险，并简单地通过应用过滤器的任何建筑物，其中主体可以是透明或半透明表面改善眼睛患神经退行性疾病，保护发现以提供针对光（短波长）的神经变性部件保护。

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