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21. 发明公开

EP0656945A1 STRESS PROTEIN EPITOPES 失效转让
标题翻译：应激蛋白表位。
公开(公告)号：EP0656945A1
公开(公告)日：1995-06-14
申请号：EP93918042.0
申请日：1993-08-17
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： BURNIE, James, Peter 2 Gorsefield Hey , MATTHEWS, Ruth, Christine 2 Gorsefield Hey
IPC分类号： C12N15 , A61K39 , A61P31 , A61P33 , C07K7 , C07K14 , C07K16 , C12P21 , A61K38
CPC分类号： C07K14/39 , A61K38/00 , C07K14/47
摘要： There is disclosed a functional epitope which is purified from human HSP 90 or which is synthesised to correspond to such a purified epitope, which is, if purified, unchanged or changed by substitution of selected amino acids and if synthesised is identical to a purified epitope or differs from a purified epitope by substitution of selected amino acids, and which cross-reacts with an antibody raised against a stress protein.

22. 发明公开

EP0633995A1 A WATER HEATING TANK 失效
标题翻译：热水系统。
公开(公告)号：EP0633995A1
公开(公告)日：1995-01-18
申请号：EP93908040.0
申请日：1993-04-13
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： AXCELL, Brian P.
IPC分类号： F24D17 , F24H1
CPC分类号： F24H1/202 , F24D17/0073 , F24H9/0021
摘要： A hot water cylinder (10) having upper and lower horizontally extending immersion heaters (13, 12) is provided with a pair of spaced parallel upright baffle plates (14) positioned one on each side of the lower heating element (12) to cause a column of heated water to rise centrally within the cylinder (10) and to circulate downwardly outside the baffles thus to create substantially complete circulation by convection of heated water within at least the lower part of the cylinder to ensure a substantially uniform water temperature therein. In an alternative arrangement of a helical upright heating coil (23) the baffle plate is formed as a cylindrical sleeve (24) within the coil such that heated water rises outside the sleeve (24) and circulates downwardly inside the latter. The provision of the baffle avoids the creation of pockets of cooler water in the base of the cylinder (10) in which bacteria may breed.

23. 发明公开

EP0503943A1 Sensor devices 失效
标题翻译： Sensorgeräte。
公开(公告)号：EP0503943A1
公开(公告)日：1992-09-16
申请号：EP92302131.5
申请日：1992-03-12
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Vadgama, Pankaj Madganlal , Rosenberg, Mark Franklyn , Christie, Ian McIntyre
IPC分类号： C12Q1/00 , G01N33/94
CPC分类号： C12Q1/005
摘要： Analytical sensor devices incorporating a permselective medium immobilised as a continuous liquid or gel phase barrier between sample and detector.
The barrier is electrically insulating, impermeable to charged non-lipophilic species, selectively partitions lipophilic species diffusing through it, and its selectivity can be controlled or optimised by pH adjustments. The preferred barrier form has the permselective medium (e.g. a lipid or ester) immobilised by incorporation as plasticiser in a polymer (especially PVC). The preferred detector is an electrode, especially of non-potentiometric type.
The sensor can be used to detect components as such or indirectly by allowing them to react to produce other materials to which the detector responds (e.g. an ionic species or an ion concentration or activity change) and is also applicable to detecting neutral or small uncharged hydrophilic species, e.g. hydrogen peroxide -- especially that formed by enzyme action in the sensor or detector system.
摘要翻译：分析传感器装置，其包含固定为样品和检测器之间的连续液体或凝胶相屏障的选择性选择性介质。屏障是电绝缘的，不带电的非亲脂性物质是不可渗透的，选择性地将通过其扩散的亲油物质分隔开，并且其选择性可以通过pH调节来控制或优化。优选的屏障形式具有通过作为增塑剂并入聚合物（特别是PVC）中固定的选择性选择性介质（例如脂质或酯）。优选的检测器是电极，特别是非电位型。传感器可用于通过允许它们反应以产生检测器所响应的其他材料（例如离子种类或离子浓度或活性变化）来反应或间接检测组分，并且还可用于检测中性或小的不带电亲水物种，例如过氧化氢 - 特别是在传感器或检测器系统中通过酶作用形成的过氧化氢。

24. 发明授权

EP0371049B1 METHOD FOR THE DIAGNOSIS OF INFECTIONS WITH DETECTION OF LIPOPOLYSACCHARIDE ANTIGENS 失效
标题翻译：用于检测脂多糖抗原的感染诊断方法
公开(公告)号：EP0371049B1
公开(公告)日：1992-06-03
申请号：EP88905974.7
申请日：1988-07-12
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： RICHMOND, Shirley, Jean , STOREY, Christopher, Charles
IPC分类号： G01N33/569 , G01N33/571 , G01N33/543
CPC分类号： G01N33/92 , G01N33/56927
摘要： Method for diagnosing infections by agents with distinct lipopolysaccharide antigens in which clinical samples are applied to a support which absorbs the lipopolysaccharide antigen and then the support, carrying the antigen, is treated with a solution of antibody (especially monoclonal antibody) which has affinity for the antigen and a means for rendering it detectable, especially a radio-label. The absorbing support's preferred material is nitrocellulose, and its preferred form is a membrane. Accuracy and efficiency are improved by treating samples, before application to the absorbing support, with a proteolytic enzyme which is later deactivated. Treatment of the support or membrane with a solution of high-protein content, after it has absorbed the antigen, gives further improvement. The method is easily used by the immune blot technique and can be used as a genus-specific method for diagnosing Chlamydia (C.trachomatis and C.psittaci).

25. 发明公开

EP0440693A1 GYNAECOLOGICAL PROCEDURE 失效
标题翻译：妇科手术。
公开(公告)号：EP0440693A1
公开(公告)日：1991-08-14
申请号：EP89911854.0
申请日：1989-10-24
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： CHANTLER, Eric, Nelson 45 Longhurst Lane , SHARMA, Rekha 19 Haw Lane
IPC分类号： A61K38 , A61K35 , A61P1
CPC分类号： A61K35/52
摘要： L'invention concerne un procédé de traitement de sperme/spermatozoïdes afin d'augmenter le pouvoir de fécondation d'oeufs, utilisant une solution de réactifs contenant une protéase (notamment la chymotrypsine) et un saccharide (notamment le D-galactose) afin d'éliminer des anticorps antagonistes et de protéger les spermatozoïdes. Les spermatozoïdes traités sont libérés de matières étrangères par lavage et concentrés par centrifugation, et peuvent alors être utilisés dans des techniques de conception assistée. On peut les conserver à l'aide de moyens classiques. L'invention concerne également une forme adaptée de ''kit'' permettant une préparation clinique facile de la solution de réactifs.

26. 发明公开

EP0397745A1 A FACE LEVEL SAMPLING DEVICE 失效
标题翻译：器件提供样品，票面金额。
公开(公告)号：EP0397745A1
公开(公告)日：1990-11-22
申请号：EP89901870.0
申请日：1989-02-01
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： BELLINGER, Edward, George
IPC分类号： G01N1 , G01N35
CPC分类号： G01N35/00732 , G01N1/2202 , G01N1/24 , G01N1/26 , G01N2001/2223
摘要： Ce dispositif se compose d'un bandeau pour la tête (10) sur lequel sont fixés une pompe aspirante (11) et un bloc d'alimentation (13). La pompe (11) est reliée à une tige tubulaire rigide ou semi-rigide (12) pourvue en son extrémité d'une tête de prélèvement d'échantillon qui se trouve ainsi à proximité du nez et de la bouche du sujet de manière à prélever un échantillon d'air ambiant dans la zone proche de ses voies respiratoires.

27. 发明公开

EP0372702A1 Gynaecological procedure 失效
标题翻译： GynäkologischesVerfahren。
公开(公告)号：EP0372702A1
公开(公告)日：1990-06-13
申请号：EP89310917.3
申请日：1989-10-24
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Chantler, Eric Nelson , Sharma, Rekha
IPC分类号： A61K35/52
CPC分类号： A61K35/52
摘要： A method for treatment of semen/spermatozoa to enhance their ability to fertilise ova, using a reagent solution containing a protease (especially chymotrypsin) and a saccharide (especially D-galactose) to remove antagonistic antibodies and protect the spermatozoa. The treated spermatozoa are freed from extraneous materials by washing and concentrated by centrifugation, and may then be used in assisted conception techniques. They may be preserved by conventional means. Also provided is a convenient form of "kit" for easy clinical preparation of the reagent solution.
摘要翻译：使用含有蛋白酶（特别是胰凝乳蛋白酶）和糖（特别是D-半乳糖）的试剂溶液以去除拮抗性抗体并保护精子的治疗精液/精子以提高其施用卵的能力的方法。通过洗涤将处理的精子从外来物质中除去，并通过离心浓缩，然后可以用于辅助受孕技术。它们可以通过常规手段保存。还提供了用于容易地临床制备试剂溶液的“试剂盒”的方便形式。

28. 发明公开

EP0251461A3 Parallel free storage management method and device 失效
标题翻译：并行自由存储管理方法和设备
公开(公告)号：EP0251461A3
公开(公告)日：1989-10-18
申请号：EP87304321.0
申请日：1987-05-15
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER , MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： Gurd John Richard , Kawakami Katsura
IPC分类号： G06F12/02
CPC分类号： G06F12/023 , Y10S707/99957
摘要： A parallel storage allocation method and device in which each space in a memory section that is available for use is associated with a respective allocator and stores an identifier for the respective allocator, data identifying allocators not in use is stored, and a list of allocators associated with spaces which are available for use is maintained. Each time a memory space is no longer in use a check is made to determine the allocator identifier of any already free space which can be combined with the memory space that is no longer in use. A liberate space token is generated which includes a first identifier corresponding to an allocator which is not in use and a second identifier which corresponds to any already free space to be combined. If the list of allocators relating to available space does not contain the allocator having the second identifier, the allocator having the first identifier is entered in ' the list with details of the no longer in use space, lf the list does contain the allocator having the second identifier, the space that is ro longer in use is combined with the space to which the second identifier relates and then the allocator having the first ident fier is entered in the list with details of the combined space.

29. 发明公开

EP0312539A1 NEW ORGANIC COMPOUNDS HAVING OPIOID PROPERTIES 失效
标题翻译：有机物OPIODISCHEN性能。
公开(公告)号：EP0312539A1
公开(公告)日：1989-04-26
申请号：EP87904395.0
申请日：1987-06-30
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： ROBINSON, Brian , REES, John, Michael, Hugh , COX, Brian
IPC分类号： C07D487
CPC分类号： C07D487/08
摘要： Nouveaux dérivés d'échiboline présentant des propriétés opioïdes et correspondant à la formule (I) dans laquelle R représente un résidu d'hydrocarbure. Ces dérivés sont obtenus par désalkylation d'échibolines 6-alkoxy-9-méthyl-10-substituées correspondantes, consistant à convertir le groupe 6-alkoxy en un groupe 6-hydroxy, en utilisant notamment du tribromure de bore en tant que réactif de désalkylation. La 6-hydroxy-9,10-diméthyl-échiboline, la 6-hydroxy-9-méthyl-10-allyl-échiboline et la 6-hydroxy-9-méthyl-10-cyclopropylméthyl-échiboline représentent des exemples spécifiques. Les composés peuvent être sous la forme d'une base libre ou d'un sel et être incorporés en tant qu'ingrédients actifs dans des compositions pharmaceutiques. De même, les dérivés d'échiboline 6-alkoxy-9-méthyl-10-substituée correspondants constituent de nouveaux produits intermédiaires utiles, pouvant être obtenus à partir d'une 6-alkoxy-9-méthyl-échiboline (A) par réaction avec un réactif introduisant le substituant désiré en position 10 ou (B) par acylation afin d'introduire le substituant R-CO- en position 10 et par réduction du groupe acyle en RCH2-.

30. 发明公开

EP0157578A3 A device for recovering oil floating on water 有权
标题翻译：用于回收在水上浮油的装置
公开(公告)号：EP0157578A3
公开(公告)日：1986-11-20
申请号：EP85302087
申请日：1985-03-26
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： Turner, John Thomas , Christodoulou, Mario
IPC分类号： E02B15/04
CPC分类号： E02B15/102 , Y02A20/204 , Y10S210/923
摘要： © A device for recovering oil floating on the surface of water comprising a framework (50) and a number of discs (51) rotatably mounted thereon. The framework is supported on floats (58,59) with the discs partly immersed in the water, and each disc is associated with a scraper (57) and chute (54) so that oil removed from the disc is deposited into a collection tray (52) from which it can be removed via line (53). Each disc (51) carries at least one axially directed concentric ring (4, 5) which presents an inwardly directed surface (7,8). Each disc may carry a plurality of rings of the same or different axial depths.

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