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21. 发明公开

EP2695573A2 Fluid component analysis system and method for glucose monitoring and control 有权
标题翻译：葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：EP2695573A2
公开(公告)日：2014-02-12
申请号：EP13176471.4
申请日：2008-10-10
申请人： Optiscan Biomedical Corporation
发明人： Braig, James R. , Keenan, Richard , Rule, Peter , Rivas, Gil , Seetharaman, Mabesh
IPC分类号： A61B5/00 , A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： An analyte detection and control system to determine and regulate the concentration of one or more analytes in a sample of bodily fluid is provided, which system comprises a control system; an analyte detector configured to measure a characteristic of at least one analyte in the sample of bodily fluid and determine a concentration of the analyte in the sample based on the measured characteristic; a fluid handling system operatively coupled to the analyte detector, said fluid handling system comprising a fluid passageway in communication with a patient through a patient end; a pump unit configured to engage the fluid handling system and draw a sample of bodily fluid from the patient periodically at draw intervals of less than 1 hour for analysis; a source of infusion fluid configured to adjust glycemic levels in the patient, said infusion fluid source in fluid communication with the fluid handling system; and a treatment dosing system in communication with the body fluid analyzer, said treatment dosing system including a treatment dosing protocol and configured to determine a recommended dose for the infusion fluid, wherein the recommended dose is determined based at least in part on one or more determinations by the body fluid analyzer of the concentration of the analyte and the treatment dosing protocol.
摘要翻译：提供了确定和调节体液样品中一种或多种分析物浓度的分析物检测和控制系统，该系统包括控制系统; 分析物检测器，其被配置为测量体液样品中的至少一种分析物的特性，并且基于所测量的特性来确定样品中的分析物的浓度; 流体处理系统，所述流体处理系统可操作地连接至分析物检测器，所述流体处理系统包括通过患者端与患者通信的流体通道; 泵单元，所述泵单元构造成接合所述流体处理系统并且以小于1小时的提取间隔周期性地从所述患者抽取体液样品用于分析; 输注流体源，被配置为调节患者的血糖水平，所述输注流体源与流体处理系统流体连通; 以及与体液分析仪通信的治疗给药系统，所述治疗给药系统包括治疗给药方案并且被配置成确定输注流体的推荐剂量，其中推荐剂量至少部分基于一种或多种测定通过体液分析仪测量分析物浓度和治疗剂量方案。

22. 发明公开

EP2477536A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：系统和方法用于分析流体组件血糖监测和控制
公开(公告)号：EP2477536A1
公开(公告)日：2012-07-25
申请号：EP10815770.2
申请日：2010-05-05
申请人： Optiscan Biomedical Corporation
发明人： RULE, Peter
IPC分类号： A61B5/00
CPC分类号： G10L21/0208 , A61M5/168 , A61M5/1723
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e g insulin, dextrose, etc ) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.

23. 发明授权

EP1855592B1 APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID 有权
标题翻译：装置收集和分析体液
公开(公告)号：EP1855592B1
公开(公告)日：2011-03-30
申请号：EP06748204.2
申请日：2006-02-13
申请人： Optiscan Biomedical Corporation
发明人： CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing (821) and a first fluid passageway (111) extending from the module housing. The first fluid passageway has a patient end (120) remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator (332) is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell (903,2464) is configured to hold at least a portion of the first component.

24. 发明授权

EP1853165B1 APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 有权
标题翻译：检测方法的多分析物
公开(公告)号：EP1853165B1
公开(公告)日：2011-02-02
申请号：EP06734940.7
申请日：2006-02-13
申请人： Optiscan Biomedical Corporation
发明人： STERLING, Bernhard, B. , HALL, W., Dale , CALLICOAT, David, N. , GABLE, Jennifer, H. , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard, A.
IPC分类号： A61B5/15
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.

25. 发明公开

EP2138097A3 Apparatus and methods for analyzing body fluid samples 审中-公开
标题翻译：设备和方法，用于体液样品的分析
公开(公告)号：EP2138097A3
公开(公告)日：2010-06-23
申请号：EP09169910.8
申请日：2006-02-13
申请人： Optiscan Biomedical Corporation
发明人： Hall, Dale W. , Callicoat, David N. , Gable, Jennifer H. , Braig, James R. , Witte, Kenneth G. , Wechsler, Mark , Rule, Peter , Keenan, Richard
IPC分类号： A61B5/15 , A61M5/172 , A61B5/00 , G01N33/487 , A61M5/142
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient (6011). The apparatus comprises an infusion line (6017) and a catheter (6021) configured for insertion into a blood vessel of the patient, and a reversible infusion pump (6013) connected between a source (6015) of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly (6019) mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The apparatus further comprises a controller (6023) that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction.

26. 发明公开

EP1962687A2 FLUID HANDLING CASSETTE SYSTEM FOR BODY FLUID ANALYZER 审中-公开
标题翻译：液体处理试剂盒系统用于体液分析仪
公开(公告)号：EP1962687A2
公开(公告)日：2008-09-03
申请号：EP06816434.2
申请日：2006-10-06
申请人： Optiscan Biomedical Corporation
发明人： KEENAN, Richard , CHIOU, Jeff , GABLE, Jennifer , LI, Ken , TONG, Roger , RECKNOR, Mike , BRAIG, James, R.
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： G01N35/1097 , A61B5/14557 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/142 , A61M5/14212 , A61M5/1723 , A61M2205/12 , A61M2230/20 , B01L3/5027 , B01L3/502715 , B01L99/00 , B01L2200/027 , B01L2300/0803 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module (4002) configured to interface with a main instrument (810) . The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module (4000) separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell (2448) which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.

27. 发明公开

EP1850114A1 Spectroscopic method of determining an analyte concentration in a sample 审中-公开
标题翻译： eek Probe中的分析仪器（Spektroskopieverfahren zur Bestimmung der Analytkonzentration）
公开(公告)号：EP1850114A1
公开(公告)日：2007-10-31
申请号：EP07015609.6
申请日：2002-12-12
申请人： Optiscan Biomedical Corporation
发明人： The designation of the inventor has not yet been filed
IPC分类号： G01N21/35 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method uses spectroscopy to determine an analyte concentration in a sample. The method includes producing an absorbance spectrum of the sample. The method further includes shifting the absorbance spectrum to zero in a wavelength region. The method further includes subtracting a water or other substance contribution from the absorbance spectrum.
摘要翻译：一种方法使用光谱学来确定样品中的分析物浓度。该方法包括产生样品的吸收光谱。该方法还包括在波长区域中将吸收光谱移动到零。该方法还包括从吸收光谱中减去水或其它物质的贡献。

28. 发明公开

EP1620004A2 DUAL MEASUREMENT ANALYTE DETECTION SYSTEM 审中-公开
标题翻译：带双测量分析物检测系统
公开(公告)号：EP1620004A2
公开(公告)日：2006-02-01
申请号：EP04759514.5
申请日：2004-04-14
申请人： Optiscan Biomedical Corporation
发明人： BRAIG, James, R. , RULE, Peter , WITTE, Kenneth, G. , HARTSTEIN, Philip, C. , STERLING, Bernhard, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system (10) is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element (120, 302, 402, 602). The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

29. 发明公开

EP1606053A1 LAYERED SPECTROSCOPIC SAMPLE ELEMENT WITH MICROPOROUS MEMBRANE 审中-公开
标题翻译：与微孔膜分层光谱样本单元
公开(公告)号：EP1606053A1
公开(公告)日：2005-12-21
申请号：EP03815235.1
申请日：2003-12-22
申请人： Optiscan Biomedical Corporation
发明人： RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
IPC分类号： B01L3/00 , G01N21/31
CPC分类号： B01L3/5023 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , B01L3/5027 , B01L3/508 , B01L2200/027 , B01L2300/0654 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/8483 , G01N2021/0346
摘要： A spectroscopic sample holder (500) comprises a microporous sheet (512). The microporous sheet (512) has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening (518) configured to contact a material sample (S) and distribute the contacted material sample (S) into the microporous sheet (512). The spectroscopic sample holder (500) further comprises a first planar support member (514) positioned on, and substantially parallel to, the top surface of the microporous sheet (512). The spectroscopic sample holder (500) further comprises a second planar support member (514) positioned on the bottom surface of the microporous sheet (512), and oriented substantially parallel to the first planar support member (514).

30. 发明公开

EP1583472A2 CARTRIDGE LANCE 审中-公开
标题翻译：墨盒LANCE
公开(公告)号：EP1583472A2
公开(公告)日：2005-10-12
申请号：EP03815256.7
申请日：2003-12-30
申请人： Optiscan Biomedical Corporation
发明人： RULE, Peter , BRAIG, James, R. , HARTSTEIN, Philip, C.
IPC分类号： A61B5/15
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/15087 , A61B5/15142 , A61B5/1519 , A61B5/157 , G01N21/71
摘要： An analyte detection system (1709) for analysis of a body fluid is provided, comprising an analysis portion and a sample collection portion which is configured to be removably coupled to the analysis portion. The analysis portion comprises a detector (250) configured to detect electromagnetic radiation and a source of electromagnetic radiation (220). The source is positioned with respect to the detector such that electromagnetic radiation emitted by the source is received by the detector. The sample collection portion comprises a housing, a lance (1704) and a sample chamber (1734). The lance is mounted within and moveable with respect to the housing. The sample chamber is configured to be positionable, upon coupling of the sample collection portion to the analysis portion, with respect to the source and detector such that at least a portion of any electromagnetic radiation emitted by the source passes through the sample chamber prior to being received by the detector.
摘要翻译：提供了用于分析体液的分析物检测系统（1709），其包括分析部分和被配置为可移除地耦合到分析部分的样品收集部分。分析部分包括配置成检测电磁辐射和电磁辐射源（220）的检测器（250）。源相对于检测器定位，使得由源发射的电磁辐射被检测器接收。样品收集部分包括外壳，喷枪（1704）和样品室（1734）。喷枪安装在壳体内并相对于壳体可移动。样品室被配置成在样品收集部分与分析部分耦合时相对于源和检测器是可定位的，使得由源发射的任何电磁辐射的至少一部分在被存在之前穿过样品室由检测器接收。

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