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21. 发明公开

EP2277917A3 B7-H3L cell surface target and a family of antibodies recognizing that target 审中-公开
标题翻译： B7-H3L面目标和抗体家族识别这一目标
公开(公告)号：EP2277917A3
公开(公告)日：2012-07-11
申请号：EP10180500.0
申请日：2003-06-19
申请人： Raven Biotechnologies, Inc.
发明人： Mather, Jennie P. , Li, Rong-Hao , Pan, Zhuangyu , Roberts, Penelope E.
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , C12N15/13 , C12N5/10 , C12N5/20 , G01N33/574 , G01N33/577 , A61P35/00 , C07K14/705
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-association antigen, B7-H3L. The invention also provides a family of monoclonal antibodies that bind to antigen B7-H3L, methods of diagnosing and treating various human cancers that express B7-H3L.

22. 发明公开

EP2436400A3 Real-time detection of Influenza virus 有权转让
标题翻译： Echtzeit-Detektion des Influenzavirus
公开(公告)号：EP2436400A3
公开(公告)日：2012-06-27
申请号：EP11180769.9
申请日：2007-05-10
申请人： Theranos, Inc.
发明人： Holmes, Elizabeth A , Gibbons, Ian
IPC分类号： A61K49/00 , A61K39/00 , G01N33/543 , G01N33/569 , B01L3/00
CPC分类号： G01N33/56983 , B01L3/5027 , B01L3/502738 , B01L2200/10 , B01L2200/142 , B01L2200/16 , B01L2300/044 , B01L2300/0672 , B01L2300/0874 , B01L2400/0481 , B01L2400/049 , B01L2400/0683 , C12Q1/701 , G01N33/54366 , G01N2333/11
摘要： The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.
摘要翻译：本发明提供了用于检测指示体液样品中的流感病毒感染的分析物的系统和方法。本发明还提供了用于检测多个分析物的系统和方法，其中至少两个分析物指示体液样品中的流感病毒感染。

23. 发明公开

EP2406381A1 PRODUCTION OF FERMENTIVE END PRODUCTS FROM CLOSTRIDIUM SP. 审中-公开
标题翻译：制作成品生产发酵梭菌属
公开(公告)号：EP2406381A1
公开(公告)日：2012-01-18
申请号：EP10751311.1
申请日：2010-03-09
申请人： Qteros, Inc.
发明人： PAREKH, Sarad , KARIM, Khursheed , KILBANE, John
IPC分类号： C12P1/04 , C12P7/10 , C12N1/22
CPC分类号： C12P7/10 , C12N1/22 , C12P7/065 , Y02E50/16 , Y02E50/17
摘要： In one aspect, methods to enhance the production of ethanol and other fermentive end products from a wide variety of feedstocks by Clostridium microorganisms, such as Clostridium phytofermentans are disclosed. A method of improving fermentation performance of Clostridium microorganisms, such as Clostridium phytofermentans through the use of a fed-batch strategy is described, as well as methods of producing fermentive end products, such as alcohols and/or chemicals by fermenting Clostridium microorganisms, such as Clostridium phytofermentans in the presence of fatty acid-containing compounds and/or at reduced pH.

24. 发明公开

EP2268297A1 MODIFIED TOXINS 审中-公开
标题翻译：修饰的毒素
公开(公告)号：EP2268297A1
公开(公告)日：2011-01-05
申请号：EP08873133.6
申请日：2008-12-15
申请人： Angelica Therapeutics, INC.
发明人： DAVIS, Claude, Geoffrey , DATTA, Deepshikha , BAKER, Matthew, Paul , KEEN, Simon , RUST, Alyson, Jane
IPC分类号： A61K38/16 , A61P37/06 , A61K39/395
CPC分类号： C07K14/34 , A61K38/00 , C07K2319/035
摘要： The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.
摘要翻译：本申请涉及表现出降低的免疫原性和降低的与血管内皮或血管内皮细胞的结合的修饰毒素的组合物，由此降低血管渗漏综合征的发病率。还提供了来自修饰的白喉毒素的多肽毒素，其中修饰在至少一个T细胞表位的至少一个氨基酸残基中。另一个方面涉及来自修饰的白喉毒素的多肽的毒素，其中修饰在未修饰的天然白喉毒素的至少一个T细胞表位的至少一个氨基酸残基和至少一个VLS基序的至少一个氨基酸残基。另一方面涉及包含修饰的白喉毒素和作为细胞结合部分的非白喉毒素片段的融合蛋白。另一方面涉及修饰的白喉毒素用于治疗恶性疾病或非恶性疾病的用途。

25. 发明公开

EP2252631A2 BCR-COMPLEX-SPECIFIC ANTIBODIES AND METHODS OF USING SAME 有权转让
标题翻译： BCR-复合物特异性抗体和使用方法
公开(公告)号：EP2252631A2
公开(公告)日：2010-11-24
申请号：EP09763010.7
申请日：2009-03-25
申请人： MacroGenics, Inc.
发明人： JOHNSON, Leslie S. , HUANG, Ling
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： C07K16/28 , C07K16/2803 , C07K2317/24 , C07K2317/56
摘要： Chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the BCR complex. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

26. 发明公开

EP2245215A1 LOW-VOLTAGE ALKALINE PRODUCTION USING HYDROGEN AND ELECTROCATLYTIC ELECTRODES 审中-公开
标题翻译：低电压碱性的生成，用氢气和电催化电极
公开(公告)号：EP2245215A1
公开(公告)日：2010-11-03
申请号：EP10737735.0
申请日：2010-02-10
申请人： Calera Corporation
发明人： GILLIAM, Ryan, J. , DECKER; Valentin , BOGGS, Bryan , JALANI, Nikhil , ALBRECHT, Thomas, A. , SMITh, Matt
IPC分类号： C25B1/00
CPC分类号： C25B1/14 , B01D53/326 , B01D2257/504 , C02F1/4618 , C25B1/04 , C25B1/18 , C25B9/00 , C25B15/08 , Y02E60/366 , Y02P20/152
摘要： An alkaline production system comprising an electrochemical unit comprising a hydrogen-oxidizing anode, a cathode compartment comprising a cathode and a hydrogen delivery system configured to deliver hydrogen gas to the anode, wherein the unit is operably connected to a carbon sequestration system configured to sequester carbon dioxide with the cathode electrolyte; and methods thereof. In another embodiment, a system comprising a hydrogen-oxidizing anode in communication with a cathode electrolyte comprising bicarbonate ion; and an hydrogen delivery system configured to deliver hydrogen gas to the anode; and methods thereof.

27. 发明公开

EP3154599A1 HYBRID COMPOSITION 有权
标题翻译：混合ZUSAMMENSETZUNG
公开(公告)号：EP3154599A1
公开(公告)日：2017-04-19
申请号：EP15729885.2
申请日：2015-06-09
申请人： Cell Therapy Limited
发明人： EVANS, Martin John , REGINALD, Ajan , SULTAN, Sabena
IPC分类号： A61L27/18 , A61L27/22 , A61L27/38
CPC分类号： A61L27/3834 , A61K9/0019 , A61K9/127 , A61K35/28 , A61K47/34 , A61K47/42 , A61L27/18 , A61L27/225 , A61L27/26 , A61L2300/412 , C08L67/04
摘要： The invention relates to a novel chemical composition comprising living cells combined with biocompatible fibres and biocompatible components which are optimally chemically formulated to repair damaged human or animal tissue.
摘要翻译：本发明涉及一种新颖的化学组合物，其包含与生物相容性纤维结合的活细胞和生物相容性成分，其被最佳化学配制以修复受损的人或动物组织。

28. 发明公开

EP3146036A1 SYSTEMS AND METHODS FOR THERMAL CYCLING CROSS-REFERENCE 审中-公开
标题翻译： SYSTEME UND VERFAHRENFÜRTEMPERATURZYKLEN
公开(公告)号：EP3146036A1
公开(公告)日：2017-03-29
申请号：EP15795778.8
申请日：2015-05-21
申请人： Coyote Bioscience Co., Ltd.
发明人： LI, Xiang , LI, Chen , HAN, Yuguang , FENG, Huiying
IPC分类号： C12M1/38
CPC分类号： B01L7/52 , B01L2200/18 , B01L2300/0654
摘要： Systems and methods for low voltage power thermal cycling are provided. A nucleic acid amplification device (500) comprising a thermal cycler (510) and a detector (520) is capable of operating using a low operating voltage, such as 12 V. The nucleic acid amplification device (500) may include a portable energy storage device (530) that can provide operating power. The nucleic acid amplification device (500) may be powered by a vehicle (1120) and deployed to remote locations.
摘要翻译：提供了低压功率热循环的系统和方法。包括热循环仪和检测器的核酸扩增装置能够使用诸如12V的低工作电压进行操作。核酸扩增装置可以包括可以提供操作功率的便携式能量存储装置。核酸扩增装置可以由车辆供电并且部署到远程位置。

29. 发明公开

EP3130682A1 METHODS FOR GENERATING POLYMER ARRAYS 有权
标题翻译： VERFAHREN ZUR ERZEUGUNG VON POLYMER-ARRAYS
公开(公告)号：EP3130682A1
公开(公告)日：2017-02-15
申请号：EP16184101.0
申请日：2016-08-12
申请人： Centrillion Technology Holdings Corporation
发明人： POLLOM, Thomas Scott , ZHOU, Wei
IPC分类号： C12Q1/68
摘要： The present disclosure provides a polymer array comprising a plurality of polymers, each of which is immobilized at a distinct locations and differs from adjacent polymers by one and only one subunit. Also provided herein are methods for generating a set of masks which may define strings of synthetic steps for forming polymer arrays on a substrate.
摘要翻译：本公开内容提供了包含多个聚合物的聚合物阵列，其各自被固定在不同的位置，并且通过一个且仅一个亚单位与相邻聚合物不同。本文还提供了用于产生一组掩模的方法，其可以限定用于在基底上形成聚合物阵列的合成步骤的串。

30. 发明公开

EP3130681A1 METHODS FOR SYNCHRONIZING NUCLEIC ACID MOLECULES 有权
标题翻译： VERFAHREN ZUR SYNCHRONISIERUNG VONNUKLEINSÄUREMOLEKÜLEN
公开(公告)号：EP3130681A1
公开(公告)日：2017-02-15
申请号：EP16184099.6
申请日：2016-08-12
申请人： Centrillion Technology Holdings Corporation
发明人： ZHOU, Wei , CRNOGORAC, Filip
IPC分类号： C12Q1/68
摘要： The methods, systems, kits and reagents provided herein relate to the synchronization of dephased/prephased nucleic acid molecules during sequencing reactions by using up to three different nucleotides selected from the group consisting of: dATP, dTTP, dCTP, dGTP and dUTP and extending said plurality of sequencing products with a DNA polymerase. The methods, systems, kits and reagents provided herein can be utilized to improve the efficiency and accuracy of sequencing technologies.
摘要翻译：本文提供的方法，系统，试剂盒和试剂涉及通过使用至多三种选自dATP，dTTP，dCTP，dGTP和dUTP的不同核苷酸，在测序反应期间同步脱相/预先核酸分子，并延伸所述多个具有DNA聚合酶的测序产物。本文提供的方法，系统，试剂盒和试剂可用于提高测序技术的效率和准确性。

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