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21. 发明公开

EP2622069A2 BETA-GLUCOSIDASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 有权
标题翻译：大豆蛋白酶基因多态性
公开(公告)号：EP2622069A2
公开(公告)日：2013-08-07
申请号：EP11767880.5
申请日：2011-09-30
申请人： Novozymes, Inc.
发明人： WOGULIS, Mark , HARRIS, Paul , OSBORN, David
IPC分类号： C12N9/42
CPC分类号： C12N9/2445 , C12P19/14 , C12Y302/01021 , Y02E50/16
摘要： The present invention relates to variants of a parent beta-glucosidase. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及亲本β-葡糖苷酶的变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

22. 发明公开

EP2603594A1 COMPOSITIONS COMPRISING A POLYPEPTIDE HAVING CELLULOLYTIC ENHANCING ACTIVITY AND A BICYCLIC COMPOUND AND USES THEREOF 有权
标题翻译：与作用的多肽和ZELLULOLYSEVERSTÄRKENDER双环化合物及其使用的组合物
公开(公告)号：EP2603594A1
公开(公告)日：2013-06-19
申请号：EP11746728.2
申请日：2011-08-05
申请人： Novozymes, Inc.
发明人： XU, Feng , SWEENEY, Matthew , QUINLAN, Jason
IPC分类号： C12P7/10 , C12P19/14 , C12N9/42
CPC分类号： C12P19/14 , B01J31/06 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/96 , C12P7/10 , C12P7/14 , C12P19/02 , C12P2203/00 , C12Y302/01021 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a dioxy compound. The present invention also relates to methods of using the compositions.
摘要翻译：本发明涉及组合物，其包括：具有纤维素分解增强活性和二氧基化合物的多肽。因此，本发明涉及使用该组合物的方法。

23. 发明公开

EP2603593A1 COMPOSITIONS COMPRISING A POLYPEPTIDE HAVING CELLULOLYTIC ENHANCING ACTIVITY AND A NITROGEN-CONTAINING COMPOUND AND USES THEREOF 审中-公开
标题翻译：与ZELLULOLYSEVERSTÄRKENDER作用的多肽和氮肥连接和使用组合物
公开(公告)号：EP2603593A1
公开(公告)日：2013-06-19
申请号：EP11746726.6
申请日：2011-08-05
申请人： Novozymes, Inc.
发明人： XU, Feng , SWEENEY, Matthew , QUINLAN, Jason
IPC分类号： C12P7/10 , C12P19/14 , C12N9/42
CPC分类号： C12P19/14 , B01J31/06 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/96 , C12P7/10 , C12P7/14 , C12P19/02 , C12P2203/00 , C12Y302/01021 , Y02E50/16 , Y02P20/52
摘要： The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a nitrogen-containing compound. The present invention also relates to methods of using the compositions.
摘要翻译：本发明涉及组合物，其包括：具有纤维素分解增强活性和二氧基化合物的多肽。因此，本发明涉及使用该组合物的方法。

24. 发明公开

EP2455460A3 Lipase variants for pharmaceutical use 审中-公开
公开(公告)号：EP2455460A3
公开(公告)日：2012-12-26
申请号：EP12155315.0
申请日：2007-12-12
申请人： Novozymes A/S , Novozymes Inc.
发明人： Svendsen, Allan , Skjoet, Michael , Yaver, Debbie , Christensen, Lars Lehmann Hylling , Larsen, Signe Eskildsen , Lundin, Nina Vibeke Fabricius , Lamsa, Michael , Gregory, Peter Colin
IPC分类号： C12N9/20 , A61K38/46 , A61K38/54
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , C12N9/20
摘要： The present invention relates to a lipase which (a) has at least 50% identity to the sequence of amino acids 1-269 of SEQ ID NO: 2; (b) has lipase activity; and which, (c) as compared to the sequence of amino acids 1-269 of SEQ ID NO: 2, comprises a substitution in position 39.

25. 发明公开

EP2507372A1 POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
标题翻译：具有葡糖淀粉酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：EP2507372A1
公开(公告)日：2012-10-10
申请号：EP10785298.0
申请日：2010-11-30
申请人： Novozymes A/S , Novozymes North America, Inc.
发明人： LANDVIK, Sara , MORANT, Marc Dominique , AYABE, Keiichi , COWARD-KELLY, Guillermo
IPC分类号： C12N9/34 , C12P19/14 , C12P7/06
CPC分类号： C12P7/14 , C12N9/242 , C12N9/2428 , C12P7/06 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01001 , C12Y302/01003 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to isolated polypeptides having glucoamylase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有葡糖淀粉酶活性的分离的多肽和编码该多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

26. 发明公开

EP2491122A1 CELLOBIOHYDROLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：碳酸氢钠溶解在DAFÜRKODIERENDE POLYNUCLEOTIDE
公开(公告)号：EP2491122A1
公开(公告)日：2012-08-29
申请号：EP10768848.3
申请日：2010-10-20
申请人： Novozymes Inc.
发明人： WOGULIS, Mark
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N15/8257 , C12P19/02 , C12P19/14 , C12P2203/00 , C12Y302/01091 , Y02P20/52
摘要： The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及亲本纤维二糖水解酶II的变体。本发明还涉及编码这些变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

27. 发明公开

EP2483403A1 POLYPEPTIDES HAVING XYLANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
标题翻译：多肽MIT XYLANASE-AKTIVITÄTUND DIESE KODIERENDE＆xA; POLYNUKLEOTIDE
公开(公告)号：EP2483403A1
公开(公告)日：2012-08-08
申请号：EP10763939.5
申请日：2010-09-29
申请人： Novozymes Inc. , Novozymes A/S
发明人： TANG, Lan , LIU, Ye , DUAN, Junxin , DING, Hanshu
IPC分类号： C12N9/24 , C07K14/385
CPC分类号： C12N9/2482 , C12N15/8246 , C12Y302/01008
摘要： The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有木聚糖酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

28. 发明公开

EP2455462A2 Lipase variants for pharmaceutical use 有权
标题翻译：用于药物的脂肪酶变体
公开(公告)号：EP2455462A2
公开(公告)日：2012-05-23
申请号：EP12155319.2
申请日：2007-12-12
申请人： Novozymes A/S , Novozymes Inc.
发明人： Svendsen, Allan , Skjoet, Michael , Yaver, Debbie , Christensen, Lars Lehmann Hylling , Larsen, Signe Eskildsen , Lundin, Nina Vibeke Fabricius , Lamsa, Michael , Gregory, Peter Colin
IPC分类号： C12N9/20 , A61K38/46 , A61K38/54
CPC分类号： A61K38/465 , A61K38/47 , A61K38/48 , C12N9/20
摘要： The present invention relates to a lipase which (a) has at least 50% identity to the sequence of amino acids 1-269 of SEQ ID NO: 2; (b) has lipase activity; and which, (c) as compared to the sequence of amino acids 1-269 of SEQ ID NO: 2, comprises a substitution in position 163.
摘要翻译：本发明涉及一种脂肪酶，其（a）与SEQ ID NO：2的氨基酸1-269的序列具有至少50％的同一性; （b）具有脂肪酶活性; 并且（c）与SEQ ID NO：2的氨基酸1-269的序列相比，在位置163包含取代。

29. 发明授权

EP1546138B1 RALOXIFENE L-LACTATE OR A HEMIHYDRATE THEREOF, THEIR USES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESSES 有权
标题翻译：雷洛昔芬-L-LACTAT半水和它们的用途，其药物组合物及方法
公开(公告)号：EP1546138B1
公开(公告)日：2012-01-18
申请号：EP03747847.6
申请日：2003-09-30
申请人： A/S GEA Farmaceutisk Fabrik
发明人： KARUP, Gunnar, Leo , PEDERSEN, Soren, Bols
IPC分类号： C07D409/12 , A61K31/445 , A61K31/381 , A61P35/00 , A61P19/00 , C07D333/56 , C07D295/08
CPC分类号： C07D333/56
摘要： Raloxifene acid addition salts or solvates thereof, having improved dissolution properties in media comprising hydrochloric acid are described, The disclosed acid addition salts or solvates thereof show an improved bioavailability in media comprising hydrochloric acid, such as the gastric juice. The acid addition salts or solvates thereof are addition salts or solvates of raloxifene and a pharmaceutical acceptable acid selected among succinic acid, lactic acid, malonic acid or sulphuric acid. Further, crystalline forms of the raloxifene salts and solvates thereof are disclosed. The raloxifene acid addition salts and/or solvates thereof are useful for the preparation of pharmaceutical composition for oral administration capable of fast and reliable release of the active ingredients in the stomach of the patient, in particular for the treatment of cancer or osteoporosis, or for inhibiting cartilage degradation. A new method for preparation of raloxifene lactate is also disclosed.

30. 发明公开

EP2352831A1 METHODS FOR PRODUCING POLYPEPTIDES IN ENZYME-DEFICIENT MUTANTS OF FUSARIUM VENENATUM 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON POLYPEPTIDEN IN ENZYMMANGELMUTANTEN VON FUSARIUM VENENATUM
公开(公告)号：EP2352831A1
公开(公告)日：2011-08-10
申请号：EP09793185.1
申请日：2009-09-30
申请人： Novozymes Inc.
发明人： SHASKY, Jeffrey , YODER, Wendy
IPC分类号： C12N15/80
CPC分类号： C12P21/00 , C12N9/242 , C12N9/58 , C12N9/88 , C12N15/80 , C12P21/02 , C12Y302/01001 , C12Y401/01023 , Y02P20/52
摘要： The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent
Fusarium venenatum strain in a medium for the production of the polypeptide, wherein the mutant strain comprises a polynucleotide encoding the polypeptide and one or more (several) genes selected from the group consisting of
pyrG ,
amyA , and
alpA , wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of orotidine-5'-monophosphate decarboxylase, alpha-amylase, and alkaline protease, respectively, compared to the parent
Fusarium venenatum strain when cultivated under identical conditions; and (b) recovering the polypeptide from the cultivation medium. The present invention also relates to enzyme-deficient mutants of
Fusarium venenatum strains and methods for producing such mutants.
摘要翻译：本发明涉及产生多肽的方法，其包括：（a）在用于产生多肽的培养基中培养母本镰孢镰刀菌菌株的突变体，其中所述突变株包含编码多肽的多核苷酸和一个或多个（几种）选自pyrG，amyA和alpA的基因，其中所述一个或多个（若干）基因被修饰，使所述突变菌株缺乏产生选自下组的一种或多种（几种） -5'-单磷酸脱羧酶，α-淀粉酶和碱性蛋白酶，与相同条件下培养的亲本镰刀菌镰孢菌株相比; 和（b）从培养基中回收多肽。本发明还涉及镰状镰孢菌株的酶缺陷型突变体及其生产方法。

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