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11. 发明公开

EP2155675A1 KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH 有权
标题翻译：激酶抑制剂，其成分和它们的使用方法
公开(公告)号：EP2155675A1
公开(公告)日：2010-02-24
申请号：EP08768252.2
申请日：2008-06-09
申请人： Provid Pharmaceuticals, Inc. , The United States of America as represented by the Department of Health and Human Services
发明人： SHOEMAKER, Robert , CARDELLINA, John , CURRENS, Michael , KONDAPAKA, Sudhir , POMMIER, Yves , JOBSON, Andy , SCUDIERO, Dominic , WAUGH, David , LOUNTOS, George , COOK, Charles, M. , ZHANG, Guangtao , COLASANTI, Andrew , SELF, Christopher, R.
IPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04 , A61K31/34
CPC分类号： C07D209/42 , C07D209/60 , C07D213/86 , C07D217/26 , C07D231/56 , C07D233/52 , C07D239/42 , C07D277/50 , C07D277/82 , C07D307/68 , C07D307/85 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Provided herein are Compounds having the following structure: formula (I) wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.

12. 发明公开

EP1918286A1 Thiazolhydrazides for treatment of neurodegenerative diseases 有权
标题翻译： Thiazolhydrazide及其对神经退行性疾病的治疗
公开(公告)号：EP1918286A1
公开(公告)日：2008-05-07
申请号：EP06022992.9
申请日：2006-11-05
申请人： MPG Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Technische Universität Darmstadt , The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
发明人： Mandelkow, Eckhard , Mandelkow, Eva-Maria , Pickhardt, Markus , Biernat, Jacek , Lioyd, David George
IPC分类号： C07D277/50 , C07D417/04 , A61K31/427 , A61P25/00 , C07D417/12
CPC分类号： C07D417/12 , C07D277/50 , C07D417/04
摘要： The present invention relates to compounds of formula (I) having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.

Formula (I)

13. 发明公开

EP1753734A1 NITRIC OXIDE DONORS AND USES THEREOF 审中-公开
标题翻译：一氧化氮供体和其用途
公开(公告)号：EP1753734A1
公开(公告)日：2007-02-21
申请号：EP05737588.3
申请日：2005-05-05
申请人： RENOPHARM LTD.
发明人： ASSAF, Peter , GAZALEEN-MARIEE, Elham , NAVEH, Michael
IPC分类号： C07D277/24 , C07D277/34 , C07D277/40 , C07D417/04 , C07D277/50 , C07D417/12 , C07D277/46 , A61K31/426 , A61K31/4439
CPC分类号： A61K31/427 , C07D277/22 , C07D277/24 , C07D277/34 , C07D277/36 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D495/04
摘要： Disclosed are novel NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, and thus a development of tolerance to the compounds upon repetitive administration is prevented or decreased. Also disclosed are methods of preparing such NO-donating compounds, pharmaceutical compositions and medical devices containing such compounds and methods utilizing such compounds in the treatment of various medical conditions.

14. 发明公开

EP0507154A1 Verfahren zur Bestimmung von Alkoholen und Verwendung einer Vorrichtung zur Alkoholbestimmung 失效
标题翻译：半缩醛，其被可逆地从醇类和酮化合物形成的，它们的制备方法，到装置的醇的光学测定，以及它们的用途。
公开(公告)号：EP0507154A1
公开(公告)日：1992-10-07
申请号：EP92104755.1
申请日：1992-03-19
申请人： Willi Möller AG
发明人： Simon, Wilhelm, Prof. Dr. , Seiler, Kurt, Dr.
IPC分类号： C07C233/33 , C07C233/25 , C07D277/50 , G01N33/98
CPC分类号： G01N33/98 , C07C233/25 , C07C233/33 , C07D277/50 , G01N2800/307 , Y10T436/20 , Y10T436/203332 , Y10T436/204165 , Y10T436/255
摘要： Es werden neue Hemiacetale der Formel II

beschrieben, worin

R' ein aliphatischer oder cycloaliphatischer Rest ist,
Ar einen unsubstitutierten oder substituierten einkernigen oder mehrkernigen Rest aromatischen oder heteroaromatischen Charakters darstellt, der allenfalls unpolare, schwach polare oder basische Substituenten trägt und/oder chromophore Gruppen aufweist, beziehungsweise Gruppen, die eine Fluoreszenz oder Lumineszenz induzieren.

Mindestens einer der Substituenten X¹, X² und X³, vorzugsweise sämtliche drei der genannten Substituenten, müssen stark elektronenanziehende Substituenten sein, ausgewählt aus der Gruppe Fluoratome, Chloratome, Bromatome oder Nitrogruppen, vorzugsweise Fluoratome. Die Hemiacetale bilden sich reversibel aus den entsprechenden Ketoverbindungen bei einem Kontakt mit einem Alkohol der Formel R'OH, und bei dieser Reaktion ändert sich die Lichtabsorption im ultravioletten, sichtbaren oder infraroten Lichtbereich, oder es entsteht dabei eine Fluoreszenz oder Lumineszenz oder eine solche wird gelöscht. Vorrichtungen, welche die Ketoverbindungen enthalten, dienen als optische Sensoren zur Bestimmung der genannten Alkohole.
摘要翻译：式II 的新颖的半缩醛：其中R描述“是脂族或环脂族基中，Ar darstellt到unsubstituiertem或substituiertem单核或多核基团，具有芳族或杂芳族字符和，如果合适的话，具有非极性，弱极性或碱性取代基和/或发色团或诱导荧光或发光的基团。至少取代基X中的一个<1>中，X <2>和X <3>，优选全部三个提到的取代基的，必须是强大的吸电子取代基和选自氟原子，氯原子被选择，溴原子或硝基，优选为氟原子。半缩醛可逆从相应的酮化合物在接触时与上式R'OH的醇形成，并且该反应的光中的紫外线的吸收，可见或红外范围的改变，或发光或荧光或始发期间是淬火。含酮基化合物的器件作为光传感器，用于所述醇的确定。

15. 发明公开

EP0011221A1 Carbamoyl-oxime, Verfahren zu deren Herstellung, Schädlingsbekämpfungsmittel enthaltend solche Verbindungen sowie Verwendung solcher Verbindungen als Schädlingsbekämpfungsmittel 有权
标题翻译：氨基甲酰基肟类，它们的制备方法，含有这些化合物和使用作为杀虫剂这种化合物的杀虫剂。
公开(公告)号：EP0011221A1
公开(公告)日：1980-05-28
申请号：EP79104345.8
申请日：1979-11-06
申请人： F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft
发明人： Winternitz, Paul, Dr.
IPC分类号： C07D277/50 , A01N47/24
CPC分类号： A01N47/24 , C07D277/50
摘要： Die Erfindung betrifft Carbamoyloxime der allgemeinen Formel

worin R 1 und R 3 nieder Alkyl, nieder Alkenyl, Cycloalkyl oder Aryl bedeuten, wobei der Arylrest gegebenenfalls mit einem Halogenatom substituiert sein kann, R 2 nieder Alkyl, R 4 nieder Alkyl oderCycloalkyl und R 3 Wasserstoff, nieder Alkyl, nieder Alkylcarbonyl oder mit Halogen substituiertes nieder Alkylcarbonyl bedeuten,
und Säureadditionssalze dieser Verbindung, Verfahren zu deren Herstellung, Schädlingsbekämpfungsmittel, die diese Verbindung als Wirkstoffe enthalten, sowie die Verwendung solcher Mittel zur Bekämpfung von Schädlingen.
摘要翻译：本发明涉及通式其中R 1和R 3，低级烷基，低级链烯基，环烷基或芳基，其中芳基可被卤原子任选被取代，R 2是低级烷基，R的氨基甲酰肟<4>是低级烷基或环烷基和 [R <5>是氢，低级烷基，低级烷基羰基或卤素取代的低级烷基羰基，以及该化合物的酸加成盐，以它们的制备方法，含有该化合物作为活性成分，和用于防治害虫的用途这样的组合物的农药。

16. 发明授权

EP2772488B1 2,4,5-trisubstituted thiazole compounds,preparation methods,pharmaceutical compositions and medical uses thereof 有权
标题翻译： 2,4,5-三取代的噻唑化合物，制造工艺，药物组合物和医疗用途及其
公开(公告)号：EP2772488B1
公开(公告)日：2016-11-02
申请号：EP13198379.3
申请日：2006-08-15
申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China
发明人： Li, Song , Xiao, Junhai , Guo, Changbin , Zhong, Wu , Jiang, Xiancheng
IPC分类号： C07D277/24 , C07D277/40 , C07D277/44 , C07D277/42 , C07D277/46 , C07D277/50 , C07D277/52
CPC分类号： C07D277/40 , C07D277/24 , C07D277/42 , C07D277/44 , C07D277/46 , C07D277/50 , C07D277/52

18. 发明授权

EP2170260B1 AZO DERIVATIVES CONTAINING A PYRAZOLINONE UNIT FOR DYEING KERATIN FIBRES 有权
标题翻译：含有吡唑啉酮单元的AZO衍生物用于染料角蛋白纤维
公开(公告)号：EP2170260B1
公开(公告)日：2010-11-17
申请号：EP08761244.6
申请日：2008-06-19
申请人： L'Oréal
发明人： FADLI, Aziz , METAIS, Eric
IPC分类号： A61K8/49 , A61Q5/10 , C07D213/77 , C07D231/04 , C07D231/44 , C07D233/88 , C07D235/30 , C07D277/04 , C07D277/50 , C07D277/82 , C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04
CPC分类号： C07D487/04 , C07D213/77 , C07D231/04 , C07D231/44 , C07D233/88 , C07D235/30 , C07D277/04 , C07D277/50 , C07D277/82 , C07D401/12 , C07D417/12
摘要： The subject of the present invention is azo derivatives containing a pyrazolinone unit having the following formula (I), their mesomeric forms, their addition salts with an acid and their solvates and their use for dyeing keratin fibres. The subject of the invention is also a composition for dying keratin fibres comprising at least one azo derivative containing a pyrazolinone unit of formula (I) as direct dye, and the method for dyeing keratin fibres using this composition. The present invention makes it possible in particular to obtain chromatic colours that are resistant to the various attacks to which the hair may be subjected, in particular to shampoos and to light.
摘要翻译：本发明的主题是含有具有下式（I）的吡唑啉酮单元的偶氮衍生物，它们的中间体形式，它们与酸的加成盐和它们的溶剂化物以及它们用于染色角蛋白纤维的用途。本发明的主题还是用于染色角蛋白纤维的组合物，其包含至少一种含式（I）吡唑啉酮单元作为直接染料的偶氮衍生物，以及使用该组合物染色角蛋白纤维的方法。本发明尤其使得可以获得能够抵抗头发可能受到的各种攻击的彩色，特别是洗发水和发光。

19. 发明公开

EP2170260A1 AZO DERIVATIVES CONTAINING A PYRAZOLINONE UNIT FOR DYEING KERATIN FIBRES 有权
标题翻译：甲PYRAZOLINONEINHEIT含偶氮衍生物用于染色角蛋白纤维
公开(公告)号：EP2170260A1
公开(公告)日：2010-04-07
申请号：EP08761244.6
申请日：2008-06-19
申请人： L'Oréal
发明人： FADLI, Aziz , METAIS, Eric
IPC分类号： A61K8/49 , A61Q5/10 , C07D213/77 , C07D231/04 , C07D231/44 , C07D233/88 , C07D235/30 , C07D277/04 , C07D277/50 , C07D277/82 , C07D401/12 , C07D403/12 , C07D417/12 , C07D487/04
CPC分类号： C07D487/04 , C07D213/77 , C07D231/04 , C07D231/44 , C07D233/88 , C07D235/30 , C07D277/04 , C07D277/50 , C07D277/82 , C07D401/12 , C07D417/12
摘要： The subject of the present invention is azo derivatives containing a pyrazolinone unit having the following formula (I), their mesomeric forms, their addition salts with an acid and their solvates and their use for dyeing keratin fibres. The subject of the invention is also a composition for dying keratin fibres comprising at least one azo derivative containing a pyrazolinone unit of formula (I) as direct dye, and the method for dyeing keratin fibres using this composition. The present invention makes it possible in particular to obtain chromatic colours that are resistant to the various attacks to which the hair may be subjected, in particular to shampoos and to light.

20. 发明公开

EP2074097A2 COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
标题翻译：治疗增殖性疾病的化合物
公开(公告)号：EP2074097A2
公开(公告)日：2009-07-01
申请号：EP07811437.8
申请日：2007-08-20
申请人： Synta Pharmaceuticals Corporation
发明人： SUN, Lijun , KOYA, Keizo , CHEN, Shoujun , DEMKO, Zachary , XIA, Zhi-qiang
IPC分类号： C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/30 , C07D333/36 , C07D333/38 , C07D207/416 , C07C243/24 , C07C327/00 , A61K31/16 , A61K31/165
CPC分类号： C07C327/56 , C07C243/24 , C07C255/56 , C07C255/58 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D213/81 , C07D213/86 , C07D231/08 , C07D237/04 , C07D277/50 , C07D303/48 , C07D307/66 , C07D307/68 , C07D309/38 , C07D333/36 , C07D333/38
摘要： Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要翻译：公开了使用本发明化合物治疗患有增殖性疾病如癌症的受试者的化合物和方法，以及治疗对Hsp70诱导和/或自然杀伤诱导有反应的病症的方法。还公开了包含本发明化合物和药学上可接受的载体的药物组合物。

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