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11. 发明公开

EP0241043A3 Novel diarylalkanoids having activity as lipoxygenase inhibitors 失效
标题翻译：具有作为LIPOXYGENASE抑制剂的活性的新型二元醇
公开(公告)号：EP0241043A3
公开(公告)日：1988-09-14
申请号：EP87105330
申请日：1987-04-10
申请人： WARNER-LAMBERT COMPANY
发明人： Connor, David Thomas , Flynn, Daniel Lee
IPC分类号： C07C49/255 , C07C49/248 , C07C97/10 , C07C149/36 , C07C131/00 , C07D307/46 , C07D307/52 , C07D307/54 , C07C59/90
CPC分类号： C07D307/52 , C07C45/72 , C07C45/74 , C07C49/248 , C07C49/255 , C07C65/38 , C07C205/45 , C07D307/46
摘要： The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.

12. 发明授权

EP0080301B1 Herbicidal cyclohexane-1,3-dione derivatives 有权
公开(公告)号：EP0080301B1
公开(公告)日：1988-08-24
申请号：EP82306000.9
申请日：1982-11-11
申请人： ICI AUSTRALIA LIMITED
发明人： Warner, Richard Burridge , Serban, Alexander , Watson, Keith Geoffrey , Bird, Graham John , Cross, Lindsay Edwin , Farquharson, Graeme John
IPC分类号： C07C131/00 , C07C49/747 , A01N35/10
CPC分类号： C07C49/835 , A01N35/10 , A01N37/02 , A01N37/10 , C07C45/455 , C07C45/64 , C07C45/673 , C07C49/217 , C07C49/657 , C07C49/747

13. 发明公开

EP0264737A2 2-(2-substituted benzoyl)-4-(substituted imino, oximino or carbonyl)-1,3-cyclo-hexanediones, a process for their production, and a herbicidal composition containing them 失效
标题翻译： 2-（取代基 - 苯甲酰基）-4-（亚氨基 - ，肟基羰基取代基）-1,3-环己二酮，Herstellungsverfahren und Herbizides Mittel。
公开(公告)号：EP0264737A2
公开(公告)日：1988-04-27
申请号：EP87114758.3
申请日：1987-10-09
申请人： STAUFFER CHEMICAL COMPANY
发明人： Knudsen, Christopher G.
IPC分类号： C07C131/00 , C07C147/06 , A01N35/10 , A01N41/10
CPC分类号： A01N35/06 , A01N35/10 , A01N41/10 , C07C49/792 , C07C49/813 , C07C49/835 , C07C49/84 , C07C49/86 , C07C205/45
摘要： Herbicidal compounds of the formula
wherein
X is oxygen or NR⁹ wherein R⁹ is hydrogen, C₁-C₄ alkyl, or C₁-C₄ alkoxy;
R is halogen; C₁-C₂ alkyl; C₁-C₂ alkoxy trifluoromethoxy or difluoromethoxy; nitro; cyano; C₁-C₂ haloalkyl; RªSO n - wherein n is 0 or 2 Rª is C₁-C₂ alkyl, trifluoromethyl or difluoromethyl.
R¹ is hydrogen; C₁-C₄ alkyl, phenyl; or substituted phenyl;
R² is hydrogen or C₁-C₄ alkyl; or
R¹ and R² together are C₂-C₅ alkylene;
R³ is hydrogen; C₁-C₄ alkyl, phenyl; or substituted phenyl, with the proviso that R¹ and R³ are not both phenyl or substituted phenyl;
R⁴ is hydrogen or C₁-C₄ alkyl;
R⁵ is hydrogen or C₁-C₄ alkyl;
R⁶ is hydrogen, C₁-C₄ alkyl or C₁-C₄ haloalkyl;
R⁷ and R⁸ independently are (1) hydrogen; (2) halogen; (3) C₁-C₄ alkyl; (4) C₁-C₄ alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C₁-C₄ haloalkyl; (9) R b SO n - wherein n is the integer 0, 1 or 2; and R b is (a) C₁-C₄ alkyl; (b) C₁-C₄ alkyl substituted with halogen or cyano; (c) phenyl; or (d) benzyl; (10) -NR c R d wherein R c and R d independently are hydrogen or C₁-C₄ alkyl; (11) R e C(O)- wherein R e is C₁-C₄ alkyl or C₁-C₄ alkoxy; or (12) -SO₂NR c R d wherein R c and R d are as defined; or
(13) -N(R c )C(O)R d wherein R c and R d are as defined; and (13) -N(R c )C(O)R d wherein R c and R d are as defined and their salts.
摘要翻译：式CHEM的除草化合物，其中X是氧或NR 9，其中R 9是氢，C 1 -C 4烷基或C 1 -C 4烷氧基; R是卤素; C1-C2烷基; C 1 -C 2烷氧基三氟甲氧基或二氟甲氧基; 硝基; 氰基; C 1 -C 2卤代烷基; 其中n是0或2，R a是C 1 -C 2烷基，三氟甲基或二氟甲基。 R 1是氢; C 1 -C 4烷基，苯基; 或取代的苯基; R 2是氢或C 1 -C 4烷基; 或R 1和R 2一起是C 2 -C 5亚烷基; R 3是氢; C 1 -C 4烷基，苯基; 或取代的苯基，条件是R 1和R 3不同时为苯基或取代的苯基; R 4是氢或C 1 -C 4烷基; R 5是氢或C 1 -C 4烷基; R 6是氢，C 1 -C 4烷基或C 1 -C 4卤代烷基; R 7和R 8独立地为（1）氢; （2）卤素; （3）C 1 -C 4烷基; （4）C1-C4烷氧基; （5）三氟甲氧基; （6）氰基; （7）硝基; （8）C 1 -C 4卤代烷基; （9）R bnn-其中n是整数0,1或2; 和R b是（a）C 1 -C 4烷基; （b）被卤素或氰基取代的C 1 -C 4烷基; （c）苯基; 或（d）苄基; （10）-NR c R d其中R c和R d独立地是氢或C 1 -C 4烷基; （11）R e（O） - 其中R e是C 1 -C 4烷基或C 1 -C 4烷氧基; 或（12）-SO 2 NR c R d其中R c和R d如定义; 或（13）-N（R c）C（O）R d，其中R c和R d如定义; 和（13）-N（R c）C（O）R d，其中R c和R d如上定义，及其盐。

14. 发明公开

EP0251552A2 Process for producing aminothiophenols and their derivatives 失效
标题翻译： Verfahren zur Herstellung von Aminothiophenolen und ihren Derivaten。
公开(公告)号：EP0251552A2
公开(公告)日：1988-01-07
申请号：EP87305323.5
申请日：1987-06-16
申请人： CELANESE CORPORATION
发明人： Davenport, Kenneth G.
IPC分类号： C07C148/00 , C07C149/42 , C07C131/00 , C07C155/02 , C07C103/38
CPC分类号： C07C333/02
摘要： A process is provided for preparing N-acyl-aminothiophenols, e.g., N-acetyl-para-aminothiophenol, or aminothiophenols, e.g., para-aminothiophenol, by reacting a hydroxy aromatic ketone, e.g., 4-hydroxyacetophenone (4-HAP), with hydroxylamine or a hydroxylamine salt, to form the oxime of the ketone, subjecting the oxime to a Beckmann rearrangement in the presence of a catalyst to form the N-acyl-hydroxy aromatic amine, e.g., N-acetyl-para-aminophenol (APAP), reacting the N-acyl-hydroxyaromatic amine with an N,N-di-(organo) thiocarbamoyl halide, e.g., N,N-dimethylthiocarbamoyl chloride, to form an O-(N-acyl-aminoaryl)-N,N-di-(organo) thiocarbamate, e.g., 0-(N-acetyl-para-aminophenyl)-N,N-dimethylthiocarbamate, pyrolytically rearranging the 0-(N-acyl-aminoaryl)-N,N-di(organo)thiocarbamate to form an S-(N-acyl-aminoaryl)-N,N-di(organo)-thiocarbamate, e.g., S-(N-acetyl-para-aminophenyl)-N,N-dimethylthiocarbamate, and hydrolyzing the latter compound to obtain the N-acyl aminothiophenol or aminothiophenol. The N-acyl aminothiophenol may be reacted with an acylating agent to form the N,S-diacyl-aminothiophenol, e.g., N,S-diacetyl-p-aminothiophenol, or may be further hydrolyzed to the aminothiophenol, e.g., p-aminothiophenol.
摘要翻译：提供了一种制备N-酰基 - 氨基噻吩酚的方法，例如N-乙酰基 - 对氨基苯硫酚或氨基硫酚，例如对氨基苯硫酚，通过使羟基芳族酮例如4-羟基苯乙酮（4-HAP）与羟胺或羟胺盐形成酮的肟，在催化剂存在下使肟进行贝克曼重排以形成N-酰基 - 羟基芳族胺，例如N-乙酰基对氨基苯酚（APAP），使N-酰基 - 羟基芳族胺与N，N-二（有机）硫代氨基甲酰卤如N，N-二甲基硫代氨基甲酰氯反应形成O-（N-酰基 - 氨基芳基）-N，N-二（有机基）硫代氨基甲酸酯，例如O-（N-乙酰基对氨基苯基）-N，N-二甲基硫代氨基甲酸酯，热解地重排N（N-酰基 - 氨基芳基）-N，N-二（有机））硫代氨基甲酸酯，形成S - （N-酰基 - 氨基芳基）-N，N-二（有机）硫代氨基甲酸酯，例如S-（N-乙酰基 - 对氨基苯基）-N，N-二甲基硫代氨基甲酸酯，并水解后一种化合物，得到N-酰基氨基苯硫酚或氨基苯硫酚。 N-酰基氨基苯硫酚可以与酰化剂反应以形成N，S-二酰基 - 氨基苯硫酚，例如N，S-二乙酰基对氨基苯硫酚，或者可以进一步水解成氨基苯硫酚，例如对氨基苯硫酚。

15. 发明公开

EP0250206A2 Process for producing N,O-diacetyl-6-amino-2-naphthol 失效
标题翻译： Verfahren zur Herstellung von N，O-二乙酰基-6-氨基-2-萘酚。
公开(公告)号：EP0250206A2
公开(公告)日：1987-12-23
申请号：EP87305325.0
申请日：1987-06-16
申请人： CELANESE CORPORATION
发明人： Davenport, Kenneth G. , Hilton, Charles B.
IPC分类号： C07C102/00 , C07C103/38 , C07C45/46 , C07C131/00
CPC分类号： C07C49/83 , C07C45/46 , C07C45/54
摘要： N,O-diacetyl-6-amino-2-naphthol is produced by subjecting 2-naphthyl acetate to a Fries rearrangement or 2-naphthol and an acetylating agent to a Friedel-Crafts acetylation to form 6-hydroxy-2-acetonaphthone which is then reacted as is or as its acetate ester with hydroxylamine or a hydroxylamine salt to form 6-hydroxy-2-acetonaphthone oxime. The oxime is then subjected to a Beckmann rearrangement and accompanying acetylation with acetic anhydride to form the N,O-diacetyl-6-amino-2-naphthol.
摘要翻译： N，O-二乙酰基-6-氨基-2-萘酚是通过使乙酸2-萘基酯进行Fries重排或2-萘酚和乙酰化剂进行Friedel-Crafts乙酰化反应形成6-羟基-2-乙醛，其为然后以羟基胺或羟胺盐的形式或作为其乙酸酯反应形成6-羟基-2-乙醛缩酮肟。然后将肟进行贝克曼重排，并伴随乙酸酐乙酰化形成N，O-二乙酰基-6-氨基-2-萘酚。

16. 发明公开

EP0198687A3 Alpha-polyhaloketoximes 失效
标题翻译： ALPHA-多囟酮肟
公开(公告)号：EP0198687A3
公开(公告)日：1987-09-23
申请号：EP86302707
申请日：1986-04-11
申请人： ROHM AND HAAS COMPANY
发明人： Chi-Tung Hsu, Adam
IPC分类号： C07C131/00 , A01N37/16 , A01N47/06 , A01N47/24
CPC分类号： A01N37/36 , A01N37/16 , A01N37/40 , A01N37/48 , A01N43/08 , A01N47/06 , A01N47/24 , C07D307/68
摘要： Alpha-polyhaloketoximes having the formula:
wherein
X and X' are the same or different halogen atoms; R is methyl or halomethyl; and R 1 is (C 1 -C 12 )alkyl optionally substituted with one or more halogen, (C 1 -C 4 )alkoxy, cyano or nitro; (C 3 -C 6 )cycloalkyl; straight or branched chain (C 1 -C 4 )alkoxy optionally substituted with one or more halogen; an amino group of the formula NHR 2 where R is hydrogen, straight or branched chain (C 1 -C 4 )alkyl optionally substituted with one or more of the same or different halogen, (C 3 -C 6 )cycloalkyl, straight or branched chain (C z -C 6 )alkenyl, or aryl; a thio group of the formula SR 3 where R 3 is straight or branched chain (C 1 -C 4 )alkyl optionally substituted with one or more of the same or different halogen, or aryl; (C 2 -C 6 )alkenyl optionally substituted with one or more halogen; aryl optionally substituted with one or more of the same of different halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )-alkoxy, or (C 1 -C 4 )haloalkyl, a heterocyclic group; phenalkyl where the alkyl moiety contains one to four carbon atoms and the phenyl ring is optionally substituted with one or more of the same or different halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or (C 1 -C 4 )haloalkyl; phenalkenyl where the alkenyl moiety contains two to five carbon atoms and the phenyl ring is optionally substituted with one or more of the same or different halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or (C 1 -C 4 )haloalkyl; phenoxy optionally substituted with one or more of the same or different halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or (C 1 -C 4 )haloalkyl; or benzyloxy where the phenyl ring is optionally substituted with one or more of the same or different halogen, cyano, nitro, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, or (C 1 -C 4 )haloalkyl are useful biocides, fungicides or pesticides.

17. 发明公开

EP0230230A2 Verfahren zur Herstellung von Hydroxybenzaldoxim-O-ethern 失效
标题翻译： Verfahren zur Herstellung von Hydroxybenzaldoxim-O-ethern。
公开(公告)号：EP0230230A2
公开(公告)日：1987-07-29
申请号：EP87100170.7
申请日：1987-01-09
申请人： BAYER AG
发明人： Elbe, Hans-Ludwig, Dr. , Lantzsch, Reinhard, Dr.
IPC分类号： C07C131/00
CPC分类号： C07C249/12 , C07C251/48
摘要： Nach einem neuen Verfahren werden bekannte Hydroxybenzaldoxim-O-ether der Formel
in welcher
R¹ für Alkyl steht,
dadurch erhalten, daß man Hydroxybenzaldoxime der Formel
mit Dialkylsulfaten der Formel
R¹ - O - SO₂ - O - R¹ (III)
in welcher
R¹ die oben angegebene Bedeutung hat,
oder mit Alkylhalogeniden der Formel
R¹X (IV)
in welcher
R¹ die oben angegebene Bedeutung hat und
X für Halogen steht,
in Gegenwart einer starken Base und in Gegenwart eines Verdünnungsmittels bei Temperaturen zwischen 0° C und 60 °C umsetzt.
摘要翻译：通过使式“IMAGE”的羟基苯甲醛肟与式R 1 -O-SO 2 -OR 1的二烷基硫酸盐反应获得其中R 1表示烷基的式“IMAGE”的已知羟基苯甲醛肟O-醚， III）其中R 1具有上述含义，或与式R 1 X（Ⅳ）的烷基卤化物反应，其中R 1具有上述含义，X表示卤素，在强碱存在下并在0℃至60℃的温度下在稀释剂存在下进行。

18. 发明公开

EP0184256A3 Diphenyl ether herbicides 有权
标题翻译：二苯醚除草剂
公开(公告)号：EP0184256A3
公开(公告)日：1987-05-27
申请号：EP85201914
申请日：1985-11-19
申请人： SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
发明人： Bit, Rino Antonio , Munro, David , Searle, Robert John Griffith
IPC分类号： C07C131/00 , C07D213/53 , C07D307/52 , C07D333/22 , A01N35/10
CPC分类号： C07D213/53 , A01N35/10 , A01N37/50 , A01N37/52 , A01N57/22 , C07D307/52 , C07D333/22 , C07F9/4006
摘要： diphenyl ether derivatives having the general formula:-
wherein n is 1, 2 or 3 and each group A. which may be the same or different when n is greater than 1, represents a halogen atom or a cyano, nitro, alkyl or haloalkyl group; Z represents a halogen atom or a nitro or cyano group; and X and Y, which may be the same or different, each independently represents a hydrogen or halogen atom or an alkyl, cycloalkyl, haloalkyl, alkoxy, alkylthio, acyl, or optionally substituted aryl or heteroaromatic group, or one of X and Y represents one of such groups and the other represents a cyano, carboxyl, alkoxycarbonyl, phosphonic ester or alkylamino group, or X and Y together with the interjacent carbon atom may jointly represent a cycloalkyl group. The preparation of such compounds, Herbicidal compositions containing them and their use as herbicides.

19. 发明公开

EP0207600A3 Phenoxyethylamine derivatives 失效
标题翻译：苯甲酰胺衍生物
公开(公告)号：EP0207600A3
公开(公告)日：1987-05-13
申请号：EP86303502
申请日：1986-05-08
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： Husbands, George Edward Morris
IPC分类号： C07C93/12 , C07C93/24 , C07C103/737 , C07C121/46 , C07C103/19 , C07C79/347 , C07C131/00 , A61K31/13 , A61K31/215
CPC分类号： C07C233/12
摘要： This invention provides a group of hydroxycycloal- kanephenoxyethylamine antidepressant derivatives of the following structural formula:
in which
R, is hydrogen or alkyl of 1 to 6 carbon atoms; R 2 is alkyl of 1 to 6 carbon atoms; R 3 and R 4 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, halo or trifluoromethyl; R 5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkanoyl of 2 to 7 carbon atoms; and n is one of the integers 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof. Also provided are intermediates for compounds of formula lincluding amides, primary amines, nitriles and oximes.

20. 发明公开

EP0127342A3 Process for acylation with novel acylating agent 失效
标题翻译：与新型ACLLENT AGENT进行聚合的方法
公开(公告)号：EP0127342A3
公开(公告)日：1987-04-08
申请号：EP84302958
申请日：1984-05-02
申请人： NITTO BOSEKI CO., LTD.
发明人： Hayashi, Ikuo , Ogihara, Keizo , Itikawa, Tadao , Shimizu, Kiyoshi
IPC分类号： C07C102/00 , C07C103/00 , C07C103/52 , C07C131/00
CPC分类号： C07K5/0823 , A61K38/00 , C07K1/084 , C07K1/10 , C07K5/06086
摘要： This invention relates to a novel acylation process which comprises using as the acylating agent an o-hydroxy-substituted aromatic oxime ester represented by the general formula (I)
and mixing said acylating agent with an amine substance represented by the general formula (III)
to form a compound represented by the general formula (IV)
摘要翻译：本发明涉及一种新的酰化方法，其包括使用由通式（I）表示的邻羟基取代的芳族肟酯作为酰化剂，将所述酰化剂与由通式（III）表示通式（IV）表示的化合物（Ⅳ）

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