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11. 发明公开

EP2334327A1 WEST NILE VIRUS VACCINE 有权转让
标题翻译：疫苗对西方-尼罗河病毒
公开(公告)号：EP2334327A1
公开(公告)日：2011-06-22
申请号：EP09792117.5
申请日：2009-08-31
申请人： Boehringer Ingelheim Vetmedica, Inc.
发明人： HENNESSY, Kristina, J. , HAYES, Philip, W.
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： A61K39/12 , A61K39/08 , A61K39/145 , A61K39/193 , A61K39/245 , A61K2039/521 , A61K2039/5252 , A61K2039/543 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/16034 , C12N2710/16071 , C12N2710/16734 , C12N2760/16134 , C12N2760/16171 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , C12N2770/36134 , C12N2770/36171
摘要： The invention provides for immunogenic compositions against West Nile Virus. The immunogenic compositions, in alternate embodiments, also include other equine pathogens. The West Nile Virus composition of the present invention advantageously provides for protection against North American Dominant West Nile Virus strains or isolates.

12. 发明公开

EP2287288A1 Animal protein free media for cultivation of cells 有权转让
标题翻译： Tellproteinfreies Zellkulturmedium
公开(公告)号：EP2287288A1
公开(公告)日：2011-02-23
申请号：EP10010584.0
申请日：2003-07-08
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Reiter, Manfred , Mundt, Wolfgang , Grillberger, Leopold, Dr. , Kraus, Barbara
IPC分类号： C12N5/00 , C12N5/10 , C12N7/00 , C12P21/00 , C12N5/07
CPC分类号： C12N5/005 , A61K39/12 , A61K39/145 , A61K39/275 , A61K39/285 , C12N5/0043 , C12N7/00 , C12N2500/74 , C12N2500/76 , C12N2710/24134 , C12N2760/16134 , C12N2770/36134 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a methods for producing a virus or an immunogenic composition comprising a virus or virus antigen using a culture of cells that have been grown in an animal protein free medium comprising soy hydrolysate and yeast hydrolysate.
摘要翻译：本发明涉及使用已经在含有大豆水解物和酵母水解产物的无动物蛋白质的培养基中生长的细胞培养物来生产病毒的方法或包含病毒或病毒抗原的免疫原性组合物。

13. 发明公开

EP1647281A3 Formule de vaccin polynucléotidique contre les pathologies du cheval 失效
标题翻译：对马的疾病的多核苷酸疫苗制剂
公开(公告)号：EP1647281A3
公开(公告)日：2009-08-05
申请号：EP05025200.6
申请日：1997-07-15
申请人： MERIAL
发明人： Audonnet, Jean-Christophe , Bouchardon, Annabelle , Riviere, Michel
IPC分类号： A61K39/295 , C12N15/38 , C12N15/44 , C12N15/31
CPC分类号： A61K39/12 , A61K39/145 , A61K39/205 , A61K39/27 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K14/33 , C12N2710/16034 , C12N2710/16122 , C12N2710/16722 , C12N2710/16734 , C12N2760/16122 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134 , C12N2770/36122 , C12N2770/36134
摘要： La présente invention est relative à une formule de vaccin pour équidés, notamment des chevaux, comprenant un ou plusieurs plasmides intégrant, de manière à l'exprimer in vivo dans les cellules au moins un gène codant pour un antigène du virus de l'encéphalite.

14. 发明公开

EP1928898A1 FISH VACCINE 有权
标题翻译： FISH疫苗
公开(公告)号：EP1928898A1
公开(公告)日：2008-06-11
申请号：EP06793552.8
申请日：2006-09-15
申请人： Intervet International B.V.
发明人： BREMONT, Michel , LE BERRE, Monique , MORIETTE, Coralie , VILLOING, Stephane
IPC分类号： C07K14/18 , A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/552 , A61K2039/55566 , C07K2319/00 , C07K2319/21 , C12N2770/36122 , C12N2770/36134
摘要： The present invention relates to veterinary immunology, namely to the immunological response of fish to a virus. More specifically, the invention provides an epitope of salmonid alphaviruses which epitope is capable of inducing a virus neutralising immune response. In particular the invention relates to a polypeptide comprising a certain amino acid sequence, a protein comprising such polypeptide, to a carrier comprising such protein, and to a method of producing antibodies. Further the invention relates to a nucleic acid encoding such polypeptide or such protein, and to a carrier comprising such a nucleic acid. Also, the invention relates to a vaccine and a diagnostic kit comprising such a polypeptide, protein, carrier, or nucleic acid.

15. 发明公开

EP1687033A4 ENHANCEMENT OF VACCINE-INDUCED IMMUNE RESPONSES AND PROTECTION BY HETEROLOGOUS BOOSTING WITH ALPHAVIRUS REPLICON VACCINES 审中-公开
标题翻译：疫苗诱导的免疫应答和保护通过与甲病毒疫苗复制异源增益提高
公开(公告)号：EP1687033A4
公开(公告)日：2008-06-11
申请号：EP04811324
申请日：2004-11-10
申请人： US NAVY , ALPHAVAX INC
发明人： DOOLAN DENISE L , CARUCCI DANIEL , KAMRUD KURT , CHULAY JEFFREY , BRICE GARY , SMITH JONATHAN F
IPC分类号： A61K39/015 , A61K20060101 , A61K39/12 , A61K39/193 , A61K39/275 , A61K48/00 , A61P33/06
CPC分类号： A61K39/12 , A61K39/015 , A61K39/193 , A61K39/275 , A61K48/00 , A61K2039/5258 , A61K2039/541 , A61K2039/545 , C12N2710/24043 , C12N2770/36134 , C12N2770/36143
摘要： The inventive subject matter relates to an immunogenic composition and method of enhancing immunogenicity and protective immunity induced by any subunit or whole organism vaccine or combination of vaccines comprising administering to the subject a priming immunization preparation containing an antigen or fragment thereof, said preparation being selected from the group consisting of: a recombinant virus expression system; a recombinant protein antigen or a recombinant polypeptide; a synthetic peptide; a polynucleotide vector; a whole organism or extract and combinations thereof; and a boosting immunization of at least one alphavirus replicon containing an antigen or fragment thereof. The inventive subject matter further relates to an immunogenic composition and method of inducing an immune response that activates both cellular and humoral arms of the immune system.

16. 发明公开

EP1687033A2 ENHANCEMENT OF VACCINE-INDUCED IMMUNE RESPONSES AND PROTECTION BY HETEROLOGOUS BOOSTING WITH ALPHAVIRUS REPLICON VACCINES 审中-公开
标题翻译：疫苗诱导的免疫应答和保护通过与甲病毒疫苗复制异源增益提高
公开(公告)号：EP1687033A2
公开(公告)日：2006-08-09
申请号：EP04811324.5
申请日：2004-11-10
申请人： The United States of America as Represented by The Secretary of The Navy , Alphavax, Inc.
发明人： DOOLAN, Denise, L. , CARUCCI, Daniel , KAMRUD, Kurt , CHULAY, Jeffrey , BRICE, Gary , SMITH, Jonathan, F.
IPC分类号： A61K48/00
CPC分类号： A61K39/12 , A61K39/015 , A61K39/193 , A61K39/275 , A61K48/00 , A61K2039/5258 , A61K2039/541 , A61K2039/545 , C12N2710/24043 , C12N2770/36134 , C12N2770/36143 , Y02A50/412
摘要： The inventive subject matter relates to an immunogenic composition and method of enhancing immunogenicity and protective immunity induced by any subunit or whole organism vaccine or combination of vaccines comprising administering to the subject a priming immunization preparation containing an antigen or fragment thereof, said preparation being selected from the group consisting of: a recombinant virus expression system; a recombinant protein antigen or a recombinant polypeptide; a synthetic peptide; a polynucleotide vector; a whole organism or extract and combinations thereof; and a boosting immunization of at least one alphavirus replicon containing an antigen or fragment thereof. The inventive subject matter further relates to an immunogenic composition and method of inducing an immune response that activates both cellular and humoral arms of the immune system.

17. 发明授权

EP0936922B1 FORMULE DE VACCIN POLYNUCLEOTIDIQUE CONTRE LES PATHOLOGIES DU CHEVAL 失效
标题翻译：多核苷酸疫苗配方AGAINST HORSE疾病
公开(公告)号：EP0936922B1
公开(公告)日：2005-11-30
申请号：EP97934569.1
申请日：1997-07-15
申请人： MERIAL
发明人： AUDONNET, Jean-Christophe , BOUCHARDON, Annabelle , RIVIERE, Michel
IPC分类号： A61K39/295
CPC分类号： A61K39/12 , A61K39/145 , A61K39/205 , A61K39/27 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K14/33 , C12N2710/16034 , C12N2710/16122 , C12N2710/16722 , C12N2710/16734 , C12N2760/16122 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134 , C12N2770/36122 , C12N2770/36134
摘要： A vaccine formula for treating equine and particularly horse diseases, including at least three polynucleotide vaccine valencies that each include a plasmid containing an equine pathogen valency gene capable of being expressed in vivo in host cells. Said valencies are selected from the group which consists of equine rhinopneumonitis virus EHV, equine influenza virus EIV and tetanus antitoxin. Said plasmids include one or more genes per valency, and said genes are selected from the group which consists of gB and gD for equine rhinopneumonitis virus, HA, NP and N for equine influenza virus, and a gene coding for all or part of subunit C of Cl. tetani.

18. 发明公开

EP1520008A1 ANIMAL PROTEIN FREE MEDIA FOR CULTIVATION OF CELLS 有权转让
标题翻译：无动物蛋白的细胞培养基
公开(公告)号：EP1520008A1
公开(公告)日：2005-04-06
申请号：EP03762657.9
申请日：2003-07-08
申请人： BAXTER INTERNATIONAL INC. , Baxter Healthcare S.A.
发明人： REITER, Manfred , MUNDT, Wolfgang , GRILLBERGER, Leopold , KRAUS, Barbara
IPC分类号： C12N5/00 , C12N5/06 , C12N5/10 , C12N7/00 , C12P21/00
CPC分类号： C12N5/005 , A61K39/12 , A61K39/145 , A61K39/275 , A61K39/285 , C12N5/0043 , C12N7/00 , C12N2500/74 , C12N2500/76 , C12N2710/24134 , C12N2760/16134 , C12N2770/36134 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a methods for producing a virus or an immunogenic composition comprising a virus or virus antigen using a culture of cells that have been grown in an animal protein free medium comprising soy hydrolysate and yeast hydrolysate.

19. 发明公开

EP0936922A1 FORMULE DE VACCIN POLYNUCLEOTIDIQUE CONTRE LES PATHOLOGIES DU CHEVAL 失效
标题翻译：多核苷酸疫苗配方AGAINST HORSE疾病
公开(公告)号：EP0936922A1
公开(公告)日：1999-08-25
申请号：EP97934569.0
申请日：1997-07-15
申请人： MERIAL
发明人： AUDONNET, Jean-Christophe , BOUCHARDON, Annabelle , RIVIERE, Michel
IPC分类号： C12N15 , A61K39 , A61P31 , C07K14
CPC分类号： A61K39/12 , A61K39/145 , A61K39/205 , A61K39/27 , A61K2039/51 , A61K2039/53 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K14/33 , C12N2710/16034 , C12N2710/16122 , C12N2710/16722 , C12N2710/16734 , C12N2760/16122 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134 , C12N2770/36122 , C12N2770/36134
摘要： A vaccine formula for treating equine and particularly horse diseases, including at least three polynucleotide vaccine valencies that each include a plasmid containing an equine pathogen valency gene capable of being expressed in vivo in host cells. Said valencies are selected from the group which consists of equine rhinopneumonitis virus EHV, equine influenza virus EIV and tetanus antitoxin. Said plasmids include one or more genes per valency, and said genes are selected from the group which consists of gB and gD for equine rhinopneumonitis virus, HA, NP and N for equine influenza virus, and a gene coding for all or part of subunit C of Cl. tetani.

20. 发明公开

EP0562136A1 Live vaccine to getah virus infectious disease, and trivalent live vaccine to Japanese encephalitis virus, porcine parvovirus and getah virus infectious diseases 失效
标题翻译：针对病毒感染性疾病盖塔和日本脑炎病毒三价活疫苗，并Schweinparvovirus盖塔病毒活疫苗。
公开(公告)号：EP0562136A1
公开(公告)日：1993-09-29
申请号：EP92105058.9
申请日：1992-03-24
申请人： DIVISION OF MICROBIOLOGY, KYOTO BIKEN LABORATORIES, INC.
发明人： Izumida, Akihiro , Kodama, Kazuo , Kubota, Michio , Matsui, Osamu , Ishida, Yasuhisa
IPC分类号： A61K39/12 , A61K39/23
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N2750/14334 , C12N2770/24134 , C12N2770/36134
摘要： A trivalent live vaccine to Japanese encephalitis virus, porcine parvovirus and Getah virus infectious diseases, which comprises a mixture of (i) a live vaccine to Getah virus infectious disease as created by cultivating an attenuated Getah virus KB/VT strain, as obtained by continuous serial passages of a virulent Getah virus strain in Vero cells to 70 generations at 30°C followed by two times cloning by a plaque method to get purified virus, to HAL cells in such a way that the multiplicity of infection (amount of inoculated viruses/number of cells) is about 0.1; adsorbing the viruses to the cells for 60 minutes at 37 °C; then removing the inoculated viral fluid from the cells; adding a culture medium for cultivation of the viruses thereto; incubating the cells for 48 to 72 hours at 30°C; and, after the cytopathic effect (CPE) has been confirmed to progress to the middle degree or more, collecting the culture medium fluid to obtain an intended living vaccine to Getah virus infectious disease, (ii) a viral fluid as obtained by inoculating an attenuated Japanese encephalitis virus m strain to HmLu-1 cells as admitted to be suitable for propagation of the attenuated Japanese encephalitis virus m strain therewith, and (iii) a viral fluid as obtained by inoculating an attenuated porcine parvovirus HT⁻ /SK strain to swine kidney culture cells as admitted to be suitable for propagation of the attenuated porcine parvovirus HT⁻ /SK strain therewith, in such a proportion that the viral content in each viral fluid in the mixture is almost the same.
摘要翻译：三价活疫苗，以日本脑炎病毒，猪细小病毒和盖塔病毒感染性疾病，通过连续而获得，包括（i）如通过培养上减毒的盖塔病毒KB / VT应变创建的活疫苗，以盖塔病毒感染性疾病，的混合物在30℃，然后两次用噬斑方法克隆在Vero细胞中强毒盖塔病毒株至70代的连续传代来获得纯化的病毒，对HAL细胞在寻求一种方式并感染的接种病毒的多重性（量/ 细胞数）为约0.1; 在37℃下吸附病毒向细胞60分钟; 然后除去从细胞接种的病毒液; 增加了对其的病毒培养的培养基; 温育48至72小时的细胞在30℃; 并且，该致细胞病变效应（CPE）已被证实进步到中间程度以上，收集培养介质液，得到在预期活疫苗，以盖塔病毒感染性疾病，（ⅱ）的病毒液后得到由减毒接种日本脑炎病毒米菌株HmLu-1细胞作为承认其是适合于与减毒日本脑炎病毒米应变那里的传播，和（iii）的病毒液通过减毒猪细小病毒HT的接种而获得< - > / SK应变猪肾培养细胞作为承认其是适合于减毒猪细小病毒HT的传播< - > /斯克·斯特兰那里，在寻求的比例并在混合物中的每病毒流体病毒含量几乎是相同的。

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