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    • 19. 发明公开
    • IMPROVED HYDROGEL SYNTHESIS
    • 改进的水凝胶合成
    • EP2526140A1
    • 2012-11-28
    • EP11705658.0
    • 2011-01-20
    • The University of Reading
    • KHUTORYANSKIY, VitaliyKHUTORYANSKAYA, OlgaCOOK, Joseph PeterGOODALL, Glenn William
    • C08J3/075
    • C08J3/075C08J2329/00C08J2329/04C08J2333/00C08J2339/00
    • The invention provides a method for preparing a hydrogel from a hydrophilic polymer having one or more functional groups which are capable of co-reacting in a condensation reaction which method comprises the steps of: (i) preparing a solution of the polymer; (ii) heating the solution to a temperature sufficient for the condensation reaction to take place for a period of time sufficient for the hydrogel to cross-link wherein where the hydrophilic polymer comprises a first and a second hydrophilic polymer, step (i) comprises a step of mixing the hydrophilic polymers to prepare a homogeneous intimate mixture of the polymers; and wherein the heating step (ii) is carried out at a pressure greater than atmospheric pressure. The method of the invention is advantageous because it is relatively low cost, it is a safer procedure with less health & safety concerns, it is carried out in a liquid state and is not limited by film thickness.
    • 本发明提供了由具有一个或多个能够在缩合反应中共反应的官能团的亲水性聚合物制备水凝胶的方法,该方法包括以下步骤:(i)制备聚合物溶液; (ii)将所述溶液加热至足以使所述缩合反应进行足以使所述水凝胶交联的时间,其中在所述亲水聚合物包含第一亲水性聚合物和第二亲水性聚合物的情况下,步骤(i)包含 混合亲水性聚合物以制备聚合物的均匀紧密混合物的步骤; 并且其中所述加热步骤(ii)在高于大气压的压力下进行。 本发明的方法是有利的,因为它成本相对较低,它是一种更安全的程序,具有较少的健康和安全问题,它以液态进行并且不受薄膜厚度的限制。