专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明公开

EP2168972A2 Preparation and use of carbohydrate-based ring structures with antimicrobial and cytostatic activity 审中-公开
标题翻译：生产和使用具有抗微生物和细胞毒活性碳水化合物基的环结构的
公开(公告)号：EP2168972A2
公开(公告)日：2010-03-31
申请号：EP09160439.7
申请日：2002-10-15
申请人： Kemin Pharma Europe
发明人： Sas, Benedikt , Van Der Eycken, Johan , Van Hemel, Johan , Blom, Petra , Vandenkerckhove, Jan , Ruttens, Bart
IPC分类号： C07H9/02 , C07H9/06 , A61K31/7052 , A61K31/7048 , A61P31/04 , A61P31/12 , A61P35/00 , C07H15/207 , C07H5/10 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203 , A61K31/351 , A61K31/357 , C07D309/16 , C07D319/08
CPC分类号： C07H15/10 , C07D309/10 , C07D493/04 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203
摘要： A compound of the formula :

wherein
R 1 is -H, -SPh, -Ph, -allyl or -benzyl;
R 2 is -H, -Et, -allyl, -Me or -benzyl;
R 3 is -H, -Et, -Me, -allyl or -benzyl; and
R 4 and R 5 are both -OH or R 4 and R 5 together form a ring and are -OCH(Ph)O- ;

or a pharmaceutically active derivative thereof.
Pharmaceutical compositions comprising the above compounds and their use in therapy are also provided.
摘要翻译：式的化合物：worin R 1为-H，-SPh，-Ph，烯丙基或苄基; R 2为-H，ET，烯丙基，苄基或-Me; R 3为-H，-Et，-Me，烯丙基或苄基; 且R 4和R 5均为-OH或R 4和R 5一起形成环，且为-OCH（PH）O-; 或其药学活性衍生物。因此，提供含有上述化合物和它们在治疗中使用的药物组合物。

12. 发明授权

EP1305284B1 PROCESS AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PYRROLIDINES 有权
标题翻译：过程和中间产品用于制备吡咯烷
公开(公告)号：EP1305284B1
公开(公告)日：2008-11-12
申请号：EP01935453.9
申请日：2001-05-14
申请人： Michigan State University
发明人： HOLLINGSWORTH, Rawle, I.
IPC分类号： C07D207/00 , C07D305/12 , C07D307/62 , C07D207/26 , C07C69/716 , C07H7/02
CPC分类号： C07D207/273 , C07C69/716 , C07D207/12 , C07H7/02
摘要： Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.

13. 发明公开

EP1585529A2 PROCESS FOR THE PRODUCTION OF 2'-BRANCHED NUCLEOSIDES 审中-公开
标题翻译：用于生产2'-了支链核苷
公开(公告)号：EP1585529A2
公开(公告)日：2005-10-19
申请号：EP03812993.8
申请日：2003-12-12
申请人： Idenix (Cayman) Limited
发明人： STORER, Richard , MOUSSA, Adel , CHAUDHURI, Narayan , WALIGORA, Frank
IPC分类号： A61K31/7072 , C07H19/067
CPC分类号： C07H1/00 , C07H7/02 , C07H19/06 , C07H19/16 , Y02P20/55
摘要： The present invention provides an improved process for preparing ß-D and ß-L 2'-C-methyl-nucleosides and 2'-C-methyl-3'-O-ester nucleosides.

14. 发明公开

EP0944639A4 SYNTHETIC GLYCOAMINES, METHODS FOR THEIR USE THAT AFFECT CELL 失效
标题翻译：合成CYCLO胺中的方法使用细胞而影响
公开(公告)号：EP0944639A4
公开(公告)日：2005-09-28
申请号：EP97949612
申请日：1997-11-24
申请人： GLINSKII GUENNADI V
发明人： GLINSKII GUENNADI V
IPC分类号： A61K38/00 , A61K31/70 , A61K31/7056 , A61P35/00 , A61P43/00 , C07G3/00 , C07H7/02 , C07H13/04 , C07H15/04 , C07H15/12 , C07K5/00 , C12N9/00 , C07H5/04
CPC分类号： A61K31/70 , A61K31/7008 , A61K31/7016 , A61K31/7024 , A61K31/7056 , C07H7/02 , C07H13/04 , C07H15/04 , C07H15/12
摘要： A class of molecules and methods that alter cell adhesion, inhibit cancer metastasis, and induce apoptosis. A method according to the present invention comprises bringing cells into contact with compounds that essentially consist of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a compound chosen from the group consisting of Schiff bases, N-glycosides, esters, and Amadori products. The carbohydrate is preferably a monosaccharide or a small digosaccharide. The carbohydrate and amino acid sub-units may be chemically modified. For example, the amino acid may be modified by covalently bonding other groups to the amino group, carboxyl group, or side chain group of the amino acid. The carbohydrate sub-unit is preferably a pentose such as arabinose, xylose, ribose, ribulose, a hexose such as fructose, deoxyfructose, galactose, glucose, mannose, tagatose, rhamnose, or a disaccharide based on two of the above such as maltose, lactose, maltulose, or lactulose.

15. 发明公开

EP1446391A2 PREPARATION AND USE OF CARBOHYDRATE-BASED RING STRUCTURES WITH ANTIMICROBIAL AND CYTOSTATIC ACTIVITY 审中-公开
标题翻译：生产和具有抗微生物和环形结构的使用碳水化合物为主生长抑制作用
公开(公告)号：EP1446391A2
公开(公告)日：2004-08-18
申请号：EP02770578.9
申请日：2002-10-15
申请人： Kemin Pharma Europe
发明人： SAS, Benedikt , VAN DER EYCKEN, Johan , VAN HEMEL, Johan , BLOM, Petra , VANDENKERCKHOVE, Jan , RUTTENS, Bart
IPC分类号： C07D267/22 , A61K31/355 , A61P43/00
CPC分类号： C07H15/10 , C07D309/10 , C07D493/04 , C07H7/02 , C07H7/04 , C07H9/04 , C07H15/203
摘要： Novel carbohydrate-based compounds with an attached ring system that have antimicrobial or cytostatic activity. The compounds are administered to humans and animals for the treatment or amelioration of bacterial, fungal, viral or protozoal infections or tumors. The compounds are of the the general Formula (I).

16. 发明公开

EP1062362A1 LEVO-MONOSACCHARIDE IN A NUCLEOSIDE ANALOG FOR USE AS AN ANTIRETROVIRAL AGENT 审中-公开
标题翻译：含有核苷类似物L-单糖作为抗逆转录病毒AGENS
公开(公告)号：EP1062362A1
公开(公告)日：2000-12-27
申请号：EP99907037.8
申请日：1999-02-16
申请人： Promelas Research Corporation
发明人： TILLMAN, Timothy, N. , THOMPSON, Daryl, L. , RAFOOL, Gordon, J.
IPC分类号： C12Q1/68 , C12N7/00 , C12N15/00 , C12N15/11 , C07H21/04 , A61K48/00
CPC分类号： A61K31/7052 , C07H7/02 , C07H19/06 , C07H19/16
摘要： An antiretroviral composition for inhibiting the action of reverse transcriptase includes a nucleoside analog containing a six-carbon levo hexose sugar, for example, L-rhamnose or L-fucose. Treatment is achieved by delivering the antiretroviral to the infected system, wherein the reverse transcription process is inhibited via steric hindrance, halting the viral RNA replication. Delivery may be accomplished by conventional methods, such as via oral dosing or injection. Additional delivery methods are also contemplated, including packaging in liposomes and protein targeting. The composition and method are also useful for inhibiting the proliferation of cancer cells by halting the transcription process.

17. 发明授权

EP0531642B1 Antibiotic LL-E19020 Zeta and LL-E 19029 Eta 失效
标题翻译：抗生素LL-E19020泽塔和抗生素LL-E19020埃塔
公开(公告)号：EP0531642B1
公开(公告)日：1997-05-21
申请号：EP92110975.7
申请日：1992-06-29
申请人： F. HOFFMANN-LA ROCHE AG
发明人： Carter, Guy Thomas , Williams, David R. , Korshalla, Joseph D.
IPC分类号： C07H7/02 , C12P19/02 , A61K31/71
CPC分类号： C07H15/26 , C07H7/02 , C12P19/00 , C12P19/02

18. 发明公开

EP0772617A1 7-O-CARBAMOYL-HEPTOSE-DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG, UND DEREN VERWENDUNG SOWIE SCREENING-VERFAHREN ZU DEREN BESTIMMUNG 失效
标题翻译： 7-O-carbamoylheptose衍生物，METHOD FOR THEIR，它们的用途和筛选方法用于确定
公开(公告)号：EP0772617A1
公开(公告)日：1997-05-14
申请号：EP95926894.0
申请日：1995-07-14
申请人： Forschungsinstitut Borstel Institut für Experimentelle Biologie und Medizin
发明人： ZÄHRINGER, Ulrich , BECKMANN, Frank , MOLL, Hermann
IPC分类号： C07H7 , A61K31 , A61P31 , C07H3 , C07H15
CPC分类号： C07H3/04 , C07H7/02 , G01N2333/21 , G01N2400/50
摘要： The invention describes 7-O-carbamoyl heptose derivatives of general formula (I) in which R is the substituent R1 or a group of general formula (II) in which R1 is a hydrogen atom, a methyl group or a suitable linker substituent suitable for a covalent coupling, a process for their production and their use in producing reagents and compositions for the diagnosis and therapy of pseudomona infections in humans and animals, and a screening process for their detection in Gram-negative bacteria.

19. 发明公开

EP0731704A1 SYNTHETIC GLYCOAMINES THAT PROMOTE OR INHIBIT CELL ADHESION 失效
标题翻译：合成葡萄糖胺的ZELLADHÄDION促进或抑制
公开(公告)号：EP0731704A1
公开(公告)日：1996-09-18
申请号：EP95923854.0
申请日：1995-06-12
申请人： METASTAT, INC. , Glinskii, Guennadi, V.
发明人： GLINSKII, Guennadi V.
IPC分类号： A61K31 , C07H7 , C07H13 , C07H15
CPC分类号： A61K31/7008 , A61K31/70 , A61K31/7016 , A61K31/7024 , A61K31/7056 , C07H7/02 , C07H13/04 , C07H15/04 , C07H15/12
摘要： A class of molecules that alter cell adhesion. A cell adhesion affector according to the present invention essentially consists of an amino acid linked to a carbohydrate wherein the amino acid and the carbohydrate are linked to form a compound chosen from the group consisting of Schiff bases, N-glycosides, esters, and Amadori products. The carbohydrate is preferably a monosaccharide or a small oligosaccharide. The carbohydrate and amino acid sub-units may be chemically modified. For example, the amino acid may be modified by covalently bonding other groups to the amino group, carboxyl group, or side chain group of the amino acid. The carbohydrate sub-unit is preferably a pentose such as arabinose, xylose, ribose, ribulose, a hexose such as fructose, deoxyfructose, galactose, glucose, mannose, tagatose, rhamnose, or a disaccharide based on two of the above such as maltose, lactose, maltulose, or lactulose.

20. 发明公开

EP0629633A2 Dinucleotide analogues, intermediates therefor and oligonucleotides derived therefrom 失效
标题翻译： Dinukleotidanaloga，Zwischenproduktehierfürund daraus abgeleitete寡核苷酸。
公开(公告)号：EP0629633A2
公开(公告)日：1994-12-21
申请号：EP94303883.6
申请日：1994-05-27
申请人： CIBA-GEIGY AG
发明人： Baxter, Anthony David , Baylis, Eric Keith , Collingwood, Stephen Paul , Taylor, Roger John , Weetman, John
IPC分类号： C07H21/00 , C07H19/04 , A61K31/70
CPC分类号： C07H9/04 , C07F9/5304 , C07F9/65586 , C07H7/02 , C07H15/18 , C07H19/06 , C07H21/00 , C07H21/02 , C07H21/04 , Y02P20/55
摘要： A compound of formula

where R 1 is hydrogen, R 1 a or a group of formula

R 1 a is R l b or a protecting group Q,
R 1 b is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 3 -C 10 cycloalkyl, C 6 -C 15 aryl, C 7 -C 16 aralkyl or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom,
R 2 is an unsubstituted or substituted C 1 -C 20 alkyl or C 2 -C 20 alkenyl group, an unsubstituted or substituted C 3 -C 10 cycloalkyl group, an unsubstituted or substituted C 6 -C 15 aryl group, an unsubstituted or substituted C 7 -C 16 aralkyl group, or a 5- or 6- membered heterocyclic group attached by a carbon atom in the heterocyclic group to the indicated phosphorus atom,
R 3 is hydrogen, halogen, hydroxy, R 15 , -OR 15 or -OSO 2 R 15
R 4 is R 4 a or together with R 6 denotes a valence bond,
R 4 a is hydrogen, halogen or R 16 ,
R 5 is hydrogen, halogen, hydroxy, R 17 , -OR 17 , -OCOR 17 or -OSO 2 R 17 ,
R 6 is hydrogen, halogen or R 18 , or together with R 4 denotes a valence bond,
R 7 is hydrogen, alkyl-N, N-dialkylphosphoramidyl or R 7 a , or R 7 0- together with R 8 a denotes a C 1 -C 15 hydrocarbylidenedioxy group,
R 7 a is R 19 , -COR 19 , -SO 2 R 19 or tri(C 1 -C 15 hydrocarbyl)silyl,
R 8 is R 8 a or Z,
R 8 a is hydrogen, halogen, hydroxy, R 20 , -OR 20 , -OCOR 20 , -OSO 2 R 20 , or tri(C 1 -C 15 hydrocarbyl)silyloxy, or together with R 9 denotes a C 1 -C 15 hydrocarbylidenedioxy group, or together with R 7 0- denotes a C 1 -C 15 hydrocarbylidenedioxy group,
R 9 is halogen, hydroxy, -OR 21 , -OCOR 21 , -OSO 2 R 21 , or B 2 , or together with R 8 a denotes a C 1 -C 15 hydrocarbylidenedioxy group,
R 10 is hydrogen or R 10 a ,
R 10 a is R 22 , -COR 22 , -SO 2 R 22 or tri(C 1 -C 15 hydrocarbyl)silyl,
R 11 is hydrogen, halogen, hydroxy, R 23 , -OR 23 , -OCOR 23 , -OSO 2 R 23 or Z,
R 12 is hydrogen, halogen or R 24 ,
R 13 is R 13 a or Z,
R 13 a is hydrogen, halogen, hydroxy, R 25 , -OR 25 , -OCOR 25 , -OSO 2 R 25 , or tri(C 1 -C 15 hydrocarbyl)silyloxy, or together with R 14 denotes a C 1 -C 15 hydrocarbylidenedioxy group,
R 14 is halogen, hydroxy, -OR 26 , -OCOR 26 , -OSO 2 R 26 , or B l , or together with R 13 a denotes a C 1 -C 15 hydrocarbylidenedioxy group,
R 15 , R16 , R17 , R18 , R19 R 20, R 21, R 22, R 23, R 24 , R 25 and R 26 are independently a C 1 to C 10 aliphatic group, a C 3 to C 10 cycloaliphatic group, a C 6 to C 15 aromatic group or a C 7 -C 30 araliphatic group,
B 1 and B 2 are independently each a monovalent nucleoside base radical, and
Z is substituted or unsubstituted C 6 -C 10 aryloxythiocarbonyloxy; provided that compounds where simultaneously R 1 , R 3 , R 4 and R 6 are hydrogen, R 2 is isopropyl, R 5 is methoxy, R 7 is methyl, R 8 and R 9 are each hydroxy or each acetoxy or R 8 and R 9 together denote isopropylidenedioxy, compounds where simultaneously R 1 , R 3 , R 4 and R 6 are hydrogen, R 2 is butyl, R 5 is methoxy, R 7 is benzyl, R 8 and R 9 are each hydroxy or each acetoxy or R 8 and R 9 together denote isopropylidenedioxy, and compounds where simultaneously R 1 , R 3 , R 4 , R 5 , R 6 and R 7 are hydrogen, R 2 is phenyl and R 8 and R 9 together denote isopropylidenedioxy are excluded.
摘要翻译：式的化合物，其中R 1是氢，R 1a或式 R 1a的基团是R 1b或保护基Q，R 1b 是C 1 -C 20烷基，C 2 -C 20烯基，C 3 -C 10环烷基，C 6 -C 15芳基，C 7 -C 16芳烷基或通过杂环基中的碳原子与所指示的磷原子连接的5-或6-元杂环基， R 2是未取代或取代的C 1 -C 20烷基或C 2 -C 20烯基，未取代或取代的C 3 -C 10环烷基，未取代或取代的C 6 -C 15芳基，未取代或取代的C 7 -C 16芳烷基，或由杂环基中的碳原子连接到所指示的磷原子上的5或6元杂环基，R 3是氢，卤素，羟基，R 5，-OR 1， R 5或-OSO 2 R 5 R 4是R 4或a与R 6一起代表价键，R 4是氢，卤素或R 1' R 5是氢，卤素，羟基，R 1-7，-OR 1 7，-OCOR 1或7 -OSO 2 R 1，R 6 >是氢，卤素或R 1 <8 >，或与R 4一起表示价键，R 7是氢，烷基-N，N-二烷基磷酰胺基或R 7a，或R 7 O-与R 8一起代表a C 1 -C 15亚烷基二氧基，R 7是R 9，-COR 1 9，-SO 2 R 1 9或三（C 1 -C 15烃基）甲硅烷基， R 8是R 8 a或Z，R 8是氢，卤素，羟基，R 2，-OR 2，-OCOR 2， - 或者三（C 1 -C 15烃基）甲硅烷氧基，或与R 9一起表示C 1 -C 15烃亚基二氧基，或与R 7一起代表C 1 -C 15亚烃基二氧基， R 9是卤素，羟基，-OR 2，-OCOR 2，-OSO 2 R 2，或B 2，或与R 8 a一起表示C1-C15烃基亚二氧基，R 1是氢或R 1，a，R 1a，R 2，R 2，-COR 2， 2，-SO 2 R 2或3（C 1 -C 15烃基）甲硅烷基，R 1是氢，卤素，羟基，R 2，-OR 2， >，-OCOR 2，3，-OSO 2 R 2或Z，R 1，R 2，R 2，R 3，R 4，R 5， R 1 a或Z，R 1'3是氢，卤素，羟基，R 2， OR 2 <5>，-OCOR 2，5-OSO 2 R 2或3（C 1 -C 15烃基）甲硅烷氧基，或与R 1一起表示C1- C 15烃亚基二氧基，R 1 4是卤素，羟基，-OR 2，-OCOR 2，6，-OSO 2 R 2，或B 1，或与R 1'3一起，a表示C 1 -C 15烃基亚二氧基，R 1，R 5，R 1，R 6，R 17，R 18， R 1，R 2，R 2，R 2，R 2，R 2，R 2， 2 <5>和R 2 <6>独立地为C 1至C 10脂族基团，C 3至C 10脂环族基团，C 6至C 15芳族基团或C 7 -C 30芳脂基基团，B 1和B 2， 2>各自独立地为一价核苷碱基，Z为取代或未取代的C6-C10芳氧基硫代羰基氧基; 条件是其中R 1，R 3，R 4和R 6同时为氢，R 2为异丙基，R 5为甲氧基，R 7为甲基， 8>和R 9各自为羟基或每个乙酰氧基，或R 8和R 9一起表示异丙二烯基，其中R 1，R 3，R 4和R 6同时为氢，R 2是丁基，R 5是甲氧基，R 7是苄基，R 8和R 9各自是羟基或每个乙酰氧基或R 8和R 9共同表示异丙烯二氧基和其中R 1，R 3，R 4，R 5，R 6和R 7同时为氢的化合物，R 2为苯基，R 8和 R 9一起表示异亚丙二氧基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式