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11. 发明公开

EP4355302A1 COMPOSITIONS FOR TREATMENT OF VAGINAL ATROPHY 审中-实审
公开(公告)号：EP4355302A1
公开(公告)日：2024-04-24
申请号：EP22824433.1
申请日：2022-06-12
申请人： INNOCAN PHARMA LTD.
发明人： AVRAM, Nir
IPC分类号： A61K9/00 , A61K31/352 , A61K31/715 , A61K31/716 , A61K31/728 , A61K36/00 , A61P15/00 , A61P15/02
CPC分类号： A61P15/00 , A61K31/716 , A61K31/728 , A61P15/02 , A61K31/352 , A61K36/185 , A61K36/48 , A61K31/05 , A61K9/0034

12. 发明公开

EP4353713A1 T-TYPE CALCIUM CHANNEL BLOCKER 审中-实审
公开(公告)号：EP4353713A1
公开(公告)日：2024-04-17
申请号：EP22820195.0
申请日：2022-06-06
申请人： Kinki University , National University Corporation University Of Toyama , Fuso Pharmaceutical Industries, Ltd.
发明人： KAWABATA, Atsufumi , SEKIGUCHI, Fumiko , TOYOOKA, Naoki , OKADA, Takuya , NISHIKAWA, Hiroyuki
IPC分类号： C07D235/26 , A61K31/4184 , A61K31/454 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00
CPC分类号： A61K31/4184 , A61K31/454 , A61P3/10 , A61P9/00 , A61P13/10 , A61P13/12 , A61P15/00 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/04 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P35/00 , A61P43/00 , C07D235/26 , C07D401/04
摘要： The present invention provides a compound of formula (I) :

wherein R1, R2, R3, R4, k, 1, m and n are as defined in the specification,
or a pharmaceutically acceptable salt thereof with the effect of inhibiting T-type calcium channels and a medicament useful for the treatment of a disease associated with the activation of T-type calcium channels.

13. 发明公开

EP3384930A1 COMPOSITIONS FOR USE IN TREATING HEAVY MENSTRUAL BLEEDING 无效
公开(公告)号：EP3384930A1
公开(公告)日：2018-10-10
申请号：EP18171240.7
申请日：2014-03-14
申请人： AbbVie Inc.
发明人： CHWALISZ, Kristof , WILLIAMS, Laura , JAIN, Rita , NORTH, Janine , NG, Wing-Keung Juki
IPC分类号： A61K45/06 , A61K31/513 , A61K31/565 , A61K31/57 , A61P15/00 , A61K35/00
CPC分类号： A61K31/513 , A61K31/565 , A61K31/57 , A61K45/06 , A61P15/00 , A61K2300/00
摘要： The present invention relates to the method of treating heavy menstrual bleeding in a subject with or without uterine fibroids and in need of treatment by administering an effective amount of 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof, in combination with estrogens and progestogens.

14. 发明公开

EP3384913A1 SELECTIVE PROGESTERONE RECEPTOR MODULATORS AND STABILIZED ESTROGEN LEVEL IN PATIENT 审中-公开
公开(公告)号：EP3384913A1
公开(公告)日：2018-10-10
申请号：EP17164666.4
申请日：2017-04-03
申请人： Bayer Pharma Aktiengesellschaft
发明人： Schultze-Mosgau, Marcus-Hillert
IPC分类号： A61K31/57 , A61K38/09 , A61K31/505 , A61P5/34 , A61P15/00 , A61P15/12
CPC分类号： A61K31/57 , A61K31/505 , A61K38/09 , A61P5/34 , A61P15/00 , A61P15/12 , A61K2300/00
摘要： The present invention is related to Selective Progesterone Receptor Modulators (SPRM) as described and defined herein, and covers the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of sexual hormone dependent diseases in particular Endometriosis or Uterine Fibroids (UF), as a sole agent or in combination with other active ingredients wherein circulating endogenous estrogen concentration of treated women is maintained to a level in a range of 40 pg/mL to 85 pg/mL.

15. 发明公开

EP3368051A1 GENERATING HPV ANTIGEN-SPECIFIC T CELLS FROM A NAIVE T CELL POPULATION 审中-公开
公开(公告)号：EP3368051A1
公开(公告)日：2018-09-05
申请号：EP16861028.5
申请日：2016-10-31
申请人： Children's National Medical Center
发明人： BOLLARD, Catherine, M. , CRUZ, Conrad , HANLEY, Patrick, J.
IPC分类号： A61K35/12 , A61P37/04 , C12N5/0783 , C12N5/0784
CPC分类号： C12N5/0636 , A61K35/17 , A61P15/00 , A61P31/00 , A61P37/04 , C07K14/5412 , C07K14/5418 , C07K14/5434 , C07K14/5443 , C07K14/55 , C07K14/70514 , C07K14/70517 , C07K14/70521 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/59 , C12N2502/1121 , C12N2502/1157
摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.

16. 发明公开

EP3302513A1 COMPOSITION AND USES THEREOF 审中-公开
标题翻译：组合物和用途
公开(公告)号：EP3302513A1
公开(公告)日：2018-04-11
申请号：EP15892804.4
申请日：2015-07-14
申请人： Arborvitae Health And Wellbeing Pty. Ltd.
发明人： DAVIDSON, Victor Patrick
IPC分类号： A61K36/886 , A61K36/15 , A61K38/48
CPC分类号： A61K38/4873 , A61K9/0053 , A61K9/0095 , A61K31/155 , A61K36/15 , A61K36/886 , A61K47/02 , A61K47/12 , A61K47/46 , A61P1/16 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/06 , A61P19/02 , A61P37/02 , C12Y304/22002 , A61K2300/00
摘要： The invention relates to compositions comprising Pinus pinaster stem bark extract, papain, and Aloe vera extract, and methods of manufacturing same. There are also described methods of treating or preventing a variety of conditions, including treating or preventing elevated blood glucose, pre-diabetes, type 2 diabetes, autoimmune diseases, reducing or decreasing inflammation, treating or preventing diseases characterised by elevated levels of inflammation, and lowering blood cholesterol, said methods comprising administering an effective amount of a composition according to the invention to a subject in need thereof. Uses of the composition of the invention for the manufacture of a medicament for treating or preventing a variety of conditions are also described.

17. 发明公开

EP3194386A2 SGC STIMULATORS 无效转让
标题翻译： SGC刺激剂
公开(公告)号：EP3194386A2
公开(公告)日：2017-07-26
申请号：EP15778428.1
申请日：2015-09-16
申请人： Ironwood Pharmaceuticals, Inc.
发明人： RENNIE, Glen Robert , PERL, Nicholas , MERMERIAN, Ara , JUNG, Joon , JIA, James , IYENGAR, Rajesh R. , IM, G-Yoon Jamie , BARDEN, Timothy Claude , SHEPPECK, James Edward , RENHOWE, Paul Allan , NAKAI, Takashi , LEE, Thomas Wai-Ho , IYER, Karthik
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4155 , A61P9/08 , A61P37/06
CPC分类号： C07D487/04 , A61P9/10 , A61P15/00 , A61P29/00 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.
摘要翻译：本专利申请公开了至少如下所示的根据式I'的化合物或其药学上可接受的盐，其中环D，环A，环E，JB，n，JD，J，X，Z，Z 1 ，RC1，RC2，Y，R9，o和W如本文所定义。

18. 发明公开

EP2926821A1 COMPOSITIONS TO SUPPORT TISSUE INTEGRATION AND INOSCULATION OF TRANSPLANTED TISSUE AND TRANSPLANTED ENGINEERED PENILE TISSUE WITH ADIPOSE STROMAL CELLS 有权转让
标题翻译： FOR组织整合支持和移植的组织移植接种组合物和养殖阴茎织物基质FAT COVER
公开(公告)号：EP2926821A1
公开(公告)日：2015-10-07
申请号：EP15164924.1
申请日：2010-03-05
申请人： Tissue Genesis, Inc.
发明人： Williams, Stuart, K. , Paek, Hyun, Joon , Vossman, Erik , Hoying, James Beatty
IPC分类号： A61K35/28 , A61K35/44 , A61K35/48 , A61K35/12 , A61K35/33
CPC分类号： A61K35/48 , A61K35/28 , A61K35/33 , A61K35/44 , A61P15/00 , A61P41/00
摘要： The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells.
Another aspect provides a composition comprising an engineered corpus cavernosum tissue comprising SVF cells and corpus cavernosum cells, wherein the SVF cells can be mixed with or encasing the corpus cavernosum cells, and methods of uses thereof, for example in method for the treatment of impotence and erectile dysfunction and/or enhance or contruct a penis. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors.
摘要翻译：本发明基因的反弹涉及方法，组合物及其用途用于增强组织或细胞移植用于移植的血管形成进入受试者。特别地，本发明的一个方面提供了一种方法和组合物包括使用基质血管级分（SVF）细胞群的封装或围绕组织或细胞移植，以增强组织或细胞移植的血管形成。本发明的另一个方面提供了通过SVF细胞群与组织或细胞移植的组合，以形成具有SVF细胞混合移植增强的组织或细胞移植的血管形成的方法和组合物。另一个方面提供了一种组合物工程化海绵体组织的包含含有SVF细胞和海绵体细胞，worin的SVF细胞可以用或包住阴茎海绵体细胞混合，以及它们的用途的方法，例如在方法阳萎的治疗和勃起功能障碍和/或增强或contruct阴茎。在一些实施方案中，SVF细胞可以是一般性地改造成分泌的治疗性蛋白或促血管生成因子。

19. 发明公开

EP4422612A1 METHODS OF TREATING ENDOMETRIOSIS AND OTHER NON-CANCER GYNECOLOGICAL DISORDERS WITH HEMP EXTRACT 审中-公开
公开(公告)号：EP4422612A1
公开(公告)日：2024-09-04
申请号：EP22821790.7
申请日：2022-10-26
申请人： The University of Newcastle , Ecofibre USA Inc.
发明人： CAPANO, Alexandra M. , TANWAR, Pradeep Singh , NANCE, Alex
IPC分类号： A61K31/05 , A61K31/192 , A61K31/337 , A61K31/555 , A61K36/185 , A61P15/00
CPC分类号： A61P15/00 , A61K36/185 , A61K31/658 , A61K45/06 , A61K31/01 , A61K31/352 , A61K31/015

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