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11. 发明公开

EP1888765A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF VENOUS THROMBOEMBOLIC DISEASE 审中-公开
标题翻译：方法和组合物诊断静脉疾病血栓栓塞
公开(公告)号：EP1888765A2
公开(公告)日：2008-02-20
申请号：EP06784711.1
申请日：2006-06-09
申请人： Biosite Incorporated
发明人： MCPHERSON, Paul, H. , BUECHLER, Kenneth, F.
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/00 , G01N33/543
CPC分类号： G01N33/6893 , G01N2333/58 , G01N2800/226
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such conditions.

12. 发明公开

EP1794588A2 METHODS AND COMPOSITIONS FOR MEASURING CANINE BNP AND USES THEREOF 审中-公开
标题翻译：用于测量狗和方法和组合物及其用途BNP
公开(公告)号：EP1794588A2
公开(公告)日：2007-06-13
申请号：EP05794898.6
申请日：2005-09-07
申请人： Biosite Incorporated
发明人： BUECHLER, Kenneth, F. , BUECHLER, Joseph
IPC分类号： G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： G01N33/6848 , C07K16/26 , C07K2317/622 , G01N33/54313 , G01N33/582 , G01N33/6854 , G01N33/6887 , G01N33/6893 , G01N33/74 , G01N2333/72 , G01N2800/325
摘要： The present invention describes compositions and methods designed to determine the presence or amount of BNP or fragments thereof in a sample. In particular, the invention provides materials that may be configured to bind canine BNP in a sandwich assay format. The present invention provides, inter alia, assays designed to rapidly and accurately measure BNP-related species in non-human animals.

13. 发明授权

EP1019724B1 DIAGNOSTIC TESTS AND KITS FOR CLOSTRIDIUM DIFFICILE 失效
标题翻译：诊断测试和试剂盒，艰难梭菌
公开(公告)号：EP1019724B1
公开(公告)日：2006-09-13
申请号：EP98918009.6
申请日：1998-04-03
申请人： Biosite Incorporated
发明人： VALKIRS, Gunars, E.
IPC分类号： G01N33/554 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/545 , G01N33/549 , G01N33/553 , C12Q1/32 , C12Q1/68 , G01N33/569 , G01N33/573
CPC分类号： G01N33/56911 , C12Q1/32 , G01N33/573 , Y10S435/973 , Y10S436/808 , Y10S436/811
摘要： This invention provides method, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile detection that involve assaying for both C. difficile glutamate dehydrogenase and C. difficile toxin A or toxin B. In another embodiment, the invention provides a highly sensitive assay for C. difficile toxin A that is useful for determining whether a C. difficile strain is toxigenic. This embodiment involves binding of toxin A to a moiety that reversibly binds to capture moiety present on a magnetic bead. A magnetic field is applied to the sample to concentrate the toxin A, after which the magnetic beads are dissociated and removed from the solution to obtain a highly concentrated preparation of toxin A, thus making possible a very sensitive assay.

14. 发明授权

EP1046028B1 IMMUNOASSAY FLUOROMETER 有权
标题翻译：荧光免疫测定
公开(公告)号：EP1046028B1
公开(公告)日：2005-10-26
申请号：EP98963919.0
申请日：1998-12-15
申请人： Biosite Incorporated
发明人： BUECHLER, Kenneth, F. , ANDERBERG, Joseph, M. , MCPHERSON, Paul, H.
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , Y10T436/112499 , Y10T436/115831
摘要： A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

15. 发明公开

EP1555328A2 Recombinant library screening methods 失效
标题翻译：重组文库筛选方法
公开(公告)号：EP1555328A2
公开(公告)日：2005-07-20
申请号：EP05075052.0
申请日：1991-05-01
申请人： Biosite Incorporated
发明人： Dower, William J. , Cwirla, Steven E.
IPC分类号： C12Q1/70 , G01N33/53 , C12N7/00 , C07K16/00 , C12N1/21
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C12N15/1037
摘要： Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vector, or into a sequence encoding a protein which may be linked by means of a ligand to a phage coat protein. By employing affinity purification techniques the phage particles containing sequences encoding the desired protein may be selected and the desired nucleotide sequences obtained therefrom. Thus, for example, novel proteins such as monoclonal antibodies may be produced and conventional hybridoma technology avoided.
摘要翻译：使用噬菌体从DNA文库中分离编码感兴趣蛋白质的核苷酸序列以将蛋白质连接至编码它的序列。从编码感兴趣的蛋白质的细胞制备DNA文库，并将其插入噬菌体载体的外壳蛋白或其附近，或插入编码可通过配体连接至噬菌体外壳蛋白的蛋白质的序列中。通过采用亲和纯化技术，可以选择含有编码所需蛋白质的序列的噬菌体颗粒，并从中获得所需的核苷酸序列。因此，例如，可以生产新的蛋白质如单克隆抗体，并避免常规的杂交瘤技术。

16. 发明公开

EP2156187A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND/OR PROGNOSIS OF OVARIAN CANCER AND LUNG CANCER 审中-公开
标题翻译：方法和组合物用于诊断和/或预后卵巢癌和肺癌
公开(公告)号：EP2156187A1
公开(公告)日：2010-02-24
申请号：EP08771054.7
申请日：2008-06-13
申请人： Biosite Incorporated
发明人： RODEMS, Kelline, M. , OELSCHLAGER, David, W. , VEERAMALLU, Uday, Kumar , BUECHLER, Joseph
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/57449 , G01N33/57423 , G01N2333/4703
摘要： Methods and compositions for diagnosis, prognosis and monitoring of ovarian cancer and lung cancer are provided. Assays that detect NHERF-I (or one or more markers related thereto) and NHERF-I -containing complexes are used to assign a diagnosis to a subject being assessed for the presence of ovarian or lung cancer; assign a prognostic risk to a subject suffering from ovarian or lung cancer; or monitor the course of ovarian or lung cancer treatment in a subject.

17. 发明授权

EP1236514B1 Devices incorporating filter with region-specific compression 失效
标题翻译：含过滤装置用于过滤流体样本
公开(公告)号：EP1236514B1
公开(公告)日：2009-11-18
申请号：EP02077188.7
申请日：1997-08-25
申请人： Biosite Incorporated
发明人： Buechler, Kenneth Francis , Batt, Richard Roger
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01D61/18 , B01D61/20 , B01D63/081 , B01D65/003 , B01D69/00 , B01D69/02 , B01L2300/0681 , B01L2300/0825 , B01L2400/0406 , B01L2400/084 , G01N1/34 , G01N1/4077 , G01N33/491 , Y10T436/25375

18. 发明授权

EP1322957B1 DIAGNOSTIC MARKERS OF ACUTE CORONARY SYNDROMES AND METHODS OF USE THEREOF 无效
标题翻译：治疗急性心脏疾病和诊断标志物的使用方法
公开(公告)号：EP1322957B1
公开(公告)日：2009-08-12
申请号：EP02734211.2
申请日：2002-05-04
申请人： Biosite Incorporated
发明人： VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard , BUECHLER, Kenneth, F.
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/53 , G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

19. 发明公开

EP1555328A3 Recombinant library screening methods 失效
标题翻译： Siebtestverfahren图书馆（重组文库）
公开(公告)号：EP1555328A3
公开(公告)日：2009-05-06
申请号：EP05075052.0
申请日：1991-05-01
申请人： Biosite Incorporated
发明人： Dower, William J. , Cwirla, Steven E.
IPC分类号： C12Q1/70 , G01N33/53 , C12N7/00 , C07K16/00 , C12N1/21
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C12N15/1037
摘要： Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vector, or into a sequence encoding a protein which may be linked by means of a ligand to a phage coat protein. By employing affinity purification techniques the phage particles containing sequences encoding the desired protein may be selected and the desired nucleotide sequences obtained therefrom. Thus, for example, novel proteins such as monoclonal antibodies may be produced and conventional hybridoma technology avoided.

20. 发明公开

EP2024395A2 USE OF NATRIURETIC PEPTIDES AS DIAGNOSTIC AND PROGNOSTIC INDICATORS IN VASCULAR DISEASES 审中-公开
标题翻译：作为诊断利钠肽和预后指标血管疾病
公开(公告)号：EP2024395A2
公开(公告)日：2009-02-18
申请号：EP07797656.1
申请日：2007-05-22
申请人： Biosite Incorporated
发明人： BUECHLER, Kenneth, F.
IPC分类号： C07K16/40 , A61K39/395
CPC分类号： G01N33/6893 , G01N2800/323
摘要： The present invention relates to methods for the diagnosis and evaluation of subclinical atherosclerosis. In particular, patient test samples are analyzed for the presence and amount of one or more natriuretic peptides. A variety of additional markers are disclosed for assembling a panel of markers for such diagnosis and evaluation.

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