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11. 发明授权

EP2003451B1 T1r1-t1r3 hetero-oligomeric umami taste receptors and cell lines that express said receptors and use thereof for identification of umami taste compounds 有权转让
标题翻译： T1r1-t1r3异源寡聚鲜味受体和表达所述受体的细胞系及其用于鉴别鲜味化合物的用途
公开(公告)号：EP2003451B1
公开(公告)日：2012-05-30
申请号：EP08075748.7
申请日：2002-06-26
申请人： Senomyx, Inc.
发明人： Zoller, Mark T. , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey , Adler, Jon Elliot , Xu, Hong , Echeverri, Fernando
IPC分类号： C07K14/705
CPC分类号： C07K14/705 , A01K2217/00 , A01K2217/05 , G01N2333/726

12. 发明公开

EP2293067A2 T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds 有权
标题翻译：异源寡聚T1R味觉受体，并且这些受体表达细胞系及其对风味化合物的鉴定使用
公开(公告)号：EP2293067A2
公开(公告)日：2011-03-09
申请号：EP10180335.1
申请日：2002-06-26
申请人： Senomyx, Inc.
发明人： Zoller, Mark T. , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey , Adler, Jon Elliot , Xu, Hong , Echeverri, Fernando
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A01N37/18 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/00 , A01K2217/05 , G01N2333/726
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

13. 发明公开

EP2003451A3 T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds 有权转让
标题翻译：异源寡聚T1R味觉受体，并且这些受体表达细胞系及其对风味化合物的鉴定使用
公开(公告)号：EP2003451A3
公开(公告)日：2008-12-24
申请号：EP08075748.7
申请日：2002-06-26
申请人： Senomyx, Inc.
发明人： Zoller, Mark T. , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey , Adler, Jon Elliot , Xu, Hong , Echeverri, Fernando
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A01N37/18 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/00 , A01K2217/05 , G01N2333/726
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

14. 发明公开

EP1985630A2 T1R taste receptors and genes encoding same 有权转让
标题翻译： T1R2 Hybrid-Geschmacksrezeptor
公开(公告)号：EP1985630A2
公开(公告)日：2008-10-29
申请号：EP08153652.6
申请日：2002-01-03
申请人： Senomyx, Inc.
发明人： Adler, Jon, Elliott , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey
IPC分类号： C07K14/705
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that clicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体来说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定味觉刺激的味觉感觉的方法，以及用于产生新鲜分子或分泌哺乳动物预定味觉的分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

15. 发明授权

EP2327985B1 T1R Hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds 有权转让
标题翻译：异源寡聚T1R味觉受体，并且这些受体表达细胞系及其对风味化合物的鉴定使用
公开(公告)号：EP2327985B1
公开(公告)日：2016-05-25
申请号：EP10180331.0
申请日：2002-06-26
申请人： Senomyx, Inc.
发明人： Zoller, Mark T. , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey , Adler, Jon Elliot , Xu, Hong , Echeverri, Fernando
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A01N37/18 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/00 , A01K2217/05 , G01N2333/726
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.
摘要翻译：本发明涉及做了T1R受体组装以形成功能性味觉受体的发现。特别是，已经发现的确在味觉受体T1R1的和T1R3结果共表达没有来响应鲜味刺激，包括味精。因此，已发现的确在味觉受体T1R2的和T1R3受体结果的共表达没有来响应甜味刺激包括天然和人工甜味剂。另外，根据本发明涉及在测定中使用异源寡聚味觉受体T1R1包括/ T1R3和T1R2 / T1R3的标识化合物也分别鲜味味觉刺激和甜味刺激作出反应。此外，本发明涉及到的细胞系组成性共表达T1R1和T1R3的组合稳定或瞬时那样; 或T1R2和T1R3; 组成型或诱导条件下。在基于细胞的测定中使用的合成的细胞系，以确定鲜味和甜味调节化合物因此被提供，特别是高通量筛选测定并通过使用荧光成像的检测受体活性。最后，本发明涉及这样的发现，做了一些化合物，例如，lactisole，抑制人T1R2 / T1R3和T1R1 / T1R3受体的两个活动，并且相应地，甜味和鲜味，表明确实论文受体可能是唯一的甜味和鲜味受体。

16. 发明公开

EP2568287A3 Modulation of chemosensory receptors and ligands associated 审中-公开
标题翻译：化学感应受体和相关的配体的调节
公开(公告)号：EP2568287A3
公开(公告)日：2013-07-17
申请号：EP12175761.1
申请日：2008-06-03
申请人： Senomyx, Inc.
发明人： Tachdjian, Catherine , Karanewsky, Donald S. , Tang, Xiao-qing , Li, Xiaodong , Zhang, Feng , Servant, Guy , Chen, Qing , Darmohusodo, Vincent , Fine, Richard , Fotsing, Joseph R. , Hammaker, Jeffrey Robert , Kang, Xinshan , Kimmich, Rachel, D.A. , Klebansky, Boris , Liu, Haitian , Petrovic, Goran , Rinnova, Marketa , Adamski-Werner, Sara , Yamamoto, Jeffrey , Zhang, Hong , Zlotnik, Albert , Zoller, Mark
IPC分类号： G01N33/53 , C07D487/04 , G06F19/16
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention includes processes for preparing the modifiers of chemosensory receptors and their ligands.

17. 发明授权

EP2143732B1 T1R1 Taste receptor domains and genes encoding same 有权转让
标题翻译： T1R1味觉受体域及其编码基因
公开(公告)号：EP2143732B1
公开(公告)日：2012-10-03
申请号：EP09174166.0
申请日：2001-03-07
申请人： Senomyx, Inc.
发明人： Alder, Jon Elliot , Zozulya, Sergey , O'Connell, Shawn M , Li, Xiaodong , Staszewski, Lena
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C07K16/18 , C12Q1/68 , C12N5/10 , G01N33/50
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal arc also disclosed.

18. 发明授权

EP1985630B1 T1R2 hybrid taste receptor 有权转让
标题翻译： T1R2味觉受体杂交
公开(公告)号：EP1985630B1
公开(公告)日：2012-04-18
申请号：EP08153652.6
申请日：2002-01-03
申请人： Senomyx, Inc.
发明人： Adler, Jon, Elliott , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C07K16/18 , C12Q1/68 , C12N5/10 , G01N33/50
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00 , C12Q1/6883 , G01N33/5041 , G01N33/6872 , G01N33/74 , G01N2333/726 , G06F19/12
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular taste stimulus in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that clicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.

19. 发明公开

EP2293067A3 T1R hetero-oligomeric taste receptors and cell lines that express said receptors and use thereof for identification of taste compounds 有权
标题翻译：异源寡聚T1R味觉受体，并且这些受体表达细胞系及其对风味化合物的鉴定使用
公开(公告)号：EP2293067A3
公开(公告)日：2012-01-18
申请号：EP10180335.1
申请日：2002-06-26
申请人： Senomyx, Inc.
发明人： Zoller, Mark T. , Li, Xiaodong , Staszewski, Lena , O'Connell, Shawn , Zozulya, Sergey , Adler, Jon Elliot , Xu, Hong , Echeverri, Fernando
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , A01N37/18 , A61K38/00
CPC分类号： C07K14/705 , A01K2217/00 , A01K2217/05 , G01N2333/726
摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging. Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

20. 发明公开

EP2298802A1 T1R3 taste receptors and genes encoding same 有权转让
标题翻译： T1R3Geschmacksrezeptorendomänenund ihre kodierenden Gene
公开(公告)号：EP2298802A1
公开(公告)日：2011-03-23
申请号：EP10180329.4
申请日：2001-03-07
申请人： Senomyx, Inc.
发明人： Alder, Jon Elliot , Zozulya, Sergey , O'Connell, Shawn M , Li, Xiaodong , Staszewski, Lena
IPC分类号： C07K14/705 , C12N15/12 , C12N15/62 , C07K16/18 , C12Q1/68 , C12N5/10 , G01N33/50
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signalling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体来说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

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