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11. 发明公开

EP2615110A1 Biomarker for diagnosing cancer and method of isolating cancer cell using the same 审中-公开
标题翻译：生物标记zur诊断von Krebs und Verfahren zur隔离冯Krebszellen damit
公开(公告)号：EP2615110A1
公开(公告)日：2013-07-17
申请号：EP12193633.0
申请日：2012-11-21
申请人： Samsung Electronics Co., Ltd , Ajou University Industry Cooperation Foundation
发明人： Kim, Yeon-jeong , Kim, You-sun , Lee, Jeong-gun , Baek, Sang-hyun , Oh, Jin-mi , Jeong, Hyo-young
IPC分类号： C07K14/705 , G01N33/50 , G01N33/574
CPC分类号： C07K14/705 , C12Q1/6881 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： A biomarker for detecting a cancer stem cell or a circulating cancer cell that has undergone epithelial-mesenchymal transition, a kit for detecting a cancer stem cell or a circulating cancer cell that has undergone epithelial-mesenchymal transition, the kit including an antibody against the biomarker, a method of diagnosing cancer by using the kit, and a method of isolating a cancer stem cell or a circulating cancer cell that has undergone epithelial-mesenchymal transition. By using the biomarker for cancer diagnosis and the kit including an antibody against the biomarker, a cancer stem cell or a circulating cancer cell that has undergone epithelial-mesenchymal transition is efficiently detected and isolated.
摘要翻译：用于检测已经经历上皮 - 间质转化的癌症干细胞或循环癌细胞的生物标志物，用于检测癌干细胞的试剂盒或经历上皮 - 间质转化的循环癌细胞，所述试剂盒包括针对生物标记的抗体，使用试剂盒诊断癌症的方法，以及分离癌干细胞或经历上皮 - 间质转化的循环癌细胞的方法。通过使用用于癌症诊断的生物标志物和包含针对生物标志物的抗体的试剂盒，有效检测和分离已经经历上皮 - 间质转化的癌干细胞或循环癌细胞。

12. 发明公开

EP2605012A1 Cell capturing filter having high aspect ratio 审中-公开
标题翻译： Zellerfassungsfilter mit hohemAspektverhältnis
公开(公告)号：EP2605012A1
公开(公告)日：2013-06-19
申请号：EP12196935.6
申请日：2012-12-13
申请人： Samsung Electronics Co., Ltd
发明人： Sim, Tae-seok , Kim, Min-seoks. , Song, Mi-jeong , Lee, Jeong-gun , Lee, June-young , Kim, Yeon-jeong , Baek, Sang-hyun , Oh, Jin-mi , Jeong, Hyo-young
IPC分类号： G01N33/49 , B01L3/00 , C12M1/26
CPC分类号： G01N1/34 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0668 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/087 , B01L2400/086 , C12M33/14 , C12M47/04 , G01N1/4077
摘要： Embodiments disclose a cell capturing filter, in which cells or particles having a predetermined size or greater in a sample may be easily captured, and clogging of a flow passage due to the captured cells or particles may be prevented, and stresses acting on the captured cells or particles may be reduced. The filter has a first substrate having a first surface and a second substrate having a second surface that is bonded to the first surface, wherein the first substrate may include a flow passage formed in the first surface of the first substrate so that a sample flows in the flow passage, and a barrier that protrudes across the flow passage, and the second substrate may include a fine groove formed in an area on the second surface corresponding to the barrier, and a gap may exist between a surface of the barrier and the fine groove.
摘要翻译：实施方案公开了一种细胞捕获过滤器，其中可以容易地捕获样品中具有预定尺寸或更大尺寸的细胞或颗粒，并且可以防止由于捕获的细胞或颗粒引起的流动通道的堵塞，并且可以防止作用在捕获的细胞上的应力或者可以减少颗粒。所述过滤器具有第一衬底，所述第一衬底具有第一表面，所述第二衬底具有接合到所述第一表面的第二表面，其中所述第一衬底可以包括形成在所述第一衬底的所述第一表面中的流路，使得样品流入流动通道和跨过流动通道突出的屏障，并且第二基板可以包括形成在与屏障相对应的第二表面上的区域中的细槽，并且在屏障的表面和精细之间可能存在间隙槽。

13. 发明公开

EP2573540A1 Fluid controlling apparatus and filter and biochip including the fluid controlling apparatus 失效
标题翻译： Fluidsteuerungsvorrichtung und Filter和Biochip mit der Fluidsteuerungsvorrichtung
公开(公告)号：EP2573540A1
公开(公告)日：2013-03-27
申请号：EP12185817.9
申请日：2012-09-25
申请人： Samsung Electronics Co., Ltd
发明人： Kim, Min-seok , Kim, Sun-soo , Kim, Jin-hoon , Lee, Won-ho , Lee, Jeong-gun , Sim, Tae-seok , Baek, Sang-hyun , Jeong, Hyo-young
IPC分类号： G01N1/28 , G01N21/05
CPC分类号： B01L3/502753 , B01L3/502746 , B01L2200/10 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/0887 , B01L2400/0487 , B01L2400/086 , G01N21/05 , G01N2001/4088 , G01N2021/0325 , G01N2021/0346
摘要： A fluid controlling apparatus (100) including an inlet (110) through which a fluid is introduced, a channel portion (130) connected to the inlet, an outlet (150) that is connected to the channel portion (130) and through which the fluid is discharged, and at least one fluid resisting portion (160) disposed between the inlet (110) and the outlet (150), as well as a filter and a biochip including the fluid controlling apparatus.
摘要翻译：一种流体控制装置（100），其包括入口（110），流体通过该入口（110），连接到入口的通道部分（130），连接到通道部分（130）的出口（150）流体被排出，并且设置在入口（110）和出口（150）之间的至少一个流体阻力部分（160）以及包括流体控制装置的过滤器和生物芯片。

14. 发明公开

EP2460589A1 Hydrodynamic filter, filtering apparatus including the same, and filtering method using the hydrodynamic filter 失效转让
标题翻译：流体动力过滤器，过滤器过滤器和过滤器过滤器
公开(公告)号：EP2460589A1
公开(公告)日：2012-06-06
申请号：EP11191837.1
申请日：2011-12-05
申请人： Samsung Electronics Co., Ltd.
发明人： Kim, Min-seok , Sim, Tae-seok , Park, Jong-myeon , Lee, Jeong-gun , Lee, Hun-Joo
IPC分类号： B01L3/00
CPC分类号： B01L3/502761 , B01L2300/0816 , B01L2300/0851 , B01L2400/086 , Y10T436/25 , Y10T436/25375
摘要： A hydrodynamic filter including a first portion that includes a plurality of protrusions protruding in a first direction, and a second portion that is spaced apart from the first portion to face the first portion and includes a plurality of protrusions protruding in a second direction facing the first direction. A filtering apparatus including a body that includes a plurality of the hydrodynamic filters and filters a fluid including target molecules, an inlet portion, and an outlet portion.
摘要翻译：一种流体动力过滤器，包括：第一部分，其包括在第一方向上突出的多个突起;以及第二部分，其与所述第一部分间隔开以面对所述第一部分，并且包括沿朝向所述第一部分的第二方向突出的多个突起方向。一种过滤装置，包括：主体，其包括多个所述流体动力过滤器，并且对包括目标分子，入口部分和出口部分的流体进行过滤。

15. 发明授权

EP1650297B1 Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser 有权
标题翻译：一种用于细胞和病毒的通过使用微磁珠和激光的快速中断的方法和装置
公开(公告)号：EP1650297B1
公开(公告)日：2011-04-13
申请号：EP05022672.9
申请日：2005-10-18
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Jeong-gun , Kwon, Young-nam , Kim, Young-a 245-1804 Hwanggol Maeul Ssangyong Apt , Lee, Myo-yong , Yoo, Shin-i , Cho, Yeon-ja , Cheong, Kwang-ho , Yoo, Chang-eun , Yang, Seung-yeon,904-1704 Cheongsol Maeul
IPC分类号： C12N15/10
CPC分类号： C12M47/06 , B01F11/0266 , B01F13/0059 , B01L3/502761 , B01L2300/0816 , C12N1/066 , C12N13/00

16. 发明授权

EP1662008B1 Apparatus for and method of purifying nucleic acids by using beads with different laser absorption 有权
标题翻译：通过用不同的激光吸收特性粒子的装置的设备和方法的核酸Aufreinignug
公开(公告)号：EP1662008B1
公开(公告)日：2009-12-16
申请号：EP05015561.3
申请日：2005-07-18
申请人： Samsung Electronics Co., Ltd
发明人： Lee, Jeong-gun , Kwon, Young-nam 104-306 , Lee, Myo-yong 306-1102 LG Xi Apt. , Yoo, Shin-i 101-2102 Ssangyong Apt. , Cho, Yeon-ja 1-132 Jeonnong 3-dong , Kim, Young-a 245-1804
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： B01L3/502753 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2400/0487

17. 发明公开

EP2128614A1 Microfluidic device containing lyophilized reagent therein and analyzing method using the same 审中-公开
标题翻译： Mik。。。。。。。。。。。。。。。。
公开(公告)号：EP2128614A1
公开(公告)日：2009-12-02
申请号：EP09160095.7
申请日：2009-05-13
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Yoon-kyoung , Lee, Jeong-gun
IPC分类号： G01N33/53 , C12Q1/68 , B01L3/00
CPC分类号： C12Q1/00 , B01L3/502738 , B01L2200/10 , B01L2200/16 , B01L2400/0677 , G01N21/07 , G01N33/5302 , Y10T436/25
摘要： Provided is a microfluidic device suitable for analyzing a liquid sample. The device includes a substrate comprising a plurality of chambers; a solid reagent contained in at least one of the plurality of chambers, wherein at least a portion of the shape of the solid reagent is identical to at least a portion of the configuration of the inner surface of the at least one chamber.
摘要翻译：提供了适用于分析液体样品的微流体装置。该装置包括：包括多个室的基板; 包含在所述多个室中的至少一个室中的固体试剂，其中所述固体试剂形状的至少一部分与所述至少一个室的内表面的构型的至少一部分相同。

18. 发明公开

EP1752213A1 Device for printing droplet or ink on substrate or paper 审中-公开
标题翻译：设备用于打印Tröpchen或色的底物或纸张上
公开(公告)号：EP1752213A1
公开(公告)日：2007-02-14
申请号：EP06254255.0
申请日：2006-08-14
申请人： Samsung Electronics Co., Ltd.
发明人： Kim, Su-hyeon , Chung, Jong-suk , Lee, Jeong-gun , Cho, Hye-jung , Huh, Nam , Kang, In-seok, Pohang University of Science and , Lee, Beom-seok, Pohang University of Science
IPC分类号： B01J19/00 , C40B60/14
CPC分类号： B41J2/06 , B01J19/0046 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743 , B41J2/04535 , B41J2/0456 , B41J2/04576
摘要： Provided is a device (100) for printing a droplet onto a substrate (30). The device includes (100): a droplet generating member that is needle-shaped (20) and comprises a receiving portion that is disposed vertically and receives a solution (22), and a discharge hole (23) connected to the receiving portion and formed on the bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate (30) that is disposed below the droplet generating member, and includes a target portion to which the droplet discharged (10a) from the discharge hole (23) of the droplet generating member (20) is dropped and attached; a voltage applier (50) applying a voltage to the droplet (10a) so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet (60,62,63,64,66).
摘要翻译：提供了一种用于印刷的液滴到基片（30）的装置（100）。该装置包括（100）：一个液滴产生部件所做的是针形（20），并且包括一个接收部分并垂直地设置，并接收连接到接收部分和形成的溶液（22），和一个排出孔（23）在接收部的底部，以便做的解决方案可以从接收部分被排出; 一个基片（30）没有设置在液滴生成部件的下方，并包括从（20）被丢弃，并且附着液滴产生构件的排出孔（23），以哪个液滴排出的目标部分（10A）; 电压施加器（50）将电压施加到液滴（10A）因此做了液滴可以到基底的目标部分被丢弃; 音量测量单元测量所述液滴的体积; 和液滴控制单元维护基于液滴（60,62,63,64,66）的所测得的体积上液滴的在预定水平的体积。

19. 发明公开

EP1655366A3 Apparatus and method for purification of nucleic acids by phase separation using laser and beads 有权
标题翻译：设备和方法，用于通过相分离的核酸纯化通过使用激光和珠的
公开(公告)号：EP1655366A3
公开(公告)日：2006-07-12
申请号：EP05024014.2
申请日：2005-11-03
申请人： Samsung Electronics Co., Ltd.
发明人： Lee, Jeong-gun , Kwon, Young-nam , Kim, Young-a 202-906, Ssangyong 2-cha Apt.
IPC分类号： C12N15/10
CPC分类号： B01L3/502761 , B01L3/502738 , B01L7/52 , B01L2200/0668 , B01L2300/0838 , B01L2300/087 , B01L2400/0633 , G01N35/0098 , Y10T436/143333
摘要： An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to the capillary and mixing the samples and the magnetic beads in the capillary; a laser generator attached to the capillary and supplying a laser to the capillary; and a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall. According to the method and apparatus, PCR yield can be increased since PCR inhibitors can be readily removed by means of a phase separation in a capillary. The use of an electromagnet ensures the removal of the PCR inhibitors. In addition, since cell lysis and DNA purification process can be simultaneously performed, LOC steps can be reduced.

20. 发明公开

EP1552887A2 Device and method for printing biomolecules onto substrate using electrohydrodynamic effect 有权
标题翻译：装置和方法，用于打印的生物分子上利用静电流体动力效应的基板
公开(公告)号：EP1552887A2
公开(公告)日：2005-07-13
申请号：EP04026799.9
申请日：2004-11-11
申请人： Samsung Electronics Co., Ltd.
发明人： Cho, Hye-jung , Lee, Jeong-gun
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00371 , B01J2219/00527 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/0262 , B01L2300/0838 , B01L2400/027 , B01L2400/0415 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A device and a method for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect are provided. The device for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect includes at least one capillary having an outlet through which a feeding solution of biomolecules selected from the group consisting of nucleic acids, proteins, and oligopeptides is discharged, the nucleic acids being selected from the group consisting of probe DNA, RNA, peptide nucleic acid (PNA), and LNA and the proteins being selected from the group consisting of antigen and antibody; a printer body supporting the at least one capillary; a substrate below the outlet having a target surface onto which the biomolecules are deposited; a first electric field forming electrode located on the printer body around the circumference of the outlet; a second electric field forming electrode spaced apart from the first electrode by a predetermined distance; and a voltage applying unit which is electrically connected to the first electrode and the second electrode to apply an alternating current (AC) voltage between the first electrode and the second electrode so that an electric field may be formed around the biomolecule solution suspended in the outlet, and due to the interaction of the electric field and a difference in dielectric constant between the biomolecule solution having a free surface and the surrounding atmosphere, the electric force acts inward on the biomolecule solution from the surroundings, thereby dropping a predetermined amount of the biomolecule solution onto the target surface of the substrate. By using an EHD effect, the advantages of the device and method are that the process is quick, the biomolecule spots are uniform and easily aligned, and especially it is possible to spot the biomolecules correctly and reproducibly even when the printer body is not fully aligned with the substrate. In addition, the device and method are applicable to proteins which are sensitive to heat and biomolecules which have neutral charges.
摘要翻译：本发明提供一种装置和用于印刷到使用电水动力学（EHD）效应的基板的生物分子的方法。走上使用的底物为印刷生物分子的装置的电流体力学（EHD）效应包括具有到出口，通过它选自核酸，蛋白质和寡肽选择的生物分子的进料溶液被排出至少一个毛细管，所述核酸是选自探针DNA，RNA，肽核酸（PNA），和LNA和蛋白质的选择选自抗原和抗体的被选择; 打印机主体支撑所述至少一个毛细管; 具有在其上所述生物分子沉积在目标表面上的出口下方的基板; 第一电场形成位于上围绕所述出口的圆周上的打印机主体电极; 从以预定距离与第一电极间隔开的第二电场成形电极; 以及电压施加单元的所有电连接到第一电极，并施加到第一电极和第二电极在电场所以没有之间交流（AC）电压的第二电极可围绕悬浮在出口处的生物分子溶液中形成，并且由于电场的相互作用和在具有自由表面的生物分子的溶液与周围大气中，电力作用向内从周围的生物分子的溶液之间的介电常数的差异，从而丢弃所述生物分子的预定量的溶液到基片的目标表面。通过使用EHD效应，设备和方法的优点是没有过程快，生物分子斑点均匀，容易地对准，特别喜欢的是能够正确和可重复当场生物分子，即使打印机身体不完全一致与基板。另外，该装置和方法也适用于这对热并且具有中性电荷的生物分子敏感的蛋白质。

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