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11. 发明公开

EP2507257A4 MYBL2 PEPTIDES AND VACCINES CONTAINING THE SAME 审中-公开
标题翻译： MYBL2肽和疫苗
公开(公告)号：EP2507257A4
公开(公告)日：2013-04-03
申请号：EP10834386
申请日：2010-12-02
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C07K7/06 , A61K39/00 , A61P35/00 , C07K14/47 , C07K14/82 , C12N15/09
CPC分类号： C07K14/82 , A61K39/0011 , C07K14/4748

12. 发明公开

EP2382314A4 C1ORF59 PEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
标题翻译： C1ORF59肽和疫苗含有它们的
公开(公告)号：EP2382314A4
公开(公告)日：2013-03-06
申请号：EP09834363
申请日：2009-12-17
申请人： ONCOTHERAPY SCIENCE INC
发明人： TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C12N15/00 , A61K39/00 , A61P35/00 , C07K7/06 , C07K14/705
CPC分类号： C07K7/06 , A61K39/00 , A61K39/0011 , C07K14/4748 , C12N2710/16222 , G01N33/57484 , G01N2333/47

13. 发明公开

EP2771350A4 TOPK PEPTIDES AND VACCINES INCLUDING THE SAME 有权
标题翻译： TOPK-PEPTIDE UNDESE ENTHALTENDE IMPFSTOFFE
公开(公告)号：EP2771350A4
公开(公告)日：2015-07-15
申请号：EP12844519
申请日：2012-10-25
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA , NAKAYAMA GAKU
IPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , A61P35/00 , C07K16/18 , C12N5/10 , C12N15/09 , G01N33/574
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/0005 , A61K2039/5154 , A61K2039/572 , C07K7/06 , C07K14/4748 , C07K16/18 , C07K16/40 , C07K2317/34 , C12N9/12 , C12N9/1205 , C12Y207/12002 , G01N33/505 , G01N33/574
摘要： As discussed in greater detail herein, isolated epitope peptides derived from TOPK and immunogenic fragments thereof have an ability to induce cytotoxic T lymphocytes (CTLs) and thus are suitable for use in cancer immunotherapy, more particularly as cancer vaccines. The peptides of the present invention encompass both of peptides including a TOPK-derived amino acid sequence and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted and/or added, provided such modified versions have CTL inducibility. Further provided are polynucleotides encoding any of the aforementioned peptides as well as pharmaceutical compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, and pharmaceutical compositions of this invention find particular utility in either or both of the treatment and prevention of cancers and tumors, including, for example, acute myeloid leukemia (AML), bladder cancer, breast cancer, cervical cancer, cholan-giocellular carcinoma, colorectal cancer, diffuse-type gastric cancer, non small cell lung cancer (NSCLC), lymphoma, osteosarcoma, prostate cancer, renal carcinoma, small cell lung cancer (SCLC) and soft tissue tumor.
摘要翻译：本发明提供了衍生自TOPK的分离的表位肽，其免疫原性片段具有诱导细胞毒性T淋巴细胞（CTL）的能力，因此适用于癌症免疫治疗，更特别是癌症疫苗。本发明的肽包括包括TOPK衍生的氨基酸序列和其修饰形式的两种肽，其中一个，两个或几个氨基酸被取代，缺失，插入和/或添加，只要这些修饰版本具有CTL 诱导性。进一步提供编码任何前述肽的多核苷酸以及包括任何上述肽或多核苷酸的药物组合物。本发明的肽，多核苷酸和药物组合物在多种癌症的治疗和预防中的任一者或两者中都特别有用。

14. 发明公开

EP2718435A4 SEMA5B PEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
标题翻译： SEMA5B-PEPTIDE UND IMPFSTOFFE DAMIT
公开(公告)号：EP2718435A4
公开(公告)日：2014-11-26
申请号：EP12797231
申请日：2012-06-07
申请人： ONCOTHERAPY SCIENCE INC
发明人： TSUNODA TAKUYA , OSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA , NAKAYAMA GAKU , NAKAMURA YUSUKE
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/078 , C12N5/10 , G01N33/574
CPC分类号： C07K16/18 , A61K38/00 , A61K39/0011 , C07K14/4703 , G01N33/57492 , G01N2333/70539

15. 发明公开

EP2553096A4 ECT2 PEPTIDES AND VACCINES INCLUDING THE SAME 有权转让
标题翻译： ECT2肽和包含它们的疫苗
公开(公告)号：EP2553096A4
公开(公告)日：2013-11-13
申请号：EP11762265
申请日：2011-03-30
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C12N15/09 , A61K39/00 , C07K7/06
CPC分类号： C07K7/06 , A61K39/0011 , A61K2039/572
摘要： Isolated peptides derived from SEQ ID NO: 42 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines, are described herein. The inventive peptides encompass both the afore-mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted or added, provided such modified versions retain the requisite HLA binding and/or CTL inducibility of the original sequences. Further provided are nucleic acids encoding any of the aforementioned peptides as well as pharmaceutical agents, substances and/or compositions that include or incorporate any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors, including, for example, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, esophageal cancer, NSCLC, lymphoma, pancreatic cancer, prostate cancer, renal carcinoma and SCLC.

16. 发明公开

EP2303909A4 IQGAP3 EPITOPE PEPTIDES AND VACCINES CONTAINING THE SAME 审中-公开
标题翻译： IQGAP3表位肽和疫苗含
公开(公告)号：EP2303909A4
公开(公告)日：2012-10-31
申请号：EP09762266
申请日：2009-06-10
申请人： ONCOTHERAPY SCIENCE INC
发明人： TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C07K4/12 , A61K39/00 , A61P35/00 , C07K7/06 , C07K14/74 , C12N15/09 , C12N5/06
CPC分类号： C07K14/4722 , A61K39/0011 , C07K7/06 , C07K14/4706

17. 发明公开

EP2630237A4 C18ORF54 PEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
标题翻译： C18ORF54肽和疫苗含有它们的
公开(公告)号：EP2630237A4
公开(公告)日：2014-04-09
申请号：EP11834046
申请日：2011-10-19
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , C07K7/06 , C07K14/47
CPC分类号： A61K39/0011 , A61K38/00 , C07K14/47

18. 发明公开

EP2630238A4 WDHD1 PEPTIDES AND VACCINES INCLUDING THE SAME 审中-公开
标题翻译： WDHD1肽和疫苗含有它们的
公开(公告)号：EP2630238A4
公开(公告)日：2014-02-19
申请号：EP11834052
申请日：2011-10-20
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P35/00 , C07K7/06 , C07K14/47
CPC分类号： C07K7/06 , A61K38/00 , A61K39/0011 , C07K14/47
摘要： Peptide vaccines against cancer are described herein. In particular, isolated epitope peptides or immunogenic fragments derived from SEQ ID NO: 32, that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) are provided. The amino acid sequence of the peptide of interest may be optionally modified with the substitution, deletion, insertion, or addition of one, two, or several amino acids sequences. Pharmaceutical compositions and methods of treating cancer that include such peptides are also provided.

19. 发明公开

EP2370454A4 WDRPUH EPITOPE PEPTIDES AND VACCINES CONTAINING THE SAME 审中-公开
标题翻译： WDRPUH-EPITOP-PEPTIDE IN DIESE ENTHALTENDE IMPFSTOFFE
公开(公告)号：EP2370454A4
公开(公告)日：2013-11-20
申请号：EP09830200
申请日：2009-12-03
申请人： ONCOTHERAPY SCIENCE INC
发明人： TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C07K7/06 , A61K39/00 , A61P35/00 , C12N5/0783 , C12N5/0786 , C12N15/09
CPC分类号： C07K7/06 , A61K38/00 , A61K38/1764 , A61K39/0011 , C07K14/47 , C07K14/4748 , C12N5/0638 , C12N5/0639
摘要： The present invention provides peptides containing the amino acid sequence of SEQ ID NOs: 1, 2, 3, 4, 16, 17, 30, 31, 34, 36, 37, 40, 41, 45, 49, 55, 57 and 61, as well as peptides containing the above-mentioned amino acid sequences in which 1, 2, or several amino acid(s) are substituted, deleted, inserted or added, but still have cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing tumors, which drugs containing these peptides. The peptides of the present invention can also be used as vaccines.
摘要翻译：本发明提供了含有SEQ ID NO：1,2,3,4，16，17，30，31，34，36，37，40，41，45，49，55，57和61的氨基酸序列的肽，以及含有上述氨基酸序列的肽，其中1,2或几个氨基酸被取代，缺失，插入或添加，但仍具有细胞毒性T细胞诱导性。本发明还提供了用于治疗或预防肿瘤的药物，其含有这些肽的药物。本发明的肽也可以用作疫苗。

20. 发明公开

EP2545171A4 HJURP PEPTIDES AND VACCINES INCLUDING THE SAME 有权
标题翻译： HJURP-PEPTIDE UNDEE ENTHALTENDE IMPFSTOFFE
公开(公告)号：EP2545171A4
公开(公告)日：2013-09-18
申请号：EP11753055
申请日：2011-03-10
申请人： ONCOTHERAPY SCIENCE INC
发明人： NAKAMURA YUSUKE , TSUNODA TAKUYA , OHSAWA RYUJI , YOSHIMURA SACHIKO , WATANABE TOMOHISA
IPC分类号： C12N15/09 , A61K35/00 , A61K38/00 , C07K7/06 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10
CPC分类号： C07K14/4748 , A61K35/12 , A61K38/00 , A61K39/00 , C07K7/06 , C07K16/18
摘要： Isolated peptides derived from SEQ ID NO: 50 and fragments thereof that bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL) and thus are suitable for use in the context of cancer immunotherapy, more particularly cancer vaccines are described herein. The inventive peptides encompasses both the above mentioned amino acid sequences and modified versions thereof, in which one, two, or several amino acids sequences substituted, deleted, added or inserted, provided such modified versions retain the requisite cytotoxic T cell inducibility of the original sequence. Further provided are nucleic acids encoding any of the aforementioned peptides as well as pharmaceutical agents, substances and/or compositions that include or incorporate any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents, substances and compositions of this invention find particular utility in the treatment of cancers and tumors, including, for example, AML, bladder cancer, breast cancer, cervical cancer, cholangiocellular carcinoma, CML, colorectal cancer, esophagus cancer, Diffused-type gastric cancer, liver cancer, NSCLC, lymphoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal carcinoma, SCLC, soft tissue tumor and testicular tumor.
摘要翻译：衍生自SEQ ID NO：50的分离的肽及其与HLA抗原结合并诱导细胞毒性T淋巴细胞（CTL）的片段，因此适用于癌症免疫治疗的上下文，更具体地说，本文描述了癌症疫苗。本发明的肽包括上述氨基酸序列及其修饰形式，其中一个，两个或几个氨基酸序列被取代，缺失，添加或插入，只要这些修饰版本保留原始序列的必需细胞毒性T细胞诱导性。还提供了编码任何前述肽的核酸以及包括或掺入任何前述肽或核酸的药物，物质和/或组合物。本发明的肽，核酸，药物，物质和组合物在治疗癌症和肿瘤方面特别有用，包括例如AML，膀胱癌，乳腺癌，宫颈癌，胆管细胞癌，CML，结肠直肠癌，食管癌，扩散型胃癌，肝癌，NSCLC，淋巴瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌，肾癌，SCLC，软组织肿瘤和睾丸肿瘤。

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