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11. 发明公开

EP3995571A1 METHOD FOR PRODUCING NUCLEIC ACID-ENCAPSULATED AAV HOLLOW PARTICLE 审中-实审
公开(公告)号：EP3995571A1
公开(公告)日：2022-05-11
申请号：EP20835079.3
申请日：2020-07-02
申请人： Nippon Medical School Foundation , Takara Bio Inc.
发明人： OKADA, Takashi , MINENO, Junichi , CHONO, Hideto
IPC分类号： C12N5/10 , C12N7/01 , C12N15/864
摘要： A method for producing a nucleic acid-encapsulated adeno-associated virus (AAV) hollow particle, comprising the following steps: (1) preparing a linear nucleic acid fragment comprising a sequence for A region and a sequence for D' region in an AAV inverted terminal repeat (ITR) (i.e., an AD sequence) or a sequence complementary to the AD sequence and a target gene sequence; (2) introducing the nucleic acid fragment prepared in step (1) into a cell capable of producing an AAV hollow particle; and (3) culturing the cell obtained in step (2).

12. 发明公开

EP3744832A1 LYMPHOCYTE PRODUCTION METHOD 审中-公开
公开(公告)号：EP3744832A1
公开(公告)日：2020-12-02
申请号：EP19744513.3
申请日：2019-01-24
申请人： Takara Bio Inc.
发明人： OTSUJI, Tomomi , HIRASE, Yuka , HATSUYAMA, Asako , OKAMOTO, Sachiko , ENOKI, Tatsuji , MINENO, Junichi
IPC分类号： C12N5/078 , C07K14/78 , C12M3/00 , C12N15/13
摘要： In the present invention, lymphocytes are efficiently grown by culturing lymphocytes in the presence of a novel recombinant fibronectin fragment.

13. 发明授权

EP3168298B1 PRODUCTION METHOD FOR NON-ENVELOPED VIRUS PARTICLES 有权
公开(公告)号：EP3168298B1
公开(公告)日：2019-04-17
申请号：EP15819589.1
申请日：2015-07-09
申请人： Takara Bio Inc.
发明人： NISHIE, Toshikazu , KAWANO, Yasuhiro , SAKAMOTO, Shuhei , ENOKI, Tatsuji , TAKAKURA, Hikaru , MINENO, Junichi
IPC分类号： C12N7/02

14. 发明授权

EP2612909B1 METHOD FOR PRODUCING VIRUS VECTOR 有权转让
标题翻译：用于生产病毒载体
公开(公告)号：EP2612909B1
公开(公告)日：2015-02-25
申请号：EP11830659.6
申请日：2011-10-04
申请人： Takara Bio, Inc.
发明人： SHINMURA, Kazuhisa , KATAYAMA, Yoshinori , SAKAI, Kensuke , SHODAI, Toshihiro , YOSHIOKA, Hirofumi , MINENO, Junichi
IPC分类号： C12N5/10 , C12N7/02 , C12N15/867
CPC分类号： C12N15/64 , C12N7/00 , C12N2500/36 , C12N2501/065 , C12N2501/39 , C12N2740/10051

15. 发明授权

EP2138580B1 VECTOR FOR GENE THERAPY 有权
标题翻译：载体基因治疗
公开(公告)号：EP2138580B1
公开(公告)日：2013-03-20
申请号：EP08740493.5
申请日：2008-04-16
申请人： Takara Bio, Inc.
发明人： CHONO, Hideto , MATSUMOTO, Kazuya , MATSUMURA, Hajime , MINENO, Junichi , KATO, Ikunoshin
IPC分类号： C12N15/09 , A61K35/76 , A61K38/46 , A61K48/00 , A61P43/00 , C12N5/10 , C12N9/22
CPC分类号： C12N9/22 , A61K38/00 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2740/16043

16. 发明公开

EP2471901A1 METHOD FOR PRODUCING T CELL POPULATION UNDER PRESENCE OF RETINOIC ACID 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER T-ZELLEN人口统计VERWENDUNG VON RETINSURE
公开(公告)号：EP2471901A1
公开(公告)日：2012-07-04
申请号：EP10811841.5
申请日：2010-08-24
申请人： Takara Bio, Inc.
发明人： KATAYAMA, Yoshinori , SAKAI, Kensuke , YOSHIOKA, Hirofumi , TAKAKURA, Hikaru , CHONO, Hideto , SAITO, Naoki , MINENO, Junichi
IPC分类号： C12N5/00 , C12N5/07 , C12N5/10 , C07K14/78
CPC分类号： C12N5/0636 , C12N2501/385 , C12N2501/515 , C12N2501/58 , C12N2510/00
摘要： Disclosed is a method for producing a cell population containing memory-like T cells, said method being characterized by including a step for in vitro culturing of a cell population containing T cells or T cell precursor cells using a retinoic acid and a CD3 ligand. Further disclosed is a method for producing a cell population wherein the proportion of memory-like T cells is increased and wherein a desired gene is introduced with a high efficiency and is highly expressed.
摘要翻译：公开了一种生产含有记忆样T细胞的细胞群的方法，所述方法的特征在于包括使用视黄酸和CD3配体体外培养含有T细胞或T细胞前体细胞的细胞群的步骤。进一步公开了一种生产细胞群的方法，其中记忆样T细胞的比例增加，并且其中以高效率引入所需基因并高度表达。

17. 发明公开

EP1304377A1 METHOD OF DETECTING CANCER 有权
标题翻译： VERFAHREN ZUM NACHWEIS VON KREBS
公开(公告)号：EP1304377A1
公开(公告)日：2003-04-23
申请号：EP01984244.2
申请日：2001-07-18
申请人： TAKARA BIO INC.
发明人： TSUBOSA, Yasuhiro , AOYAGI, Kazuhiko , SASAKI, Hiroki , TERADA, Masaaki , MINENO, Junichi , ASADA, Kiyozo , KATO, Ikunoshin
IPC分类号： C12N15/12 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158
摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.
摘要翻译：提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各个基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。因此，本发明对癌症的诊断，治疗等有用。

18. 发明公开

EP4205762A1 IMPROVED DNA VACCINE FOR SARS-COV-2 无效
公开(公告)号：EP4205762A1
公开(公告)日：2023-07-05
申请号：EP21875809.2
申请日：2021-09-30
申请人： OSAKA UNIVERSITY , Takara Bio Inc. , AnGes, Inc.
发明人： NAKAGAMI, Hironori , MORISHITA, Ryuichi , HAYASHI, Hiroki , AMAISHI, Yasunori , OKAMOTO, Sachiko , MINENO, Junichi , IKAI, Hisato , MICHIBATA, Junko , KOMATSUNO, Takao
IPC分类号： A61K39/215 , A61K39/39 , A61P31/14 , C12N15/50 , C12N15/63 , C12N15/86 , A61K35/76 , A61K31/711
摘要： Provided is DNA that: encodes a coronavirus (SARS CoV-2) spike protein or a fragment thereof; and has been optimized to partially or fully exhibit a codon included in a DNA sequence.

19. 发明公开

EP3960755A1 AAV MUTANT HAVING BRAIN-TARGETING PROPERTY 审中-实审
公开(公告)号：EP3960755A1
公开(公告)日：2022-03-02
申请号：EP20795029.6
申请日：2020-04-23
申请人： Takara Bio Inc.
发明人： NISHIE, Toshikazu , TAKASHIMA, Fuyuko , ENOKI, Tatsuji , MINENO, Junichi , TANAKA, Yoshinori
IPC分类号： C07K14/015 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/35 , C40B50/06
摘要： The present invention provides a nucleic acid which encodes an adeno-associated virus (AAV) capsid protein mutant that contains a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62 or a peptide comprising an amino acid sequence produced by substituting, deleting, inserting and/or adding one or several amino acid residues in an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62; DNA comprising the nucleic acid; a cell harboring the DNA; and a method for producing the cell.

20. 发明授权

EP2940131B1 AAV VARIANT 有权转让
公开(公告)号：EP2940131B1
公开(公告)日：2019-02-20
申请号：EP13867056.7
申请日：2013-12-20
申请人： Takara Bio Inc.
发明人： NISHIE, Toshikazu , TAKASHIMA, Fuyuko , ENOKI, Tatsuji , MINENO, Junichi
IPC分类号： C12N15/09 , C07K14/075 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00

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