专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

EP0927184B1 3-SUBSTITUIERTE PYRIDO 4',3':4,5] THIENO 2,3-D]PYRIMIDIN-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 失效
标题翻译： 3-取代的吡啶并4”，3' ：4,5]噻吩并-2,3--D]嘧啶衍生物，其生产和使用
公开(公告)号：EP0927184B1
公开(公告)日：2003-10-22
申请号：EP97940118.9
申请日：1997-08-22
申请人： ABBOTT GmbH & Co. KG
发明人： STEINER, Gerd , LUBISCH, Wilfried , BACH, Alfred , EMLING, Franz , WICKE, Karsten , TESCHENDORF, Hans-Jürgen , BEHL, Berthold , KERRRIGAN, Frank , CHEETHAM, Sharon
IPC分类号： C07D495/14 , A61K31/435
CPC分类号： C07D495/14
摘要： The invention concerns 3-substituted 3,4,5,6,7,8-hexahydro-pyrido[4,3':4,5]thieno-[2,3-d]pyrimidine derivatives of formula (I) in which: R1 designates a hydrogen atom, a C¿1?-C4 alkyl group, an acetyl or benzoyl group, a phenylalkyl C1-C4 group - the aromatic optionally being substituted by halogen, C1-C4 alkyl, trifluoromethyl, hydroxy, C1-C4 alkoxy, amino, cyano or nitro groups - a naphthylalkyl C1-C3 group, a phenylalkanone C2-C3 group or a phenylcarbamoylalkyl C2 group, wherein the phenyl group can be substituted by halogen; R?2¿ designates a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which can optionally be mono-, di- or tri-substituted by halogen atoms, C¿1?-C4 alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, C1-C4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and can optionally be anellated with a benzene nucleus, which can optionally be mono- or di-substituted by halogen atoms, C1-C4 alkyl, hydroxy, trifluoromethyl, C1-C4 alkoxy, amino, cyano or nitro groups and can optionally contain 1 nitrogen atom, or with a 5- or 6-member ring which can contain between 1 and 2 oxygen atoms, or can be substituted by a phenyl-C1-C2 alkyl or alkoxy group, wherein the phenyl group can be substituted by halogen, a methyl, trifluoromethyl or methoxy group; A designates NH or an oxygen atom; B designates hydrogen or methyl; C designates hydrogen, methyl or hydroxy; X designates a nitrogen atom; Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH; Z designates a nitrogen atom, a carbon atom or CH, wherein the bond between Y and Z can also be a double bond; and n is the number 2, 3 or 4, and their physiologically compatible salts. These compounds are suitable as medicaments for treating diseases in which the serotonin concentration is reduced and in which the activity of the presynaptic receptors 5-HT1B, 5-HT1A, 5HT1D is to be blocked within a therapeutic context without greatly influencing other receptors. Such diseases include, for example, depression.

12. 发明授权

EP0988306B1 3-SUBSTITUIERTE 3,4-DIHYDRO-THIENO 2,3-D]PYRIMIDIN-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 失效
标题翻译： 3-取代的-3,4-二氢 - 噻吩并-2,3--D]嘧啶衍生物，其生产和使用
公开(公告)号：EP0988306B1
公开(公告)日：2003-07-09
申请号：EP98929405.3
申请日：1998-05-29
申请人： Abbott GmbH & Co. KG
发明人： STEINER, Gerd , DULLWEBER, Uta , STARCK, Dorothea , BACH, Alfred , WICKE, Karsten , TESCHENDORF, Hans-Jürgen , GARCIA-LADONA, Francisco-Javier , EMLING, Franz
IPC分类号： C07D495/04 , A61K31/495
CPC分类号： C07D495/04
摘要： The invention relates to 3-substituted 3,4 dihydro-thieno[2, 3-d] pyrimidine derivatives of formula (I) wherein R?1 and R2¿ mean a hydrogen atom or a C¿1?-C4 alkyl group, R?3¿ represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group optionally mono- or disubstituted by halogen atoms, C¿1?-C4 alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, C1-C4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups, said group being optionally anellated with a benzene nucleus which is optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, hydroxy, trifluoromethyl, C1-C4 alkoxy, amino, cyano or nitro groups and may contain optionally 1 nitrogen atom, or with a 5 or 6-membered ring which may contain 1-2 oxygen atoms, A represents NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z represents a nitrogen atom, carbon atom or CH and the bond between Y and Z can also be a double bond, and n is the number 2, 3 or 4. The invention also relates to the physiologically compatible salts of the inventive 3-substituted 3,4 dihydro-thieno[2,3-d] pyrimidine derivatives.

13. 发明授权

EP2217583B1 BENZENESULFONANILIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR 有权
标题翻译： BENZOLSULFONANILIDVERBINDUNGEN参与疾病治疗的适合ON血清素5-HT6受体应答的调节
公开(公告)号：EP2217583B1
公开(公告)日：2011-11-30
申请号：EP08845310.5
申请日：2008-10-31
申请人： Abbott GmbH & Co. KG , Abbott Laboratories
发明人： BRAJE, Wilfried , TURNER, Sean Colm , HAUPT, Andreas , LANGE, Udo , DRESCHER, Karla , WICKE, Karsten , UNGER, Liliane , MEZLER, Mario , WERNET, Wolfgang , MAYRER, Matthias , JONGEN-RELO, Ana Lucia , BESPALOV, Anton , ZHANG, Min
IPC分类号： C07D295/12 , C07D405/12 , A61K31/495 , A61K31/496 , A61P3/04 , A61P25/00 , A61P25/18 , A61P25/28 , A61P25/30
CPC分类号： C07D295/12 , C07D405/12
摘要： The present invention relates to novel benzenesulfonanilide compounds of the formulae I and I' and physiologically tolerated acid addition salts and the N-oxides thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. wherein R1 is hydrogen or methyl R2 is hydrogen or methyl R3 hydrogen, fluorine C1-C2 alkoxy or fluorinated C1-C2 alkoxy; R4 is hydrogen, C1-C4 alkyl or fluorinated C1-C4 alkyl; R5 is hydrogen, fluorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; and R6 is hydrogen, fluorine or chlorine.

14. 发明公开

EP2185555A1 QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR 有权
标题翻译：喹啉用于治疗疾病的血清素5-HT6受体调节RESPONSE
公开(公告)号：EP2185555A1
公开(公告)日：2010-05-19
申请号：EP08786942.6
申请日：2008-08-06
申请人： Abbott GmbH & Co. KG
发明人： TURNER, Sean, Colm , BRAJE, Wilfried , HAUPT, Andreas , LANGE, Udo , DRESCHER, Karla , WICKE, Karsten , UNGER, Liliane , MEZLER, Mario , WERNET, Wolfgang , MAYRER, Matthias
IPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61K31/4709 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel quinoline compounds of the formula (I) and to the salts thereof. The compounds possess valuable therapeutic properties and are particularly suitable, for treating diseases that respond to modulation of the serotonin 5-HT6 receptor. In formula (I) R is a moiety of the formula (R) wherein * indicates the binding site to the quinolinyl radical and wherein A, B, X', Y, Q, R1, R2, R3, R4, R5, m, n, p, q, Ra, Rb, X and Ar are as defined in claim 1.

15. 发明公开

EP1572698A1 3-SUBSTITUIERTE 3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDIN-4-ONE-DERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 有权
标题翻译： 3-取代的-3,4-二氢THIENO¬2,3-D嘧啶-4-酮衍生物，其生产和使用
公开(公告)号：EP1572698A1
公开(公告)日：2005-09-14
申请号：EP03813137.1
申请日：2003-12-17
申请人： Abbott GmbH & Co. KG
发明人： BAKKER, Margaretha , HORNBERGER, Wilfried , KLING, Andreas , LANGE, Udo , MACK, Helmut , MOELLER, Achim , MUELLER, Reinhold , SCHELLHAAS, Kurt , SCHMIDT, Martin , STEINER, Gerd , WICKE, Karsten
IPC分类号： C07D495/14 , A61K31/519 , A61P25/00
CPC分类号： C07D495/14
摘要： The invention relates to 3,4-dihydro-thieno[2,3-d]pyrimidinde-4-one-derivatives which are substituted at 3-position with 5-membered heteroaryl which can be condensed with an aryl or heteroaryl radical. The heteroaryl and, optionally, the condensed aryl or heteroaryl radical 1,2 or 3 can independently include selected substitutents from C1-5-alkyl, C1-5-alkoxy, C1-5-alkylthio, halogen, CN, halogen-C1-5-alkyl, halogen-C1-5alkoxy, hydroxy, -NH2, -N(R6)2, -NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl 1,2 or 3 independently include selected substituents from C1-5-alkythio, halogen, CN, halogen-C1-5-alkyl, halogen-C1-5alkoxy, hydroxy, -NH2, -N(R6)2 and -NH(R6). The invention also relates to the production and use of said derivatives, especially for therapeutical purposes, e.g. in the treatment of depression.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式