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11. 发明公开

EP2427771A1 METHODS FOR ANTIMICROBIAL RESISTANCE DETERMINATION 有权
标题翻译：法微生物耐药性的抗生素检测
公开(公告)号：EP2427771A1
公开(公告)日：2012-03-14
申请号：EP10718002.8
申请日：2010-05-06
申请人： Biomerieux, Inc
发明人： WALSH, John , HYMAN, Jones
IPC分类号： G01N33/569
CPC分类号： C12Q1/04 , C12Q1/025 , G01N33/56911
摘要： The present invention relates to methods and systems for determining the antibiotic-resistance status of microorganisms. The invention further provides methods for determining the antibiotic-resistance status of microorganisms in situ within a single system.

12. 发明公开

EP2364447A1 METHODS FOR THE ISOLATION AND IDENTIFICATION OF MICROORGANISMS 有权
标题翻译： VERFAHREN ZUR ISOLIERUNG UND IDENTIFIZIERUNG VON MIKROORGANISMEN
公开(公告)号：EP2364447A1
公开(公告)日：2011-09-14
申请号：EP09760033.2
申请日：2009-10-30
申请人： Biomerieux, Inc
发明人： WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
IPC分类号： G01N33/68 , C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be useful for the separation, characterization and/or identification of microorganisms from complex samples such as blood-containing culture media. The invention further provides methods for separating, characterizing and/or identifying microorganisms in situ within a single system.
摘要翻译：本发明涉及一种用于在测试样品中分离，表征和/或鉴定微生物的方法。本发明的方法包括用于裂解可能存在于测试样品中的非微生物细胞的任选裂解步骤，随后是随后的分离步骤。该方法可用于从诸如含血培养基的复杂样品中分离，表征和/或鉴定微生物。本发明还提供了在单个系统内原位分离，表征和/或鉴定微生物的方法。

13. 发明公开

EP2364356A1 METHODS FOR DETECTION, CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS IN A SEALED CONTAINER 有权
标题翻译：方法认证，适用于鉴别和/或鉴定微生物在密闭的容器
公开(公告)号：EP2364356A1
公开(公告)日：2011-09-14
申请号：EP09748538.7
申请日：2009-10-30
申请人： Biomerieux, Inc
发明人： WALSH, John , HYMAN, Jones , THORPE, Thurman , CLAY, Bradford
IPC分类号： C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N21/47 , G01N21/64 , G01N21/65 , G01N33/6848
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample. The method may be accomplished in a sealed container by utilizing a first step time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle that may be present in the sample. The method further provides for a subsequent step for the separation, characterizion and/or identification of the microorganisms in the sealed container.
摘要翻译：本发明提供了一种方法和系统，用于监测，检测和/或表征生物颗粒并可能存在于样品中。该方法可以在密闭容器内通过利用第一步骤中与时间相关的光谱技术，以获得生长成分的至少两个测量结果，包括用于生物颗粒的检测和/或表征的样品和相关所述的测量也可以是实现存在于样品英寸该方法还提供了用于在密闭容器的分离，characterizion和/或标识微生物的后续步骤。

14. 发明公开

EP2364218A1 SEPARATION DEVICE FOR USE IN THE SEPARATION, CHARACTERIZATION AND/OR IDENTIFICATION OF MICROORGANISMS 有权转让
标题翻译：分离器，用于使用在分离，鉴别和/或鉴定微生物
公开(公告)号：EP2364218A1
公开(公告)日：2011-09-14
申请号：EP09760034.0
申请日：2009-10-30
申请人： Biomerieux, Inc
发明人： WALSH, John , HYMAN, Jones , RONSICK, Christopher , LINK, John , ROBINSON, Ron , WILSON, Mark
IPC分类号： B01L3/14
摘要： The present invention is directed to a separation device or container that can be used in the separation, isolation or pelleting of microorganisms from a test samples known to contain or suspected of containing said microorganisms. Subsequently, the separated, isolated or pelleted microorganism sample can undergo one or more interrogation steps to provide measurements useful for the characterization and/or identification of microorganism. In one aspect of the present invention, the interrogation steps can occur in situ in the separation device or container described herein.
摘要翻译：本发明涉及一种分离设备或容器也可以在从已知含有或怀疑含有所述微生物的测试样品的分离，分离或微生物的造粒中使用。随后，分离的，分离的或丸状的微生物样品可以经历一个或多个询问步骤，以提供用于表征和/或微生物的鉴定有用的测量。在本发明的一个方面中，询问步骤，可以在所描述的分离设备或容器原位好发。

15. 发明公开

EP2334780A2 INCUBATION SYSTEM WITH LOW TEMPERATURE ENCLOSURE 有权
标题翻译：低温范围孵化
公开(公告)号：EP2334780A2
公开(公告)日：2011-06-22
申请号：EP09789051.1
申请日：2009-07-30
申请人： Biomerieux, Inc
发明人： FANNING, Mark, J. , YAM, Jacky , ROBBINS, David, M. , KETSENBURG, Kevin, G. , BISHOP, James, C.
IPC分类号： C12M1/00
CPC分类号： B23P6/00 , C12M41/14 , Y10T29/49716
摘要： An incubator is fitted with an enclosure which surrounds the incubator. A cold air generation system supplies relatively cold air to a space formed between enclosure and the incubator. The system supplying the cold air can be embodied in a cart or base upon which the incubator sits. The enclosure is also placed on the base in a manner such that it substantially envelops the incubator. The top of the cart has openings for egress of cold air and return of air so that air may circulate in a closed loop. The incubator, cold air supply system and enclosure present a solution for incubating samples in a nominal 20-25°C temperature environment. The enclosure, which is preferably insulated, may include a void or opening which exposes doors or other access device of the incubator, allowing direct access to the samples in the incubator while the rest of the incubator is enveloped by the enclosure.

16. 发明授权

EP1252191B1 ANTIBODIES TO SUBERIC ACID CROSSLINKERS AND METHODS FOR USING THE SAME 有权
标题翻译：抗体SUBERSÄURE-CROSS左派及其应用
公开(公告)号：EP1252191B1
公开(公告)日：2008-06-11
申请号：EP00978502.3
申请日：2000-11-10
申请人： Biomerieux, Inc.
发明人： SARNGADHARAN, Mangalasseril, G. , PAL, Ranajit , DEVICO, Anthony, L.
IPC分类号： C07K16/44 , G01N33/53 , C12N15/11 , C12Q1/68
CPC分类号： C07K16/44 , Y10S530/809
摘要： The present invention is directed to the discovery of antibodies that will react to proteins or nucleic acids bound to particular suberic acid crosslinkers, but not to the free crosslinkers or free proteins or nucleic acids. Monoclonal antibodies with such binding specificity have widespread applications in receptor-ligand binding, immunodiagnostic and nucleic acid diagnostics.

17. 发明公开

EP1678506A1 SEALER FOR TEST SAMPLE DEVICES 有权
标题翻译： VERSCHLUSSGERÄTFÜRTESTPROBENVORRICHTUNGEN
公开(公告)号：EP1678506A1
公开(公告)日：2006-07-12
申请号：EP04781140.1
申请日：2004-08-13
申请人： Biomerieux, Inc.
发明人： BISHOP, James, Clement , JUSTIN, Michael, James , FANNING, Mark, Joseph
IPC分类号： G01N35/00 , G01N35/02 , G01N1/00
CPC分类号： G01N35/00029 , G01N2035/00148 , G01N2035/0465 , Y10T156/1313 , Y10T436/115831 , Y10T436/12
摘要： A sealer for a sample testing instrument is disclosed that cuts and seals a fluid conduit that connects a test sample device with a fluid receptacle containing a fluid sample. The sealer includes an enclosure and a protective shield to protect a user or technician from contact with the cutting element assembly in the sealer. The cutting element assembly includes a spring-loaded element that engages the test sample device and holds it in a fixed position while a cutting element (e.g., hot wire) cuts the fluid conduit. A motor driving the cutting element assembly is positioned at an angle having both vertical and horizontal components, whereby adjustment of the motor firmware allows for adjustment of the position of the cutting element relative to the instrument in both horizontal and vertical directions.
摘要翻译：公开了一种用于样品测试仪器的密封器，其用于切割和密封将测试样品装置与含有流体样品的流体容器连接的流体导管。密封件包括外壳和保护罩，用于保护使用者或技术人员不与密封件中的切割元件组件接触。切割元件组件包括弹簧加载元件，其接合测试样品装置并将其保持在固定位置，同时切割元件（例如热丝）切割流体导管。驱动切割元件组件的马达定位成具有垂直和水平分量的角度，由此马达固件的调整允许在水平和垂直方向上调节切割元件相对于乐器的位置。

18. 发明授权

EP1309857B1 A METHOD FOR DETECTING A LIPOPROTEIN-ACUTE PHASE PROTEIN COMPLEX 有权
标题翻译：检测方法的脂蛋白急性期蛋白复合物
公开(公告)号：EP1309857B1
公开(公告)日：2005-08-24
申请号：EP01944378.7
申请日：2001-06-08
申请人： Biomerieux, Inc.
发明人： FISCHER, Timothy, J. , DOWNEY, Colin , NESHEIM, Mike , SAMIS, John, A. , TEJIDOR, Liliana , TOH, Cheng, Hock , WALKER, John, B.
IPC分类号： G01N33/49
CPC分类号： G01N33/557 , G01N33/86 , G01N33/92 , G01N2800/52 , Y10T436/25
摘要： A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample from the patient, in order to cause formation of a complex comprising at least one acute phase protein at at least one human lipoprotein, while causing substantially no fiber polymerization; (b) measuring the formation of the complex over time so as to derive a time-dependent measurement profile, and (c) determining a slope and/or total change in the time-dependent measurement profile, so as to diagnose a condition of the patient. A greater formation of the complex is correlated to increased probability of death of the patient.

19. 发明公开

EP1436628A2 A METHOD FOR PREDICTING AN INCREASED LIKELIHOOD OF ANTIPHOSPHOLIPID SYNDROME IN A PATIENT 审中-公开
标题翻译：用于预测患者中的抗磷脂综合征的可能性增加
公开(公告)号：EP1436628A2
公开(公告)日：2004-07-14
申请号：EP02806824.5
申请日：2002-06-28
申请人： BioMerieux, Inc. , Duke University
发明人： ORTEL, Thomas, L. , SU, Zuowei , BRAUN, Paul, J. , TEJIDOR, Liliana
IPC分类号： G01N33/92 , G01N33/557 , G01N33/68 , G01N33/86 , G01N21/47 , G06F19/00
CPC分类号： G01N33/92 , G01N21/47 , G01N21/77 , G01N33/557 , G01N33/6854 , G01N33/6893 , G01N33/86 , G01N2021/7773 , G01N2021/7783 , G06F19/00 , G16H10/40 , G16H15/00 , G16H40/63 , G16H50/20
摘要： A method for predicting that an individual has antiphospholipid syndrome or an increased likelihood of having antiphospholipid syndrome, includes: a) providing a test sample from an individual; b) combining the test sample with phospholipids; c) directing a light beam at the test sample and monitoring light scattering or transmittance over time so as to provide a time-dependent measurement profile; d) determining if a value or a slope at or over a particular time in the time-dependent measurement profile is beyond a corresponding predetermined value or slope threshold; and if the value or slope in the time-dependent measurement profile is beyond the predetermined threshold, then determining that the individual has antiphospholipid syndrome or an increased risk of antiphospholipid syndrome. The phospholipids can be provided as part of a coagulation reagent, or as part of a reagent where coagulation is not activated. Confirmatory assays for particular antibodies to phospholipid binding proteins can be performed.

20. 发明公开

EP1146961A1 DISPOSABLE TEST DEVICES FOR PERFORMING NUCLEIC ACID AMPLIFICATION REACTIONS 有权
标题翻译：试验装置进行核酸扩增反应
公开(公告)号：EP1146961A1
公开(公告)日：2001-10-24
申请号：EP00967055.5
申请日：2000-09-29
申请人： Biomerieux, Inc.
发明人： KLUTTZ, Brian , BURG, Lawrence , TEGELER, Garry , GRAZIANO, Louis , COTTER, Christopher , GUY, Michel , GREER, James , MCKINLEY, Geoff, A. , CATANZARITI, Luigi , GLASSFIELD, Robert , BISHOP, James, Clement , COLIN, Bruno , PARIS, Cecile , WANG, Thomas , MORIN, Michael
IPC分类号： B01L3/00
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/026 , B01L2300/0825 , B01L2300/0861 , B01L2400/049 , B01L2400/0644 , B01L2400/0655 , G01N2035/00366
摘要： A unit dose test device for a nucleic acid amplification reaction has the form of an elongate disposable test strip. The test strip includes a dual-chamber reaction vessel preloaded with nucleic acid amplication reaction agents, a plurality of wells for processing a reaction occuring in the reaction vessel, and a hinge cover above a membrane, sealing both reaction chambers. A desiccant is loaded in proximity to and in communication with first or second reaction chamber.

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