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    • 11. 发明公开
    • EP0675917A4 -
    • EP0675917A4 - Google专利
    • EP0675917A4
    • 1995-11-08
    • EP94903293
    • 1993-11-29
    • US NAVY
    • C08F299/08C08F2/46C08F290/00C08G77/48C08G77/50C08G77/56C08G79/00C08G79/08
    • C08G77/50C08G77/56
    • This invention relates to a new class of novel inorganic-organic hybrid polymers that are formed from linear inorganic-organic hybrid polymers of varying molecular weight. These new high temperature oxidatively stable thermosetting polymers are formed from linear polymeric materials having repeat units that contain at least one alkynyl group for cross-linking purposes and at least one bis(silyl or siloxanyl)carboranyl group. These novel organoboron thermoset polymers contain an unsaturated cross-linked hydrocarbon moiety. These inorganic-organic hybrid polymers can be further converted into ceramics at elevated temperatures to prepare engine parts, turbine blades and matrices.
    • 本发明涉及由不同分子量的线型无机 - 有机杂化聚合物形成的一类新型无机 - 有机杂化聚合物。 这些新的高温氧化稳定的热固性聚合物由具有重复单元的线性聚合物材料形成,所述重复单元包含至少一个用于交联目的的炔基和至少一个双(甲硅烷基或硅氧烷基)碳硼烷基。 这些新型有机硼热固性聚合物含有不饱和交联烃部分。 这些无机 - 有机杂化聚合物可以在高温下进一步转化成陶瓷以制备发动机部件,涡轮叶片和基体。
    • 13. 发明公开
    • PROTECTIVE MALARIA SPOROZOITE SURFACE PROTEIN IMMUNOGEN AND GENE
    • 保护性疟疾SPOROZOITE表面蛋白质免疫原和基因
    • EP0522136A4
    • 1993-07-14
    • EP92904372
    • 1992-01-03
    • US NAVY
    • HOFFMAN, STEPHEN, L.CHAROENVIT, YUPINHEDSTROM, RICHARDKHUSMITH, SRISINROGERS, WILLIAM, O., IV
    • A61K39/00C07K14/445C12N15/30A61K37/02C07K5/00C07K7/00
    • C07K14/445A61K39/00
    • A protein antigen (SSP2) on the surface of Plasmodium sporozoites is disclosed as a candidate immunogen for vaccination against malaria. This use of this protein, which is distinct from the extensively characterized circumsporozoite (CS) protein, will also facilitate research into host immunological responses to malaria. This antigen is detected by a monoclonal antibody (NYS4) which is specific for a 140 kilodalton (kD) protein on the sporozoite cell surface. Immunoreactive genomic clones are described which express this surface antigen gene and the primary nucleic acid sequence and the deduced amino acid sequence derived from this DNA sequence are disclosed. Unique repetitive sequences of amino acids are described which further demonstrate the distinction between SSP2 and the CS protein. A synthetic peptide containing repeating epitopes of SSP2 derived protein antigen and which are substantially shorter in length than the intact antigen are disclosed. The peptide when administered to a host elicits antibodies which bind to the SSP2 protein on the sporozoite surface. A recombinant plasmid bearing SSP2 DNA sequences expresses SSP2 epitopes in mammalian cells and the introduction of these transfected cells into mice elicits antibody and cytotoxic T-cell lymphocytic responses which confer partial protection to the recipient animals against challenge infection. In combination, the SSP2 protein and the CS protein elicit immunological responses in the mammalian host which confer 100% protection against challenge infection.