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11. 发明公开

EP1090283A1 RESPONSE ASSESSMENT 有权
标题翻译：回答判断
公开(公告)号：EP1090283A1
公开(公告)日：2001-04-11
申请号：EP99926664.6
申请日：1999-06-24
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： LLOYD, Christopher James
IPC分类号： G01N21/64
CPC分类号： G01N21/6408
摘要： A method and apparatus for assessing the characteristic response of a medium to an excitation transient of predetermined duration which causes the medium to emit a series of signals over a period of time which is long relative to the duration of the excitation transient. The signals are detected and the duration of each interval between successive signals is measured. A relationship relating the interval between the excitation transient and the emission of each signal to the interval between each signal and the preceding signal in the series is derived to represent the characteristic response. The interval between the excitation transient and the emission of each signal may be plotted against the interval between each signal and the preceding signal in the series and a curve may be fitted to that plot. The position of a minimum value of the interval between the excitation transient and the emission of each signal as represented by the curve is then determined, and the interval between successive signals corresponding to the position of the minimum is then determined to provide a measure of the characteristic response of the medium. The excitation transient may be a pulse.

12. 发明公开

EP1066327A2 EXPRESSION OF FUSION PROTEINS 审中-公开
标题翻译：表达融合蛋白
公开(公告)号：EP1066327A2
公开(公告)日：2001-01-10
申请号：EP99901731.2
申请日：1999-01-18
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： HAWKINS, Robert, Edward , WHITTINGTON, Hayley, Ann,Bristol Oncology Centre
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K38/00 , A61K48/00 , C07K14/535 , C07K14/55 , C07K16/3007 , C07K16/44 , C07K2319/00 , C12N2799/022
摘要： This invention provides a method of producing a fusion protein comprising an antibody portion and a further biologically active portion, the method comprising forming a virus-based construct including a DNA sequence encoding the fusion protein and infecting cells or an organism with the thus constructed virus-based construct whereby the fusion protein is expressed in in vitro in the cells, or in vivo in the organism.

13. 发明公开

EP0930876A2 USE OF SEX STEROID FUNCTION MODULATORS TO TREAT WOUNDS AND FIBROTIC DISORDERS 失效
标题翻译：使用的物质属于哪一雌激素影响PROMOTE伤口的治疗
公开(公告)号：EP0930876A2
公开(公告)日：1999-07-28
申请号：EP97932922.0
申请日：1997-07-22
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： FERGUSON, Mark, William, James , ASHCROFT, Gillian, Sarah
IPC分类号： A61K45 , A61K31 , A61P17
CPC分类号： A61K31/573 , A61K31/05 , A61K31/135 , A61K31/138 , A61K31/167 , A61K31/222 , A61K31/4184 , A61K31/4196 , A61K31/56 , A61K31/565 , A61K31/566 , A61K31/567 , A61K31/568 , A61K31/5685 , A61K31/569 , A61K31/57 , A61K31/575 , A61K31/58 , Y10S514/928
摘要： The present application relates to the use of compounds that influence the sex hormone system for the treatment of wounds and/or fibrotic disorders. Preferred compounds for use in such treatments are steroid hormones and especially the oestrogens.

14. 发明授权

EP0675678B1 METHOD OF HATCHING AVIAN EGGS 失效转让
标题翻译：法鸟类孵化蛋
公开(公告)号：EP0675678B1
公开(公告)日：1998-07-29
申请号：EP94902876.5
申请日：1993-12-16
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： FERGUSON, Mark William James
IPC分类号： A01K67/02 , A01K41/00
CPC分类号： A01K41/00 , A01K67/02
摘要： A method of hatching eggs of avian species, especially chickens, which comprises carrying out at least one cycle of steps (a) to (c) as follows: (a) incubating the eggs in a first, baseline ambient environment which is normal for hatchery incubation of the eggs of the avian species in the prevailing climatic conditions and then during a sex-sensitive time window of embryonic development, (b) altering the ambient environment to shifted conditions for a period of time effective to bias the normal phenotypic sex ratio of the embryos, without significant adverse effect on the average mortality rate, and (c) thereafter restoring the incubation conditions to or towards normal and allowing the eggs to hatch. Preferably the ambient environment comprises a temperature of 37.5-38 DEG C and the shifted conditions comprise reduced temperature, especially a temperature maintained at about 22 DEG C for a period of from 18 to 42 hours. The method may be used to produce birds which are chromosomally male (ZZ) but phenotypically female or chromosomally female (ZW) but phenotypically male.

15. 发明授权

EP0741796B1 SENSOR DEVICE 失效
标题翻译：传感器装置
公开(公告)号：EP0741796B1
公开(公告)日：1998-06-10
申请号：EP95906425.4
申请日：1995-01-25
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： TRELOAR, Paul, Howard , CHRISTIE, Ian, Mcintyre , VADGAMA, Pankaj, Maganlal
IPC分类号： C12Q1/00 , G01N27/333
CPC分类号： C12Q1/002 , G01N27/3271
摘要： A sensor device (1) for detecting a predetermined component present in a fluid sample (6) and providing an output representative thereof. The device (1) comprises a permselective membrane (2) incorporating a charged organic species. The membrane (2) is at least partially impermeable to charged substantially non-lipophilic species that may be present in the sample. The sensor (1) further incorporates an electrode arrangement (3, 4) in intimate contact with the membrane (2) but not exposed to the side thereof to be presented to the fluid sample (6).

16. 发明公开

EP0845038A1 DEUTERIATED SUBSTANCES 失效
标题翻译：氘化物质
公开(公告)号：EP0845038A1
公开(公告)日：1998-06-03
申请号：EP96927785.0
申请日：1996-08-14
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： BARBER, Jill
IPC分类号： C12N15 , C07K14 , C12N1 , C12P21 , C12R1
CPC分类号： C12P21/02 , C07K14/245 , C12N1/20 , C12N1/36
摘要： The present invention provides a method for producing a substantially deuteriated substance comprising the steps of growing on a deuteriated medium an organism producing the substance, wherein the organism has been adapted to deuteriated medium such that on a deuteriated medium it produces approximately the same quantity of the deuteriated substance as the non-adapted organism produces of the non-deuteriated substance on a non-deuteriated medium. Also provided are substances produced according to the method of the present invention, MRE600 for use in a method of production of a substantially deuteriated substance, and substantially deuteriated EFTu having a substantially greater half-life in the presence of chymotrypsin in protiated media than protiated EFTu.

17. 发明公开

EP0845007A2 PHARMACEUTICAL COMPOSITION CONTAINING INHIBITORS OF INTERFERON-GAMMA 失效
标题翻译：药物组合物含干扰素γ抑制剂
公开(公告)号：EP0845007A2
公开(公告)日：1998-06-03
申请号：EP96927141.0
申请日：1996-08-09
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： FERGUSON, Mark, William, James
IPC分类号： A61K45 , A61K31 , A61K38 , A61K39 , A61P17 , C07K16
CPC分类号： C07K16/249 , A61K38/217 , A61K2039/505
摘要： The present invention provides compositions and methods for promoting the healing of wounds or fibrotic disorders with reduced scarring, comprising inhibitors and inhibiting IFN-η, together with compositions and methods for promoting the healing of chronic wounds, comprising stimulating and stimulators of IFN-η.

18. 发明授权

EP0548150B1 ENZYME ELECTRODES WHEREIN THE ENZYME IS ENCLOSED WITHIN LIPOSOMES 失效
标题翻译：其中在脂质体中的酶包括酶电极
公开(公告)号：EP0548150B1
公开(公告)日：1997-12-03
申请号：EP91916040.8
申请日：1991-09-12
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： VADGAMA, Pankaj Madganlal , ROSENBERG, Mark Franklyn , JONES, Malcolm Norcliffe
IPC分类号： G01N27/327 , C12M1/40
CPC分类号： C12Q1/002
摘要： Enzyme electrodes with the enzyme enclosed within liposomes, which are preferably supported on or in a membrane and immobilised there, for example in the membrane pores. The liposomes may be made using lipids (especially phospholipids) and conveniently by 'reverse phase evaporation'. They may incorporate conventional electrode elements, e.g. the Clark electrode pair (Platinum/Silver) and additional membranes or screens, and used particularly in amperometric measurements. They are preferably used near the phase transition temperature of the lipid and give improved selectivity and facility to measure higher concentrations of active components in the analyte. The enzyme is preferably an oxidase (e.g. glucose oxidase) and useful for measurement (directly or indirectly) of low molecular weight species e.g. hydrogen peroxide generated by enzymic action, and effective for study of biological fluids e.g. blood. Also, modified membranes and electrolytic sensors using the liposome-enclosed enzymes.

19. 发明授权

EP0705368B1 REDUCTION OF OPENNESS OF MATERIALS 失效转让
标题翻译： VERMINDERUNG DERPOROSITÄTVON MATERIALIEN
公开(公告)号：EP0705368B1
公开(公告)日：1997-09-17
申请号：EP94917108.6
申请日：1994-06-08
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： TALLENTIRE, Alan , SINCLAIR, Colin, Samuel
IPC分类号： D21H27/08 , D21H21/54 , D06M15/693 , D06M23/12 , B01J20/28
CPC分类号： B01J20/28019 , B01D39/083 , B01D2239/0241 , B01D2239/0407 , B01D2239/045 , B01D2239/0618 , B01D2239/0627 , B01J20/28004 , B01J20/28028 , B01J20/28033 , B01J20/28069 , B01J47/018 , D04H3/007 , D04H3/02 , D06M15/693 , D06M23/00 , D06M23/12 , D21H21/54 , D21H27/08 , Y10T428/1352 , Y10T428/249955 , Y10T428/249994 , Y10T428/249999 , Y10T428/29 , Y10T428/2907 , Y10T428/2938
摘要： A material, which may have a highly open structure such that it has negligible barrier properties, is treated with expandable particles. These are then caused to expand within the material, reducing its openness and improving its barrier properties. The product may be a porous material. The pores may be modified by an agent applied together with the particles or after the expansion. The particles may be thermoplastic microspheres containing gas. The material may be a network material, with a 3-D fibre matrix with many voids.
摘要翻译： PCT No.PCT / GB94 / 01236 Sec。 371日期：1996年5月15日 102（e）日期1996年5月15日PCT提交1994年6月8日PCT公布。第WO94 / 29525号公报日期1994年12月22日可以具有高度开放结构以使其具有可忽略的阻隔性的材料用可膨胀颗粒处理。然后使其在材料内膨胀，降低其开放性并改善其阻隔性能。产品可以是多孔材料。可以通过与颗粒一起施加的试剂或膨胀之后来修饰孔。颗粒可以是含有气体的热塑性微球。材料可以是具有许多空隙的纤维基质的网状材料。

20. 发明授权

EP0652941B1 SENSOR DEVICES 失效
标题翻译：传感器设备
公开(公告)号：EP0652941B1
公开(公告)日：1996-09-18
申请号：EP93917907.3
申请日：1993-07-23
申请人： THE VICTORIA UNIVERSITY OF MANCHESTER
发明人： VADGAMA, Pankaj Madganlal , CHRISTIE, Ian McIntyre , BENMAKROHA, Yazid Mouloud
IPC分类号： C12M1/40 , G01N27/40 , G01N27/30
CPC分类号： C12Q1/002
摘要： Sensor devices for detecting components in fluid samples, especially by electrolytic analytical methods, comprising a detecting means (usually an anode, especially one of platinum) surrounded by a selectively permeable membrane barrier composed of a mixture of polyvinyl chloride and polyaryl sulphone polymers. Preferred proportions of the polymers are 1 to 9 parts of polyaryl sulphone for each part of polyvinyl chloride, and the mixture may be formed into membranes by solution casting. Preferably this barrier is used with an inner membrane, especially of porous polycarbonate. In use, these polymer mixtures are especially useful in their selective permeability to glucose. Also provided are methods for their use in analysis, and the polyvinyl chloride/polyaryl sulphone polymer compositions themselves and membranes made from them.

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