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11. 发明授权

EP2610813B1 Biomarker evaluation through image analysis 失效转让
公开(公告)号：EP2610813B1
公开(公告)日：2019-08-07
申请号：EP12189735.9
申请日：2012-10-24
申请人： Definiens AG
发明人： Binnig, Gerd , Athelogou, Maria , Schmidt, Günter
IPC分类号： G06T7/00 , G06T7/11

12. 发明授权

EP3223236B1 SYSTEM FOR PREDICTING THE RECURRENCE OF CANCER IN A CANCER PATIENT 有权转让
公开(公告)号：EP3223236B1
公开(公告)日：2019-07-31
申请号：EP17159881.6
申请日：2017-03-08
申请人： Definiens AG
发明人： HARDER, Nathalie , ATHELOGOU, Maria
IPC分类号： G06T7/00

13. 发明公开

EP3387155A1 METHODS FOR TREATMENT AND SELECTION OF PATIENTS RESPONSIVE TO IMMUNE MEDIATED CANCER THERAPY 审中-公开
公开(公告)号：EP3387155A1
公开(公告)日：2018-10-17
申请号：EP16873900.1
申请日：2016-12-09
申请人： Definiens AG , MedImmune, LLC
发明人： BINNIG, Gerd , ALTHAMMER, Sonja , SCHMIDT, Gunter , HIGGS, Brandon , STEELE, Keith
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57423 , A61K2039/505 , A61P35/00 , C07K16/2827 , C07K2317/21 , C12Q1/68 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： Provided herein are methods of treating a tumor comprising administering an effective amount of one or more immune-mediated cancer therapies, including durvalumab (MEDI4736) or an antigen-binding fragment thereof. Analysis of tumor sample sections using image analysis and gene expression identified patients for which immune-mediated cancer therapy would be effective. Durvalumab was effective at treating non-small cell lung cancers characterized by image analysis using tumor cell and immune cell markers (e.g., PD-Lq1 and CD8) and gene expression (e.g. IFN#).

14. 发明公开

EP3200152A2 EVALUATION OF CO-REGISTERED IMAGES OF DIFFERENTLY STAINED TISSUE SLICES 审中-公开
标题翻译：对不同染色的组织切片的共同注册图像的评估
公开(公告)号：EP3200152A2
公开(公告)日：2017-08-02
申请号：EP17161436.5
申请日：2012-12-18
申请人： Definiens AG
发明人： SCHÖNMEYER, Ralf , BINNIG, Gerd , SCHMIDT, Günter , ATHELOGOU, Maria , ELLENBERG, Peter
IPC分类号： G06T7/00 , G06T7/33 , G06K9/00
CPC分类号： G06K9/0014 , G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.
摘要翻译：用于对用不同生物标志物染色的组织切片的图像进行配准的方法在图形用户界面上显示第一组织切片的第一数字图像，使得第一图像的区域被框围绕。然后显示第二组织切片的第二图像的一部分，使得由该帧包围的第一图像的区域与第二图像的显示部分共同配准。第二图像的显示部分具有框架的形状。组织切片都是在x和y维度的相应位置拍摄的组织样本的z切片。当用户在框架下移动第一图像时，第二图像的显示部分在x和y维度上被移位以与被框架包围的第一图像的区域重合。

15. 发明公开

EP2936431A1 IMPROVED GLEASON GRADING BY SEGMENTING AND COMBINING CO-REGISTERED IMAGES OF DIFFERENTLY STAINED TISSUE SLICES 有权转让
标题翻译：改进格里森分级方法分割和组合CO-登记的图像不同颜色的布DISCS
公开(公告)号：EP2936431A1
公开(公告)日：2015-10-28
申请号：EP13782715.0
申请日：2013-10-24
申请人： Definiens AG , Ludwig-Maximilians-Universität München
发明人： ATHELOGOU, Maria , KIRCHNER, Thomas , HESSEL, Harald , BINNIG, Gerd
IPC分类号： G06T7/00
CPC分类号： G06K9/00127 , G06T7/0012 , G06T7/174 , G06T2207/10056 , G06T2207/30024 , G06T2207/30081 , G06T2207/30242
摘要： An improved histopathological score is obtained by generating image objects from images of tissue containing stained epithelial cells. First objects are generated that correspond to basal cells stained with a first stain, such as p63. Second objects are generated that correspond to luminal cells stained with a second stain, such as CK18. If the same tissue is not stained with both stains, then the images of differently stained tissue are co-registered. Third objects are defined to include only those second objects that have more than a minimum separation from any first object. A scoring region includes the third objects, and the histopathological score is determined based on tissue that falls within the scoring region. For example, a Gleason score of prostate tissue is determined by classifying tissue patterns in the scoring region. Alternatively, a Gleason pattern is assigned by counting the number of third objects that possess a predetermined form.

16. 发明公开

EP2608150A2 Evaluation of co-registered images of differently stained tissue slices 审中-公开
标题翻译：不同颜色的组织切片的图像coregistrierten评价
公开(公告)号：EP2608150A2
公开(公告)日：2013-06-26
申请号：EP12197658.3
申请日：2012-12-18
申请人： Definiens AG
发明人： Schönmeyer, Ralf , Binnig, Gerd , Schmidt, Günter , Athelogou, Maria , Ellenberg, Peter
IPC分类号： G06T7/00
CPC分类号： G06K9/0014 , G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.

17. 发明公开

EP2546802A2 Generating artificial hyperspectral images using correlated analysis of co-registered images 有权转让
标题翻译：分析冯·克里斯蒂安
公开(公告)号：EP2546802A2
公开(公告)日：2013-01-16
申请号：EP12176077.1
申请日：2012-07-12
申请人： Definiens AG
发明人： Schönmeyer, Ralf , Ellenberg, Peter , Binnig, Gerd , Athelogou, Maria , Schmidt, Günter
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T11/206 , G06T2207/10061 , G06T2207/20016 , G06T2207/20021 , G06T2207/20221
摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.
摘要翻译：获取组织样本的相邻切片的高分辨率数字图像，并且在图像中定义瓦片。计算与每个图块中检测到的图像对象相关联的值。相邻图像中的图块共同注册。使用第一图像生成第一高光谱图像，并且使用第二图像生成第二高光谱图像。第一高光谱图像的第一像素具有对应于使用第一图像中的图块分析图像分析获得的局部值的第一像素值。第二高光谱图像的第二像素具有对应于从第二图像中的图块计算的局部值的第二像素值。通过组合第一和第二高光谱图像来生成第三高光谱图像。然后，使用使用第一和第二像素值生成的伪色编码，在计算机监视器上显示第三高光谱图像。

18. 发明公开

EP1299847A2 VERFAHREN ZUM VERARBEITEN VON MEHREREN UNTERSCHIEDLICHEN DATENSTRUKTUREN 有权
标题翻译：一种用于处理几个不同的数据结构的
公开(公告)号：EP1299847A2
公开(公告)日：2003-04-09
申请号：EP01953192.0
申请日：2001-07-06
申请人： Definiens AG
发明人： ATHELOGOU, Maria
IPC分类号： G06F19/00
CPC分类号： G06N5/02
摘要： A method for the processing of structurally different data structures with differing content by means of mutually-networked semantic units is disclosed. Said method comprises the following steps, a recording of data, from which the various data structures may be derived, each data structure is displayed in each mutually-networked set of semantic structural units and a creation, analysis, modification, erasure and/or storage of the semantic structural units and/or the networking thereof is performed, based on the recorded data, by using a knowledge base derived from a network of semantic knowledge units. The semantic structural units and/or the networking thereof is thus classified in iterative steps and, based on said classification, a specific processing may be activated, which modifies a particular semantic structural unit and/or a particular partial network.

19. 发明公开

EP1117083A3 Verfahren zur dezentralen Übertragung und Verteilung von Nutzdaten zwischen Teilnehmern eines Telekommunikationsnetzwerkes 有权
标题翻译：一种用于电信网络的用户之间的分散传输和用户数据的分发处理
公开(公告)号：EP1117083A3
公开(公告)日：2002-10-02
申请号：EP00124556.2
申请日：2000-11-09
申请人： Definiens AG
发明人： Kiendl, Robert
IPC分类号： G08G1/09 , H04L12/56
CPC分类号： H04L45/04 , H04L45/02 , H04L45/26 , H04L45/36 , H04L45/44 , H04W40/20 , H04W88/04 , H04W92/18
摘要： Beim Kommunikationsverfahren nach der Erfindung werden die Nutzdaten zwischen Teilnehmern (A, B) iterativ weitergeleitet, wobei die Nutzdatenkommunikation Auslöser für eine Kommunikation zweiter Ordnung (Explorer-Kommunikation) ist, mittels der Netzwerkstrukturdaten ermittelt und/oder aufgefrischt werden. Die Explorer-Daten werden iterativ auf derselben oder einer anderen Kommunikationsinfrastruktur übertragen wie die Nutzdaten, wobei die Daten bei der Übermittlung in unveränderter oder aufbereiteter Form weitergegeben werden. Die Explorer-Daten beinhalten explizite Anfragen über Netzwerkstrukturdaten und können somit aktiv die Herbeischaffung von Netzwerkstrukturdaten anstoßen. Geeignete Kommunikationspfade (a, b, c) zur iterativen Nutzdatenweiterleitung werden anhand der Netzwerkstrukturdaten berechnet, welche lokal insbesondere aufgrund früherer Kommunikationsprozesse bereits zur Verfügung stehen oder welche durch Anfragen herbeigeschafft werden. Das Verfahren nach der Erfindung kann bei kapazitätsbegrenzten oder/und strukturierten Telekommunikationsnetzwerken Anwendung finden.

20. 发明授权

EP0870275B1 VERFAHREN ZUR MUSTERERKENNUNG UND VERFAHREN ZUM ERSTELLEN EINES N-DIMENSIONALEN OBJEKTES 失效
标题翻译：法用于模式识别AND METHOD FOR CREATING A N的三维物体
公开(公告)号：EP0870275B1
公开(公告)日：2002-06-12
申请号：EP96905681.1
申请日：1996-03-04
申请人： Definiens AG.
发明人： ENTLEITNER, Renate , SÖGTROP, Michael
IPC分类号： G06K9/52
CPC分类号： G06K9/52
摘要： The invention concerns a method of pattern recognition in which the pattern of an n-dimensional object is captured by a data-processing device which can image and process the n-dimensional object with different degrees of precision (s) within a computer. The invention comprises the following steps: the n-dimensional object is imaged in the computer with at least two different degrees of precision (s); at least one parameter (U) of the n-dimensional object is determined by integration or summation for each imaged degree of precision (s); and the functional dependency (U(s)) of the integrated or summed parameter or parameters on the degree of precision (s) is determined and used as a measure for the pattern to be recognized. The pattern-recognizing method according to the invention is likewise based on these method steps.

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