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    • 20. 发明公开
    • Compounds useful to treat premature aging and in particular progeria
    • 组合物过早老化的治疗和在使用中的特定哈钦森-吉尔福德综合征
    • EP2261214A1
    • 2010-12-15
    • EP09162630.9
    • 2009-06-12
    • Splicos SasCNRS (Centre National de La Recherche Scientifique)Institut CurieUniversité Montpellier 2
    • Mahuteau, FlorenceTazi, JamalNajman, Romain
    • C07D215/38C07D401/12A61K31/33A61P43/00
    • C07D401/12C07D215/38
    • The present invention relates to a compound of formula (I):

      wherein:

      means an aromatic ring wherein V is C or N and when V is N, V is in ortho, meta or para of Z, i.e. forms respectively a pyridazine, a pyrimidine or a pyrazine group,
      R independently represents a hydrogen atom, a halogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a -CN group, a -COOH group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a -NO 2 group, a -NR 1 R 2 group and a (C 1 -C 3 )alkoxy group,
      R 1 and R 2 are independently a hydrogen atom or a (C 1 -C 3 )alkyl group,
      n is 1 or 2,
      R' is a hydrogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a halogen atom, a hydroxy group, a -COOH group and a -CN group,
      R" is a hydrogen atom or a (C 1 -C 4 )alkyl group,
      Z is N or C,
      Y is N or C,
      X is N or C,
      W is N or C,

      and wherein at most two of the groups Z, Y, X and W are N,
      or anyone of its pharmaceutically acceptable salt,
      for use as an agent for preventing, inhibiting or treating pathological or nonpathological conditions linked with premature aging.
    • 本发明涉及式(I)的化合物:worin:芳环worinⅤ的手段是C或N,并且当V是N,V是在邻位,间位或Z的对位,即 分别形成哒嗪,嘧啶或吡嗪基,R独立地darstellt氢原子,卤原子或(C 1 -C 3)烷基,-CN基,-COOH基,一个中选择的基团( C 1 -C 3)氟烷基,(C 1 -C 3)氟烷基,-NO 2基,-NR 1 R 2基团和(C 1 -C 3)烷氧基,R 1和R 2 独立地为氢原子或(C 1 -C 3)烷基基团,n是1或2,R“为氢原子或(C 1 -C 3)中选择的烷基基团,一个卤素原子,一个基团 羟基基团,-COOH基团和-CN基团,R“是氢原子或(C 1 -C 4)烷基基团,Z为N或C,Y是N或C,X为N或C,W 是N或C,以及worin至多两个基团Z,Y,X和W的为N,或其药学上可接受的盐中的任何一个,其用作用于预防,抑制性或治疗与过早老化联的病理或nonpathological条件的试剂 ,